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Specialty: Cardiology
Procedure: Transplants
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Total 261 results found since Jan 2013.
Troubleshooting Left Ventricular Assist Devices: Modern Technology and Its Limitations
AbstractPurpose of reviewAs the incidence of heart failure continues to rise, modern generation left ventricular assist devices (LVADs) have become the primary therapeutic modality used as both bridge to transplant (BTT) and destination therapy (DT) in patients with acute and chronic heart failure. This review aims to highlight the progression of LVAD technology, outline LVAD complications and manifestations, and provide evidence-based therapeutic methods to troubleshoot such adverse events.Recent findingsDespite modern innovation, LVAD adverse events continue to hinder the progress of HF paradigms and are associated with ...
Source: Current Treatment Options in Cardiovascular Medicine - August 2, 2021 Category: Cardiology Source Type: research
Left Ventricular Assist Device
Left ventricular assist devices (LVADs) are indicated in inotrope-dependent heart failure (HF) patients with pure or predominant LV dysfunction. Survival benefit is less clear in ambulatory, advanced HF. Timing is crucial: early, unnecessary exposure to the risks of surgery, and device-related complications (infections, stroke, and bleeding) should be weighed against the probability of dying or developing irreversible right ventricular and/or end-organ dysfunction while deferring implant. The interplay between LVAD and heart transplantation depends largely on donor availability and allocation rules. Postoperatively, qualit...
Source: Heart Failure Clinics - July 21, 2021 Category: Cardiology Authors: Maria Frigerio Source Type: research
Effect of Bariatric Surgery on Cardiovascular Function and Heart Failure Outcomes
In this article, we explore the influence of obesity on cardiovascular health and the role of bariatric surgery in reducing cardiovascular comorbidities, preventing the onset of heart failure and improving mortality and quality of life in those with cardiac dysfunction. We highlight the mechanisms by which obesity leads to cardiovascular remodeling, diastolic dysfunction, and eventual heart failure. These mechanisms include systemic inflammation, local lipotoxicity by way of ectopic fat deposition, and hemodynamic alterations that have significant effects on cardiac structure and function. Bariatric surgery has been shown ...
Source: Cardiology in Review - June 11, 2021 Category: Cardiology Tags: Review Articles Source Type: research
Primary results of long ‐term outcomes in the MOMENTUM 3 pivotal trial and continued access protocol study phase: a study of 2200 HeartMate 3 left ventricular assist device implants
ConclusionsThe primary results of accumulating HM3 LVAD experience suggest a lower adverse event burden and similar survival compared to the pivotal MOMENTUM 3 trial.
Source: European Journal of Heart Failure - May 19, 2021 Category: Cardiology Authors: Mandeep R. Mehra,
Joseph C. Cleveland,
Nir Uriel,
Jennifer A. Cowger,
Shelley Hall,
Douglas Horstmanshof,
Yoshifumi Naka,
Christopher T. Salerno,
Joyce Chuang,
Christopher Williams,
Daniel J. Goldstein, on behalf of the MOMENTUM 3 Investigator Tags: Research Article Source Type: research
Primary Results of Long ‐Term Outcomes in the MOMENTUM 3 Pivotal Trial and Continued Access Protocol Study Phase: A Study of 2200 HeartMate 3 Left Ventricular Assist Device Implants
ConclusionsThe primary results of accumulating HM3 LVAD experience suggest a lower adverse event burden and similar survival compared to the pivotal MOMENTUM 3 trial.This article is protected by copyright. All rights reserved.
Source: European Journal of Heart Failure - May 1, 2021 Category: Cardiology Authors: Mandeep R. Mehra,
Joseph C. Cleveland,
Nir Uriel,
Jennifer A. Cowger,
Shelley Hall,
Douglas Horstmanshof,
Yoshifumi Naka,
Christopher T. Salerno,
Joyce Chuang,
Christopher Williams,
Daniel J. Goldstein,
on behalf of the MOMENTUM 3 Investigators Tags: Research Article Source Type: research
Complications of left ventricular assist devices causing high urgency status on waiting list: impact on outcome after heart transplantation
ConclusionsLeft ventricular assist device therapy can impair the outcome after HTx. However, the occurrence of LVAD complications may not impact on outcome after HTx. Thus, we cannot support the prioritization or discrimination of HTx candidates according to distinct mechanical circulatory support ‐associated complications. Future allocation strategies have to respect that device‐related complications may define urgency but do not impact on the outcome after HTx.
Source: ESC Heart Failure - March 29, 2021 Category: Cardiology Authors: Moritz Benjamin Immohr,
Udo Boeken,
Franziska Mueller,
Emir Prashovikj,
Michiel Morshuis,
Charlotte B öttger,
Hug Aubin,
Jan Gummert,
Payam Akhyari,
Artur Lichtenberg,
René Schramm Tags: Original Research Article Source Type: research
Clinical characteristics and outcomes in childhood-onset hypertrophic cardiomyopathy
ConclusionPatients with childhood-onset HCM are more likely to have sarcomeric disease, carry a higher risk of life-threatening ventricular arrythmias, and have greater need for advanced HF therapies. These findings provide insight into the natural history of disease and can help inform clinical risk stratification.
Source: European Heart Journal - March 26, 2021 Category: Cardiology Source Type: research
AHA News: Stroke, Blindness, a Heart Transplant – And a Can-Do Spirit
Title: AHA News: Stroke, Blindness, a Heart Transplant – And a Can-Do SpiritCategory: Health NewsCreated: 3/23/2021 12:00:00 AMLast Editorial Review: 3/24/2021 12:00:00 AM
Source: MedicineNet Heart General - March 24, 2021 Category: Cardiology Source Type: news
Propensity score ‐based analysis of long‐term outcome of patients on HeartWare and HeartMate 3 left ventricular assist device support
ConclusionsSurvival was not significantly different between both groups after PS matching, but was better for HM3, with a significantly lower incidence of haemorrhagic stroke and pump thrombosis for HM3. These results need to be interpreted carefully, because matching may have introduced greater imbalance on unmeasured covariates. A multicentre approach of carefully selected centres is recommended to enlarge the number of matched patients.
Source: ESC Heart Failure - February 26, 2021 Category: Cardiology Authors: Lieke Numan,
Faiz Z. Ramjankhan,
Daniel L. Oberski,
Martinus I.F.J. Oerlemans,
Emmeke Aarts,
Monica Gianoli,
Joris J. Van Der Heijden,
Nicolaas De Jonge,
Niels P. Van Der Kaaij,
Christiaan L. Meuwese,
Mostafa M. Mokhles,
Anne ‐Marie Oppelaar, Tags: Original Research Article Source Type: research
Comparison of levosimendan, NO, and inhaled iloprost for pulmonary hypertension reversibility assessment in heart transplant candidates
ConclusionsLevosimendan may be a safe and effective alternative for pulmonary hypertension reversibility assessment or a valuable pre ‐test medical optimization tool in end‐stage heart failure patient assessment for heart transplantation offering extended haemodynamic benefits. Whether it increases the rate of positive responses or allows a better selection of candidates to heart transplantation remains to be established.
Source: ESC Heart Failure - February 23, 2021 Category: Cardiology Authors: Marta Tavares ‐Silva,
Francisca Saraiva,
Roberto Pinto,
Sandra Amorim,
João Carlos Silva,
Adelino F. Leite‐Moreira,
Maria Júlia Maciel,
André P. Lourenço Tags: Original Research Article Source Type: research
Complications of left ventricular assist devices causing high urgency status on waiting list: impact on outcome after heart transplantation
ConclusionsLeft ventricular assist device therapy can impair the outcome after HTx. However, the occurrence of LVAD complications may not impact on outcome after HTx. Thus, we cannot support the prioritization or discrimination of HTx candidates according to distinct mechanical circulatory support ‐associated complications. Future allocation strategies have to respect that device‐related complications may define urgency but do not impact on the outcome after HTx.
Source: ESC Heart Failure - January 21, 2021 Category: Cardiology Authors: Moritz Benjamin Immohr,
Udo Boeken,
Franziska Mueller,
Emir Prashovikj,
Michiel Morshuis,
Charlotte B öttger,
Hug Aubin,
Jan Gummert,
Payam Akhyari,
Artur Lichtenberg,
René Schramm Tags: Original Research Article Source Type: research
Cardiac surgery outcomes in patients with antecedent kidney, liver, and pancreas transplantation: a meta-analysis.
Authors: Bacusca AE, Enache M, Tarus A, Litcanu CI, Burlacu A, Tinica G
Abstract
Cardiovascular events are among the most common causes of late death in the transplant recipient (Tx) population. Moreover, major cardiac surgical procedures are more challenging and risky due to immunosuppression and the potential impact on the transplanted organ's functional capacity. We aimed to assess open cardiac surgery safety in abdominal solid organ transplant recipients, comparing the postoperative outcomes with those of nontransplant (N-Tx) patients. Electronic databases of PubMed, EMBASE, and SCOPUS were searched. The endpoi...
Source: Reviews in Cardiovascular Medicine - January 5, 2021 Category: Cardiology Tags: Rev Cardiovasc Med Source Type: research
Neural Progenitor Cell-Derived Extracellular Vesicles Enhance Blood-Brain Barrier Integrity by NF- κB (Nuclear Factor-κB) Dependent Regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in Stroke Mice.
CONCLUSIONS: Our findings suggest that EVs enhance poststroke BBB integrity via ABCB1 and MMP-9 regulation, attenuating inflammatory cell recruitment by inhibition of the NF-κB pathway.
PMID: 33327747 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 17, 2020 Category: Cardiology Authors: Zhang L, Graf I, Kuang Y, Zheng X, Haupt M, Majid A, Kilic E, Hermann DM, Psychogios MN, Weber MS, Ochs J, Bähr M, Doeppner TR Tags: Arterioscler Thromb Vasc Biol Source Type: research
