Medical therapy, radiofrequency ablation or cryoballoon ablation as first-line treatment for paroxysmal atrial fibrillation: interpreting efficacy through restricted mean survival time and network meta-analysis
In conclusion, we found that radiofrequency was the most effective treatment for paroxysmal atrial fibrillation according to a Bayesian probabilistic model.PMID:34565059 | DOI:10.31083/j.rcm2203067 (Source: Reviews in Cardiovascular Medicine)
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Andrea Messori Laura Bartoli Elisa Ferracane Sabrina Trippoli Source Type: research

Cardionephrology and cardiorenal disease in Italy: state of the art
Rev Cardiovasc Med. 2021 Sep 24;22(3):563-572. doi: 10.31083/j.rcm2203068.ABSTRACTThe interactions and feedback mechanisms involved in heart and renal failure are more complex than previously thought and are grouped under the term "cardio-renal axis". In the last decades, it has always been emphasized that renal dysfunction in patients with heart failure can be attributed exclusively to low renal plasma flow resulting from reduced cardiac output. In the last two decades cardiorenal syndrome has been established to set complex and close interactions between heart and kidney. Cardiologists and nephrologist should i...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Luca Di Lullo Antonio Bellasi Vincenzo Barbera Claudio Ronco Source Type: research

The 'diamond' approach to personalized drug treatment of heart failure with reduced ejection fraction
Rev Cardiovasc Med. 2021 Sep 24;22(3):573-584. doi: 10.31083/j.rcm2203069.ABSTRACTHeart failure (HF) is a complex clinical syndrome with symptoms and signs due to cardiac dysfunction, leading to high hospitalization and morbidity. HF treatment has rapidly developed in recent decades, and breakthroughs have been made. Although conventional neurohormonal blockade therapies, including β-blockers, angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and mineralocorticoid receptor antagonists (MRAs), significantly improve the prognosis of patients with heart failure with reduced ejection fr...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Hongbo Gan Heng Tang Yujie Huang Dan Wang Peng Pu Zhong Zuo Source Type: research

Progress on developing an effective below-the-knee drug-coated balloon
Rev Cardiovasc Med. 2021 Sep 24;22(3):585-595. doi: 10.31083/j.rcm2203070.ABSTRACTInfrapopliteal atherosclerotic disease continues to present the greatest conundrum for effective endovascular therapies. To date, conventional angioplasty has been fraught with early restenosis and recoil in these complex, long, calcified, and occlusive lesions. The success of metallic drug-eluting stents in coronary arteries has not carried over to below-the-knee arteries. Initial promise in paclitaxel-coated balloons has not been demonstrated in large randomized clinical trials. Furthermore, the potential association between paclitaxel and ...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Rym El Khoury Marianne Brodmann Peter A Schneider Source Type: research

Long-term management of Takotsubo syndrome: a not-so-benign condition
Rev Cardiovasc Med. 2021 Sep 24;22(3):597-611. doi: 10.31083/j.rcm2203071.ABSTRACTTakotsubo syndrome (TTS) is an intriguing clinical entity, characterized by usually transient and reversible abnormalities of the left ventricular systolic function, mimicking the myocardial infarction with non-obstructive coronary arteries. TTS was initially regarded as a benign condition, however recent studies have unveiled adverse outcomes in the short- and long-term, with rates of morbidity and mortality comparable to those experienced after an acute myocardial infarction. Given the usual transient nature of TTS, this is an unexpected fi...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Matteo Sclafani Luca Arcari Domitilla Russo Giacomo Tini Luca Rosario Limite Luca Cacciotti Massimo Volpe Camillo Autore Maria Beatrice Musumeci Source Type: research

A scoping review of exercise-based cardiac rehabilitation for patients with aortic dissection
Rev Cardiovasc Med. 2021 Sep 24;22(3):613-624. doi: 10.31083/j.rcm2203072.ABSTRACTOur objective was to provide evidence for exercise-based cardiac rehabilitation (ECR) for patients with aortic dissection (AD), so as to better improve the prognosis of patients and improve the quality of life (QoL) after discharge. The database PubMed, Embase, MEDLINE, Web of Science, Cochrane Library, WanFang Chinese database, ZhiWang Chinese database, Chinese Clinical Trials Registry from establishment of each database until February 2021 were included. A total of 1684 records were found by searching the database and clinical trial registr...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Danni Feng Jian Ke Sufang Huang Xiaorong Lang Source Type: research

Management of myocardial infarction with Nonobstructive Coronary Arteries (MINOCA): a subset of acute coronary syndrome patients
Rev Cardiovasc Med. 2021 Sep 24;22(3):625-634. doi: 10.31083/j.rcm2203073.ABSTRACTMyocardial infarction with non-obstructive coronary artery disease (MINOCA) represents a significant proportion (up to 15%) of acute myocardial infarction (AMI) population. MINOCA is diagnosed in patients who fullfilled the fourth universal definition of AMI in the absence of significant obstructive coronary artery disease on coronary angiography. MINOCA is a group of heterogeneous diseases with different pathophysiological mechanisms requiring multimodality imaging. Left ventriculography, cardiac magnetic resonance imaging and intra-coronary...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Anthony G Matta Vanessa Nader Jerome Roncalli Source Type: research

Atrial fibrillation and coronary artery disease: a review on the optimal use of oral anticoagulants
Rev Cardiovasc Med. 2021 Sep 24;22(3):635-648. doi: 10.31083/j.rcm2203074.ABSTRACTAtrial fibrillation (AF) represents the most prevalent supraventricular arrhythmia in adults population and up to 15% of AF patients undergo percutaneous coronary intervention (PCI) for coronary artery disease (CAD) during their life. While oral anticoagulants (OACs) exert a protective effect in the setting of stroke prevention and systemic embolization in AF patients, patients undergoing PCI are recommended to receive dual antiplatelet therapy (DAPT) to reduce the risk of cardiovascular death, recurrent myocardial infarction and stent thromb...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Pier Paolo Bocchino Filippo Angelini Elisabetta Toso Source Type: research

Peritoneal dialysis in heart failure: focus on kidney and ventricular dysfunction
Rev Cardiovasc Med. 2021 Sep 24;22(3):649-657. doi: 10.31083/j.rcm2203075.ABSTRACTHeart failure is a significant health problem worldwide. Despite all the new therapies available nowadays, many patients will reach advanced stages of the disease. Diuretic resistance, kidney dysfunction, and refractory congestion, all highly prevalent in advanced heart failure, frequently complicate the situation, making it more challenging to manage. Ultrafiltration through hemodialysis or peritoneal dialysis can be alternative options to treat fluid overload. Peritoneal dialysis has gained increased interest in the last decades due to seve...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Ronald O Morales Francesc Barbosa Nuria Farre Source Type: research

Management of antithrombotic therapy in patients with atrial fibrillation and acute coronary syndromes
Rev Cardiovasc Med. 2021 Sep 24;22(3):659-675. doi: 10.31083/j.rcm2203076.ABSTRACTIf atrial fibrillation (AF) and acute coronary syndrome (ACS) coexist, they should be treated with combined antithrombotic therapy. To reduce the risk of bleeding while maintaining the desired antithrombotic effect, choices should be made for each patient according to the balance between the bleeding and the thrombotic risk. There are many ways to select the type and dose of the oral anticoagulant (OAC) and P2Y12 inhibitors. As a rule of thumb, aspirin and P2Y12 inhibitors should be recommended to all patients. The duration of this combinatio...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: C ălin Pop Diana Țînț Antoniu Petris Source Type: research

The relevance of specific heart failure outpatient programs in the COVID era: an appropriate model for every disease
Rev Cardiovasc Med. 2021 Sep 24;22(3):677-690. doi: 10.31083/j.rcm2203077.ABSTRACTHeart Failure (HF) is characterized by an elevated readmission rate, with almost 50% of events occurring after the first episode over the first 6 months of the post-discharge period. In this context, the vulnerable phase represents the period when patients elapse from a sub-acute to a more stabilized chronic phase. The lack of an accurate approach for each HF subtype is probably the main cause of the inconclusive data in reducing the trend of recurrent hospitalizations. Most care programs are based on the main diagnosis and the HF stages, but...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Matteo Beltrami Simone Bartolini Massimo Milli Alberto Palazzuoli Source Type: research

Current evidence in the diagnosis and management of cardiogenic shock complicating acute coronary syndrome
Rev Cardiovasc Med. 2021 Sep 24;22(3):691-715. doi: 10.31083/j.rcm2203078.ABSTRACTCardiogenic shock (CS) is a hemodynamically complex and highly morbid syndrome characterized by circulatory collapse and inadequate end-organ perfusion due to impaired cardiac output. It is usually associated with multiorgan failure and death. Mortality rate is still high despite advancement in treatment. CS has been conceptualised as a vicious cycle of injury and decompensation, both cardiac and systemic. Interrupting the vicious cycle and restoring the hemodynamic stability is a fundamental treatment of CS. Acute coronary syndrome (ACS) is ...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Rasha Kaddoura Salah Elbdri Source Type: research

Changes in left ventricular size, geometry, pump function and left heart pressures during healthy aging
Rev Cardiovasc Med. 2021 Sep 24;22(3):717-729. doi: 10.31083/j.rcm2203079.ABSTRACTThere are cross-sectional and longitudinal imaging studies using echocardiography and cardiac magnetic resonance in healthy adult subjects which have demonstrated associations of left ventricular (LV) structure and pump function with age. There are also cross-sectional data regarding the relationships of age with invasively measured left heart chamber pressures. Increasing age is associated with decreases in LV end-diastolic volume (LVEDV), end-systolic volume (LVESV), end-diastolic length (LVEDL), stroke volume (SV) and cardiac output (CO), ...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Roger E Peverill Source Type: research

Current management and prognosis of patients with recurrent myocardial infarction
Rev Cardiovasc Med. 2021 Sep 24;22(3):731-740. doi: 10.31083/j.rcm2203080.ABSTRACTRecurrent myocardial infarction (re-MI) is a common event following acute coronary syndrome (ACS), especially during the first year. According to epidemiological studies, patients who experience re-MI are at higher risk of all-cause cardiovascular events and mortality. The cornerstones of re-MI prevention include complete functional coronary revascularization, effective dual antiplatelet therapy and secondary prevention strategies. Notwithstanding this, some controversy still exists on the definition and management of re-MI, and no dedicated ...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Leonardo De Luca Luca Paolucci Annunziata Nusca Rita Lucia Putini Fabio Mangiacapra Enrico Natale Gian Paolo Ussia Furio Colivicchi Francesco Grigioni Francesco Musumeci Domenico Gabrielli Source Type: research

Role of transthoracic echocardiogram in acute heart failure
Rev Cardiovasc Med. 2021 Sep 24;22(3):741-754. doi: 10.31083/j.rcm2203081.ABSTRACTAcute Heart Failure (AHF) is an increasingly common condition with a poor prognosis. In contrast to CHF where advances in medical therapy and devices has led to significant improvement in morbidity and mortality, the prognosis for AHF has not changed significantly in the last few decades despite efforts to find effective treatment. There are multiple factors that contribute to the high mortality and morbidity of AHF; it can be a diagnostic challenge, determining whether decongestion has been achieved can be difficult, and persisting congestio...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Sarah Fitzsimons Robert N Doughty Source Type: research

Pathophysiological mechanisms and clinical evidence of relationship between Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease
Rev Cardiovasc Med. 2021 Sep 24;22(3):755-768. doi: 10.31083/j.rcm2203082.ABSTRACTEvidence suggests a close connection between Nonalcoholic Fatty Liver Disease (NAFLD) and increased cardiovascular (CV) risk. Several cross-sectional studies report that NAFLD is related to preclinical atherosclerotic damage, and to coronary, cerebral and peripheral vascular events. Similar results have been showed by prospective studies and also by meta-analyzes on observational studies. The pathophysiological mechanisms of NAFLD are related to insulin resistance, which causes a dysfunction in adipokine production, especially adiponectin, fr...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Raffaele Galiero Alfredo Caturano Erica Vetrano Arturo Cesaro Luca Rinaldi Teresa Salvatore Raffaele Marfella Celestino Sardu Elisabetta Moscarella Felice Gragnano Paolo Calabr ò Ferdinando Carlo Sasso Source Type: research

Role of the ACE2/Ang-(1-7)/Mas axis in glucose metabolism
This article reviews the main characteristics and functions of the ACE2/Ang-(1-7)/Mas axis and its regulation of glucose metabolism in order to demonstrate its potential as a target for the treatment of metabolic diseases such as diabetes.PMID:34565075 | DOI:10.31083/j.rcm2203083 (Source: Reviews in Cardiovascular Medicine)
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Shiyuan Zhao Wenxue Sun Pei Jiang Source Type: research

Non-ST segment elevation myocardial infarction in the elderly
This article aims to review clinical presentation, identification and management of NSTEMI in the elderly population.PMID:34565076 | DOI:10.31083/j.rcm2203084 (Source: Reviews in Cardiovascular Medicine)
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: C ésar Jiménez-Méndez Pablo D íez-Villanueva Fernando Alfonso Source Type: research

Trimethylamine N-oxide-a marker for atherosclerotic vascular disease
Rev Cardiovasc Med. 2021 Sep 24;22(3):787-797. doi: 10.31083/j.rcm2203085.ABSTRACTAs a potential causative factor in various cardiovascular diseases, the gut microbe-generated metabolite trimethylamine N-oxide (TMAO) has courted considerable research interest as a potential biomarker. TMAO is a small molecule considered to be beneficial for the health of deep-water animals due to its ability to protect proteins against hydrostatic pressure stress. However, it may cause deleterious effects in humans as mounting evidence suggests that TMAO may enhance atherosclerosis, independent of traditional risk factors. This may be medi...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Guinan Xie An Yan Peng Lin Yi Wang Liping Guo Source Type: research

The blooming intersection of subfatin and metabolic syndrome
Rev Cardiovasc Med. 2021 Sep 24;22(3):799-805. doi: 10.31083/j.rcm2203086.ABSTRACTMetabolic Syndrome (MS) remains the leading cause of mortality and morbidity globally. Adipose tissue releases adipokines that play key roles in metabolic and cardio-cerebro-vascular homeostasis. Subfatin, induced after exercise or upon cold exposure in adipose tissue, is a novel secreted protein homologous to Metrn, a neutrophic factor with angiogenic properties. The protein was proved to be of great significance in the browning of white adipose tissue (BWT) and insulin resistance (IR). It affected insulin sensitivity at least via its local ...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Shenglei Huang Lei Cao Hongwei Cheng Dongliang Li Yi Li Zhixian Wu Source Type: research

Sudden cardiac death in patients with myocardial infarction: 1.5 primary prevention
Rev Cardiovasc Med. 2021 Sep 24;22(3):807-816. doi: 10.31083/j.rcm2203087.ABSTRACTSudden cardiac death (SCD) is one of the most common causes of death in the world. Coronary heart disease (CHD) is the root cause of most patients with SCD, and myocardial infarction (MI) is the main cause of SCD among all types of CHD. Early identification of high-risk patients after an MI, and the application of related prevention strategies and disease-specific treatments will be the key to reduce SCD. The mechanism of SCD after MI varies over time, and the relevant risk prediction indicators are also dynamic and different. In the existing...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Yun-Tao Feng Xiang-Fei Feng Source Type: research

Dyslipidemia in pediatrician's practice
Rev Cardiovasc Med. 2021 Sep 24;22(3):817-834. doi: 10.31083/j.rcm2203088.ABSTRACTAtherosclerosis ranks first among cardiovascular system diseases. It is the "disease of the century", and more than 50% of people with circulatory pathology die of it. The clinical manifestation of atherosclerosis is observed at the middle and older ages, but it is known that the pathological process develops much earlier. There has been a clear trend in theoretical and practical cardiology in recent years to study the earliest atherogenic markers. Epidemiological, clinical, and morphological studies have proved the presence in chil...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Alla V Burlutskaya Victoria E Tril Lily V Polischuk Vladimir M Pokrovskii Source Type: research

Apple or apple polyphenol consumption improves cardiovascular disease risk factors: a systematic review and meta-analysis
Rev Cardiovasc Med. 2021 Sep 24;22(3):835-843. doi: 10.31083/j.rcm2203089.ABSTRACTMany fruits and vegetables have been found to have a protective effect against cardiovascular diseases. We conducted a systematic review and meta-analysis to determine the relationship between apple or apple polyphenol intake and cardiovascular disease risk. The PubMed, Embase, Cochrane, and Web of Science databases were searched up to August 4, 2020. Studies that had an intervention time of>1 week; used apple or apple polyphenols as the intervention; were designed as a randomized controlled trial; and measured blood pressure, cholesterol,...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Xiaoqing Zhu Guanhua Xu Wangyan Jin Yingying Gu Xuhua Huang Lidan Ge Source Type: research

Accurate and early detection of sleepiness, fatigue and stress levels in drivers through Heart Rate Variability parameters: a systematic review
In conclusion, HRV represents a potentially valuable marker for sleepiness, fatigue, and stress monitoring in car drivers. HRV measurements could be implemented in future clinical models and sensors to detect early sleepiness and fatigue and prevent car crashes. More studies with larger populations are needed to support this evidence.PMID:34565082 | DOI:10.31083/j.rcm2203090 (Source: Reviews in Cardiovascular Medicine)
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Alexandru Burlacu Crischentian Brinza Adrian Brezulianu Adrian Covic Source Type: research

A qualitative meta-synthesis of patients with heart failure perceived needs
Rev Cardiovasc Med. 2021 Sep 24;22(3):853-864. doi: 10.31083/j.rcm2203091.ABSTRACTSupportive care may have significant input into the treatment of patients with heart failure (HF). Support, understanding and being treated as a whole and unique person are vital for patients with HF. In order to develop a person-centred program, it is important to know patients' needs from their perspectives. The aim of the current review and meta-synthesis was to explore the needs of patients with HF from their perspective. A qualitative review was conducted using the keywords: ("needs" OR "need") AND ("heart failur...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Martha Kyriakou Anastasia Samara Katerina Philippou Ioanna Lakatamitou Ekaterini Lambrinou Source Type: research

Intravenous morphine use in acute heart failure increases adverse outcomes: a meta-analysis
This study aimed to evaluate and compare the efficacy of intravenous morphine treatment vs. no morphine treatment in AHF patients. Relevant research conducted before June 2020 was retrieved from electronic databases. One unpublished study of our own was also included. Studies were eligible for inclusion if they compared AHF patients treated with intravenous morphine and patients who did not receive morphine. This meta-analysis included three propensity-matched cohorts and two retrospective analyses, involving a total of 149,967 patients (intravenous-morphine group, n = 22,072; no-morphine group, n = 127,895). There was a n...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Yaowang Lin Yang Chen Jie Yuan Xinli Pang Huadong Liu Shaohong Dong Qiuling Chen Source Type: research

Effects of alirocumab on cardiovascular events and all-cause mortality: a systematic review and meta-analysis
Rev Cardiovasc Med. 2021 Sep 24;22(3):873-881. doi: 10.31083/j.rcm2203093.ABSTRACTEvaluation of the effects of alirocumab on cardiovascular (CV) events, CV mortality and all-cause mortality. Data search was carried out using the Cochrane Library, PubMed, Web of Science and Embase. The search time is up to November 18, 2020. All randomized clinical trials (AEs) comparing alirocumab with placebo were searched. Meta-analysis was performed by Review Manager version 5.3 (The Cochrane Collaboration, Copenhagen, Denmark), and the heterogeneity between studies was tested by Cochrane's Q test and measured with I2 statistics. A tota...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Wanting Wang Zhaoqiang Feng Jinghui Bai Source Type: research

Cardiac amyloidosis presenting with coronary artery embolization
We report the unusual case of a 57-year-old female patient with AL amyloidosis presenting with an ST segment elevation myocardial infarction due to coronary artery embolization (CE). The patient reported a history of exertional dyspnoea along with episodes of haemoptysis for the last few months. Her coronary angiography demonstrated embolization of the distal segment of the left anterior descending artery. The main findings of her cardiac ultrasound included concentric left ventricular hypertrophy, mildly impaired left ventricular systolic function, left atrium enlargement and a restrictive-like filling pattern, while her ...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Christos Papageorgiou Eleftheria Tsagalou Ioannis Baraboutis Konstantinos Tampakis Efstathios Kastritis Meletios-Athanasios Dimopoulos Source Type: research

A preliminary study on the radiation dose reduction during catheterization procedures using simple partial patient shielding
Rev Cardiovasc Med. 2021 Sep 24;22(3):891-894. doi: 10.31083/j.rcm2203095.ABSTRACTReduction in X-ray exposure during cardiac catheterization is important to reduce radiation risks to operators and personnel. Reducing scattered radiation from the patient can achieve this goal. The goal of this study was to evaluate the reduction in radiation using simple partial shielding of patients undergoing cardiac catheterization. By putting a lead-based apron on the lower extremities of patients undergoing cardiac catheterization, we analyzed the reduction in total radiation dose with and without this shielding. One hundred and twelve...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Alireza Serati Ashkan Hashemi Babak Sharifkashani Sourmah Nourbakhsh Arash Hashemi Sepideh Emami Mohammad Reza Movahed Source Type: research

Association of polymorphisms in endothelial dysfunction-related genes with susceptibility to essential hypertension in elderly Han population in Liaoning province, China
Rev Cardiovasc Med. 2021 Sep 24;22(3):895-901. doi: 10.31083/j.rcm2203096.ABSTRACTHypertension is a complex disease which is mainly influenced by genetic factors. Recently, genome-wide association study (GWAS) found three novel endothelial dysfunction-related sites: Vascular endothelial growth factor A (VEGFA) rs9472135, Faciogenital dysplasia 5 (FGD5) rs11128722, Zinc Finger C3HC-type Containing 1 (ZC3HC1) rs11556924. Endothelial dysfunction is one of the early events in pathophysiology of essential hypertension. To investigate the association of endothelial dysfunction-related genes with essential hypertension, we conduc...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Na Ta Mengwei Liu Yue Wang Fanxin Zeng Fangfang Nie Mengke Shang Xiaotong Wang Yuetian Yang Man Liang Lu Wen Lanxin Ou Zhibin Yang Wanyang Liu Xiuping Liu Source Type: research

Cardiac rehabilitation in elderly myocardial infarction survivors: focus on circulatory power
Rev Cardiovasc Med. 2021 Sep 24;22(3):903-910. doi: 10.31083/j.rcm2203097.ABSTRACTExercise-based cardiac rehabilitation (EBCR) is paramount after an acute myocardial infarction (AMI). Older individuals have been reported as having a worse prognosis after an AMI, and some series have reported differences in the functional response to EBCR. The peak circulatory power (CP), a non-invasive parameter, has been described as a surrogate for the cardiac power, showing promising results as a comprehensive measure of the cardiovascular response. Whilst this, data concerning the impact of EBCR on CP, particularly among elderly indivi...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Eduardo Matos Vilela Ricardo Ladeiras-Lopes Ana Jo ão Susana Torres Jos é Ribeiro Lilibeth Campos F átima Miranda Jos é Pedro Nunes Madalena Teixeira Ricardo Fontes-Carvalho Source Type: research

Clinical characteristics and outcomes in acute myocardial infarction patients aged ≥65 years in Western Romania
In this study, we aimed to investigate age-related differences in treatment protocols, in-hospital and 1-year mortality. This retrospective observational single-center study enrolled consecutive AMI patients with an urgent percutaneous coronary intervention (PCI) as the main method of myocardial revascularization. The patients divided were divided by age into group I (≥65 years) and group II (
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Florina Caruntu Diana Aurora Bordejevic Mirela Cleopatra Tomescu Ioana Mihaela Citu Source Type: research

Serum endothelin-1 level positively correlates with waist and hip circumferences in stable coronary artery disease patients
This study aims to examine the correlation between serum endothelin-1 level and waist and hip circumferences as parameters of central obesity in patients with stable CAD. This was a cross-sectional study. Consecutive subjects were enrolled among those who underwent elective coronary angiography with significant CAD. Serum endothelin-1 was measured from peripheral blood samples taken before coronary angiography procedure. The measurement of waist circumference, hip circumference, and ratio derived from them, was performed. Central obesity was determined by waist circumference cut-off for Indonesian population. The correlati...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Anggoro Budi Hartopo Jajah Fachiroh Ira Puspitawati Fatwa Sari Tetra Dewi Source Type: research

Clinical outcomes in patients with heart failure with and without cirrhosis: an analysis from the national inpatient sample
Rev Cardiovasc Med. 2021 Sep 24;22(3):925-929. doi: 10.31083/j.rcm2203100.ABSTRACTOutcomes of heart failure (HF) hospitalization are driven by the presence or absence of comorbid conditions. Cirrhosis is associated with worse outcomes in patients with HF, and both HF and cirrhosis are associated with worse renal outcomes. Using a nationally representative sample we describe inpatient outcomes of all-cause mortality and length of stay (LOS) among patients with and without cirrhosis hospitalized for decompensated with HF. We conducted a cross sectional analysis using Nationwide Inpatient Sample (2010-2014) data including pat...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Ali Yazdanyar Muhammad Haisum Maqsood Jerald Pelayo Julien Sanon Eduardo Quintero Kevin Bryan Lo Roy O Mathew Janani Rangaswami Source Type: research

Comparison of standard versus modified stenting technique for treatment of tapered coronary artery lesions
This study sought to compare clinical outcomes between the modified single stenting (MSS) and conventional overlapped stenting (COS) in treatment of TCALs. 150 patients were treated with MSS (MSS group), another 150 patients were matched with propensity score matching from 5055 patients treated with COS (COS group). Quantitative coronary angiography was performed to measure minimal lumen diameter (MLD), late lumen loss (LLL). The primary endpoint was immediate angiographic success, one-year cumulative major cardiac adverse events (MACEs) composing cardiac death, target vessel myocardial infarction (TVMI), target lesion/ves...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Dan Ke Xi He Chaogui Lin Lianglong Chen Source Type: research

The antegrade reperfusion test avoids the risk of mitral regurgitation recurrence optimizing valve repair
We report our results with this combined approach. Data were obtained from the medical records and our mitral valve repair database. In 32 (35.1%) patients, evident or undetectable minor regurgitation at the saline test were respectively unconfirmed or detected by the antegrade reperfusion test leading to their complete correction. In only three patients (3.2%) major discrepancies was present between the intraoperative evaluation and the post-pump transesophageal echocardiography. Two of them (2.1%) required a second cardiopulmonary bypass run to fix the residual regurgitation. The antegrade reperfusion test is a simple dy...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Amir Youssari Jean-Paul Couetil Mariantonietta Piscitelli C éline Zerbib Oph élie Brault-Meslin Sanjeet Singh Avtaar Singh Francesco Nappi Antonio Fiore Source Type: research

Abnormal expression of < em > TGFBR2 < /em > , < em > EGF < /em > , < em > LRP10 < /em > , and < em > IQGAP1 < /em > is involved in the pathogenesis of coronary artery disease
In this study, we investigated the pathogenesis of CAD. We downloaded the GSE98583 dataset, including 12 CAD samples and 6 normal samples, from the Gene Expression Omnibus (GEO) database and screened differentially expressed genes (DEGs) in CAD versus normal samples. Next, we performed functional enrichment analysis, protein-protein interaction (PPI) network, and functional module analyses to explore potential functions and regulatory functions of identified DEGs. Next, transcription factors (TFs) and microRNAs (miRNAs) targeting DEGs were predicted. In total, 456 DEGs were identified in CAD and normal samples, including 1...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Yanwei Du Yanan Hu Naiyan Wen Shuang Fu Guorong Zhang Li Li Tiantian Liu Xuejiao Lv Wenfeng Zhang Source Type: research

Evaluation of the aortic velocity propagation, epicardial fat thickness, and carotid intima-media thickness in patients with subclinical hypothyroidism
This study aimed to evaluate thyroid stimulating hormone (TSH), AVP, EFT, and CIMT in SH patients, and determine the associations among these parameters. Eighty patients with SH and 43 euthyroid (EU) individuals were enrolled. Blood samples were collected to measure laboratory parameters. Patients were divided into two groups based on their TSH values (TSH ≥10 or TSH
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Emin Aso ğlu Tayyar Akbulut Zeki Do ğan Ramazan Aso ğlu Source Type: research

Validity of SOFA score as a prognostic tool for critically ill elderly patients with acute infective endocarditis
Rev Cardiovasc Med. 2021 Sep 24;22(3):967-973. doi: 10.31083/j.rcm2203105.ABSTRACTThe prognostic value of the sequential organ failure assessment (SOFA) score for critically ill elderly patients with acute infective endocarditis (IE) remains unknown. From January 2015 to December 2019, 111 elderly (≥65 years) patients with acute IE were consecutively included and divided into a low SOFA (
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Yaowang Lin Feng Liu Shuying Gong Bihong Liao Huadong Liu Jie Yuan Danqing Yu Haiyan Qin Meishan Wu Shaohong Dong Source Type: research

The comparison between the effects of aspirin and clopidogrel monotherapy on postoperative bleeding in diabetic patients after off-pump coronary artery bypass surgery
Rev Cardiovasc Med. 2021 Sep 24;22(3):975-981. doi: 10.31083/j.rcm2203106.ABSTRACTThere is limited data about the bleeding complication of antiplatelet therapy after coronary artery bypass graft (CABG) operations focused on diabetic patients. Herein, we aimed to evaluate the effects of aspirin and clopidogrel monotherapies on postoperative bleeding in these patients. A total of 165 diabetic patients who underwent isolated off-pump beating heart coronary artery bypass (OPCAB) operation were evaluated, 84 patients were included in this retrospective study. Patients were divided into groups according to the type of antiplatel...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Levent Alt ınay Erdem Çetin Source Type: research

Echocardiographic and clinical outcomes of patients undergoing septal myectomy plus anterior mitral leaflet extension for hypertrophic cardiomyopathy
Rev Cardiovasc Med. 2021 Sep 24;22(3):983-990. doi: 10.31083/j.rcm2203107.ABSTRACTSeptal myectomy is indicated in patients with obstructive hypertrophic cardiomyopathy (HCM) and intractable symptoms. Concomitant mitral valve (MV) surgery is performed for abnormalities contributing to systolic anterior motion (SAM), or for SAM-mediated mitral regurgitation (MR) with or without left ventricular outflow tract (LVOT) obstruction. One MV repair technique is anterior mitral leaflet extension (AMLE) utilizing bovine pericardium, stiffening the leaflet and enhancing coaptation posteriorly. Fifteen HCM patients who underwent combin...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Rafle Fernandez Francesco Nappi Sofia A Horvath Sarah A Guigui Christos G Mihos Source Type: research

The association between serum uric acid levels and 10-year cardiovascular disease incidence: results from the ATTICA prospective study
Rev Cardiovasc Med. 2021 Sep 24;22(3):991-1001. doi: 10.31083/j.rcm2203108.ABSTRACTLimited data suggests possible gender-specific association between serum uric acid (SUA) and cardiovascular disease (CVD) incidence. The aim of the present analysis was to evaluate the association between SUA levels and 10-year CVD incidence (2002-2012) in the ATTICA study participants. Overall, 1687 apparently healthy volunteers, with SUA measurements, residing in the greater metropolitan Athens area (Greece), were included. Multivariable Cox-regression models were used to estimate the hazard ratios for SUA in relation to 10-year CVD incide...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Niki Katsiki Matina Kouvari Demosthenes B Panagiotakos Claudio Borghi Christina Chrysohoou Dimitri P Mikhailidis Christos Pitsavos Source Type: research

Trends and distribution of coronary heart disease mortality rate in Hexi Corridor, Gansu, China from 2006 to 2015
This study described the trend and distribution of coronary heart disease (CHD) in the Hexi Corridor region of Gansu. The CHD mortality rates from 2006-2015 were obtained through the Death Reporting System of Gansu Centers for Disease Control (CDC) for 2006-2015. The overall mortality rate of CHD in the Hexi Corridor showed a decreasing trend, increasing in winter and spring and lowest in summer. The CHD mortality rate was higher in men than in women (P
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Xinghui Li Zhihe Da Xiaolan Ren Yan Qiao Ping Xie Xiaolong Sun Lijun Wang Junxian Han Yongfeng Hua Source Type: research

Predictive and prognostic value of v-set and transmembrane domain-containing 1 expression in monocytes for coronary artery disease
Rev Cardiovasc Med. 2021 Sep 24;22(3):1009-1017. doi: 10.31083/j.rcm2203110.ABSTRACTThe aim of this study was to investigate the correlation between v-set and transmembrane domain-containing 1 (VSTM1) expression and incidence of major adverse cardiac events (MACE) in patients with coronary heart disease (CHD). A total of 310 patients were divided into a non-acute coronary syndrome (non-ACS) group (containing the stable angina group, and the asymptomatic coronary artery diseaseand other patients group) and an ACS group (containing unstable angina and acute myocardial infarction patients). Monocytic VSTM1 expression levels (...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Xiao-Fei Wang Meng-Cheng Xu Cheng-Yu Mao None En-Zhou Qing He Xing-Qian Qu Yu-Qi Fan Chang-Qian Wang Jun-Feng Zhang Source Type: research

Simulation of anticoagulation in atrial fibrillation patients with rivaroxaban-from trial to target population
This study aimed to estimate the real-world outcomes of rivaroxaban in patients with AF accurately. A discrete event simulation (DES) was used to predict the counterfactual results of the ROCKET AF study. The hypothetical cohorts of patients were generated using Monte Carlo simulation according to the baseline covariate distributions that matched the marginal distribution of covariates reported in the ROCKET AF and three observational studies. The DES model structure was constructed based on a priori knowledge about disease progression and possible outcomes of patients with AF. The DES model accurately replicated the overa...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Chi Zhang Wei-Wei Wang Mang-Mang Pan Zhi-Chun Gu Source Type: research

Endovascular repair of traumatic aortic dissection: a single-center experience
Rev Cardiovasc Med. 2021 Sep 24;22(3):1029-1035. doi: 10.31083/j.rcm2203112.ABSTRACTThe data on endovascular aortic repair (EVAR) for traumatic aortic dissection (TAD) are lacking. Hence, this study aimed to evaluate the efficacy of EVAR for TAD and report our experience based on patients from our medical center with a relatively long follow-up. A total of 25 consecutive patients with TAD underwent EVAR from October 2015 to October 2020. The demographics, imaging characteristics, clinical features, treatment details, and follow-up results were reviewed. Urgent EVAR was performed in 3 patients (12%), while the remaining 22 ...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Yingliang Wang Tongqiang Li Jiacheng Liu Qin Shi Chen Zhou Chongtu Yang Songjiang Huang Yang Chen Bin Xiong Source Type: research

Histone deacetylase inhibitor, mocetinostat, regulates cardiac remodelling and renin-angiotensin system activity in rats with transverse aortic constriction-induced pressure overload cardiac hypertrophy
Rev Cardiovasc Med. 2021 Sep 24;22(3):1037-1045. doi: 10.31083/j.rcm2203113.ABSTRACTHistone deacetylase (HDAC) inhibitors have shown cardioprotective or renoprotective effects in various animal models. Our study proposed that the HDAC inhibitor, mocetinostat, regulates cardiac remodelling and renin-angiotensin system (RAS) activity in rats with transverse aortic constriction (TAC)-induced pressure overload cardiac hypertrophy. Cardiac remodelling was evaluated using echocardiography. Cardiac hypertrophy was visualized with haematoxylin and eosin staining, and related gene (Nppa and Nppb) expression was quantified by quanti...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Gun Jik Kim Hanna Jung Eunjo Lee Sung Woon Chung Source Type: research

Influence of excess weight and obesity on performance and outcome of pulmonary vein isolation with the cryoballoon
In conclusion, CB PVI in overweight and obese patients is safe with similar levels of complications and recurrence of AF as patients of normal weight. However, obese patients and operators are exposed to higher radiation doses.PMID:34565106 | DOI:10.31083/j.rcm2203114 (Source: Reviews in Cardiovascular Medicine)
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Christian Blockhaus Hans-Peter Waibler Jan-Erik G ülker Alexander Bufe Melchior Seyfarth Buelent Koektuerk Dong-In Shin Source Type: research

Predictive potential of biomarkers and risk scores for major adverse cardiac events in elderly patients undergoing major elective vascular surgery
The objectives of the study were: (1) To determine the individual discriminatory ability of four risk prediction models and four biomarkers in predicting MACEs in elderly patients undergoing major elective vascular surgery; (2) to find a prognostic model with the best characteristics; (3) to examine the significance of all preoperative parameters; and (4) to determine optimal cut-off values for biomarkers with best predictor capabilities. We enrolled 144 geriatric patients, aged 69.97 ± 3.73 years, with a 2:1 male to female ratio. Essential inclusion criteria were open major vascular surgery and age>65 years. The...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Velimir S Peri ć Mladjan D Golubovi ć Milan V Lazarevi ć Tomislav L Kosti ć Dragana S Stokanovi ć Miodrag N Đorđević Vesna G Marjanovi ć Marija D Sto šić Dragan J Mili ć Source Type: research

Early combination therapy with hydroxychloroquine and azithromycin reduces mortality in 10,429 COVID-19 outpatients
Rev Cardiovasc Med. 2021 Sep 24;22(3):1063-1072. doi: 10.31083/j.rcm2203116.ABSTRACTWe evaluated the age-specific mortality of unselected adult outpatients infected with SARS-CoV-2 treated early in a dedicated COVID-19 day hospital and we assessed whether the use of hydroxychloroquine (HCQ) + azithromycin (AZ) was associated with improved survival in this cohort. A retrospective monocentric cohort study was conducted in the day hospital of our center from March to December 2020 in adults with PCR-proven infection who were treated as outpatients with a standardized protocol. The primary endpoint was 6-week mortality, and se...
Source: Reviews in Cardiovascular Medicine - September 26, 2021 Category: Cardiology Authors: Matthieu Million Jean-Christophe Lagier Herv é Tissot-Dupont Isabelle Ravaux Catherine Dhiver Christelle Tomei Nadim Cassir L éa Delorme S ébastien Cortaredona Sophie Amrane Camille Aubry Karim Bendamardji Cyril Berenger Barbara Doudier Sophie Edouard Source Type: research