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Specialty: Cardiology
Procedure: Transplants

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Total 261 results found since Jan 2013.

Immediate and long-term clinical performance of bioresorbable vascular scaffolds in a real world population.
CONCLUSIONS: Strict adherence to expert recommendation for BVS placement may minimize device related peri-procedural and mid-long term MACCEs in a real world population. PMID: 26963445 [PubMed - as supplied by publisher]
Source: Minerva Cardioangiologica - March 12, 2016 Category: Cardiology Tags: Minerva Cardioangiol Source Type: research

Fully Magnetically Levitated Left Ventricular Assist System for Treating Advanced HF A Multicenter Study
ConclusionsThe results show that the fully magnetically levitated centrifugal-flow chronic LVAS is safe, with high 30-day and 6-month survival rates, a favorable adverse event profile, and improved quality of life and functional status. (HeartMate 3™ CE Mark Clinical Investigation Plan [HM3 CE Mark]; NCT02170363)
Source: Journal of the American College of Cardiology - December 7, 2015 Category: Cardiology Source Type: research

Short and long term outcomes of 200 patients supported by continuous-flow left ventricular assist devices.
CONCLUSION: Short and long term survival for patients on LVAD support are excellent, although outcomes still remain inferior compared to heart transplantation. The incidence of driveline infections, pump thrombosis and pump exchange have declined significantly in recent years. PMID: 26635927 [PubMed - as supplied by publisher]
Source: World Journal of Cardiology - November 26, 2015 Category: Cardiology Authors: Tsiouris A, Paone G, Nemeh HW, Borgi J, Williams CT, Lanfear DE, Morgan JA Tags: World J Cardiol Source Type: research

Mortality following a cardiovascular or renal event in patients with type 2 diabetes in the ALTITUDE trial
Conclusion The majority of deaths occurred in patients who did not experience a non-fatal CV or renal event, although the risk of death was higher following an event. Our findings illustrate continuing opportunities to reduce morbidity and mortality in patients with type 2 diabetes.
Source: European Heart Journal - September 21, 2015 Category: Cardiology Authors: Jhund, P. S., McMurray, J. J. V., Chaturvedi, N., Brunel, P., Desai, A. S., Finn, P. V., Haffner, S. M., Solomon, S. D., Weinrauch, L. A., Claggett, B. L., Pfeffer, M. A. Tags: Prevention and epidemiology Source Type: research

Initial 3‐year outcomes with left ventricular assist devices in a country with a nascent heart transplantation program
ConclusionsLVADs are an important therapeutic alternative to heart transplantation in the context of a developing heart transplant programme with outcomes that are comparable to those reported by other centres.
Source: ESC Heart Failure - September 1, 2015 Category: Cardiology Authors: Yuriy Pya, Makhabbat Bekbossynova, Saltanat Jetybayeva, Serik Bekbossynov, Saltanat Andossova, Roman Salov, Assel Medressova, Svetlana Novikova, Muradym Murzagaliyev Tags: Original Research Article Source Type: research

Hepatocyte growth factor suppresses hypoxia/reoxygenation-induced XO activation in cardiac microvascular endothelial cells
Abstract Hypoxia/reoxygenation (H/R) is one of the cellular stresses in pathological conditions, such as myocardial infarction, stroke and organ transplantation. Oxidative stress caused by reactive oxygen species (ROS) is a crucial element of H/R injury in vascular endothelial cells (ECs). Xanthine oxidase (XO) has been recognized to contribute to H/R injury. Of note, xanthine oxidoreductase is synthesized as xanthine dehydrogenase (XDH) and needs to be converted to XO to become a source of superoxide. Hepatocyte growth factor (HGF) has been found to protect ECs against H/R injury. The relation, however, between ...
Source: Heart and Vessels - July 1, 2015 Category: Cardiology Source Type: research

Comparison of 2-Year Outcomes of Extended Criteria Cardiac Transplantation versus Destination Left Ventricular Assist Device Therapy Using Continuous Flow
Alternatives have emerged for patients ineligible for cardiac transplantation under standard criteria (SCCT). The purpose of our study was to compare outcomes in patients ineligible for SCCT, treated either with extended criteria cardiac transplantation (ECCT) or a continuous flow destination therapy left ventricular assist device (CF DT-LVAD). From 2005 to 2012, patients treated with either ECCT or CF DT-LVAD at our institution were retrospectively analyzed. In the overall unmatched cohort, we examined mortality and other outcomes, including index hospitalization length of stay, renal function, stroke, and readmission rates.
Source: The American Journal of Cardiology - May 20, 2015 Category: Cardiology Authors: Mani A. Daneshmand, Arun Krishnamoorthy, Marc D. Samsky, G. Michael Felker, John A. Pura, Yuliya Lokhnygina, Adrian F. Hernandez, Paul B. Rosenberg, Laura J. Blue, Jacob N. Schroder, Joseph G. Rogers, Carmelo A. Milano, Chetan B. Patel Source Type: research

Incidence and Predictors of Cognitive Decline in Patients with Left Ventricular Assist Devices Original Articles
Conclusions— Cognitive decline occurs commonly in patients in the year after LVAD and is associated with older age and destination therapy. These results could have important implications for patient selection and improved communication of risks before LVAD implantation. Additional studies are needed to explore the association between cognitive decline and subsequent stroke, health status, and mortality in patients after LVAD.
Source: Circulation: Cardiovascular Quality and Outcomes - May 19, 2015 Category: Cardiology Authors: Fendler, T. J., Spertus, J. A., Gosch, K. L., Jones, P. G., Bruce, J. M., Nassif, M. E., Flint, K. M., Dunlay, S. M., Allen, L. A., Arnold, S. V. Tags: Other heart failure Original Articles Source Type: research

Hypertrophic Cardiomyopathy in Adulthood Associated With Low Cardiovascular Mortality With Contemporary Management Strategies
ConclusionsIn a large longitudinally assessed adult HCM cohort, we have demonstrated that contemporary management strategies and treatment interventions, including ICDs for SD prevention, have significantly altered the clinical course, now resulting in a low disease-related mortality rate of 0.5%/year and an opportunity for extended longevity.
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - May 4, 2015 Category: Cardiology Source Type: research

Abstract 328: Cardiovascular Disease Associated with Ability to Achieve Renal Transplant and Post-Transplant Adverse Events Session Title: Poster Session III
Conclusions: CVD is common in patients listed for renal transplant. CAD is independently associated with lower odds of receiving a transplant. CAD and rEF are independently associated with increased hazard of post-transplant death or graft failure. Future efforts should focus measures to optimize outcomes in patients with CVD awaiting transplant.
Source: Circulation: Cardiovascular Quality and Outcomes - April 29, 2015 Category: Cardiology Authors: Ismail, S. J., Patel, M., Gindi, R., Salah, A., Tang, I., Benedetti, E., Ardati, A. Tags: Session Title: Poster Session III Source Type: research

Abstract 225: Frequency and Assessment of Poor Global Outcome in Patients with Left Ventricular Assist Devices Session Title: Poster Session II
Conclusion: In this large, single-center study assessing global outcome after LVAD implantation, we found that about a third of all patients had experienced a poor global outcome at 1 year. While LVAD therapy remains life-saving and the standard of care for many patients with advanced heart failure, these findings could help guide discussions with eligible patients and families. Future work should compare patients’ pre-LVAD expectations with likely outcomes and create risk models to estimate the probability of poorer outcomes for individual patients using pre-procedural factors.
Source: Circulation: Cardiovascular Quality and Outcomes - April 29, 2015 Category: Cardiology Authors: Fendler, T. J., Nassif, M. E., Kennedy, K. F., Spertus, J. A., LaRue, S. J., Vader, J. M., Silvestry, S. C., Joseph, S. M., Arnold, S. V. Tags: Session Title: Poster Session II Source Type: research

Incidence, etiology, and outcome of primary graft dysfunction in adult heart transplant recipients: a single-center experience in Japan
This study aimed to clarify how donor and recipient characteristics affect the clinical course after HTx. The medical records of all the patients who underwent HTx at the National Cerebral and Cardiovascular Center from 1999 to 2014 were retrospectively reviewed. Sixty-one patients (48 males) underwent HTx. Six recipients (9.8 %) developed primary graft dysfunction (PGD) determined by criteria recently established at a consensus conference. Development of PGD was associated with high-dose inotropic support for the donor heart and a history of stroke in the recipient (p = 0.04 and p = 0.002, respectively). Recipients w...
Source: Heart and Vessels - February 14, 2015 Category: Cardiology Source Type: research

Neurological Complications and Outcomes in the Berlin Heart EXCOR(R) Pediatric Investigational Device Exemption Trial Pediatric Cardiology
Conclusions Of children treated with the Berlin Heart EXCOR® device as a bridge to transplant, 29% experienced at least 1 neurological event. The majority of neurological events were ischemic strokes, and many of those occurred early in the course of support. Neurological injury was the leading cause of death after implantation of the Berlin Heart EXCOR® device. Risk stratification for stroke or neurological injury is not possible based on baseline preimplantation characteristics. Clinical Trial Registration URL: www.clinicaltrials.gov. Unique Identifier: NCT00583661.
Source: JAHA:Journal of the American Heart Association - January 22, 2015 Category: Cardiology Authors: Jordan, L. C., Ichord, R. N., Reinhartz, O., Humpl, T., Pruthi, S., Tjossem, C., Rosenthal, D. N. Tags: Pediatric Cardiology Source Type: research

Percutaneous Mechanical Ventricular Support in Acute Cardiac Care: A UK Quaternary Centre Experience Using 2.5L, 3.8L and 5.0L Impella Catheters
Conclusions In this large real-world registry, we have demonstrated the safety and feasibility of the Impella device for a wide range of indications. This includes the first series of the 3.8L device which provides superior support with no increase in vascular complications.
Source: Cardiology and Therapy - December 17, 2014 Category: Cardiology Source Type: research

RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension
Conclusions The adequacy of RV functional adaptation to afterload predicts survival in patients referred for PH. Whether this can simply be evaluated using RV volumetric imaging will require additional confirmation.
Source: Heart - December 12, 2014 Category: Cardiology Authors: Vanderpool, R. R., Pinsky, M. R., Naeije, R., Deible, C., Kosaraju, V., Bunner, C., Mathier, M. A., Lacomis, J., Champion, H. C., Simon, M. A. Tags: Hypertension Pulmonary vascular disease Source Type: research