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Specialty: Cardiology
Procedure: Transplants

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Total 261 results found since Jan 2013.

The enigmatic role of VCAM-1 expressed by macrophages in mitochondrial metabolism and atherosclerosis
CONCLUSION: We conclude that macrophage-specific VCAM-1 augments mitochondrial biogenesis and DNA oxidation via Cmpk2. Oxidized mitochondrial DNA in plaque macrophages increases inflammation via Sting, resulting in exacerbation of atherosclerosis.PMID:35557156 | DOI:10.1096/fasebj.2022.36.S1.R6141
Source: Atherosclerosis - May 13, 2022 Category: Cardiology Authors: Niranjana Natarajan Jonathan Florentin Scott P O'Neil Lee L Ohayon Partha Dutta Source Type: research

Comparing short ‐term/long‐term outcomes of heart transplants that occur inside and outside of normal working hours
ConclusionThere was no significant difference in clinical outcomes between heart transplants taking place inside or outside of working hours. A high quality of care can be provided for heart transplant patients even during after hours.
Source: ESC Heart Failure - April 23, 2022 Category: Cardiology Authors: Hidefumi Nishida, Christopher Salerno, David Onsager, Tae Song, Ann Nguyen, Jonathan Grinstein, Bow Chung, Bryan Smith, Sara Kalantari, Nitasha Sarswat, Gene Kim, Sean Pinney, Valluvan Jeevanandam, Takeyoshi Ota Tags: Original Article Source Type: research

Assessment of Hypertension, Guideline-Directed Counseling, and Outcomes in the ACHD Population
AbstractGuidelines for the diagnosis and treatment of hypertension were published by the American Heart Association (AHA) in 2017. The prevalence of hypertension in adults with congenital heart disease (ACHD) under these guidelines has yet to be characterized. We sought to assess the prevalence, impact, and provider response to hypertension under current guidelines. Data were obtained retrospectively from records of routine clinic visits over a 10  year period. Potential hypertension-related adverse outcomes including stroke, myocardial infarction, surgical intervention for aortic aneurysm, aortic dissection, atrial fibri...
Source: Pediatric Cardiology - April 5, 2022 Category: Cardiology Source Type: research

Longitudinal Observational Study of Cardiac Outcome Risk Factor Prediction in Children, Adolescents, and Adults with Barth Syndrome
AbstractBarth Syndrome (BTHS) is an X-linked mitochondrial cardioskeletal myopathy caused by defects inTAFAZZIN, a gene responsible for cardiolipin remodeling. Altered mitochondrial levels of cardiolipin lead to cardiomyopathy (CM), muscle weakness, exercise intolerance, and mortality. Cardiac risk factors predicting outcome are unknown. Therefore, we conducted a longitudinal observational study to determine risk factors for outcome in BTHS. Subjects with minimum two evaluations (or one followed by death or transplant) were included. Cardiac size, function, and QTc data were measured by echocardiography and electrocardiogr...
Source: Pediatric Cardiology - March 3, 2022 Category: Cardiology Source Type: research

Stroke epidemiology and outcomes in the modern era of left ventricular assist devices
AbstractThe care for the patients with end-stage heart failure has been revolutionized by the introduction of durable left ventricular assist devices, providing a substantial improvement in patient survival and quality of life and an alternative to heart transplantation. The newest devices have lower instances of mechanical dysfunction and associated pump thrombosis. Despite these improvements in complications, the use of continuous flow assist devices is still associated with high rates of thrombotic and hemorrhagic complications, most notably stroke in approximately 10% of continuous flow assist devices patients per year...
Source: Heart Failure Reviews - January 16, 2022 Category: Cardiology Source Type: research

Prognostic Importance of Pulmonary Artery Pulsatility Index and Right Ventricular Stroke Work Index in End-Stage Heart Failure Patients
Conclusion: The low PAPi was an ind ependent risk for ACE and it had a linear association with it. However, RVSWI seems to be have a nonlinear association with ACE (J-curve pattern).
Source: Cardiology - January 3, 2022 Category: Cardiology Source Type: research

Heart transplantation strategies in arrhythmogenic right ventricular cardiomyopathy: a tertiary ARVC centre experience
ConclusionsHeart transplantation is a curative treatment for ARVC, but due to frequent ventricular arrhythmias and RV predominant pathology, patients require unique considerations in regard to timing of evaluation, haemodynamic support options, and wait listing qualification.
Source: ESC Heart Failure - December 25, 2021 Category: Cardiology Authors: Paul J. Scheel, Katherine Giuliano, Crystal Tichnell, Cynthia James, Brittney Murray, Harikrishna Tandri, Debra Carter, Tracey Fehr, Priya Umapathi, Joban Vaishnav, Sabra C. Lewsey, Steven Hsu, Hugh Calkins, Kavita Sharma, Chun Woo Choi, Ni Tags: Original Article Source Type: research

Ten-year, single center experience of ambulatory axillary intra-aortic balloon pump support for heart failure
CONCLUSIONS: Axillary intra-aortic balloon pumps allow most patients to ambulate during support, improve hemodynamics, and lead to the intended goals successfully.PMID:34895789 | DOI:10.1016/j.jjcc.2021.11.010
Source: Journal of Cardiology - December 13, 2021 Category: Cardiology Authors: Hidefumi Nishida Takeyoshi Ota David Onsager Jonathan Grinstein Valluvan Jeevanandam Tae Song Source Type: research

Chronic Rejection and Atherosclerosis in Post-Transplant Cardiovascular Mortality: Two Sides of the Same Coin
Cardiovascular disease (CVD) as defined by the American Heart Association includes ischaemic heart disease, stroke, heart failure and thromboembolism [1]. Solid organ transplantation is associated with an increased risk of CVD morbidity and mortality [2], a relationship which was first observed in the context of kidney transplantation by Foley in 1998 [3]. This manifests clinically as an increased rate of major adverse cardiovascular events (MACE), defined as the composite of cardiac death, non-fatal myocardial infarction, non-fatal stroke, unstable angina and heart failure [4,5].
Source: Heart, Lung and Circulation - November 27, 2021 Category: Cardiology Authors: Afolarin A. Otunla, Kumaran Shanmugarajah, Maria Lucia Madariaga, Alun H. Davies, Joseph Shalhoub Tags: Editorial Source Type: research

Predictors of mortality and cardiovascular outcomes in Emery-Dreifuss Muscular Dystrophy in a long-term follow-up
CONCLUSIONS: LMNA mutation and higher NT-proBNP concentration were associated with increased mortality in EDMD. Lower TAPSE was a predictor of a composite secondary endpoint in EDMD.PMID:34783354 | DOI:10.33963/KP.a2021.0159
Source: Kardiologia Polska - November 16, 2021 Category: Cardiology Authors: Micha ł Marchel Agnieszka Madej-Pilarczyk Roman Steckiewicz Przemys ław Stolarz Micha ł Peller Agata Tymi ńska Ewa Ostrowska Krzysztof Oziera ński Pawe ł Balsam Marcin Grabowski Grzegorz Opolski Source Type: research