Neural Progenitor Cell-Derived Extracellular Vesicles Enhance Blood-Brain Barrier Integrity by NF- κB (Nuclear Factor-κB) Dependent Regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in Stroke Mice.

CONCLUSIONS: Our findings suggest that EVs enhance poststroke BBB integrity via ABCB1 and MMP-9 regulation, attenuating inflammatory cell recruitment by inhibition of the NF-κB pathway.
PMID: 33327747 [PubMed - as supplied by publisher]

Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 17, 2020 Category: Cardiology Authors: Zhang L, Graf I, Kuang Y, Zheng X, Haupt M, Majid A, Kilic E, Hermann DM, Psychogios MN, Weber MS, Ochs J, Bähr M, Doeppner TR Tags: Arterioscler Thromb Vasc Biol Source Type: research