Prolargin and matrix metalloproteinase ‐2 in heart failure after heart transplantation and their association with haemodynamics

ConclusionsThe normalization pattern in HF patients of plasma prolargin and MMP ‐2 post‐HT towards controls' levels and their associations with improved haemodynamics indicate that prolargin and MMP‐2 may reflect, in part, the aberrant ECM remodelling involved in the pathophysiology of HF and associated PH. Their potential clinical use as biomarkers or targets for future therapy in HF and related PH remains to be investigated.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research