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Specialty: Nuclear Medicine
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Total 204 results found since Jan 2013.
Simultaneous 18F-FDG PET/MRI Assists Diagnosis of a Rare Disease, MELAS
MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) is a rare congenital mitochondrial DNA mutation disease. Here, we report a 4-year-old girl, who presented with short stature, mental retardation, and recurrent seizures, underwent simultaneous 18F-FDG PET/MRI examination. An interesting contradiction images were found on bilateral frontal, left temporal, occipital, and parietal lobes, which were with high blood flow shown on 3D-ASL perfusion images, but low uptake of 18F-FDG on PET images. The contradiction of high blood flow and low glucose metabolism gave us a clue to make the diagnosis of...
Source: Clinical Nuclear Medicine - December 23, 2018 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Brain Theranostics and Radiotheranostics: Exosomes and Graphenes In Vivo as Novel Brain Theranostics
AbstractBrain disease is one of the greatest threats to public health. Brain theranostics is recently taking shape, indicating the treatments of stroke, inflammatory brain disorders, psychiatric diseases, neurodevelopmental disease, and neurodegenerative disease. However, several factors, such as lack of endophenotype classification, blood-brain barrier (BBB), target determination, ignorance of biodistribution after administration, and complex intercellular communication between brain cells, make brain theranostics application difficult, especially when it comes to clinical application. So, a more thorough understanding of...
Source: Nuclear Medicine and Molecular Imaging - November 9, 2018 Category: Nuclear Medicine Source Type: research
Nutrition, risk factors, prevention, and imaging: The 2018 Mario Verani Lecture
AbstractHeart disease has been the leading cause of death in the United States since 1918. Cardiac mortality rates have dramatically decreased in this era of advanced medical and interventional therapies. However, this has been aptly described as “mopping up the floor instead of turning off the faucet.” With this recognition, prevention in cardiology is poised to become a central focus. Within prevention, dietary intervention is recognized as the single largest opportunity for improved cardiovascular outcomes, including improvement or el imination of cardiac risk factors, prevention of myocardial infarction, stroke and...
Source: Journal of Nuclear Cardiology - November 5, 2018 Category: Nuclear Medicine Source Type: research
IAC Grants First CT Accreditation to a Mobile Stroke Unit.
Authors: Sloper TA
PMID: 30190361 [PubMed - in process]
Source: Journal of Nuclear Medicine Technology - September 9, 2018 Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research
Super-early images of brain perfusion SPECT using 123 I-IMP for the assessment of hyperperfusion in stroke patients
ConclusionsThe addition of super-early imaging to the conventional early imaging aids assessment of postischemic hyperperfusion by123I-IMP brain perfusion SPECT and may contribute to management of stroke patients in the era of reperfusion therapy.
Source: Annals of Nuclear Medicine - September 1, 2018 Category: Nuclear Medicine Source Type: research
18 F-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques
Conclusions18F-NaF PET represents a different stage in the calcification process than CT. We observed a similar PET assessed18F-NaF uptake and pattern in culprit and non-culprit plaques of high-risk patients, indicating that this method may be of more value in early atherosclerotic stenosis development.
Source: Journal of Nuclear Cardiology - June 25, 2018 Category: Nuclear Medicine Source Type: research
Atherosclerotic Plaque Inflammation Synchronize With Inflammatory Activity of Visceral Fat
Conclusions: We demonstrated that atherosclerotic plaque inflammation was associated with increased inflammation within visceral fat. Our results need to be confirmed by comparison with histologic or other imaging findings. Further evaluation to determine whether metabolic activity of visceral adipose tissue is a marker or mediator of vascular inflammation is also needed.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Kim, S., Choi, S., Seo, H. S., Kwon, H. W., Cho, H. Y., Kwon, H. R. Tags: Advances In Imaging of Atherosclerosis Source Type: research
Correlation of noninvasive imaging of vulnerable carotid artery plaque using NaF and FDG PET/CT and black-blood MRI with cerebral ischemia on brain MRI
Conclusion] These preliminary results suggest that NaF uptake in carotid artery seems to correlate with cerebral ischemic changes.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Norikane, T., Yamamoto, Y., Maeda, Y., Okada, M., Nishiyama, Y. Tags: Cardiovascular Council YIA Symposium Source Type: research
Detection of Apoptosis with 99mTc rh Annexin-V 128 Imaging in Asymptomatic Patients with Carotid Atherosclerotic Plaque
Conclusions: 99mTc-rhAnnexin V-128 imaging is safe with no observed adverse events or lab result changes. 99mTc-rhAnnexin V-128 imaging of apoptosis is feasible with excellent image quality at one and 2 hours following tracer injection. Significant focal uptake was identified in 1/12 patients and none of the 5 controls. Quantitative analysis of the planar images showed significantly greater uptake of annexin in patients compared to controls for both carotid arteries and at one and two hours.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Massalha, S., Ferro, P., Ascah, K., Carey, C., Marvin, B., Dwivedi, G., Wells, R. G., Ravasi, L., Ruddy, T. Tags: Advances In Imaging of Atherosclerosis Source Type: research
FDG PET Imaging as A Non-invasive Method to Demonstrate Peri-infarct Depression after Stroke
Conclusion: FDG PET imaging is reliable to reflect metabolic stress imposed by peri-infarct depression. Peri-infarct depression leads to the metabolic change in neurons, including suppression of mitochondria function and overactivation of glycolysis, thus deteriorate functional and tissue consequence. The insults from PID could be alleviated by improving mitochondria function.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Yao, J., Zhou, R., Shi, J., Zhang, H. Tags: Basic Science III Source Type: research
PET imaging of ischemic brain stroke necrosis with novel agent 18F-Fluoroglucaric Acid
Conclusions: Results show that FGA has a potential to enable extremely sensitive and high resolution neuroimaging of brain infarcts. F-18-labeled FGA can be rapidly synthesized from ubiquitously available F-18-FDG in a simple reaction.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Houson, H., Mdzinarishvili, A., Awasthi, V. Tags: Basic Science III Source Type: research
A study of the brain protective effects and mechanism of stroke rats with allopurinol by 18F- FMISO PET imaging
Conclusion (1) 18F-FMISO imaging can accurately show the cerebral ischemia penumbra . (2) Allopurinol can reduce the degree of hypoxia of ischemic brain tissue.(3) Allopurinol affects the 8F-FMISO uptake of brain tissues by the activity of xanthine oxidase.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Li, Y., Li, A. Tags: Basic Science I Source Type: research
Myocardial Energetics in AL and ATTR Cardiac Amyloidosis: A C-11 Acetate PET/CT Study
Conclusions: These results suggest that myocardial structure and energy utilization patterns differ between patients with AL-CMP and ATTR-CMP. Patients with AL-CMP have much lower myocardial mass and lower energy efficiency compared to patients with ATTR-CMP, suggesting better myocardial metabolic adaptation in ATTR-CMP. These findings if confirmed in a larger cohort suggest a role for novel therapeutics to manipulate substrate utilization in AL-CMP. AL-CMP(N=20)ATTR-CMP(N=3)P-ValueAge63 ± 6.380 ± 0.8<0.0001Rate Pressure Product, systolic blood pressure X heart rate, (mm Hg bpm)9228 ± 13608318 &plus...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: El-Sady, M. S., Kijewski, M., Jacob, S., Bravo, P., Dubey, S., Nodoushani, A., Belanger, A., Park, M.-A., Falk, R., Di Carli, M., Dorbala, S. Tags: Cardiac Metabolism, Viability, and Innervation Source Type: research
Imaging of Blood-Brain Barrier Disruption by Tc-99m-Tilmanocept Molecular Imaging of a Rodent Model of Traumatic Brain Injury
Conclusions: These results are consistent with the hypothesis that microglial cells bearing CD206 trap fluorescent-labeled Tc-99m-tilmanocept in regions of BBB disruption. This provides the motivation for a clinical trial of intra-venously administered Tc-99m-tilmanocept with the goal of developing a SPECT/CT protocol for the detection of neuro-inflammation.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Vera, D., Barback, C., Wang, S., Head, B., Hoh, C. Tags: Basic Science II Source Type: research
Synthesis of 11CNR2B-SMe for evaluation as a PET radioligand for NR2B subunits in NMDA receptors
Conclusions: [11C]NR2B-SMe was readily synthesized, and showed high brain uptake in rat, which could be pre-blocked by NR2B-SMe itself, elipodil, ifenprodil, and by a selective sigma-1 receptor ligand. Because sigma-1 receptors serve as multitasking ion channel protein chaperones [4] with involvement in modulation of NMDA activity [5], and are now known to interact directly with the N-terminal domains of NR1 and NR2B subunits [6], further study is required to characterize the nature of the specific binding of [11C]NR2B-SMe in rat brain and its utility in brain research. These studies are ongoing. Research Support: Intramur...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Cai, L., Liow, J.-S., Morse, C., Davies, R., Frankland, M., Zoghbi, S., Innis, R., Pike, V. Tags: Probes for Neuroimaging I Source Type: research
