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Specialty: Nuclear Medicine
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Total 204 results found since Jan 2013.
Ventricular–arterial coupling assessment using gated single-photon emission computed tomography: relationship with reserve pulse pressure and repolarization abnormalities
Conclusion: Noninvasive assessment of VAc is feasible with gated single-photon emission computed tomography and appears to be related to ST-segment depression and reserve rPP.
Source: Nuclear Medicine Communications - October 26, 2016 Category: Nuclear Medicine Tags: Original Articles Source Type: research
18 F-FDG PET/CT imaging factors that predict ischaemic stroke in cancer patients
ConclusionOur findings suggest that arterial FDG uptake and hypermetabolic malignancy on PET and the VAT proportion on CT could be independent predictors of future ischaemic stroke in patients with cancer and could identify those patients who would benefit from medical treatment.
Source: European Journal of Nuclear Medicine and Molecular Imaging - October 4, 2016 Category: Nuclear Medicine Source Type: research
Subacute Stroke Mimicking Cerebral Metastasis in 68Ga-PSMA-HBED-CC PET/CT
Abstract: A 65-year-old man with disseminated bone metastases of prostate cancer was referred for 68Ga-PSMA-HBED-CC-PET/CT (short PSMA-PET/CT) to exclude visceral metastases before treatment of bone metastases with 223Ra-dichloride. Apart from disseminated bone metastases, PSMA-PET/CT revealed a focal cerebral tracer uptake in the right frontal lobe highly suspicious for cerebral spread. According to patient history, a cerebral infarction occurred 14 days before PSMA imaging in corresponding localization confirmed by MRI scanning. This case demonstrates the possibility of false-positive finding of cerebral metastases in PS...
Source: Clinical Nuclear Medicine - September 8, 2016 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Automatic Extraction of Myocardial Mass and Volume Using Parametric Images from Dynamic Nongated PET
Conclusion: LV mass and volume are accurately and automatically generated from dynamic 11C-acetate PET without electrocardiogram gating. This method can be incorporated in a standard routine without any additional workload and can, in theory, be extended to other PET tracers.
Source: Journal of Nuclear Medicine - August 31, 2016 Category: Nuclear Medicine Authors: Harms, H. J., Stubkjaer Hansson, N. H., Tolbod, L. P., Kim, W. Y., Jakobsen, S., Bouchelouche, K., Wiggers, H., Frokiaer, J., Sorensen, J. Tags: Clinical Investigations Source Type: research
FLT PET/CT in a Case of Demyelinating Disease
Abstract: A 32-year-old woman, with spare previous medical history, presented with neurological symptoms of numbness and diplopia. The patient underwent brain MRI, which revealed a lesion of abnormal signal in the midbrain that could be attributed to subacute stroke; however, consecutive MRIs revealed multiple lesions of abnormal signal pointing to demyelinating disease. During symptoms investigation and MRI findings assessment, the patient underwent a FLT PET/CT examination, which revealed lesions of increased FLT uptake, probably indicating active disease and blood-brain barrier disruption.
Source: Clinical Nuclear Medicine - June 8, 2016 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Automatic calculation of myocardial external efficiency using a single 11C-acetate PET/CT scan: a dual-center validation
Conclusions Myocardial efficiency can be calculated automatically using only a single 11C-acetate PET scan. This facilitates clinical applicability and provides unbiased access to a sensitive marker of cardiac dysfunction.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Harms, H. J., Hansson, N., Kero, T., A-rndahl, L., Kim, Y., Frokiaer, J., Wiggers, H., Flachskampf, F., Tolbod, L., Sorensen, J. Tags: MTA II: Cardiovascular Clinical Science Posters Source Type: research
Causal role of non-stenotic hypodense plaques with high FDG uptake detected with PET-CT angiography in patients with unknown cause of stroke?
Conclusions In this exploratory study, we found a high prevalence of non-stenotic hypodense plaques with high FDG uptake (TBR max. > 1.80) in carotid arteries ipsilateral to cerebral ischemia suggesting a causal role for these plaque in patients with unknown cause of stroke. In comparison to high-resolution MRI, the imaging criteria used in this study for the identification of complicated plaques were very simple and easy to implement. In addition, FDG-PET-CTA allows for the evaluation of non-stenotic plaques along the whole length of supra-aortic trunks. Further studies with a larger number of patients are requested to...
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Mikail, N., Mazighi, M., Meseguer, E., Guidoux, C., Leseche, G., Rouzet, F., Le Guludec, D., Amarenco, P., Hyafil, F. Tags: MTA II: Cardiovascular Clinical Science Posters Source Type: research
18FFDPN for PET Imaging of Soluble Epoxide Hydrolase (sEH)
Conclusions [18F]FDPN, a potent sEH inhibitor, readily enters the mouse and baboon brain and radiolabels sEH with high specificity (up to 95%) in both species. This first-in-class agent may enable study of sEH non-invasively in a variety of neurological diseases.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Horti, A., Wang, Y., Minn, I., Koehler, R., Dannals, R., Pomper, M. Tags: Neurosciences - Basic Science 1 Source Type: research
Periodontitis and carotid arterial inflammation
Conclusions Independent of systemic inflammation, these data suggest that periodontitis and its degree of inflammation appear to be closely associated with vascular inflammation, a crucial mechanism of the development, progression and vulnerability of atherosclerotic plaque.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Cho, J., Choe, J. G., Rhee, S., Choi, S., Eo, J. S., Kim, S. Tags: MTA II: Cardiovascular Clinical Science Posters Source Type: research
Assessment of muscle function using hybrid pet/mri: comparison of quantifying muscle activation using 18f-fdg pet and t2 mri in human subjects
Conclusions There exists a strong linear correlation between T2 changes and glucose uptake which did not vary between subjects nor between muscle groups. This is the first assessment of skeletal muscle function using hybrid PET/MRI and the first study to demonstrate the correlation between [18F]-FDG uptake and changes in muscle T2 with physical exercise. Accordingly, it seems that changes in muscle T2 may be used as a surrogate marker for glucose uptake. Such metabolic information of muscle activation could lead to an improved insight and to improved treatment strategies in neuromuscular pathologies such as stroke, spinal ...
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Haddock, B. Tags: Musculoskeletal 1 Source Type: research
Brain findings on FDG PET-MRI body sequences that include the head
Conclusions FDG PET-MRI imaging is a rapidly evolving modality that is most commonly employed for cancer evaluation. The standardized base of skull to mid thigh imaging may miss many important pathologies that are discovered even with MRI body sequences. We propose that PET-MRI body sequences that include the head may show added value in the management of patients.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Franceschi, A., Matthews, R., Bangiyev, L., Relan, N., Chaudhry, A., Franceschi, D. Tags: Outcomes/Comparative Effectiveness Research & amp; Radiation Safety Source Type: research
Time sequential monitoring of the translocator protein 18 kDa (TSPO) and acetylcholinesterase (AChE) expression in a middle cerebral artery occlusion (MCAO) rat model using PET radiotracers
Conclusions Our results indicate that an AChE level elevate in the early course of disease and becomes normal, while TSPO expression elevates later, and is sustained throughout the post-ischemic injury. It is known that different inflammatory mechanisms are involved according to the time window after stroke 4. AChE was reported to be related with early apoptosis after stroke. TSPO related cytokines such as TNF-α and IL-6 increased later. Our study shows that the brain inflammatory process can be demonstrated and quantified with PET imaging. RESEARCH SUPPORT: .
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Song, Y. S., Moon, B. S., Chung, Y. A., Lee, B. C., Kim, S. E. Tags: MTA I: Educational Exhibits Posters Source Type: research
18FFLT - A new stem cell label for in vivo tracking with positron emission tomography
Conclusions In conclusion, [18F]FLT labeling of sheep MSCs is feasible. 60min incubation time with the tracer does not perturb the biologic and functional properties of adult sheep MSCs in vitro. This labeling method and optimization strategy has led to pilot studies investigating the biodistribution of [18F]FLT-labeled MSCs in mice using small-animal PET/MRI. Future studies will also determine whether [18F]FLT-labeled MSCs can be tracked over time in a large animal model to assess the therapeutic potential of MSCs after stroke.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: GroAYmann, U., Zeisig, V., McLeod, D., Dreyer, A., Patt, M., Schildan, A., Sabri, O., Boltze, J., Barthel, H. Tags: SPECIAL MTA: Preclinical Probes for Neuroimaging Posters Source Type: research
Clinical implications for Translocator Protein (TSPO) imaging using 123ICLINDE SPECT: A feasible approach
Conclusions The preliminary results imply that [123I]CLINDE-SPECT is a feasible approach for TSPO imaging in neurological disorders associated with microglial activation and/or increased TSPO expression. The development of methods that do not need arterial blood sampling for quantification of TSPO will be important to ease implementation in a daily clinical setting. Further clinical studies are needed to determine the precise role of TSPO imaging in predicting clinical outcome and treatment response.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Thomsen, G., Jensen, P., Feng, L., Knudsen, L., Knudsen, G., Pinborg, L. Tags: Neurosciences/Neurology. Miscellaneous Source Type: research
Early detection of doxorubicin-induced cardiotoxicity using the matrix metalloproteinase (MMP) targeted radiotracer, 99mTc-RP805.
Conclusions Increases in myocardial MMP activity precede clinically used echocardiographic indices for early detection of cardiotoxicity, including ejection fraction and global myocardial strain. Therefore, 99mTc-RP805 may serve as a promising approach for early detection of DOX-induced cardiotoxicity when combined with SPECT/CT imaging.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Boutagy, N., Mikush, N., Wang, X., Hawley, C., Liu, C., Sinusas, A. Tags: MTA II: Cardiovascular Basic Science Posters Source Type: research
