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Specialty: Nuclear Medicine

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Total 204 results found since Jan 2013.

Preliminary study about the relationship between degree of internal carotid artery stenosis, wall shear stress on MR angiography and 18F-FDG uptake on PET/CT
Conclusions: These preliminary results indicated that there were significant correlations between degree of internal carotid artery stenosis, WSS and 18F-FDG uptake in patients with carotid artery stenosis. Furthermore, the relationship between WSS and 18F-FDG uptake was higher than that between degree of internal carotid artery stenosis and 18F-FDG uptake.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Takami, Y., Norikane, T., Yamamoto, Y., Fujimoto, K., Mitamura, K., Nishiyama, Y. Tags: Clinical Science (Poster Session) Source Type: research

Potential applications of FDG-PET/MRI in detecting vascular dementia
Conclusions: FDG-PET/MRI may be a valuable tool in the diagnosis of VaD. However, the paucity of data in the field necessitates a further analysis of its similarity to FDG-PET/CT in results. Novel studies should be conducted to explore various scanners, patient populations, and MRI protocols to better inform the identification of VaD.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Bhattaru, A., Zhang, V., Hancin, E., Borja, A., Rojulpote, K. V., Werner, T., Revheim, M.-E., Alavi, A. Tags: Educational Exhibits Poster Session I Source Type: research

F-18 FDG PET/CT in Management of Necrotizing Otitis Externa
1157Objectives: Necrotizing otitis externa (NOE), also referred to as "malignant otitis externa," is an uncommon complication of external ear canal infections, resulting in skull base osteomyelitis. Multiple pathogens have been implicated, the most common of which is Pseudomonas aeruginosa. Risk factors include diabetes, advanced age, and immunocompromised status. Clinical features include unremitting otalgia, otorrhea, headache, and cranial nerve involvement. Treatment consists of prolonged parenteral antibiotics and selective surgical debridement. Inadequate treatment of NOE is associated with significant morbidities, in...
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Thorsness, S., Friedman, N., Moore, D., Cohen, E., Reddy, S. Tags: Educational Exhibits Poster Session I Source Type: research

Value of SPECT/CT over planar imaging during Tc-99m MDP triple phase bone scintigraphy for detection of osteomyelitis in patients with stage IV pressure ulcers
Conclusion: SPECT/CT imaging has a significant added diagnostic value over planar imaging in accurately detecting osseous involvement with stage IV pressure ulcers. It significantly reduced equivocal results by accurate uptake localization, reducing false positive results due to other associated pathologies and reducing false negative results due to overlap by other structures or difficult patient positioning.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Nasr, H., Alfawzan, T., Alqarni, A., Farghaly, H. Tags: Infection/Pulmonary/Outcomes (Poster Session) Source Type: research

Assessing the pharmacokinetics and metabolism of 18FLMI1195 in clinical imaging populations
Conclusions: These preliminary results suggest notable differences in the clearance and metabolic profiles of [18F]LMI1195 dependent on the given disease pathology. Radiotracer parent fraction can be equally measured by column-switching HPLC or SPE. These findings offer an important consideration for estimation of myocardial sympathetic nerve density using [18F]LMI1195 in patients suffering from cardiovascular disease. Support: Heart & Stroke Foundation of Canada/CANet ERLI (Rotstein) References: [1] Zelt, J. G. E. et al. J. Nucl. Cardiol. 2019, 26 (6), 2151-2153. [2] Sinusas, A. J. et al. J. Nucl. Med. 2014, 55 (9), 1...
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Mair, B., Al Haddad, R., Zelt, J., Dinelle, K., Quigley, S., Beanlands, R., DeKemp, R., Rotstein, B. Tags: Clinical Science (Poster Session) Source Type: research

Correlation of Global Cardiac Microcalcification with CHADS2and CHADS2-VASc Scores in Individuals At-risk for Cardiovascular Disease as Assessed by NaF-PET/CT
Conclusions: Global cardiac NaF uptake on PET/CT correlated positively with both CHADS2 and CHA2DS2-VASc scores. Our data provides further evidence to support the association of these scoring systems with cardiac atherosclerotic burden.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Rojulpote, C., Patil, S., Gonuguntla, K., Revheim, M.-E., Zirakchian Zadeh, M., Werner, T., Gerke, O., Hoilund-Carlsen, P. F., Alavi, A. Tags: Clinical Science (Poster Session) Source Type: research

The Use of Random Forests to Identify Brain Regions on Amyloid and FDG PET Associated With MoCA Score
Conclusions Random forests help pinpoint clinically relevant ROIs associated with MoCA score; amyloid increased and 18F-FDG decreased with decreasing MoCA score, most significantly in the posterior cingulate gyrus.
Source: Clinical Nuclear Medicine - May 8, 2020 Category: Nuclear Medicine Tags: Original Article Source Type: research

18F-FAC PET Visualizes Brain-Infiltrating Leukocytes in a Mouse Model of Multiple Sclerosis
Conclusion: 18F-FAC PET can visualize brain-infiltrating leukocytes in a mouse MS model and can monitor the response of these cells to an immunomodulatory drug. Translating this strategy into humans will require exploring additional radiotracers.
Source: Journal of Nuclear Medicine - April 30, 2020 Category: Nuclear Medicine Authors: Chen, B. Y., Ghezzi, C., Villegas, B., Quon, A., Radu, C. G., Witte, O. N., Clark, P. M. Tags: Basic Source Type: research

18F-FDG PET/CT Brain in a Case of Agrammatic/Nonfluent Variant of Primary Progressive Aphasia (Broca’s Aphasia)
We present a case of middle-aged female patient who underwent 18F-FDG PET of the brain for evaluating progressively declining speaking ability associated with altered fluency of speech and occasional mutism. 18F-FDG PET revealed asymmetric hypometabolism involving the left inferior frontal gyrus along with left anterior cingulate gyrus suggestive of Broca's aphasia.
Source: Clinical Nuclear Medicine - April 15, 2020 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Pet tracers for vulnerable plaque imaging
AbstractMost of the acute ischemic events, such as acute coronary syndromes and stroke, are attributed to vulnerable plaques. These lesions have common histological and pathophysiological features, including inflammatory cell infiltration, neo-angiogenesis, remodelling, haemorrhage predisposition, thin fibrous cap, large lipid core, and micro-calcifications. Early detection of the presence of a plaque prone to rupture could be life-saving for the patient; however, vulnerable plaques usually cause non-haemodynamically significant stenosis, and anatomical imaging techniques often underestimate, or may not even detect, these ...
Source: Annals of Nuclear Medicine - March 19, 2020 Category: Nuclear Medicine Source Type: research

Current and novel radiopharmaceuticals for imaging cardiovascular inflammation.
Authors: Heo GS, Sultan D, Liu Y Abstract Cardiovascular disease (CVD) remains the leading cause of death worldwide despite advances in diagnostic technologies and treatment strategies. The underlying cause of most CVD is atherosclerosis, a chronic disease driven by inflammatory reactions. Atherosclerotic plaque rupture could cause arterial occlusion leading to ischemic tissue injuries such as myocardial infarction (MI) and stroke. Clinically, most imaging modalities are based on anatomy and provide limited information about the on-going molecular activities affecting the vulnerability of atherosclerotic lesion for...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - February 22, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Clinical imaging of cardiovascular inflammation.
Authors: Calcagno C, Fayad ZA Abstract Cardiovascular disease due to atherosclerosis is the number one cause of morbidity and mortality worldwide. In the past twenty years, compelling preclinical and clinical data have indicated that a maladaptive inflammatory response plays a crucial role in the development of atherosclerosis initiation and progression in the vasculature, all the way to the onset of life-threatening cardiovascular events. Furthermore, inflammation is key to heart and brain damage and healing after myocardial infarction or stroke. Recent evidence indicates that this interplay between the vasculatur...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - February 22, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Initial experience with 18 FDPA-714 TSPO-PET to image inflammation in primary angiitis of the central nervous system
Conclusions[18F]DPA-714-PET imaging may facilitate the diagnosis and treatment monitoring of PACNS. Further studies are needed to fully understand the potential of TSPO-PET in deciphering the heterogeneity of the disease.
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 19, 2020 Category: Nuclear Medicine Source Type: research

64Cu PET Imaging of the CXCR4 Chemokine Receptor Using a Cross-Bridged Cyclam Bis-Tetraazamacrocyclic Antagonist
Conclusion: The tetraazamacrocyclic small molecule 64Cu-CuCB-bicyclam has been shown to be an imaging agent for the CXCR4 receptor that is likely to be applicable across a range of species. It has high affinity and stability and is suitable for preclinical research in immunocompetent murine models.
Source: Journal of Nuclear Medicine - January 1, 2020 Category: Nuclear Medicine Authors: Burke, B. P., Miranda, C. S., Lee, R. E., Renard, I., Nigam, S., Clemente, G. S., DHuys, T., Ruest, T., Domarkas, J., Thompson, J. A., Hubin, T. J., Schols, D., Cawthorne, C. J., Archibald, S. J. Tags: Basic Source Type: research

The Use of Random Forests to Classify Amyloid Brain PET
Conclusions Random forests can classify brain PET as positive or negative for amyloid deposition and suggest key clinically relevant, regional features for classification.
Source: Clinical Nuclear Medicine - September 11, 2019 Category: Nuclear Medicine Tags: Original Articles Source Type: research