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Specialty: Nuclear Medicine
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Total 204 results found since Jan 2013.
Predicting cardiovascular events associated with normal and abnormal myocardial perfusion imaging and normal coronary angiogram
Conclusion: Abnormal MPI predicts a higher prevalence of future cardiovascular events than by CA alone. Since the MPI measures the physiology of coronary flow including the microvasculature and the coronary flow reserve, these parameters may be more accurate in predicting the likelihood of future events than coronary stenosis alone. Research support: Veterans Health Administration
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Allen, S., Singla, A., Romana, B., Chockalingam, A., Zuidema, M., Dresser, T. Tags: Cardiovascular Clinical Science Posters Source Type: research
The value of F-18 FDG PET-CT scan in the diagnosis of infection of unknown origin in a patient with aortic valve replacement. in the diagnosis of infection of unknown origin in a patient with Aortic valve replacement. value of F-18 FDG PET/CT scan in the diagnosis of infection of unknown origin in a patient with Aortic valve replacement.
Conclusion: This case illustrates the value of F-18 FDG PET/CT in the diagnosis of and localization of a periaortic valve abscess in a patient with multiple valve replacements, recurrent fevers/sepsis and inconclusive imaging with transthoracic echocardiogram, transesophageal echocardiogram and Indium-111 WBC scan. The localization of the FDG activity to the posterior aspect of the valve which corresponded to the findings on transthoracic echocardiogram was key. Research Support:
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Muhleman, M., Kaur, H., Patel, M., Rydberg, J. Tags: Educational Exhibits Posters Source Type: research
All That Glitters Is not Gold: Peals and Pitfalls in I-131 Scans for Differentiated Thyroid Cancer
Conclusion: We review thyroid gland physiology and describe a systemic overview of potential false positive and false negative lack of uptake of radioiodine in the whole body along with illustrations and cases. By understanding the physiology and characteristics of radioiodine uptake and correlating with anatomical imaging, biochemical data, and clinical findings, physicians can be more confident in establishing proper management for patients with DTC using radioiodine whole body scans. Research Support: N/A
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Lazaga, F., Sharma, S., Sharma, P., Williams, S. Tags: Educational Exhibits Posters Source Type: research
Crossed cerebellar diaschisis on F-18 FDG PET/CT and MRI/Functional MRI
Conclusion: CCD is likely to be permanent while a small percentage (15%) showed improvement or even complete resolution regardless of the causative insult (tumor or infarct). While MRI is the study of choice in evaluating the brain, it was not able to detect any evidence of abnormal morphology, signal or blood flow in the cerebellum of patients who have a supratentorial insult. Given the small number of cases with improvement of CCD, the clinical significance has yet to be determined. Research Support: None
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Bakdalieh, A., Osman, M., Muzaffar, R., Ghazala, H., Zhou, Y. Tags: Neurology Posters Source Type: research
Microglial activation in recent ischemic stroke: comparison of two TSPO tracers
Conclusion: The apparent intensity of microglial activation in ischemic stroke is closely comparable between 18F-GE180 and 11C-(R)-PK11195 PET. Research Support: The study is funded by a grant from NIHR and supported by GEHC and INMIND (EC FP7).
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Herholz, K., Hinz, R., Visi, E., Trigg, W., McDonald, K., Punter, M., Majid, A., Gerhard, A. Tags: Neurology Posters Source Type: research
PET/CT Imaging of Unstable Carotid Plaque with 68Ga-Labeled Somatostatin Receptor Ligand
Conclusion: 68Ga-DOTATATE activity on PET in recently symptomatic carotid plaques is not significantly different from contralateral carotids/plaques. Any activity seen on PET is not shown to be from specific sst2 receptor–mediated uptake in vitro. It is therefore unlikely that sst2 PET/CT imaging will have a role in the detection and characterization of symptomatic carotid plaques.
Source: Journal of Nuclear Medicine - May 1, 2017 Category: Nuclear Medicine Authors: Wan, M. Y. S., Endozo, R., Michopoulou, S., Shortman, R., Rodriguez-Justo, M., Menezes, L., Yusuf, S., Richards, T., Wild, D., Waser, B., Reubi, J. C., Groves, A. Tags: Clinical Source Type: research
Recent Progress in the Development of TSPO PET Ligands for Neuroinflammation Imaging in Neurological Diseases
AbstractNeuroinflammation is heavily associated with various neurological diseases including Alzheimer ’s disease, Parkinson’s disease, multiple sclerosis, and stroke. It is strongly characterized by the activation of microglia which can be visualized using position emission tomography (PET). Traditionally, translocator protein 18 kDa (TSPO) has been the preferred target for imaging the inflamma tory progression of the microglial component. TSPO is expressed in the outer mitochondrial membrane and present in very low concentrations in the healthy human brain, but is markedly upregulated in response to brain injury and...
Source: Nuclear Medicine and Molecular Imaging - March 15, 2017 Category: Nuclear Medicine Source Type: research
Reliability of magnetic susceptibility weighted imaging in detection of cerebral microbleeds in stroke patients
Conclusion SWI is an important reliable technique allows accurate detection of CMBs occurring in association with hemorrhage in acute and chronic stroke and should be included in the protocols for assessment of stroke to help in choice of proper treatment and prediction of future attacks.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - March 10, 2017 Category: Nuclear Medicine Source Type: research
Validation of MRI Determination of the Penumbra by PET Measurements in Ischemic Stroke
The concept of the ischemic penumbra was formulated on the basis of animal experiments showing functional impairment and electrophysiologic disturbances with decreasing flow to the brain below defined values (the threshold for function) and irreversible tissue damage with blood supply further decreased (the threshold for infarction). The perfusion range between these thresholds was termed the "penumbra," and restitution of flow above the functional threshold was able to reverse the deficits without permanent damage. In further experiments, the dependency of the development of irreversible lesions on the interaction of the ...
Source: Journal of Nuclear Medicine - January 31, 2017 Category: Nuclear Medicine Authors: Heiss, W.-D., Zaro Weber, O. Tags: The State of the Art Source Type: research
18F-NaF PET Demonstrating Unusual Focal Tracer Activity in the Brain
Abstract: A 60-year-old man with enlarged prostate, hypertension, and diabetes was referred for 18F-NaF PET/CT to evaluate possible metastatic lesions. The patient appeared asymptomatic on the day of the study, without any signs indicating stroke. Patient also had no known history of malignancy or cerebrovascular disease. He had mild elevation of the prostate-specific antigen level, and biopsy of his prostate was not performed. Patient had long-standing history of chronic back pain and abdominal pain. The PET bone scan demonstrated a large area of very intense tracer uptake in the brain. A subsequent brain MRI revealed pri...
Source: Clinical Nuclear Medicine - January 10, 2017 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
18F-Choline Uptake in Acute Ischemic Stroke
Abstract: A 75-year-old man with a history of prostate cancer was referred to our department to perform 18F-choline (FCH) PET/CT. FCH PET/CT showed a markedly increased uptake in the right temporoparietal junction brain. Three weeks earlier, acute ischemic stroke was diagnosed in the right temporoparietal junction brain on diffusion-weighted sequence and thrombosis in a distal branch of the right middle cerebral artery on MR angiography. Choline precursors promote repair and growth of cell membranes in neurologic diseases, so FCH PET/CT uptake could be explained by repair processes during early outcome of acute ischemic stroke.
Source: Clinical Nuclear Medicine - January 10, 2017 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Cardiac MR-assessed hemodynamic changes in pulmonary arterial hypertension and their relation to pulmonary artery pressure
Conclusion MR-derived ventricular mass index, right ventricular mass, and right ventricular ejection fraction had the strongest relation with the pulmonary artery pressure, and hence they could be reliable parameters on monitoring patients with pulmonary arterial hypertension.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - December 20, 2016 Category: Nuclear Medicine Source Type: research
Role of quantitative myocardial positron emission tomography for risk stratification in patients with hypertrophic cardiomyopathy: a 2016 reappraisal
ConclusionsDip-MBF confirms its role as potent predictor of outcome in HCM. However, the threshold for prediction in a contemporary cohort is higher than that reported in earlier studies. Dip-MBF impairment in the lateral wall, possibly reflecting diffuse disease extending to non-hypertrophic regions, is a sensitive predictor of mortality in HCM.
Source: European Journal of Nuclear Medicine and Molecular Imaging - November 3, 2016 Category: Nuclear Medicine Source Type: research
Erythropoietin Pretreatment of Transplanted Endothelial Colony-Forming Cells Enhances Recovery in a Cerebral Ischemia Model by Increasing Their Homing Ability: A SPECT/CT Study
Conclusion: Priming with erythropoietin before cell transplantation is an efficient strategy to amplify the migratory and engraftment capacities of ECFCs and their beneficial impact on BBB disruption, apoptosis, and CBF.
Source: Journal of Nuclear Medicine - October 31, 2016 Category: Nuclear Medicine Authors: Garrigue, P., Hache, G., Bennis, Y., Brige, P., Stalin, J., Pellegrini, L., Velly, L., Orlandi, F., Castaldi, E., Dignat-George, F., Sabatier, F., Guillet, B. Tags: Basic Science Investigations Source Type: research
18F-FNDP for PET Imaging of Soluble Epoxide Hydrolase
Conclusion: 18F-FNDP can be synthesized in suitable radiochemical yield and high specific radioactivity and purity. In vivo imaging experiments demonstrated that 18F-FNDP targeted sEH in murine and nonhuman primate brain specifically. 18F-FNDP is a promising PET radiotracer likely to be useful for understanding the role of sEH in a variety of conditions affecting the central nervous system.
Source: Journal of Nuclear Medicine - October 31, 2016 Category: Nuclear Medicine Authors: Horti, A. G., Wang, Y., Minn, I., Lan, X., Wang, J., Koehler, R. C., Alkayed, N. J., Dannals, R. F., Pomper, M. G. Tags: Basic Science Investigations Source Type: research
