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Specialty: Nuclear Medicine
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Total 204 results found since Jan 2013.
Acute Brain Stroke Evolution Detected by 18F-FDG PET/CT and MRI Justifies the Discordance of Lesions in a Patient With Lymphoproliferative Syndrome
A 50-year-old man with angioimmunoblastic T-cell lymphoma in complete response to treatment presented new hypermetabolic brain lesions on 18F-FDG PET/CT suggestive of malignancy. These findings were correlated by MRI that showed cortical-subcortical peripheral lesions typical of acute ischemic infarction. A restaging 18F-FDG PET/CT showed that hypermetabolic lesions were replaced by ametabolic areas, supporting chronic infarction. Early ischemia presents transitory FDG increase. Brain lymphomas are highly FDG avid and difficult to differentiate from acute cerebral infarction. In view of the discordance of abnormal areas of...
Source: Clinical Nuclear Medicine - February 11, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Quantifying microcalcification activity in the thoracic aorta
ConclusionsAMA is a simple, rapid and reproducible method of quantifying global18F-NaF uptake across the ascending aorta and aortic arch that correlates with cardiovascular risk scores.
Source: Journal of Nuclear Cardiology - January 20, 2021 Category: Nuclear Medicine Source Type: research
Evaluation of non-stenotic carotid atherosclerotic plaques with combined FDG-PET imaging and CT angiography in patients with ischemic stroke of unknown origin
ConclusionsIn patients with ischemic stroke of unknown origin and non-stenotic plaques, we found an increased prevalence of high-risk plaques features ipsilateral vs. contralateral to stroke on FDG-PET-CTA imaging suggesting a causal role for these plaques.
Source: Journal of Nuclear Cardiology - January 18, 2021 Category: Nuclear Medicine Source Type: research
“Skull on Fire”: Monostotic Paget Disease of the Skull Bone
An 81-year-old woman was evaluated for a stroke. CT showed no intracranial abnormalities but diffuse patchy aspect of the neurocranium. An MRI and 18F-NA PET/CT were performed to differentiate between metastases, Paget disease, hyperostosis frontalis interna, and primary malignancy. MRI yielded no additional findings. 18F-NA PET/CT showed diffusely increased uptake in the skull and 4 spots with intense uptake. No other suspicious skeletal foci were seen elsewhere. Low-dose CT showed no sign of malignancy elsewhere. Image findings together with elevated serum alkaline phosphatase levels, slightly increased calcium levels, a...
Source: Clinical Nuclear Medicine - December 9, 2020 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Prognostic value of myocardial perfusion imaging with D-SPECT camera in patients with ischemia and no obstructive coronary artery disease (INOCA)
ConclusionsD-SPECT MPI provides excellent prognostic information, with a more severe prognosis in patients with abnormal D-SPECT MPI. INOCA patients with abnormal D-SPECT MPI experience a poor prognosis similar to that of patients with obstructive CAD.
Source: Journal of Nuclear Cardiology - September 29, 2020 Category: Nuclear Medicine Source Type: research
Demarcation of Sepsis-Induced Peripheral and Central Acidosis with pH (Low) Insertion Cycle Peptide
Conclusion: Here, we demonstrate that a pH-sensitive PET tracer specifically detects acidosis in regions associated with sepsis-driven proinflammatory responses. This study suggests that [64Cu]Cu-pHLIC is a valuable tool to noninvasively assess acidosis associated with both central and peripheral innate immune activation.
Source: Journal of Nuclear Medicine - August 31, 2020 Category: Nuclear Medicine Authors: Henry, K. E., Chaney, A. M., Nagle, V. L., Cropper, H. C., Mozaffari, S., Slaybaugh, G., Parang, K., Andreev, O. A., Reshetnyak, Y. K., James, M. L., Lewis, J. S. Tags: Basic Source Type: research
Novel methodolgy for measuring regional myocardial efficiency
Conclusions: Cardiac efficiency of specific tissue regions is obtained using a FE biomechanical model of the heart to calculate work and kinetic modelling of dynamic 11C-acetate data to calculate oxygen consumption. The calculation of myocardial efficiency in patients provides a wealth of diagnostic information of functional analysis as well as biochemical and physiological characterization of inhomogeneity of cardiac efficiency.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Gullberg, G., Shrestha, U., Veress, A., Segars, W. P., Liu, J., Ordovas, K., Seo, Y. Tags: New Techniques and Tracers for Ischemic Heart Disease (Basic Science, Cardio) Source Type: research
Intrathecal injection of aptamer-conjugated DNA framework for the treatment of cerebral ischemia/reperfusion injury.
Conclusion: The high payload of an aptamer conjugated bipyramidal FNA was for cerebral IRI management was provided by intrathecal injection. This DNA framework alleviated the extent of cerebral IRI by acting as an antioxidant and inhibitor of inflammation.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Rosenkrans, Z., Li, S., Jiang, D., Engle, J., Cai, W. Tags: Center for Molecular Imaging Innovation & amp; Translation (CMIIT) YIA Symposium Source Type: research
Polyoxometalate nanoclusters act as broad-spectrum antioxidants to alleviate ischemic stroke by intrathecal injection
Conclusion: Intrathecal injection significantly improved the delivery and efficacy of POM nanoclusters to the brain, resulting in the rapid accumulation of POM nanoclusters in the ischemic penumbra. Due to this, we confirmed that the POM nanoclusters could be used as nano-antioxidants to inhibit oxidative stress as well as inflammatory damage effectively.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Rosenkrans, Z., Li, S., Jiang, D., NI, D., Engle, J., Cai, W. Tags: Center for Molecular Imaging Innovation & amp; Translation (CMIIT) YIA Symposium Source Type: research
Correlation between inflammation and neovascularization in carotid atherosclerotic plaques based on hybrid 18F-FDG PET/MRI: a pathological validation study
Conclusions: The correlation between inflammation and neovascularization in carotid atherosclerotic plaques with hybrid 18F-FDG PET/MR varied with clinical conditions, pointing to a complex interplay between macrophages and neovessels under different pathophysiological conditions. Hybrid 18F-FDG PET/MR systems can help to evaluate the correlation between inflammation and neovascularization in carotid atherosclerotic plaques. Key words: Atherosclerosis, Vulnerable plaque, Inflammation, Neovascularization, Hybrid PET/MR.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Zhang, Y., Lu, J., Yang, H., Ma, J., Song, H., Ma, Q. Tags: Radionuclide Imaging of Atherosclerosis Source Type: research
Crossed cerebellar diaschisis on 18F-FDG PET across neurodegenerative diseases: frequency and association with 11C-PIB and 18F-FTP
Conclusions: CCD is present in a significant proportion of patients with neurodegenerative diseases, and is more prevalent in specific phenotypes, especially in typically asymmetric presentations such as CBS, svPPA and lvPPA. The association between CCD on 18F-FDG and cortical 18F-FTP suggests a Tau-related disruption of cortico-ponto-cerebellar pathways in amyloid-positive patients, while amyloid does not seem to play a significant role. Further studies are required to elucidate prognostic value or clinical correlate of CCD. Table 1. Patient characteristics and prevalence of crossed cerebellar diaschisis (CCD) by diagnosi...
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Provost, K., Strom, A., Iaccarino, L., Edwards, L., Mellinger, T., Pham, J., Baker, S., Miller, B., Jagust, W., La Joie, R., Rabinovici, G. Tags: Neurodegenerative Diseases Source Type: research
Risk Prediction of Coronary Flow Reserve is Strongly Influenced by the Burden of Coronary Calcification
Conclusions: Coronary flow reserve helps to risk stratify patients with CAC > 10. These findings have significant clinical implications but will need confirmation in larger studies.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Khan, M., Bravo, P., Vidula, M., Selvaraj, S., De Feria Alsina, A. E., Wiener, P., Szapary, H., Julien, H., Litt, H., Pryma, D., Dubroff, J., Guerraty, M. Tags: Technical Considerations and Clinical Application of Absolute Myocardial Blood Flow Source Type: research
Nr2b
Conclusions: The 1 receptor-selective radioligand [18F]FTC146 was used in PET imaging of rat brain. It showed high brain uptake, which could be pre-blocked by self, a 1 receptor ligand BD1047, and a NR2B-selective ligand NR2B-SMe, but at markedly different ED50 values. The ED50 for avidly brain-penetrant NR2B-SMe gave by far the highest value, implying only weak interaction with 1 receptors. Influence of 1 receptors on the PET imaging of NR2B receptors with [11C]NR2B-SMe is therefore likely negligible. Research Support: Intramural Research Program of the National Insitutes of Health (NIMH). References: [1] Zhuo M, Neuropha...
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Cai, L., Liow, J.-S., Morse, C., Davies, R., Manly, L., Zoghbi, S., Innis, R., Pike, V. Tags: Basic Science - Synaptic activity and other mechanisms Source Type: research
Monitoring synaptic loss in a rat model of stroke: a PET imaging study with 18FSynVesT-2, radiotracer for the synaptic vesicle protein 2A (SV2A)
Conclusions: Using [18F]SynVesT-2 and PET imaging, we successfully detected synapse loss in rat MCAO model and tracked disease progression via lesion quantification. Synapse loss is mainly in hippocampus, thalamus, and neocortex, rather than cerebellum. Furthermore, most significant loss of synapses was observed to occur during the first week post reperfusion. Our results showed that the quantification of synaptic density by SV2A PET may provide an objective measure of disease progression and a primary endpoint to evaluate treatment efficacy of novel therapeutics for stroke in clinical trials. References: Bunevicius et al....
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Lyu, X., Toyonaga, T., Deng, G., Huang, Y., Carson, R., Zhou, J., Cai, Z. Tags: Basic Science - Synaptic activity and other mechanisms Source Type: research
Molecular imaging of inflammation in the brain-heart axis after ischemic stroke: comparison of two murine stroke models.
Conclusions: In contrast to topical ET-1 application after craniotomy, the intravascular MCAo model enables imaging studies of brain-heart networking after stroke, which evokes elevated TSPO PET signal in both brain and heart. The severity of cerebral ischemic damage may contribute to cardiac dysfunction via systemic inflammatory networking.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Hermanns, N., Bascunana, P., Langer, B. L. N., Wolf, B., Bankstahl, J., Ross, T., Bengel, F., Thackeray, J. Tags: Cardiovascular Council YIA Symposium Source Type: research
