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Specialty: Nuclear Medicine

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Total 204 results found since Jan 2013.

Unilateral Absence of the Basal Ganglia on 123I-Ioflupane DaTScan
This 33-year-old man presented with hemorrhagic stroke manifesting with left hemiparesis and right ptosis. Angiography revealed no patent carotids. The anterior and middle cerebral arteries were filling collaterally through the posterior vertebrobasilar pathway. The presumptive diagnosis was moyamoya disease. The etiology of the bleeding was right basilar tip aneurysm that subsequently had partial coil placement. Months later, the neck of the aneurysm perforated and second coiling was performed. Later on follow-up, patient developed left hand tremor. A radionuclide DATscan revealed total absence of right-sided basal gangli...
Source: Clinical Nuclear Medicine - September 11, 2019 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Quantitative assessment of tricuspid regurgitation using right and left ventricular stroke volumes obtained from tomographic equilibrium radionuclide ventriculography
ConclusionTR assessment using the t-ERV correlates well with PISA from TTE in patients referred for right ventricular systolic function assessment.
Source: Journal of Nuclear Cardiology - June 13, 2019 Category: Nuclear Medicine Source Type: research

Framework DNA nanocages alleviate ischemic stroke via intrathecal injection
Conclusions: Zr-89 and 800CW labeled DNA nanocage framework could be safely delivered to rat brains via intrathecal injection and imaged using PET imaging and fluorescence imaging. The delivered DNA nanocages may protected rats from ischemic stroke by neutralizing ROS. This DNA framework holds great promise for stroke prevention and potential clinical translation.
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Jiang, D., NI, D., Li, S., Ehlerding, E., Sun, T., Cao, T., Chen, W., Engle, J., Cai, W. Tags: Novel Multimodality and Nonradioactive Probes Source Type: research

Carotid plaque inflammation is associated with inflammatory activity of visceral adipose tissue
Conclusions: We demonstrated that atherosclerotic plaque inflammation was associated with increased inflammation within visceral fat. Our results need to be confirmed by comparison with histologic or other imaging findings. Further evaluation to determine whether metabolic activity of visceral adipose tissue is a marker of mediator of vascular inflammation is also needed.
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Pahk, K., Cho, H. Y., Kwon, H. R., Choi, S., Kwon, H. W., Eo, J. S., Seo, H. S., Kim, S., Kim, W.-K. Tags: Cardiovascular Clinical Science Posters Source Type: research

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Conclusions: Brown fat tissue is a normal variant in pediatric F-18 FDG studies. This diffuse activity can frustrate the radiologist reading the study and possibly cause a misdiagnosis. Propranolol may be a promising solution to reducing the brown fat in pediatric patients undergoing a F-18 FDG PET/CT scan. p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 16.0px Helvetica; -webkit-text-stroke: #000000} span.s1 {font-kerning: none} p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 16.0px Helvetica; -webkit-text-stroke: #000000} span.s1 {font-kerning: none}
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Beaird, B. Tags: Technologist Student Papers II Source Type: research

Antioxidative neuroprotective role of iron-gallic acid coordination nanoparticles and PET/MR usage in an ischemia stroke model
Conclusions: Fe-GA CPNs exhibit an impressive antioxidative neuroprotective role in ischemia stroke, which might have the potential to be translated into clinical applications for improved treatment of patients with stroke. PET/MRI is effective and accurate method for ischemic evaluation.
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: KANG, L., Jiang, D., NI, D., Ehlerding, E., Wang, R., Cai, W. Tags: Basic Science I (Neurosciences) Source Type: research

Comparison of 11C(R)-NR2B-SMe and 11C(R)-NR2B-Me as PET radioligands for imaging NR2B subunits in NMDA receptors
Conclusions: [11C](R)-NR2B-SMe and [11C](R)-NR2B-Me were readily synthesized and they showed high brain uptakes in rat, which could be pre-blocked by self, NR2B-selective ligands, or either of two sigma-1 receptor agonists. Sigma-1 antagonists showed no blocking effect at low dose, but some blocking effect at high dose. More studies are necessary to elucidate the selectivity of the two radioligands and the blocking effects of some sigma-1 receptor agonists. Research Support: Intramural Research Program of the National Insitutes of Health (NIMH). References: [1] Zhuo M, Neuropharmacology, 2017, 112, 228. [2] Kassenbrock A, ...
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Cai, L., Liow, J.-S., Morse, C., Davies, R., Telu, S., Frankland, M., Zoghbi, S., Innis, R., Pike, V. Tags: Basic Science II (Neurosciences) Source Type: research

Evaluation of hybrid 18F-FDG PET/MR imaging of vulnerable plaque features in patients with carotid plaques
Conclusions: Morphological and biological features of vulnerable plaques can be detected with 18F-FDG PET/MRI in patients with known increased risk of atherosclerosis. Hybrid 18F-FDG PET/MRI systems might help in the evaluation of patients with vulnerable carotid atherosclerotic plaques. Key words: Atherosclerosis, Vulnerable plaque, Carotid arteries, Positron emission tomography, Magnetic resonance imaging, PET/MR, 18F-FDG
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Zhang, Y., Lu, J., Yang, H., Ma, J., Song, H., Ma, Q. Tags: Cardiovascular Clinical Science: Vulnerable Plaque and Innervation Imaging Source Type: research

Preclinical evaluation of a new 18F-labled probe as a potent PET imaging ligand for GluN2B subunit in NMDA receptors
Conclusions: [18F]1 showed high selective and specific binding to GluN2B subunit in in vitro ARG with brain sections of both rat and NHP, which could be preciously blocked by compound 1 itself and BMT-108908. Furthermore, [18F]1 possessed good capability of BBB penetration and fast washout rate from the mice brain. These results suggested that [18F]1 had great potential utility in PET imaging of GluN2B subunit. Acknowledgments: We thank Drs. Thomas Brady (Nuclear Medicine, MGH) for his helpful discussion. References: 1. Mony L et al. Br. J. Pharmacol. 2009;157:1301-1317.2. Marcin LR et al. ACS Med. Chem. Lett. 2018;9:472-4...
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Fu, H., Shao, T., Chen, Z., Shao, Y., Sun, S., Josephson, L., Wey, H.-Y., Daunais, J., Li, Z., Liang, S. Tags: Preclinical Probes for Neuroimaging Posters Source Type: research

Alzheimers Disease: A Review of Recent Developments and the Role of Imaging
1114Purpose: Alzheimer’s disease (AD), the most common form of dementia, is a devastating illness that will affect an estimated 5.7 million Americans and almost 50 million people worldwide in 2018, with numbers expected to nearly triple by 2050. While mortality related to heart disease and stroke has continued to decline, the rate of AD-related death in the United States more than doubled in the period from 2000-2015. Now the 6th leading cause of death, it is the least preventable and treatable of the major causes, and places a tremendous financial, physical, and emotional burden on the estimated 16 million unpaid ca...
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Ismail, H., Wang, L. Tags: Educational Exhibit Posters Source Type: research

Current Challenges for Imaging of Hypoxia in 2019
1128Introduction: Tissues with low levels of oxygen often respond poorly to radiation therapy and chemo / immune therapies. Hypoxia in tumor bearing tissue is associated with worse clinical outcome and this has been known for over 50 years. Alterations to radiation therapy planning via providing localized boost to hypoxic tissues cannot be made without knowing exactly where hypoxia exists. However, there is no FDA approved agent to assess for hypoxia in tumor tissues, there is no accepted standard methodology for measuring hypoxia in patients, nor are there FDA approved agents for treating hypoxia. There are multiple PET i...
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Rodgers, B., Kotlyarov, E. Tags: Educational Exhibit Posters Source Type: research

FDG atrial uptake is associated with an increased prevalence of stroke in patients with atrial fibrillation
ConclusionsThis study shows a significant correlation between FDG atrial uptake and AF. While inconsistent, this pattern seems to be associated with an increased prevalence of cardioembolic stroke.
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 27, 2019 Category: Nuclear Medicine Source Type: research

Bioinks and in vitro neurovascular unit production - New prospects in Alzheimer's disease research.
Authors: Lougiaki P, Tsolaki M, Pantazaki A Abstract Neurovascular dysfunction is a central process in the pathogenesis of the stroke and most neurodegenerative diseases, including Alzheimer's disease. The multi-cell neurovascular unit (NVU) combines the components of the neural, vascular and extracellular matrix (ECM) into an important interface whose proper function is critical to maintaining brain health. Tissue engineering now offers new tools and information to promote understanding of NVU's operation. A promising area for the development of NVU models is their bio-production through 3D bio-printing to produce...
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Regional, Artery-Specific Thresholds of Quantitative Myocardial Perfusion by PET Associated with Reduced Myocardial Infarction and Death After Revascularization in Stable Coronary Artery Disease
Conclusion: CFC by PET provides objective, regional, artery-specific, size–severity physiologic quantification of CAD severity associated with high risk of DMS that is significantly reduced after revascularization within 90 d after PET, an association not seen for moderate to mild perfusion abnormalities or medical treatment alone.
Source: Journal of Nuclear Medicine - February 28, 2019 Category: Nuclear Medicine Authors: Gould, K. L., Johnson, N. P., Roby, A. E., Nguyen, T., Kirkeeide, R., Haynie, M., Lai, D., Zhu, H., Patel, M. B., Smalling, R., Arain, S., Balan, P., Nguyen, T., Estrera, A., Sdringola, S., Madjid, M., Nascimbene, A., Loyalka, P., Kar, B., Gregoric, I., S Tags: Clinical Source Type: research

11C-DPA-713 Versus 18F-GE-180: A Preclinical Comparison of Translocator Protein 18 kDa PET Tracers to Visualize Acute and Chronic Neuroinflammation in a Mouse Model of Ischemic Stroke
Conclusion: 11C-DPA-713 and 18F-GE-180 PET enable detection of neuroinflammation at acute and chronic time points after cerebral ischemia in mice. 11C-DPA-713 PET reflects the extent of microglial activation in infarcted distal middle cerebral artery occlusion mouse brain tissue more accurately than 18F-GE-180 and appears to be slightly more sensitive. These results highlight the potential of 11C-DPA-713 for tracking microglial activation in vivo after stroke and warrant further investigation in both preclinical and clinical settings.
Source: Journal of Nuclear Medicine - January 2, 2019 Category: Nuclear Medicine Authors: Chaney, A., Cropper, H. C., Johnson, E. M., Lechtenberg, K. J., Peterson, T. C., Stevens, M. Y., Buckwalter, M. S., James, M. L. Tags: Basic Source Type: research