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Specialty: Nuclear Medicine
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Total 204 results found since Jan 2013.
Echocardiographic indices of left ventricular function and filling pressure are not related to blood pool activity on pyrophosphate scintigraphy
ConclusionApproximately 8% of patients with a negative PYP SPECT have significant blood pool activity. Measures of cardiac function are not different among those with and without blood pool activity. PYP SPECT should be routinely performed in all patients to avoid false image interpretation.
Source: Journal of Nuclear Cardiology - May 16, 2022 Category: Nuclear Medicine Source Type: research
Atrial FDG uptake linked to ischemic stroke in patients without atrial fibrillation
Source: Journal of Nuclear Cardiology - April 26, 2022 Category: Nuclear Medicine Source Type: research
Increased 68Ga-FAPI Uptake of Symptomatic Intracranial Atherosclerotic Plaque Revealed by PET/MR
A 58-year-old man was enrolled in our 68Ga-FAPI PET/MR study for evaluation of stroke etiology. He had left thalamus and cerebellum infarction 6 months ago, and left occipital lobe infarction 2 years ago. 68Ga-FAPI PET/MR showed focal uptake along the low segment of the basilar artery. We hypothesize that the FAPI-avid plaque of basilar artery may account for the embolic events resulting in downstream infarction. Thus FAP-targeted imaging may have a potential for detection of vulnerable plaques.
Source: Clinical Nuclear Medicine - April 11, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
A Longitudinal PET/MRI Study of Colony-Stimulating Factor 1 Receptor-Mediated Microglia Depletion in Experimental Stroke
Conclusion: Longitudinal TSPO PET/MRI allows the assessment of target engagement and optimization of drug efficiency. PLX5622 has promising immunomodulatory effects, and the optimal therapeutic time window for its application needs to be defined.
Source: Journal of Nuclear Medicine - March 1, 2022 Category: Nuclear Medicine Authors: Barca, C., Kiliaan, A. J., Foray, C., Wachsmuth, L., Hermann, S., Faber, C., Schafers, M., Wiesmann, M., Jacobs, A. H., Zinnhardt, B. Tags: Featured Basic Science Article Source Type: research
Characterization in nonhuman primates of (R)-18FOF-Me-NB1 and (S)-18FOF-Me-NB1 for imaging the GluN2B subunits of the NMDA receptor
ConclusionsIn rhesus monkeys, (R)-[18F]OF-Me-NB1 exhibited fast kinetics and heterogeneous uptake across brain regions, while the (S)-enantiomer displayed a narrower dynamic range of uptake across regions. A Blocking study with a GluN2B antagonist indicated binding specificity. The value ofBPND was > 0.5 in most brain regions, suggesting goodin vivo specific binding signals. Taken together, results from the current study demonstrated the potential of (R)-[18F]OF-Me-NB1 as a useful radiotracer for imaging the GluN2B receptors.
Source: European Journal of Nuclear Medicine and Molecular Imaging - February 2, 2022 Category: Nuclear Medicine Source Type: research
Association of atrial 18F-fluorodeoxyglucose uptake and prior ischemic stroke in non-atrial fibrillation patients
ConclusionsThis study identified an association between atrial FDG activity and a history of ischemic stroke and atrial cardiomyopathy in non-AF individuals. Further longitudinal study is warranted to demonstrate their causal relationship.
Source: Journal of Nuclear Cardiology - January 26, 2022 Category: Nuclear Medicine Source Type: research
60 Years of Achievements by KSNM in Neuroimaging Research
AbstractNuclear medicine neuroimaging is able to show functional and molecular biologic abnormalities in various neuropsychiatric diseases. Therefore, it has played important roles in the clinical diagnosis and in research on the normal and pathological states of the brain. More than 400 outstanding studies have been conducted by Korean researchers over the past 60 years. In the 1990s, when multiheaded single-photon emission computed tomography (SPECT) scanners were first introduced in South Korea, stroke research using brain perfusion SPECT was conducted. With the spread of positron emission tomography (PET) scanners in...
Source: Nuclear Medicine and Molecular Imaging - January 15, 2022 Category: Nuclear Medicine Source Type: research
Role of sex hormones in modulating myocardial perfusion and coronary flow reserve
ConclusionOur experimental data in mice indicate that sex differences in myocardial perfusion are primarily driven by testosterone. Given the diagnostic importance of PET-MPI in clinical routine, further studies are warranted to determine whether testosterone levels affect the interpretation of myocardial perfusion findings in patients.
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 13, 2022 Category: Nuclear Medicine Source Type: research
Incidental 68Ga-DOTATOC PET/CT Uptake in Hemorrhagic Transformation of Stroke in a Patient With Cervical Paraganglioma
We present a case of a 75-year-old woman with clinical suspicion of stroke whose cranial CT showed ischemic changes in right precentral region, without visible vascular occlusion, and a right vagal lesion suggestive of paraganglioma. Two weeks later, 68Ga-DOTATOC PET/CT with IV iodine-based contrast administration (Biograph 6 True Point equipment; Siemens) was performed for characterization of this lesion and staging. Intraparenchymal 68Ga-DOTATOC uptake was visualized in right frontal lobe suggestive of hemorrhagic transformation of the previous stroke.
Source: Clinical Nuclear Medicine - November 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Case report of nuclear medicine, bone scan imaging on a patient with heat stroke induced rhabdomyolysis
J Nucl Med Technol. 2021 Jul 30:jnmt.121.262501. doi: 10.2967/jnmt.121.262501. Online ahead of print.ABSTRACTBone scan continues to be the second greatest-volume nuclear imaging procedure, offering the advantage of total body examination, low cost, and high sensitivity not only for metastatic lesions but also benign conditions. Its power rests in the physiological uptake and pathophysiologic behavior of 99m technetium (99m-Tc) diphosphonates. 1 The localization of radiotracers in damaged skeletal muscles is because calcium builds up in them and provides a site for radiotracer deposition when combined with phosphate.1 In ca...
Source: Journal of Nuclear Medicine Technology - July 31, 2021 Category: Nuclear Medicine Authors: Jitesh Dhingra Yoram Baum Source Type: research
