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Specialty: Nuclear Medicine

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Total 204 results found since Jan 2013.

Carotid artery atherosclerosis:plaque imaging in the personalized-medicine era
Conclusion: The evolution of atherosclerosis imaging and the emergence of new methods to measure atherosclerotic plaque vulnerability, particularly in the field of molecular imaging, have provided new insights into the pathophysiology of atherosclerosis and can be utilized in drug discovery and efficacy trials.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Gharavi, M., Saboury, B., Werner, T., Alavi, A. Tags: Educational Exhibits Source Type: research

18FDBT10 as alpha7-nAChR ligand to image stroke-associated neuroinflammation by PET
616Objectives: t is known that, after ischemic stroke, neuroinflammatory processes occur which represent interesting treatment targets. However, sufficient in vivo imaging of these processes, particularly in acute and subacute stages, was not possible upon till now. During neuroinflammation, alpha7-nicotinic acetylcholine receptors (nAChRs) are overexpressed. We, thus, tested the novel alpha7-nAChR ligand [18F]DBT10 for its potential to image post-stroke neuroinflammation. In 10 adult Merino sheep, the left middle cerebral artery was permanently occluded (pMCAO, day 1). On day 0 (baseline) as well as 4hrs after pMCAO, and ...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Barthel, H., Deuther-Conrad, W., Patt, M., Nitzsche, B., Teodoro, R., Hartig, W., Wenzel, B., Aleithe, S., Mages, B., Luthardt, J., Rullmann, M., Becker, G., Grunwald, T., Michalski, D., Boltze, J., Brust, P., Sabri, O. Tags: Probes for Neuroimaging II Source Type: research

Rates of Referral to Coronary Angiography After Positron Emission Tomography (PET) Myocardial Perfusion Imaging (MPI)
Conclusions: About 1 in 5 patients undergoing PET MPI are referred for coronary angiography within 90 days of testing, a rate greater than that reported for SPECT MPI, likely due to higher baseline risk of patients undergoing PET MPI testing. While referral rates for coronary angiography varied based on the presence or absence of prior documented clinical CAD and presence of test abnormalities, nearly 36% of patients with moderate-severe ischemia were not referred. Further work is needed to characterize why such patients are not referred for invasive evaluation to optimize the use of PET MPI in this high-risk population.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Patel, K., Spertus, J., Kureshi, F., Al Badarin, F., McGhie, A., Kennedy, K., Courter, S., Case, J., Thompson, R., Chan, P., Bateman, T. Tags: Cardiovascular Clinical Science Poster Session Source Type: research

PET imaging of NPRC receptor using targeted nanoclusters in a mouse angiogenesis model
Conclusions: We have successfully synthesized and characterized the NPRC targeted 64CuAuNCs-CANF. The rapid blood clearance of 64CuAuNCs-CANF may allow earlier PET visualization of NPR-C receptor. Initial PET imaging in HLI model indicated the potential of 64CuAuNCs-CANF for further optimization and assessment of NPR-C targeting in pre-clinical models.Research Support: This work is supported by the Mallinckrodt Institute of Radiology Summer Research Program.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Sethi, A., Heo, G. S., Woodard, P., Liu, Y. Tags: Novel Radiochemistry & amp; Chelation Posters Source Type: research

Evaluation of 11CTMI as a COX-2 selective PET tracer in baboon
Conclusion: Our PET imaging studies in baboon show that [11C]TMI penetrates the BBB and distributes to COX-2 enriched brain regions. Details of the in vivo evaluation of [11C]TMI in baboon brain will be presented. References 1. Majo VJ et al., Bioorg Med Chem Let., 2005, 15, 4268. 2. Cunningham VJ et al., J Cereb Blood Flow Metab., 2010; 30(1): 46-50. Grant Support: Diane Goldberg Foundation (NYSPI/CUMC) and Pfizer Inc.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Kumar, D., Zanderigo, F., Prabhakaran, J., Rubin-Falcone, H., Parsey, R., Mann, J. J. Tags: Neuroscience - Basic Science - Posters Source Type: research

Imaging thrombosis with 99mTc-labeled RAM.1-antibody in vivo
Platelets play a major role in thrombo-embolic diseases, notably by forming a thrombus that can ultimately occlude a vessel. This may provoke ischemic pathologies such as myocardial infarction, stroke or peripheral artery diseases, which represent the major causes of death worldwide. The aim of this study was to evaluate the specificity of radiolabeled Rat-Anti-Mouse antibody (RAM.1).
Source: Nuclear Medicine and Biology - March 16, 2018 Category: Nuclear Medicine Authors: Ali Ouadi, Virgile Bekaert, Nicolas Receveur, Lionel Thomas, Fran çois Lanza, Patrice Marchand, Christian Gachet, Pierre H. Mangin, David Brasse, Patrice Laquerriere Source Type: research

Imaging Thrombosis with 99mTc-labeled RAM.1-Antibody in vivo
Platelets play a major role in thrombo-embolic diseases, notably by forming a thrombus that can ultimately occlude a vessel. This may provoke ischemic pathologies such as myocardial infarction, stroke or peripheral artery diseases, which represent the major causes of death worldwide. The aim of this study was to evaluate the specificity of radiolabeled Rat-Anti-Mouse antibody (RAM.1).
Source: Nuclear Medicine and Biology - March 16, 2018 Category: Nuclear Medicine Authors: Ali Ouadi, Virgile Bekaert, Nicolas Receveur, Lionel Thomas, Fran çois Lanza, Patrice Marchand, Christian Gachet, Pierre H. Mangin, David Brasse, Patrice Laquerriere Source Type: research

Metabolic Changes in Central Poststroke Pain Following Thalamic Intracerebral Hemorrhage: An 18F-FDG PET Study
Purpose Central poststroke pain (CPSP) is one of the most refractory neuropathic pains following stroke. Injury in the spinothalamic pathway appears crucial for the development of CPSP, but changes in activity in multiple brain regions may also be related. We investigated brain metabolic changes in patients with CPSP following thalamic intracerebral hemorrhage (ICH). Methods Forty-three patients with thalamic ICH were examined. Overall brain metabolism was measured with 18F-FDG PET. Images were analyzed with statistical parametric mapping (SPM12). Patients with CPSP (n = 20) were compared with patients without CPSP (n...
Source: Clinical Nuclear Medicine - February 10, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Relative fractional anisotropy value using DTI: Can it help as a prognostic tool in anticipating the recovery of stroke patients?
Conclusion DTI is a prognostic tool in anticipating the recovery of the stroke patients. Moreover, the relative FA score works as more additive value in evaluation of the patient improvement.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - December 10, 2017 Category: Nuclear Medicine Source Type: research

68Ga-DOTATATE Uptake in Ischemic Stroke
Abstract A 76-year-old man known to have a pancreatic neuroendocrine tumor with hepatic and lymph nodes metastasis had a follow-up 68Ga-DOTATATE PET/CT before 177Lu-DOTATATE therapy. A new cerebral lesion expressing somatostatin receptors was discovered in the right temporal lobe, suggestive of an ischemic stroke territory. This was later confirmed from the hospital chart where an ischemic stroke was described a month ago.
Source: Clinical Nuclear Medicine - December 8, 2017 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Semi-quantitative assessment of pulmonary arterial hypertension associated with congenital heart disease through myocardial perfusion imaging.
CONCLUSION: Semi-quantitative MPI has high diagnostic value in evaluating the severity level of pulmonary arterial hypertension in patients with congenital heart disease. The diagnostic performance of MPI at pre-treatment patients was superior to that at post-treatment. More cases need to be included for further study. PMID: 29177254 [PubMed - as supplied by publisher]
Source: Hellenic Journal of Nuclear Medicine - November 29, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

18F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi
Conclusions: 18F-GP1 binds specifically with high affinity to the GPIIb/IIIa receptor involved in platelet aggregation. Because of its favorable preclinical characteristics, 18F-GP1 is currently being investigated in a human clinical study.
Source: Journal of Nuclear Medicine - July 3, 2017 Category: Nuclear Medicine Authors: Lohrke, J., Siebeneicher, H., Berger, M., Reinhardt, M., Berndt, M., Mueller, A., Zerna, M., Koglin, N., Oden, F., Bauser, M., Friebe, M., Dinkelborg, L. M., Huetter, J., Stephens, A. W. Tags: Basic Source Type: research

A bradykinin derivative differentiates vulnerable and stable plaques in rhesus monkeys with positron emission tomography
Conclusion: P05022 selectively binds to B1R in vivo and generates high contrast images of vulnerable atherosclerotic plaque in monkey model. Our results suggest that P05022 is a promising PET tracer that can differentiate vulnerable atherosclerotic plaques from stable ones with significant specificity.
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Xu, Y., Zhang, Z., Benard, F., Lin, K.-S., Liu, Z. Tags: Hermann Blumgart Lecture & amp; Award Session Source Type: research

Blood-brain barrier permeability in association with levodopa-induced dyskinesia in Parkinson's disease: a rubidium-82 PET study
Conclusion: The findings do not support the presence of significant alterations in BBB permeability in PD patients with or without LID. Research Support: This work was supported by the National Institute of Neurological Disorders and Stroke Morris K. Udall Center of Excellence for Parkinson’s Disease Research at The Feinstein Institute for Medical Research (P50 NS071675 to the last author).
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Fujita, K., Dhawan, V., Peng, S., Ma, Y., Eidelberg, D. Tags: New Approaches to Image Parkinson Syndrome Source Type: research

Robust supervised clustering analysis of 18F DPA-714 dynamic clinical PET data
Conclusion: The modified SVCA method presented here can be used with [18F]DPA-714 dynamic PET data to detect brain tissue with neuroinflammation caused by stroke. In this study where the subjects were supposedly devoid of neuroinflammation in the cerebellum, the reference curves found by the proposed approach were very similar to those of the cerebellum while not being based on any anatomical prior. Future work should continue to optimize the method and to investigate the generalizability of the current finding to other clinical cases where neuroinflammation can occur significantly in the cerebellum. Research Support: NICA...
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Love, S., Jaouen, V., Annan, M., Cottier, J.-P., Vercouillie, J., Guilloteau, D., Santiago-Ribeiro, M.-J., Tauber, C. Tags: Advanced Image Processing and Analysis Source Type: research