Crossed cerebellar diaschisis on 18F-FDG PET across neurodegenerative diseases: frequency and association with 11C-PIB and 18F-FTP

Conclusions: CCD is present in a significant proportion of patients with neurodegenerative diseases, and is more prevalent in specific phenotypes, especially in typically asymmetric presentations such as CBS, svPPA and lvPPA. The association between CCD on 18F-FDG and cortical 18F-FTP suggests a Tau-related disruption of cortico-ponto-cerebellar pathways in amyloid-positive patients, while amyloid does not seem to play a significant role. Further studies are required to elucidate prognostic value or clinical correlate of CCD. Table 1. Patient characteristics and prevalence of crossed cerebellar diaschisis (CCD) by diagnosisHC (n=76)Patients (n=197)Age (y; mean, SD)66.6 (14.0)63.7 (9.4)Sex (male, %)30 (39%)106 (54%)MMSE (mean, SD)28.9 (1.1)22.7 (6.2)Amyloid beta positive19/55110/197CCD by clinical diagnosisPrevalenceCe IA QuartileMCItADPCAlvPPACBSnfvPPAbvFTDsvPPAPSPOther7/38 (18%)12/54(22%)6/19 (32%)5/14 (36%)7/11 (64%)3/14 (21%)4/22 (18%)3/7 (43%)2/6 (33%)2/12 (17%)1st2nd4th4th4th3rd3rd2nd1st1st Table legend: CeIA= cerebellar index of asymmetry, HC = healthy controls, MCI= mild cognitive impairment, tAD = Alzheimer’s disease dementia (typical), PCA = posterior cortical atrophy, lvPPA = logopenic variant primary progressive aphasia, CBS = corticobasal syndrome, nfvPPA = non-fluent variant primary progressive aphasia, bvFTD = behavioral variant frontotemporal degeneration, svPPA = semantic variant primary progressive aphasia, PSP = progressive supranuclear palsy
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurodegenerative Diseases Source Type: research