Early detection of doxorubicin-induced cardiotoxicity using the matrix metalloproteinase (MMP) targeted radiotracer, 99mTc-RP805.

Conclusions Increases in myocardial MMP activity precede clinically used echocardiographic indices for early detection of cardiotoxicity, including ejection fraction and global myocardial strain. Therefore, 99mTc-RP805 may serve as a promising approach for early detection of DOX-induced cardiotoxicity when combined with SPECT/CT imaging.

Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Boutagy, N., Mikush, N., Wang, X., Hawley, C., Liu, C., Sinusas, A. Tags: MTA II: Cardiovascular Basic Science Posters Source Type: research