Assessment of muscle function using hybrid pet/mri: comparison of quantifying muscle activation using 18f-fdg pet and t2 mri in human subjects

Conclusions There exists a strong linear correlation between T2 changes and glucose uptake which did not vary between subjects nor between muscle groups. This is the first assessment of skeletal muscle function using hybrid PET/MRI and the first study to demonstrate the correlation between [18F]-FDG uptake and changes in muscle T2 with physical exercise. Accordingly, it seems that changes in muscle T2 may be used as a surrogate marker for glucose uptake. Such metabolic information of muscle activation could lead to an improved insight and to improved treatment strategies in neuromuscular pathologies such as stroke, spinal cord injuries and muscular dystrophies in both diagnostics and optimizing strategies for rehabilitation exercises.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Musculoskeletal 1 Source Type: research