Myocardial Energetics in AL and ATTR Cardiac Amyloidosis: A C-11 Acetate PET/CT Study

Conclusions: These results suggest that myocardial structure and energy utilization patterns differ between patients with AL-CMP and ATTR-CMP. Patients with AL-CMP have much lower myocardial mass and lower energy efficiency compared to patients with ATTR-CMP, suggesting better myocardial metabolic adaptation in ATTR-CMP. These findings if confirmed in a larger cohort suggest a role for novel therapeutics to manipulate substrate utilization in AL-CMP. AL-CMP(N=20)ATTR-CMP(N=3)P-ValueAge63 ± 6.380 ± 0.8<0.0001Rate Pressure Product, systolic blood pressure X heart rate, (mm Hg bpm)9228 ± 13608318 ± 1210NSLeft Ventricular mass (g)234 ± 68671 ± 750.005Stroke volume index26 ± 6.442.3 ± 10.20.04kmono (min-1)0.068 ± 0.0140.046 ± 0.0050.003k2 (min-1)0.16 ± 0.050.13 ± 0.010.035Rest myocardial blood flow (mL gm -1 min-1)0.64 ± 0.40.37 ± 0.10.016Myocardial mechanical work (x105 mm Hg mL m2 min-1)2.38 ± 0.583.44 ± 0.410.022Myocardial energy efficiency (x106 mm Hg mL m2)3.85 ± 1.447.42 ± 0.068<0.0001

Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: El-Sady, M. S., Kijewski, M., Jacob, S., Bravo, P., Dubey, S., Nodoushani, A., Belanger, A., Park, M.-A., Falk, R., Di Carli, M., Dorbala, S. Tags: Cardiac Metabolism, Viability, and Innervation Source Type: research