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Procedure: Splenectomy

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Total 32 results found since Jan 2013.

Splenectomy protects aged mice from injury after experimental stroke
Elderly stroke patients and aged animals subjected to experimental stroke have significantly worse functional recovery and higher mortality compared to younger subjects. Activation of the peripheral immune system is known to influence stroke outcome. Prior studies have shown that splenectomy reduces ischemic brain injury in young mice. As immune function changes with aging, it is unclear whether splenectomy will confer similar benefits in aged animals. We investigated the contribution of spleen to brain injury after cerebral ischemia in aged male mice.
Source: Neurobiology of Aging - September 27, 2017 Category: Neuroscience Authors: Anjali Chauhan, Abdullah Al Mamun, Gabriel Spiegel, Nia Harris, Liang Zhu, Louise D. McCullough Source Type: research

Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): a randomised, double-blind, placebo-controlled, phase 2 trial
This study is registered with ClinicalTrials.gov, number NCT01436487. Findings The study was done between Oct 24, 2011, and Dec 7, 2015. After safety assessments in eight patients in group 1, 129 patients were randomly assigned (67 to receive multipotent adult progenitor cells and 62 to receive placebo) in groups 2 and 3 (1200 million cells). The ITT populations consisted of 65 patients who received multipotent adult progenitor cells and 61 patients who received placebo. There were no dose-limiting toxicity events in either group. There were no infusional or allergic reactions and no difference in treatment-emergent advers...
Source: The Lancet Neurology - March 17, 2017 Category: Neurology Source Type: research

Splenectomy Does Not Improve Long-Term Outcome After Stroke Brief Report
Conclusions—Splenectomy did not alter the immune responses to brain antigens or improve outcome after stroke. Differences between this study and other studies of splenectomy and stroke are examined.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Dannielle Zierath, Angela Shen, Astiana Stults, Theresa Olmstead, Kyra J. Becker Tags: Ischemic Stroke Brief Reports Source Type: research

Splenectomy following MCAO inhibits the TLR4–NF-κB signaling pathway and protects the brain from neurodegeneration in rats
The Toll-like receptor 4(TLR4)/nuclear factor kappa B NF-κB inflammatory pathway contributes to secondary inflammation in many diseases including stroke. Moreover, the neuroprotective effect of splenectomy in stroke is supported by a vast body of experimental evidence. Nevertheless, the underlying mechanism(s) by which splenectomy enhance neuroprotection in stroke is still poorly understood. Our study aimed to investigate whether post-ischemic splenectomy modulate the TLR4/NF-κB inflammatory pathway in stroke.
Source: Journal of Neuroimmunology - March 4, 2016 Category: Allergy & Immunology Authors: Victor Fabrice Belinga, Guan-jin Wu, Fu-ling Yan, Erica Audrey Limbenga Source Type: research

Increased Risk of Hemorrhagic and Ischemic Strokes in Patients With Splenic Injury and Splenectomy: A Nationwide Cohort Study
This study revealed that splenic injury and splenectomy were significantly associated with an increased risk of hemorrhagic and ischemic strokes. The results of this study may alert physicians and patients to the complications of splenic injury and splenectomy.
Source: Medicine - September 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Immunophenotypic Parameters and RBC Alloimmunization in Children with Sickle Cell Disease on Chronic Transfusion
This article is protected by copyright. All rights reserved.
Source: American Journal of Hematology - September 1, 2015 Category: Hematology Authors: Robert S. Nickel, John T. Horan, Ross M. Fasano, Erin Meyer, Cassandra D. Josephson, Anne M. Winkler, Marianne E. M. Yee, Leslie S. Kean, Jeanne E. Hendrickson Tags: Research Article Source Type: research

Phosphatidylserine liposomes mimic apoptotic cells to attenuate atherosclerosis by expanding polyreactive IgM producing B1a lymphocytes
Conclusion Targeting B1a cell activation by PSLs may be a potentially potent therapeutic strategy to attenuate atherosclerosis and reduce the incidence of atherosclerosis-dependent myocardial infarction and stroke.
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Hosseini, H., Li, Y., Kanellakis, P., Tay, C., Cao, A., Tipping, P., Bobik, A., Toh, B.-H., Kyaw, T. Tags: Vascular biology Source Type: research

Here to Stay -- Living With Sickle Cell Disease
My name is Noah Alexander Williams and I am living with sickle cell anemia disease. Sickle cell isn't really a widely talked-about disease but it's so real and epic that it should be. Sickle cell anemia disease is a grasping chronic sickness that doesn't let go. Unfortunately I have it and have had it since I was born. I don't know life without sickle cell disease and therefore I don't know life without pain -- the daily aches, the crucial crises that come out of nowhere. Sickle cell is never predictable. Of course this disease has impacted my life beyond words. I've learned to cope with it. Just to be clear, sickle cell...
Source: Healthy Living - The Huffington Post - March 19, 2015 Category: Consumer Health News Source Type: news

The role of the carotid doppler examination in the evaluation of atherosclerotic changes in beta thalassemia patients
Conclusion:  Carotid  Doppler is very useful method in measurement of cIMT that increased in thalassemic patients which  shows a strong relationship with features of iron overload. We recommend the routine use of Doppler measurement of cIMT in these patients to predict early atherosclerotic changes as well as in the follow-up to prevent progression of atherosclerosis. 
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 16, 2015 Category: Hematology Source Type: research

Splenectomy reduces infarct volume and neuroinflammation in male but not female mice in experimental stroke
This study provides new information about the sex specific mechanisms of the peripheral immune response in neurodegeneration after stroke and demonstrates the need for representation of both sexes in basic and clinical stroke research.
Source: Journal of Neuroimmunology - November 25, 2014 Category: Allergy & Immunology Authors: Abby L. Dotson, Jianming Wang, Julie Saugstad, Stephanie J. Murphy, Halina Offner Source Type: research

Pro-Inflammatory Interferon Gamma Signaling is Directly Associated with Stroke Induced Neurodegeneration
This study was designed to determine the role of IFNγ signaling in the inflammatory response following MCAO. Expression of IP-10 increased in the brain and the spleen following MCAO. Splenectomy inhibited the increase of IP-10 in the brain post-MCAO, while recombinant IFNγ administration to splenectomized rats returned IP-10 levels in the brain to levels found in rats after MCAO only. Systemic administration of an IFNγ neutralizing antibody to MCAO-treated rats reduced infarct volume and IP-10 levels in the brain. T cell infiltration was reduced in the MCAO-damaged brains of IFNγ antibody-treated animals relative to th...
Source: Journal of NeuroImmune Pharmacology - October 23, 2014 Category: Drugs & Pharmacology Source Type: research

Growth differentiation factor-15 in young sickle cell disease patients: Relation to hemolysis, iron overload and vascular complications.
CONCLUSION: Increased GDF-15 in SCD reflects the importance of ineffective erythropoiesis in the pathophysiology and severity of anemia in SCD. GDF-15 levels are related to hemolysis and iron overload and may provide utility for identifying patients at increased risk of thrombotic events. PMID: 25065856 [PubMed - as supplied by publisher]
Source: Blood Cells, Molecules and Diseases - July 24, 2014 Category: Hematology Authors: Tantawy AA, Adly AA, Ismail EA, Darwish YW, Zedan MA Tags: Blood Cells Mol Dis Source Type: research

Role of spleen-derived monocytes/macrophages in acute ischemic brain injury
Role of spleen-derived monocytes/macrophages in acute ischemic brain injury Journal of Cerebral Blood Flow & Metabolism advance online publication, May 28 2014. doi:10.1038/jcbfm.2014.101 Authors: Eunhee Kim, Jiwon Yang, Cesar D Beltran & Sunghee Cho
Source: Journal of Cerebral Blood Flow - May 28, 2014 Category: Neurology Authors: Eunhee KimJiwon YangCesar D BeltranSunghee Cho Tags: ischemic stroke Ly-6Chigh Ly-6Clow monocytes/macrophages spleen splenectomy Source Type: research

Evaluation of Th17 related cytokines associated with clinical and laboratorial parameters in sickle cell anemia patients with leg ulcers.
Abstract Leg ulcers (LUs) represent one of the main causes of morbidity in sickle cell anemia (SCA). This manifestation has been related to hemolysis, infections predisposition and inflammation that leads cytokines secretion. In this context, our study aimed to evaluate Th17 related cytokines (IL-6, IL-17A, IL-22 and IL-23) in serum and peripheral mononuclear cells culture supernatants with and without lymphoproliferative stimulation (anti-human CD3 and anti-human CD28). The cytokines levels were also correlated to clinical, hematological and biochemical parameters in SCA patients with and without LUs history (SCA...
Source: Cytokine - December 24, 2013 Category: Molecular Biology Authors: da Silva RR, Pereira MC, Melo Rêgo MJ, Domingues Hatzlhofer BL, da Silva Araújo A, Cavalcanti Bezerra MA, da Rocha Pitta I, da Rocha Pitta MG Tags: Cytokine Source Type: research

Surgical Procedures and Outcomes Among Children with Sickle Cell Disease.
CONCLUSION:: Surgical procedures such as cholecystectomy, tonsillectomy, splenectomy, hernia repair, and appendectomy account for a small but significant proportion of hospital admissions in children with sickle cell disease. Acute chest syndrome is among the most common complications of elective surgery, while stroke and death are rare. PMID: 24108258 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - October 7, 2013 Category: Anesthesiology Authors: Hyder O, Yaster M, Bateman BT, Firth PG Tags: Anesth Analg Source Type: research