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Procedure: Splenectomy

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Total 32 results found since Jan 2013.

Hypercoagulability evaluation in congenital red blood cell disorders using thrombin generation assay
Congenital red blood cell (RBC) disorders are common diseases in the general population. The main outcomes are increased deformability due to erythrocyte instability, increased susceptibility to oxidative stress, and intravascular hemolysis. Hemolytic anemia is associated with thrombosis risk [1]. Main mechanisms are related to hypercoagulability, endothelial damage, altered blood flow, and decreased nitric oxide. Hypercoagulability is well documented in sickle cell disease (SCD) [2]. However, other RBC disorders are associated with pulmonary embolism, hypertension, non-ischemic stroke, and adverse vascular manifestations ...
Source: Thrombosis Research - March 23, 2023 Category: Hematology Authors: Guillaume Feugray, Maximilien Grall, C écile Dumesnil, Ygal Benhamou, Valery Brunel, Véronique Le Cam Duchez, Agnès Lahary, Paul Billoir Tags: Letter to the Editors-in-Chief Source Type: research

Genotype and Phenotype of Adenosine Deaminase 2 Deficiency: a Report from Saudi Arabia
AbstractAdenosine deaminase 2 deficiency (DADA2), a rare and potentially fatal systemic autoinflammatory disease, is characterized by low or lack of ADA2 activity due toADA2 mutations. DADA2 symptoms are variable and include vasculitis, immunodeficiency, and cytopenia. Minimal data are available from Saudi Arabia. This retrospective study conducted at seven major tertiary medical centers examined the phenotypic and genotypic variabilities, clinical and diagnostic findings, and treatment outcomes among 20 Saudi patients with DADA2 from 14 families. The median age of the study cohort was 9.5  years (4–26 years). The clin...
Source: Journal of Clinical Immunology - October 14, 2022 Category: Allergy & Immunology Source Type: research

The effects of splenectomy in murine models of ischemic stroke: a systematic review and meta-analysis
The spleen, a substantial reservoir of non-differentiated monocytes, may play a crucial role in the pathophysiology of post-ischemic inflammation and influence outcomes after ischemic stroke.
Source: Journal of Neuroinflammation - September 23, 2022 Category: Neurology Authors: Marko Sternak, Anton Glasnovi ć, Paula Josić, Dominik Romić and Srećko Gajović Tags: Research Source Type: research

Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia - lessons learned for prophylaxis
CONCLUSIONS: VTE in patients with SCA has a high impact on morbidity and mortality. PE was the leading presentation of VTE, with CVC insertion, high LDH, bilirubin, CRP and white blood cell counts along with low Hb and HbF constituting other significant risk factors.PMID:34855536 | DOI:10.1177/03000605211055385
Source: Cell Research - December 2, 2021 Category: Cytology Authors: Salam Alkindi Anwaar R Al-Ghadani Samah R Al-Zeheimi Said Y Alkindi Naglaa Fawaz Samir K Ballas Anil V Pathare Source Type: research

The Cardiac Physiology Underpinning Exsanguination Cardiac Arrest: Targets for Endovascular Resuscitation
Exsanguination leading to cardiac arrest is the terminal phase of uncontrolled hemorrhage. Resuscitative interventions have focused on preload and afterload support. Outcomes remain poor due to several factors but poor coronary perfusion undoubtedly plays a role. The aim of this study is to characterize the relationship between arterial pressure and flow during hemorrhage in an effort to better describe the terminal phases of exsanguination. Male swine weighing 60 kg to 80 kg underwent splenectomy and instrumentation followed by a logarithmic exsanguination until asystole. Changes in hemodynamic parameters over time w...
Source: Shock - December 21, 2020 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

Spleen is not required for therapeutic effects of 4OH-GTS-21, a selective α7 nAChR agonist, in the sub-acute phase of ischemic stroke in rats.
Abstract Acute ischemic stroke (AIS) causes both central and peripheral inflammation, while activation of α7 nicotinic acetylcholine receptors (nAChRs) provides both central and peripheral anti-inflammatory and anti-apoptotic effects. Here, we provide evidence that 4OH-GTS-21, a selective α7 agonist, produces its therapeutic effects via primarily central sites of action because 4OH-GTS-21 was found equally effective in splenectomized and non-spenectomized rats in the sub-acute phase of ischemic stroke (≤1 week). However, the spleen may boost the therapeutic efficacy of 4OH-GTS-21 in certain behavioral tasks as...
Source: Brain Research - November 4, 2020 Category: Neurology Authors: Gaidhani N, Kem WR, Uteshev VV Tags: Brain Res Source Type: research

Co-Inheritance of alpha-thalassemia and sickle cell disease in a cohort of Angolan pediatric patients.
Abstract The aim of this study was to explore the association between alpha-thalassemia, fetal hemoglobin, hematological indices, and clinical adverse events in Angolan sickle cell disease pediatric patients. A total of 200 sickle cell disease (SCD) children were sampled in Luanda and Caxito. A venous blood sample was collected and used for hematological analyses, fetal hemoglobin quantification, and genotyping of 3.7 kb alpha-thalassemia deletion by GAP-PCR. The frequency of the 3.7 kb alpha-thalassemia deletion in homozygosity was 12.5% and in heterozygosity was 55.0%. An increase in alpha-thalassemia frequency ...
Source: Molecular Biology Reports - July 5, 2020 Category: Molecular Biology Authors: Santos B, Delgadinho M, Ferreira J, Germano I, Miranda A, Arez AP, Faustino P, Brito M Tags: Mol Biol Rep Source Type: research

Splenectomy to Optimize Hemoglobin S Control in Children With Sickle Cell Anemia on Chronic Transfusion Therapy for Stroke Prevention
Chronic transfusion therapy with the goal of maintaining a hemoglobin (Hb) S
Source: Journal of Pediatric Hematology Oncology - February 21, 2019 Category: Hematology Tags: Clinical and Laboratory Observations Source Type: research

Bleeding Related Episodes, Thrombotic Events and Platelet Counts Among Immune Thrombocytopenia Patients Receiving Second Line Therapy
CONCLUSIONS: This retrospective real world evidence study compares mean platelet response and burden of both BREs and TEs in ITP patients treated with different second-line treatments. Although there were significant differences in mean platelet counts achieved with the second-line treatments, TEs were observed with similar incidence across all treatments. Patients who received splenectomy had the highest mean platelet counts and also the highest proportion of patients who experienced TEs, though differences in TEs did not reach statistical significance. Incidence proportion of patients with BREs was lower in patients trea...
Source: Blood - November 21, 2018 Category: Hematology Authors: Said, Q., Lal, L. S., Andrade, K., Nezami, B., Graves, J. A., Roy, A., Cuker, A. Tags: 311. Disorders of Platelet Number or Function: Poster II Source Type: research

Description of the First Cases with ADAMTS13 Mutations in Hungary
CONCLUSIONS:Clinical and molecular characterization of the first 5 Hungarian cases with ADAMTS13 mutations was presented. Compound heterozygous, damaging ADAMTS13 mutations with deficient plasma ADAMTS13 activity were associated with serious clinical consequences. In case of thrombotic microangiopathy in young patients with stroke, or HELLP syndrome, complete workup for ADAMTS13 activity and inhibitors is necessary, and genetic analysis should be considered. Three new ADAMTS13 mutations (c.1016_1017delCA, c.3199T>A , c.2839C>T) were identified and shown to be associated with decreased plasma ADAMTS13 activity.Disclos...
Source: Blood - November 21, 2018 Category: Hematology Authors: Reti, M., Sinkovits, G., Cseprekal, O., Csuka, D., Szilagyi, A., Farkas, Z., Klucsik, Z., Szederjesi, A., Wagner, L., Reusz, G., Kremer Hovinga, J. A., Rigo, J., Masszi, T., Prohaszka, Z. Tags: 311. Disorders of Platelet Number or Function Source Type: research

Validation of Sickle Cell Disease Severity Score in a Cohort of Hemoglobin SC Disease Patients
Conclusion: Despite having been derived from a SCD population that was 26% HbSC, the study was unable to validate the SSS within the cohort of HbSC patients. This may reflect the differences in patient population and/or therapeutic intervention between this cohort and the CSSCD cohort used in the construction of the SSS calculator. While SSS was found to correlate with 3 discrete markers of disease morbidity (TRJV, CVA, creatinine clearance), it appears that a new scoring system is required to accurately predict clinical mortality and morbidity in contemporary cohorts of adult HbSC disease patients.DisclosuresNo relevant c...
Source: Blood - November 21, 2018 Category: Hematology Authors: Rosart, R. M., Pestrin, O. A., Tomlinson, G. A., Ward, R., Pendergrast, J., Binding, A., Kuo, K. H. M. Tags: 903. Outcomes Research-Non-Malignant Hematology: Poster I Source Type: research

Impact of Immune Thrombocytopenia in Patients Admitted with Coronary Artery Disease: Results from National Inpatient Sample 2009-2011
Conclusion: Our study shows that in patients with coronary artery disease-associated ITP, adjusted LOS and mortality was significantly higher compared to patients without ITP.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Aryal, M., Basnet, S., Dhital, R., Gosain, R., Donato, A. Tags: 903. Outcomes Research-Non-Malignant Hematology Source Type: research

Reassessing the Need for Pre-Operative Transfusions in Sickle Cell Disease Patients with a High Baseline Hemoglobin
Conclusion: Patients with SCD and a baseline hemoglobin ≥90 g/L who receive a pre-operative top-up transfusion have an increased risk of post-operative complications compared to those who are not transfused. In low and medium risk surgeries, a policy of withholding transfusions for such patients may be considered. Prospective studies validating these findings are needed.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Tole, S., Yan, A. P., Wagner, A., Bair, L., Tang, K., Kirby-Allen, M. A., Simpson, E., Williams, S. Tags: 114. Hemoglobinopathies, Excluding Thalassemia-Clinical: Poster II Source Type: research

The Association between Idiopathic Thrombocytopenic Purpura and Cardiovascular Disease: a retrospective cohort study.
CONCLUSION: There is an increased risk of developing CVD in patients with ITP and even further increased risk for those patients with ITP who underwent splenectomy. This article is protected by copyright. All rights reserved. PMID: 29297977 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - January 3, 2018 Category: Hematology Authors: Chandan JS, Thomas T, Lee S, Marshall T, Willis B, Nirantharakumar K Tags: J Thromb Haemost Source Type: research

The Association between Idiopathic Thrombocytopenic Purpura and Cardiovascular Disease: a retrospective cohort study
ConclusionThere is an increased risk of developing CVD in patients with ITP and even further increased risk for those patients with ITP who underwent splenectomy.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - January 3, 2018 Category: Hematology Authors: Joht Singh Chandan, Tom Thomas, Sophie Lee, Tom Marshall, Brian Willis, Krishnarajah Nirantharakumar Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research