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Procedure: Splenectomy

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Total 32 results found since Jan 2013.

Splenectomy Does Not Improve Long-Term Outcome After Stroke Brief Report
Conclusions—Splenectomy did not alter the immune responses to brain antigens or improve outcome after stroke. Differences between this study and other studies of splenectomy and stroke are examined.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Dannielle Zierath, Angela Shen, Astiana Stults, Theresa Olmstead, Kyra J. Becker Tags: Ischemic Stroke Brief Reports Source Type: research

Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): a randomised, double-blind, placebo-controlled, phase 2 trial
This study is registered with ClinicalTrials.gov, number NCT01436487. Findings The study was done between Oct 24, 2011, and Dec 7, 2015. After safety assessments in eight patients in group 1, 129 patients were randomly assigned (67 to receive multipotent adult progenitor cells and 62 to receive placebo) in groups 2 and 3 (1200 million cells). The ITT populations consisted of 65 patients who received multipotent adult progenitor cells and 61 patients who received placebo. There were no dose-limiting toxicity events in either group. There were no infusional or allergic reactions and no difference in treatment-emergent advers...
Source: The Lancet Neurology - March 17, 2017 Category: Neurology Source Type: research

Splenectomy Protect Experimental Rats from Cerebral Damage after Stroke by Anti-Inflammation (P02.035)
CONCLUSIONS: Mechanism that splenectomy protect brain from damages induced by stroke may correlate with the decreased concentration of inflammatory cells in the ischemic zone of brain and changes in inflammatory cytokines in the central nervous system and blood.Disclosure: Dr. Zhang has nothing to disclose. Dr. Men has nothing to disclose. Dr. Lu has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Zhang, B., Men, X., Lu, Z. Tags: P02 Cerebrovascular Disease II Source Type: research

Splenectomy reduces infarct volume and neuroinflammation in male but not female mice in experimental stroke
This study provides new information about the sex specific mechanisms of the peripheral immune response in neurodegeneration after stroke and demonstrates the need for representation of both sexes in basic and clinical stroke research.
Source: Journal of Neuroimmunology - November 25, 2014 Category: Allergy & Immunology Authors: Abby L. Dotson, Jianming Wang, Julie Saugstad, Stephanie J. Murphy, Halina Offner Source Type: research

Pro-Inflammatory Interferon Gamma Signaling is Directly Associated with Stroke Induced Neurodegeneration
This study was designed to determine the role of IFNγ signaling in the inflammatory response following MCAO. Expression of IP-10 increased in the brain and the spleen following MCAO. Splenectomy inhibited the increase of IP-10 in the brain post-MCAO, while recombinant IFNγ administration to splenectomized rats returned IP-10 levels in the brain to levels found in rats after MCAO only. Systemic administration of an IFNγ neutralizing antibody to MCAO-treated rats reduced infarct volume and IP-10 levels in the brain. T cell infiltration was reduced in the MCAO-damaged brains of IFNγ antibody-treated animals relative to th...
Source: Journal of NeuroImmune Pharmacology - October 23, 2014 Category: Drugs & Pharmacology Source Type: research

Splenectomy protects aged mice from injury after experimental stroke
Elderly stroke patients and aged animals subjected to experimental stroke have significantly worse functional recovery and higher mortality compared to younger subjects. Activation of the peripheral immune system is known to influence stroke outcome. Prior studies have shown that splenectomy reduces ischemic brain injury in young mice. As immune function changes with aging, it is unclear whether splenectomy will confer similar benefits in aged animals. We investigated the contribution of spleen to brain injury after cerebral ischemia in aged male mice.
Source: Neurobiology of Aging - September 27, 2017 Category: Neuroscience Authors: Anjali Chauhan, Abdullah Al Mamun, Gabriel Spiegel, Nia Harris, Liang Zhu, Louise D. McCullough Source Type: research

Spleen is not required for therapeutic effects of 4OH-GTS-21, a selective α7 nAChR agonist, in the sub-acute phase of ischemic stroke in rats.
Abstract Acute ischemic stroke (AIS) causes both central and peripheral inflammation, while activation of α7 nicotinic acetylcholine receptors (nAChRs) provides both central and peripheral anti-inflammatory and anti-apoptotic effects. Here, we provide evidence that 4OH-GTS-21, a selective α7 agonist, produces its therapeutic effects via primarily central sites of action because 4OH-GTS-21 was found equally effective in splenectomized and non-spenectomized rats in the sub-acute phase of ischemic stroke (≤1 week). However, the spleen may boost the therapeutic efficacy of 4OH-GTS-21 in certain behavioral tasks as...
Source: Brain Research - November 4, 2020 Category: Neurology Authors: Gaidhani N, Kem WR, Uteshev VV Tags: Brain Res Source Type: research

The effects of splenectomy in murine models of ischemic stroke: a systematic review and meta-analysis
The spleen, a substantial reservoir of non-differentiated monocytes, may play a crucial role in the pathophysiology of post-ischemic inflammation and influence outcomes after ischemic stroke.
Source: Journal of Neuroinflammation - September 23, 2022 Category: Neurology Authors: Marko Sternak, Anton Glasnovi ć, Paula Josić, Dominik Romić and Srećko Gajović Tags: Research Source Type: research

Increased Risk of Hemorrhagic and Ischemic Strokes in Patients With Splenic Injury and Splenectomy: A Nationwide Cohort Study
This study revealed that splenic injury and splenectomy were significantly associated with an increased risk of hemorrhagic and ischemic strokes. The results of this study may alert physicians and patients to the complications of splenic injury and splenectomy.
Source: Medicine - September 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Splenectomy following MCAO inhibits the TLR4–NF-κB signaling pathway and protects the brain from neurodegeneration in rats
The Toll-like receptor 4(TLR4)/nuclear factor kappa B NF-κB inflammatory pathway contributes to secondary inflammation in many diseases including stroke. Moreover, the neuroprotective effect of splenectomy in stroke is supported by a vast body of experimental evidence. Nevertheless, the underlying mechanism(s) by which splenectomy enhance neuroprotection in stroke is still poorly understood. Our study aimed to investigate whether post-ischemic splenectomy modulate the TLR4/NF-κB inflammatory pathway in stroke.
Source: Journal of Neuroimmunology - March 4, 2016 Category: Allergy & Immunology Authors: Victor Fabrice Belinga, Guan-jin Wu, Fu-ling Yan, Erica Audrey Limbenga Source Type: research

Surgical Procedures and Outcomes Among Children with Sickle Cell Disease.
CONCLUSION:: Surgical procedures such as cholecystectomy, tonsillectomy, splenectomy, hernia repair, and appendectomy account for a small but significant proportion of hospital admissions in children with sickle cell disease. Acute chest syndrome is among the most common complications of elective surgery, while stroke and death are rare. PMID: 24108258 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - October 7, 2013 Category: Anesthesiology Authors: Hyder O, Yaster M, Bateman BT, Firth PG Tags: Anesth Analg Source Type: research

Here to Stay -- Living With Sickle Cell Disease
My name is Noah Alexander Williams and I am living with sickle cell anemia disease. Sickle cell isn't really a widely talked-about disease but it's so real and epic that it should be. Sickle cell anemia disease is a grasping chronic sickness that doesn't let go. Unfortunately I have it and have had it since I was born. I don't know life without sickle cell disease and therefore I don't know life without pain -- the daily aches, the crucial crises that come out of nowhere. Sickle cell is never predictable. Of course this disease has impacted my life beyond words. I've learned to cope with it. Just to be clear, sickle cell...
Source: Healthy Living - The Huffington Post - March 19, 2015 Category: Consumer Health News Source Type: news

Description of the First Cases with ADAMTS13 Mutations in Hungary
CONCLUSIONS:Clinical and molecular characterization of the first 5 Hungarian cases with ADAMTS13 mutations was presented. Compound heterozygous, damaging ADAMTS13 mutations with deficient plasma ADAMTS13 activity were associated with serious clinical consequences. In case of thrombotic microangiopathy in young patients with stroke, or HELLP syndrome, complete workup for ADAMTS13 activity and inhibitors is necessary, and genetic analysis should be considered. Three new ADAMTS13 mutations (c.1016_1017delCA, c.3199T>A , c.2839C>T) were identified and shown to be associated with decreased plasma ADAMTS13 activity.Disclos...
Source: Blood - November 21, 2018 Category: Hematology Authors: Reti, M., Sinkovits, G., Cseprekal, O., Csuka, D., Szilagyi, A., Farkas, Z., Klucsik, Z., Szederjesi, A., Wagner, L., Reusz, G., Kremer Hovinga, J. A., Rigo, J., Masszi, T., Prohaszka, Z. Tags: 311. Disorders of Platelet Number or Function Source Type: research

Cerebral Artery Velocity Determined by Transcranial Doppler Ultrasonography in Patients With {beta}-Thalassemia Intermedia Compared to {beta}-Thalassemia Major
We aimed to compare cerebral artery velocity and relevant clinical factors in patients with β-thalassemia intermedia (β-TI), β-thalassemia major (β-TM), and healthy individuals. For this study, 60 patients with β-TM and 64 with β-TI were randomly selected. Sixty healthy adults comprised the control group. Time average maximum mean velocity (TAMMV) was measured in large cerebral arteries with transcranial Doppler (TCD) ultrasonography. In all arteries, TAMMV was significantly higher in the β-TI group than that of β-TM or controls (P < .001). Patients with β-TM had significantl...
Source: Clinical and Applied Thrombosis/Hemostasis - July 3, 2013 Category: Hematology Authors: Karimi, M., Haghpanah, S., Ashjazadeh, N., Shariat, A., Nazeri, M., Emami, S., Forough, A. A., Petramfar, P., Yaghoubi, E. Tags: Original Articles Source Type: research

Evaluation of Th17 related cytokines associated with clinical and laboratorial parameters in sickle cell anemia patients with leg ulcers.
Abstract Leg ulcers (LUs) represent one of the main causes of morbidity in sickle cell anemia (SCA). This manifestation has been related to hemolysis, infections predisposition and inflammation that leads cytokines secretion. In this context, our study aimed to evaluate Th17 related cytokines (IL-6, IL-17A, IL-22 and IL-23) in serum and peripheral mononuclear cells culture supernatants with and without lymphoproliferative stimulation (anti-human CD3 and anti-human CD28). The cytokines levels were also correlated to clinical, hematological and biochemical parameters in SCA patients with and without LUs history (SCA...
Source: Cytokine - December 24, 2013 Category: Molecular Biology Authors: da Silva RR, Pereira MC, Melo Rêgo MJ, Domingues Hatzlhofer BL, da Silva Araújo A, Cavalcanti Bezerra MA, da Rocha Pitta I, da Rocha Pitta MG Tags: Cytokine Source Type: research