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Source: Neurochemical Research
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Total 300 results found since Jan 2013.
Kaempferol Mediated AMPK/mTOR Signal Pathway Has a Protective Effect on Cerebral Ischemic-Reperfusion Injury in Rats by Inducing Autophagy
Neurochem Res. 2022 May 7. doi: 10.1007/s11064-022-03604-1. Online ahead of print.ABSTRACTIschemia/reperfusion (I/R) caused by ischemic stroke treatments leads to brain injury and its pathological mechanism is related to autophagy. The underlying mechanism of kaempferol on cerebral I/R injury needs to be explored. To establish I/R injury, we used a middle cerebral artery occlusion-reperfusion (MCAO) model in rats. MCAO rats were treated with the same amount of saline (I/R group); Treatment group rats were treated orally with kaempferol (50, 100, 200 mg/kg) for 7 days before surgery. After reperfusion for 24 h, the scores o...
Source: Neurochemical Research - May 7, 2022 Category: Neuroscience Authors: Yajing Yuan Fei Xia Rong Gao Yang Chen Yu Zhang Zhongping Cheng Hongwei Zhao Liming Xu Source Type: research
Time and Brain Region-Dependent Excitatory Neurochemical Alterations in Bilateral Common Carotid Artery Occlusion Global Ischemia Model
This study investigated the influence of time and brain regions on excitatory neurochemical indices in the bilateral common carotid artery occlusion (BCCAO) model of global ischemia. Male Wistar rats were subjected to BCCAO for 15 and 60 min to evaluate the effect of ischemia duration on excitatory neurochemical indices (dopamine level, glutamine synthetase, glutaminase, glutamate dehydrogenase, aspartate aminotransferase, monoamine oxidase, acetylcholinesterase, and Na+ K+ ATPase activities) in the discrete brain regions (cortex, striatum, cerebellum, and hippocampus). BCCAO without reperfusion caused marked time and brai...
Source: Neurochemical Research - August 25, 2022 Category: Neuroscience Authors: Olubukola Benedicta Ojo Zainab Abiola Amoo Mary Tolulope Olaleye Sushil Kumar Jha Afolabi Clement Akinmoladun Source Type: research
Purpurogallin Reverses Neuronal Apoptosis and Enhances "M2" Polarization of Microglia Under Ischemia via Mediating the miR-124-3p/TRAF6/NF- κB Axis
This study aimed at investigating the role of PPG on microglial polarization post ischemic stroke as well as the underlying mechanism. Mouse hippocampal neurons HT-22 and microglial BV2 cells were treated by oxygen and glucose deprivation to simulate an in-vitro ischemia model. qRT-PCR and ELISA examined expression of cytokines in microglia. CCK8 and flow cytometry measured HT-22 cell viability and apoptosis, respectively. The levels of miR-124-3p and TRAF6/NF-κB were determined. A mouse cerebral ischemia model was set up using middle cerebral artery occlusion (MCAO) method. After being dealt with PPG, the neurological fu...
Source: Neurochemical Research - September 21, 2022 Category: Neuroscience Authors: Zongxin Cheng Xinming Li Xiaohua Ye Rong Yu Youqing Deng Source Type: research
cPKC γ Inhibits Caspase-9-Initiated Neuronal Apoptosis in an Ischemia Reperfusion Model In Vitro Through p38 MAPK-p90RSK-Bad Pathway
In conclusion, our results suggest that cPKCγ partly alleviates ischemic injury through activating the p38 MAPK-p90RSK-Bad pathway and inhibiting Caspase-9 initiated apoptosis. This may have potential as a therapeutic target for ischemic stroke.PMID:36152136 | DOI:10.1007/s11064-022-03747-1
Source: Neurochemical Research - September 24, 2022 Category: Neuroscience Authors: Hai-Ping Wei Zhi-Feng Peng Kang-Mei Shao Pei-Hao Zhang Lei Chen Jin-An Hu Hui Chai Jin-Mei Liu Source Type: research
Purpurogallin Reverses Neuronal Apoptosis and Enhances "M2" Polarization of Microglia Under Ischemia via Mediating the miR-124-3p/TRAF6/NF- κB Axis
This study aimed at investigating the role of PPG on microglial polarization post ischemic stroke as well as the underlying mechanism. Mouse hippocampal neurons HT-22 and microglial BV2 cells were treated by oxygen and glucose deprivation to simulate an in-vitro ischemia model. qRT-PCR and ELISA examined expression of cytokines in microglia. CCK8 and flow cytometry measured HT-22 cell viability and apoptosis, respectively. The levels of miR-124-3p and TRAF6/NF-κB were determined. A mouse cerebral ischemia model was set up using middle cerebral artery occlusion (MCAO) method. After being dealt with PPG, the neurological fu...
Source: Neurochemical Research - September 21, 2022 Category: Neuroscience Authors: Zongxin Cheng Xinming Li Xiaohua Ye Rong Yu Youqing Deng Source Type: research
cPKC γ Inhibits Caspase-9-Initiated Neuronal Apoptosis in an Ischemia Reperfusion Model In Vitro Through p38 MAPK-p90RSK-Bad Pathway
In conclusion, our results suggest that cPKCγ partly alleviates ischemic injury through activating the p38 MAPK-p90RSK-Bad pathway and inhibiting Caspase-9 initiated apoptosis. This may have potential as a therapeutic target for ischemic stroke.PMID:36152136 | DOI:10.1007/s11064-022-03747-1
Source: Neurochemical Research - September 24, 2022 Category: Neuroscience Authors: Hai-Ping Wei Zhi-Feng Peng Kang-Mei Shao Pei-Hao Zhang Lei Chen Jin-An Hu Hui Chai Jin-Mei Liu Source Type: research
Molecular Mechanism of the Protective Effects of M2 Microglia on Neurons: A Review Focused on Exosomes and Secretory Proteins
Neurochem Res. 2022 Oct 12. doi: 10.1007/s11064-022-03760-4. Online ahead of print.ABSTRACTMicroglia, as innate immune cells in the brain, closely monitor changes in the internal environment and participate in the maintenance of homeostasis in the central nervous system (CNS). Microglia can be polarized to the M1 or M2 phenotype in response to various stimuli in vivo or in vitro, affecting the functions of peripheral neurons. M2 microglia have attracted increasing attention in recent years owing to their beneficial effects on various diseases and injuries of the CNS, such as traumatic brain injury, stroke, Alzheimer's dise...
Source: Neurochemical Research - October 12, 2022 Category: Neuroscience Authors: Miao Chai Gang Su Juan Gao Wei Chen Qionghui Wu Ying Dong He Wang Deyi Chen Yonghong Li Xin Gao Ruixin Li Tianfei Ma Zhenchang Zhang Source Type: research
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury
Neurochem Res. 2022 Nov 19. doi: 10.1007/s11064-022-03822-7. Online ahead of print.ABSTRACTFerroptosis is characterized by excessive accumulation of iron and lipid peroxides, which are involved in ischemia, reperfusion-induced organ injury, and stroke. Propofol, an anesthetic agent, has neuroprotective effects due to its potent antioxidant, anti-ischemic, and anti-inflammatory properties. However, the relationship between propofol and ferroptosis is still unclear. In the current study, we elucidated the role of ferroptosis in the neuroprotective effect of propofol in mouse brains subjected to cerebral ischemia reperfusion ...
Source: Neurochemical Research - November 19, 2022 Category: Neuroscience Authors: Gui-Bo Fan Yan Li Gao-Shuo Xu A-Yang Zhao Hong-Jiang Jin Si-Qi Sun Si-Hua Qi Source Type: research
OIP5-AS1 Inhibits Oxidative Stress and Inflammation in Ischemic Stroke Through miR-155-5p/IRF2BP2 Axis
Neurochem Res. 2022 Dec 3. doi: 10.1007/s11064-022-03830-7. Online ahead of print.NO ABSTRACTPMID:36460840 | DOI:10.1007/s11064-022-03830-7
Source: Neurochemical Research - December 2, 2022 Category: Neuroscience Authors: Ji-Kun Zhang You Li Zheng-Tao Yu Jun-Wen Jiang Hong Tang Guo-Long Tu Ying Xia Source Type: research
