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Source: Neurochemical Research
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Total 300 results found since Jan 2013.
OIP5-AS1 Inhibits Oxidative Stress and Inflammation in Ischemic Stroke Through miR-155-5p/IRF2BP2 Axis
Neurochem Res. 2022 Dec 3. doi: 10.1007/s11064-022-03830-7. Online ahead of print.NO ABSTRACTPMID:36460840 | DOI:10.1007/s11064-022-03830-7
Source: Neurochemical Research - December 2, 2022 Category: Neuroscience Authors: Ji-Kun Zhang You Li Zheng-Tao Yu Jun-Wen Jiang Hong Tang Guo-Long Tu Ying Xia Source Type: research
Neuroprotective Roles of Apelin-13 in Neurological Diseases
This study summarizes the pathophysiological roles of apelin-13 in the development and progression of neurological related diseases.PMID:36745269 | DOI:10.1007/s11064-023-03869-0
Source: Neurochemical Research - February 6, 2023 Category: Neuroscience Authors: Yang Zhang Weiwei Jiang Wenjie Sun Weiming Guo Beibei Xia Xiangru Shen Mingyuan Fu Teng Wan Mei Yuan Source Type: research
Targeting Non-Coding RNA for CNS Injuries: Regulation of Blood-Brain Barrier Functions
Neurochem Res. 2023 Feb 14. doi: 10.1007/s11064-023-03892-1. Online ahead of print.ABSTRACTCentral nervous system (CNS) injuries are the most common cause of death and disability around the world. The blood-brain barrier (BBB) is located at the interface between the CNS and the surrounding environment, which protects the CNS from exogenous molecules, harmful agents or microorganisms in the blood. The disruption of BBB is a common feature of CNS injuries and participates in the pathological processes of secondary brain damage. Recently, a growing number of studies have indicated that non-coding RNAs (ncRNAs) play an importa...
Source: Neurochemical Research - February 14, 2023 Category: Neuroscience Authors: Li Zhang Wanshan Bai Lean Sun Yixing Lin Mi Tian Source Type: research
GATA6 Inhibits Neuronal Autophagy and Ferroptosis in Cerebral ischemia-reperfusion Injury Through a miR-193b/ATG7 axis-dependent Mechanism
Neurochem Res. 2023 Apr 15. doi: 10.1007/s11064-023-03918-8. Online ahead of print.ABSTRACTFerroptosis is a newly described form of regulated necrotic cell death, which is engaged in the pathological cell death related to stroke, contributing to cerebral ischemia-reperfusion (I/R) injury. Therefore, we performed this study to clarify the role of GATA6 in neuronal autophagy and ferroptosis in cerebral I/R injury. The cerebral I/R injury-related differentially expressed genes (DEGs) as well as the downstream factors of GATA6 were predicted bioinformatically. Moreover, the relations between GATA6 and miR-193b and that between...
Source: Neurochemical Research - April 14, 2023 Category: Neuroscience Authors: Weijian Fan Jianjie Rong Weihao Shi Wei Liu Jie Wang Jinyun Tan Bo Yu Jindong Tong Source Type: research
Correction to: The role of Circular RNAs in Ischemic Stroke
Neurochem Res. 2023 May 10. doi: 10.1007/s11064-023-03948-2. Online ahead of print.NO ABSTRACTPMID:37162600 | DOI:10.1007/s11064-023-03948-2
Source: Neurochemical Research - May 10, 2023 Category: Neuroscience Authors: Weiwei Jiang Xiongquan Long Zhicheng Li Mi Hu Yangkai Zhang Huiling Lin Wanying Tang Yuxin Ouyang Liping Jiang Jinzhi Chen Pingping He Xinping Ouyang Source Type: research
Edaravone Dexborneol Alleviates Neuroinflammation by Reducing Neuroglial Cell Proliferation and Suppresses Neuronal Apoptosis/Autophagy in Vascular Dementia Rats
In this study, we established the VD model of rats by bilateral carotid artery occlusion to explore the neuroprotective effect of EDB and its mechanism. Morris Water Maze test was applied to assess the cognitive function of rats. H&E and TUNEL staining were applied to observe the cellular structure of the hippocampus. Immunofluorescence labeling was used to observe the proliferation of astrocytes and microglia. ELISA was applied to examine the levels of TNF-α, IL-1β and IL-6, and RT-PCR was applied to examine their mRNA expression levels. Western blotting was applied to examine apoptosis-related proteins (Bax, Bcl-2,...
Source: Neurochemical Research - June 20, 2023 Category: Neuroscience Authors: Jiawei Zhang Yining Xiao Hongna Liu Lili Xu Xing Guo Yaran Gao Meixi Li Jing Xu Qianqian Qi Peiyuan Lv Source Type: research
Sodium Tanshinone IIA Sulfonate Ameliorates Oxygen-glucose Deprivation/Reoxygenation-induced Neuronal Injury via Protection of Mitochondria and Promotion of Autophagy
Neurochem Res. 2023 Jul 12. doi: 10.1007/s11064-023-03985-x. Online ahead of print.ABSTRACTSodium tanshinone IIA sulfonate (STS) has shown significant clinical therapeutic effects in cerebral ischemic stroke (CIS), but the molecular mechanisms of neuroprotection remain partially known. The purpose of this study was to explore whether STS plays a protective role in oxygen-glucose deprivation/reoxygenation (OGD/R)-induced neuronal injury by regulating microglia autophagy and inflammatory activity. Co-cultured microglia and neurons were subjected to OGD/R injury, an in vitro model of ischemia/reperfusion (I/R) injury with or ...
Source: Neurochemical Research - July 12, 2023 Category: Neuroscience Authors: Zhi Ma Yue Wu Juan Xu Hui Cao Mingyang Du Haibo Jiang Feng Qiu Source Type: research
Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance
Neurochem Res. 2023 Jul 26. doi: 10.1007/s11064-023-03983-z. Online ahead of print.ABSTRACTHot peppers, also called chilli, chilli pepper, or paprika of the plant genus Capsicum (family Solanaceae), are one of the most used vegetables and spices worldwide. Capsaicin (8-methyl N-vanillyl-6-noneamide) is the main pungent principle of hot green and red peppers. By acting on the capsaicin receptor or transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1), capsaicin selectively stimulates and in high doses defunctionalizes capsaicin-sensitive chemonociceptors with C and Aδ afferent fibers. This channe...
Source: Neurochemical Research - July 26, 2023 Category: Neuroscience Authors: Omar M E Abdel-Salam Gyula M ózsik Source Type: research
