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Source: Neurochemical Research

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Total 300 results found since Jan 2013.

Senicapoc: Repurposing a Drug to Target Microglia KCa3.1 in Stroke.
Abstract Stroke is the leading cause of serious long-term disability and the fifth leading cause of death in the United States. Treatment options for stroke are few in number and limited in efficacy. Neuroinflammation mediated by microglia and infiltrating peripheral immune cells is a major component of stroke pathophysiology. Interfering with the inflammation cascade after stroke holds the promise to modulate stroke outcome. The calcium activated potassium channel KCa3.1 is expressed selectively in the injured CNS by microglia. KCa3.1 function has been implicated in pro-inflammatory activation of microglia and th...
Source: Neurochemical Research - March 31, 2017 Category: Neuroscience Authors: Staal RG, Weinstein JR, Nattini M, Cajina M, Chandresana G, Möller T Tags: Neurochem Res Source Type: research

MiR-665 Participates in the Protective Effect of Dexmedetomidine in Ischemic Stroke by ROCK2/NF- κB Axis
Neurochem Res. 2022 May 10. doi: 10.1007/s11064-022-03597-x. Online ahead of print.ABSTRACTIschemic stroke is a grievous intimidation to the healthiness of sufferers. Previous studies have reported that dexmedetomidine (DEX) has a protective effect on a variety of organs. This paper aimed to explore the regulatory mechanism of DEX in ischemic stroke through miR-665/ROCK2 axis. The mice model of ischemic stroke was constructed by middle cerebral artery occlusion (MCAO). The cell model of ischemic stroke was constructed by oxygen-glucose deprivation (OGD). Cell viability and apoptosis were assessed by CCK-8 assay and flow cy...
Source: Neurochemical Research - May 10, 2022 Category: Neuroscience Authors: QiongHua Liu JianE Wu ShangShu Lai Gan Li Source Type: research

Emerging Targets for Modulation of Immune Response and Inflammation in Stroke
Neurochem Res. 2023 Feb 10. doi: 10.1007/s11064-023-03875-2. Online ahead of print.ABSTRACTThe inflammatory and immunological responses play a significant role after stroke. The innate immune activation stimulated by microglia during stroke results in the migration of macrophages and lymphocytes into the brain and are responsible for tissue damage. The immune response and inflammation following stroke have no defined targets, and the intricacies of the immunological and inflammatory processes are only partially understood. Innate immune cells enter the brain and meninges during the acute phase, which can cause ischemia dam...
Source: Neurochemical Research - February 10, 2023 Category: Neuroscience Authors: Komal Thapa Kumar Shivam Heena Khan Amarjot Kaur Kamal Dua Sachin Singh Thakur Gurjeet Singh Source Type: research

Protective Effect of Shikonin in Experimental Ischemic Stroke: Attenuated TLR4, p-p38MAPK, NF-κB, TNF-α and MMP-9 Expression, Up-Regulated Claudin-5 Expression, Ameliorated BBB Permeability.
Abstract Inflammatory damage plays an important role in cerebral ischemic pathogenesis and represents a new target for treatment of stroke. Shikonin has gained attention for its prominent anti-inflammatory property, but up to now little is known about shikonin treatment in acute ischemic stroke. The aim of this study was to evaluate the potential neuroprotective role of shikonin in cerebral ischemic injury, and investigate whether shikonin modulated inflammatory responses after stroke. Focal cerebral ischemia in male ICR mice was induced by transient middle cerebral artery occlusion. Shikonin (10 and 25 mg/kg) wa...
Source: Neurochemical Research - November 19, 2013 Category: Neuroscience Authors: Wang L, Li Z, Zhang X, Wang S, Zhu C, Miao J, Chen L, Cui L, Qiao H Tags: Neurochem Res Source Type: research

Prognostic Value of Serum 25-Hydroxyvitamin D in Patients with Stroke.
Abstract We aimed to evaluate the association between 25-hydroxyvitamin D [25(OH) D] levels and both clinical severity at admission and outcome at discharge in patients with acute ischemic stroke (AIS). From June 2012 to October 2013, consecutive first-ever AIS patients admitted to the Department of Emergency of The Fourth Affiliated Hospital of Harbin Medical University, China were identified. Clinical information was collected. Serum 25(OH) D levels were measured at baseline. Stroke severity was assessed at admission using the National Institutes of Health Stroke Scale (NIHSS) score. Functional outcome was evalu...
Source: Neurochemical Research - May 1, 2014 Category: Neuroscience Authors: Wang Y, Ji H, Tong Y, Zhang ZB Tags: Neurochem Res Source Type: research

T Cells and Cerebral Ischemic Stroke.
Abstract Stroke results in cerebral inflammation that causes brain injury and triggers immunodepression, resulting in an increased incidence of morbidity and mortality secondary to remote infection. It is well known that T cells modulate brain inflammation after ischemic stroke, and targeting T cells may be an innovative therapeutic strategy for stroke treatment. T cell deficiency is neuro-protective, but the observed protective effects differ between ischemic models. Recent studies suggest different T cell subsets may have distinct effects on the injured brain. In addition to their role in cerebral inflammation, ...
Source: Neurochemical Research - July 29, 2015 Category: Neuroscience Authors: Gu L, Jian Z, Stary C, Xiong X Tags: Neurochem Res Source Type: research

< sup > 1 < /sup > H NMR Spectroscopy-Based Metabolomics Approach to Study the Anti-Stroke Activity of G-3702, a Novel Better Alternative to DL-3-n-Butylphthalide
Neurochem Res. 2022 Jun 23. doi: 10.1007/s11064-022-03648-3. Online ahead of print.ABSTRACTCerebrovascular disease is the leading cause of disability and death, and ischemic stroke accounts for most stroke cases. However, few effective drugs are available for the treatment of ischemic stroke; thus, there is an urgent need to develop effective drugs to treat ischemic stroke. DL-3-n-butylphthalide (NBP) is clinically approved as an anti-ischemic drug in China, but its potential hepatotoxicity limits its use. G-3702 (a structural analogue of NBP) is synthesized with the boron hydroxyl group replacing carbonyl group. G-3702 si...
Source: Neurochemical Research - June 23, 2022 Category: Neuroscience Authors: Guanghui Li Lingyu Ruan Huihui Meng Wenya Liu Xinyu Zhong Jinran Yu Lin Zhang Minqiang Zhu Junsong Wang Source Type: research

Candesartan Reduces the Hemorrhage Associated with Delayed Tissue Plasminogen Activator Treatment in Rat Embolic Stroke.
Abstract We have previously reported that angiotensin receptor blockade reduces reperfusion hemorrhage in a suture occlusion model of stroke, despite increasing matrix metalloproteinase (MMP-9) activity. We hypothesized that candesartan will also decrease hemorrhage associated with delayed (6 h) tissue plasminogen activator (tPA) administration after embolic stroke, widening the therapeutic time window of tPA. Adult male Wistar rats were subjected to embolic middle cerebral artery occlusion (eMCAO) and treated with either candesartan (1 mg/kg) alone early at 3 h, delayed tPA (10 mg/kg) alone at 6 h, the combi...
Source: Neurochemical Research - November 6, 2013 Category: Neuroscience Authors: Ishrat T, Pillai B, Ergul A, Hafez S, Fagan SC Tags: Neurochem Res Source Type: research

Association of Serum 25-Hydroxyvitamin D with Symptoms of Depression After 6 Months in Stroke Patients.
Abstract Our aim was to determine whether there was a relationship between 25-hydroxyvitamin D (25[OH] D) and post-stroke depression (PSD). Two hundred and forty-four ischemic stroke patients admitted to the hospital within the first 24 h after stroke onset were consecutively recruited and followed up for 6 months. Clinical information was collected. Serum 25[OH] D levels were measured at baseline. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for depression at 6-month after stroke. At 6-month, 91 patients (37.3 %) showed depression and in 60 patients (24.6 %) this...
Source: Neurochemical Research - August 26, 2014 Category: Neuroscience Authors: Yue W, Xiang L, Zhang YJ, Ji Y, Li X Tags: Neurochem Res Source Type: research

UPLC-QTOF/MS-Based Metabolomics Reveals the Protective Mechanism of Hydrogen on Mice with Ischemic Stroke.
Abstract As a reductive gas, hydrogen plays an antioxidant role by selectively scavenging oxygen free radicals. It has been reported that hydrogen has protective effects against nerve damage caused by ischemia-reperfusion in stroke, but the specific mechanism is still unclear. Therefore, this study aims to investigate the protective effects of hydrogen on stroke-induced ischemia-reperfusion injury and its detailed mechanism. Two weeks after the inhalation of high concentrations (66.7%) of hydrogen, middle cerebral artery occlusion (MCAO) was induced in mice using the thread occlusion technique to establish an anim...
Source: Neurochemical Research - June 23, 2019 Category: Neuroscience Authors: Chen L, Chao Y, Cheng P, Li N, Zheng H, Yang Y Tags: Neurochem Res Source Type: research