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Source: Neurochemical Research

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Total 300 results found since Jan 2013.

Ginkgetin Promotes M2 Polarization of Microglia and Exert Neuroprotection in Ischemic Stroke via Modulation of PPAR γ Pathway
This study aims to explore the regulatory effects of ginkgetin on microglia polarization in brain ischemia. Oxygen glucose deprivation (OGD) cellular model and middle cerebral artery occlusion (MCAO) animal model was used in this study. We first observed the dynamic process of microglia polarization in ischemic stroke, and then investigated the effect of ginkgetin treatment on microglia polarization. Finally, we studied the role of PPARγ signaling pathway and the blocking effect of PPARγ antagonist GW9662 in this process. OGD and cerebral ischemia polarized microglia mainly to M1 type. However, ginkgetin treatment conver...
Source: Neurochemical Research - May 20, 2022 Category: Neuroscience Authors: Tianchi Tang Xiongwei Wang Enbo Qi Shiting Li Hui Sun Source Type: research

Retinoic Acid Prevents the Neuronal Damage Through the Regulation of Parvalbumin in an Ischemic Stroke Model
In conclusion, retinoic acid contributes to the preservation of neurons from ischemic stroke by controlling parvalbumin expression and apoptosis-related proteins.PMID:36245066 | DOI:10.1007/s11064-022-03769-9
Source: Neurochemical Research - October 16, 2022 Category: Neuroscience Authors: Ju-Bin Kang Dong-Ju Park Phil-Ok Koh Source Type: research

Acute Low Dose Naltrexone Increases β-Endorphin and Promotes Neuronal Recovery Following Hypoxia-Ischemic Stroke in Type-2 Diabetic Mice
Neurochem Res. 2023 May 11. doi: 10.1007/s11064-023-03938-4. Online ahead of print.ABSTRACTDiabetic patients experience significant mortality and poor recovery following ischemic stroke. Our clinical and basic science studies demonstrate an overall immune suppression in the periphery of diabetic stroke patients, as well as within the central nervous system (CNS) of type-2 diabetic mice following hypoxia-ischemia (HI). Low doses of naltrexone (LDN) improved clinical outcomes in many autoimmune diseases by acting on opioid receptors to release β-endorphin which in turn balances inflammatory cytokines and modulates the opioi...
Source: Neurochemical Research - May 11, 2023 Category: Neuroscience Authors: Rashmi Kumari Zainab Y Kareem Patricia J McLaughlin Source Type: research

Roles Played by the Na+/Ca2+ Exchanger and Hypothermia in the Prevention of Ischemia-Induced Carrier-Mediated Efflux of Catecholamines into the Extracellular Space: Implications for Stroke Therapy.
Abstract The release of [3H]dopamine ([3H]DA) and [3H]noradrenaline ([3H]NA) in acutely perfused rat striatal and cortical slice preparations was measured at 37 °C and 17 °C under ischemic conditions. The ischemia was simulated by the removal of oxygen and glucose from the Krebs solution. At 37 °C, resting release rates in response to ischemia were increased; in contrast, at 17 °C, resting release rates were significantly reduced, or resting release was completely prevented. The removal of extracellular Ca2+ further increased the release rates of [3H]DA and [3H]NA induced by ischemic conditions. This findi...
Source: Neurochemical Research - July 24, 2019 Category: Neuroscience Authors: Lakatos M, Baranyi M, Erőss L, Nardai S, Török TL, Sperlágh B, Vizi ES Tags: Neurochem Res Source Type: research

miR-671-5p Attenuates Neuroinflammation via Suppressing NF- κB Expression in an Acute Ischemic Stroke Model
This study was designed to investigate the role of miR-671-5p in in vitro and in vivo models of ischemic stroke (IS). Middle cerebral artery occlusion and reperfusion (MCAO/R) in C57BL/6 mice as well as oxygen-glucose deprivation and reoxygenation (OGD/R) in a mouse hippocampal HT22 neuron line were used as in vivo and in vitro models of IS injury, respectively. miR-671-5p agomir, miR-671-5p antagomir, pcDNA3.1-NF-κB, and negative controls were transfected into cells using riboFECT CP reagent. miR-671-5p agomir, pcDNA3.1-NF-κB, and negative vectors were administered into MCAO/R mice via intracerebroventricular injection....
Source: Neurochemical Research - April 19, 2021 Category: Neuroscience Authors: Ling Deng Yi Guo Jingdong Liu Xuan Wang Sha Chen Qian Wang Jianyan Rao Yuchun Wang Tianrui Zuo Qingwen Hu Xiahong Zhao Zhi Dong Source Type: research

Long Non-coding RNA ANRIL Downregulation Alleviates Neuroinflammation in an Ischemia Stroke Model via Modulation of the miR-671-5p/NF- κB Pathway
Neurochem Res. 2022 Mar 31. doi: 10.1007/s11064-022-03585-1. Online ahead of print.ABSTRACTThe aim of this study was to investigate the role and underlying mechanism of the long non-coding RNA ANRIL (antisense noncoding RNA in the INK4 locus, ANRIL) in ischemia stroke (IS) injury. Downregulation of ANRIL by right intracerebroventricular injected si-ANRIL in middle cerebral artery occlusion-reperfusion (MCAO/R) C57/BL6 mice and by transferring si-ANRIL in oxygen glucose deprivation/reperfusion (OGD/R) HT22 cells. The results showed that ANRIL levels increased in IS model, downregulation of ANRIL reduced infract area, neurol...
Source: Neurochemical Research - April 1, 2022 Category: Neuroscience Authors: Ling Deng Jin Jiang Sha Chen Xing Lin Tianrui Zuo Qingwen Hu Yu Wu Xiaomei Fan Zhi Dong Source Type: research