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Source: Neurochemical Research

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Total 300 results found since Jan 2013.

Characterization of Astrocytes in the Minocycline-Administered Mouse Photothrombotic Ischemic Stroke Model
In this study, we used a mouse photothrombotic ischemic stroke model to examine the characteristics of astrocytes after the administration of minocycline during ischemic stroke. Minocycline increased astrocyte reactivity and affected the localization of astrocytes in the penumbra region. Molecular characterization revealed that the induced expression of mRNA encoding the fatty acid binding protein 7 (FABP7) by photothrombosis was enhanced by the minocycline administration. Meanwhile, minocycline did not significantly affect the phenotype or class of astrocytes. The expression of Fabp7 mRNA was well correlated with that of ...
Source: Neurochemical Research - July 30, 2022 Category: Neuroscience Authors: Mari Kondo Haruka Okazaki Kei Nakayama Hirofumi Hohjoh Kimie Nakagawa Eri Segi-Nishida Hiroshi Hasegawa Source Type: research

CTRP3 Activates the AMPK/SIRT1-PGC-1 α Pathway to Protect Mitochondrial Biogenesis and Functions in Cerebral Ischemic Stroke.
This study aimed to clarify the underlying mechanism of how CTRP3 regulated mitochondrial functions in hippocampal neuronal cells (HPPNCs) after oxygen-glucose deprivation (OGD)/reoxygenation (R) treatment. Results showed that impeded CTRP3 expression and weakened viability were detected in OGD/R treated HPPNCs. CTRP3 showed its ability to enhance the viability and inhibited apoptosis of HPPNCs after OGD/R treatment and it could also promote the mitochondrial biogenesis and physiological functions. Silencing of PGC-1α partially abolished the protective function of CTRP3 on mitochondria and CTRP3 mediated the expression of...
Source: Neurochemical Research - October 23, 2020 Category: Neuroscience Authors: Gao J, Qian T, Wang W Tags: Neurochem Res Source Type: research

S-oxiracetam Facilitates Cognitive Restoration after Ischemic Stroke by Activating α7nAChR and the PI3K-Mediated Pathway.
In conclusion, α7nAChR and PI3K are key molecules that mediated the signaling pathway leading to S-ORC-induced cognitive restoration after MCAO/R. PMID: 33481205 [PubMed - as supplied by publisher]
Source: Neurochemical Research - January 22, 2021 Category: Neuroscience Authors: Fan W, Zhang Y, Li X, Xu C Tags: Neurochem Res Source Type: research

Glial Cell Line-Derived Neurotrophic Factor and Focal Ischemic Stroke.
Abstract Focal ischemic stroke (FIS) is a leading cause of human debilitation and death. Following the onset of a FIS, the brain experiences a series of spatiotemporal changes which are exemplified in different pathological processes. One prominent feature of FIS is the development of reactive astrogliosis and glial scar formation in the peri-infarct region (PIR). During the subacute phase, astrocytes in PIR are activated, referred to as reactive astrocytes (RAs), exhibit changes in morphology (hypotrophy), show an increased proliferation capacity, and altered gene expression profile, a phenomenon known as reac...
Source: Neurochemical Research - February 16, 2021 Category: Neuroscience Authors: Zhang Z, Sun GY, Ding S Tags: Neurochem Res Source Type: research

Bioinformatic Analysis of Exosomal MicroRNAs of Cerebrospinal Fluid in Ischemic Stroke Rats After Physical Exercise
Neurochem Res. 2021 Mar 11. doi: 10.1007/s11064-021-03294-1. Online ahead of print.ABSTRACTPhysical exercise is beneficial to the structural and functional recovery of post-ischemic stroke, but its molecular mechanism remains obscure. Herein, we aimed to explore the underlying mechanism of exercise-induced neuroprotection from the perspective of microRNAs (miRNAs). Adult male Sprague-Dawley (SD) rats were randomly distributed into 4 groups, i.e., the physical exercise group with the transient middle cerebral artery occlusion (tMCAO) surgery (PE-IS, n = 28); the physical exercise group without tMCAO surgery (PE, n = 6); the...
Source: Neurochemical Research - March 12, 2021 Category: Neuroscience Authors: Mudan Huang Chongjun Xiao Liying Zhang Lili Li Jing Luo Lilin Chen Xiquan Hu Haiqing Zheng Source Type: research

Electroacupuncture Ameliorates Cognitive Impairment Through the Inhibition of NLRP3 Inflammasome Activation by Regulating Melatonin-Mediated Mitophagy in Stroke Rats
Neurochem Res. 2022 Mar 18. doi: 10.1007/s11064-022-03575-3. Online ahead of print.ABSTRACTPrevious studies found that electroacupuncture (EA) at the Shenting (DU24) and Baihui (DU20) acupoints alleviates cognitive impairment in cerebral ischemia-reperfusion (I/R) injury rats. Nonetheless, the mechanisms of the anti-inflammatory effects of EA are unclear. Cerebral I/R injury was induced in rats by middle cerebral artery occlusion (MCAO). Following I/R injury, the rats underwent EA therapy at the Shenting (DU24) and Baihui (DU20) acupoints for seven successive days. The Morris water maze test, magnetic resonance imaging (MR...
Source: Neurochemical Research - March 18, 2022 Category: Neuroscience Authors: Xiaoyong Zhong Bin Chen Zuanfang Li Ruhui Lin Su Ruan Fang Wang Hui Liang Jing Tao Source Type: research

Transcription Factor HEY1 Improves Brain Vascular Endothelial Cell Function and Alleviates Ischemic Stroke by Upregulating NOTCH3
Neurochem Res. 2022 Mar 22. doi: 10.1007/s11064-022-03544-w. Online ahead of print.ABSTRACTTo investigate the function of hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) and Notch receptor 3 (NOTCH3) in ischemic stroke. Stroke models were established by middle cerebral artery occlusion (MCAO) and oxygen glucose deprivation (OGD) in rats and rat brain microvascular endothelial cells (BMVECs), respectively. Neurological deficit evaluation and 2,3,5-triphenyltetrazolium chloride staining were used to assess cerebral injury. The expression of HEY1 and NOTCH3 was manipulated using gain and loss of function appr...
Source: Neurochemical Research - March 22, 2022 Category: Neuroscience Authors: Tingting Zhu Hongxi Chen Cuihong He Xiaojuan Liu Source Type: research

Self-assembling Molecular Medicine for the Subacute Phase of Ischemic Stroke
Neurochem Res. 2022 Jun 6. doi: 10.1007/s11064-022-03638-5. Online ahead of print.ABSTRACTIschemic stroke leads to acute neuron death and forms an injured core, triggering delayed cell death at the penumbra. The impaired brain functions after ischemic stroke are hardly recovered because of the limited regenerative properties. However, recent rodent intervention studies manipulating the extracellular environments at the subacute phase shed new light on the regenerative potency of the injured brain. This review introduces the rational design of artificial extracellular matrix (ECM) mimics using supramolecular peptidic scaffo...
Source: Neurochemical Research - June 6, 2022 Category: Neuroscience Authors: Takahiro Muraoka Itsuki Ajioka Source Type: research

Astrocyte-Neuronal Communication and Its Role in Stroke
Neurochem Res. 2023 Jun 17. doi: 10.1007/s11064-023-03966-0. Online ahead of print.ABSTRACTAstrocytes are the most abundant glial cells in the central nervous system. These cells are an important hub for intercellular communication. They participate in various pathophysiological processes, including synaptogenesis, metabolic transformation, scar production, and blood-brain barrier repair. The mechanisms and functional consequences of astrocyte-neuron signaling are more complex than previously thought. Stroke is a disease associated with neurons in which astrocytes also play an important role. Astrocytes respond to the alte...
Source: Neurochemical Research - June 17, 2023 Category: Neuroscience Authors: Zi-Meng Yao Xiao-Rong Sun Jie Huang Lei Chen Shu-Ying Dong Source Type: research

Protective Effect of Naringenin in Experimental Ischemic Stroke: Down-Regulated NOD2, RIP2, NF-κB, MMP-9 and Up-Regulated Claudin-5 Expression.
Abstract Inflammatory damage plays a pivotal, mainly detrimental role in cerebral ischemic pathogenesis and may represent a promising target for treatment. Naringenin (NG) has gained growing appreciation for its beneficial biological effects through its anti-inflammatory property. Whether this protective effect applies to cerebral ischemic injury, we therefore investigate the potential neuroprotective role of NG and the underlying mechanisms. Focal cerebral ischemia in male Sprague-Dawley rats was induced by permanent middle cerebral artery occlusion (pMCAO) and NG was pre-administered intragastrically once daily ...
Source: Neurochemical Research - May 20, 2014 Category: Neuroscience Authors: Bai X, Zhang X, Chen L, Zhang J, Zhang L, Zhao X, Zhao T, Zhao Y Tags: Neurochem Res Source Type: research