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Source: Neurochemical Research

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Total 300 results found since Jan 2013.

Prolyl Carboxypeptidase Activity Decline Correlates with Severity and Short-Term Outcome in Acute Ischemic Stroke.
Abstract Prolyl carboxypeptidase (PRCP) is an enzyme associated with cerebrovascular risk factors such as hypertension, diabetes mellitus, obesity and hyperlipidemia. We aim to evaluate the relation between serum PRCP activity and severity, evolution and outcome of acute ischemic stroke. We used a specific RP-HPLC activity assay to measure PRCP activity in serum of 50 stroke patients at admission, and at 24 h, 72 h and 7 days after stroke onset to assess correlations with stroke severity based on the National Institutes of Health Stroke scale score (NIHSS), infarct volume on brain MRI scan, stroke outcome based...
Source: Neurochemical Research - November 5, 2014 Category: Neuroscience Authors: Kehoe K, Brouns R, Verkerk R, Engelborghs S, De Deyn PP, Hendriks D, De Meester I Tags: Neurochem Res Source Type: research

Blocking Sympathetic Nervous System Reverses Partially Stroke-Induced Immunosuppression but does not Aggravate Functional Outcome After Experimental Stroke in Rats.
This study suggests that pharmacological SNS inhibition dose not aggravate functional outcome after stroke. Stroke-induced immunosuppression may be involved in the SNS-β-arrestin2-NF-κB pathway. PMID: 27059792 [PubMed - as supplied by publisher]
Source: Neurochemical Research - April 7, 2016 Category: Neuroscience Authors: Deng QW, Yang H, Yan FL, Wang H, Xing FL, Zuo L, Zhang HQ Tags: Neurochem Res Source Type: research

Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke
Neurochem Res. 2022 Jun 8. doi: 10.1007/s11064-022-03628-7. Online ahead of print.ABSTRACTStroke is a sudden neurological disorder that occurs due to impaired blood flow to an area of the brain. Stroke can be caused by the blockage or rupture of a blood vessel in the brain, called ischemic stroke and hemorrhagic stroke, respectively. Stroke is more common in men than women. Atrial fibrillation, hypertension, kidney disease, high cholesterol and lipids, genetic predisposition, inactivity, poor nutrition, diabetes mellitus, family history and smoking are factors that increase the risk of stroke. Restoring blood flow by repos...
Source: Neurochemical Research - June 8, 2022 Category: Neuroscience Authors: Tayebeh Noori Samira Shirooie Antoni Sureda Eduardo Sobarzo-Sanchez Ahmad Reza Dehpour Marianela Sald ías Esra K üpeli Akkol Source Type: research

Neuron Specific Enolase and C-reactive Protein Levels in Stroke and Its Subtypes: Correlation with Degree of Disability.
Abstract Stroke is an emergency which threatens life and third leading cause of death and long term disability in developed countries. The use of biomarkers in diagnosing stroke and assessing prognosis is an emerging and rapidly evolving field. The study aimed to investigate the predictive value of biochemical marker of brain damage neuron-specific enolase (NSE) and systemic inflammatory marker C-reactive protein (CRP) with respect to degree of disability at the time of admission and short term in stroke patients. We investigated 120 patients with cerebrovascular stroke who were admitted within 72 h of onset of s...
Source: Neurochemical Research - May 17, 2014 Category: Neuroscience Authors: Pandey A, Shrivastava AK, Saxena K Tags: Neurochem Res Source Type: research

miR-146a and miR-196a2 Polymorphisms in Patients with Ischemic Stroke in the Northern Chinese Han Population.
This study indicates that miR-146a (rs2910164) might contribute to ischemic stroke susceptibility in the northern Chinese Han population. PMID: 24952884 [PubMed - as supplied by publisher]
Source: Neurochemical Research - June 22, 2014 Category: Neuroscience Authors: Zhu R, Liu X, He Z, Li Q Tags: Neurochem Res Source Type: research

The Neuroprotective Roles of Sonic Hedgehog Signaling Pathway in Ischemic Stroke.
Abstract Ischemic stroke is characterized by high morbidity, mortality and disability rate worldwide. Because of its complexity in pathogenesis and lack of effective therapeutic strategies and drugs, great breakthrough has not yet been made in the treatment of cerebral ischemic stroke. Therefore, to explore a more effective and safer therapeutic strategy for cerebral ischemic stroke has been the focus of numerous researchers. Neuroprotective effects of sonic hedgehog (Shh) signaling pathway in ischemic stroke have been reported in recent studies, but have not been fully elucidated. In our review, we elaborate the ...
Source: Neurochemical Research - September 28, 2018 Category: Neuroscience Authors: Liu L, Zhao B, Xiong X, Xia Z Tags: Neurochem Res Source Type: research

Silencing of TXNIP Alleviated Oxidative Stress Injury by Regulating MAPK-Nrf2 Axis in Ischemic Stroke.
This study aimed to investigate the underlying molecular mechanism and propose the potential therapeutic strategy for ischemic stroke. Bioinformatics analysis based on a public microarray profile (GSE 61616) of ischemic stroke rats was performed as a pilot research. Oxidative stress was enriched as a significantly gene ontology item, and thioredoxin-interacting protein (TXNIP) and MAPK signaling were identified as the hub gene and pathway, respectively. The experiments in middle cerebral artery occlusion rats demonstrated that ischemia induced the activation of oxidative stress. The expressions of TXNIP, p-p38, p-JNK, p-ER...
Source: Neurochemical Research - December 18, 2019 Category: Neuroscience Authors: Tian Y, Su Y, Ye Q, Chen L, Yuan F, Wang Z Tags: Neurochem Res Source Type: research

Scientific Landscape of Oxidative Stress in Stroke: From a Bibliometric Analysis to an in-Depth Review
Neurochem Res. 2023 Jul 28. doi: 10.1007/s11064-023-03999-5. Online ahead of print.ABSTRACTStroke is an acute cerebrovascular disease resulting from either obstruction or rupture of a blood vessel in the brain. Oxidative stress (OS), referred to a status where cellular oxidative capacities overwhelm antioxidative defenses, is involved in the pathophysiology of stroke. The bibliometric analysis and in-depth review aim to depict the research trend of OS in stroke. Relevant scientific publications were acquired from the Web of Science Core Collection database. Scientific landscape of OS in stroke was illustrated by general qu...
Source: Neurochemical Research - July 28, 2023 Category: Neuroscience Authors: Minqi Zhou Jiayu Xin Jinyu Chen Caiyun Sun Bingyue Huo Wenting Zhang Xiangqian Liu Source Type: research

The Relationship Between Serum Mannose-Binding Lectin Levels and Acute Ischemic Stroke Risk.
Abstract Complement activation and inflammation have been suggested in the pathogenesis of stroke, mannose-binding lectin (MBL) were found to have roles during the process. The aim of this study was to investigate the relationship between acute ischemic stroke (AIS) and serum MBL levels in Chinese population. From January 1 to June 30 2013, all patients with first-ever AIS were recruited to participate in the study. Serum MBL levels and routine test were examined. The National Institutes of Health Stroke Scale (NIHSS) score was assessed on admission blinded to MBL levels. During the inclusion period, 148 patients ...
Source: Neurochemical Research - December 6, 2013 Category: Neuroscience Authors: Wang ZY, Sun ZR, Zhang LM Tags: Neurochem Res Source Type: research