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Source: Neurochemical Research

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Total 300 results found since Jan 2013.

MiR-1202 Exerts Neuroprotective Effects on OGD/R Induced Inflammation in HM Cell by Negatively Regulating Rab1a Involved in TLR4/NF- κB Signaling Pathway.
MiR-1202 Exerts Neuroprotective Effects on OGD/R Induced Inflammation in HM Cell by Negatively Regulating Rab1a Involved in TLR4/NF-κB Signaling Pathway. Neurochem Res. 2020 Mar 02;: Authors: Song S, Pan Y, Li H, Zhen H Abstract Recent studies have shown that the level of miR-1202 in peripheral blood is closely related to brain activity and cognitive function in patients with depression, and it is involved in glioma pathological progress. However, the correlation between miR-1202 and neuroinflammation has not been reported. The expressions of miR-1202 and small GTP-ase Rab1a at mRNA level were detect...
Source: Neurochemical Research - March 1, 2020 Category: Neuroscience Authors: Song S, Pan Y, Li H, Zhen H Tags: Neurochem Res Source Type: research

Refocusing the Brain: New Approaches in Neuroprotection Against Ischemic Injury.
Abstract A new era for neuroprotective strategies is emerging in ischemia/reperfusion. This has forced to review the studies existing to date based in neuroprotection against oxidative stress, which have undoubtedly contributed to clarify the brain endogenous mechanisms, as well as to identify possible therapeutic targets or biomarkers in stroke and other neurological diseases. The efficacy of exogenous administration of neuroprotective compounds has been shown in different studies so far. However, something must be missing to get these treatments successfully applied in the clinical environment. Here, the mechani...
Source: Neurochemical Research - March 17, 2020 Category: Neuroscience Authors: Rodriguez C, Agulla J, Delgado-Esteban M Tags: Neurochem Res Source Type: research

Effects of Diclofenac Versus Meloxicam in Pentylenetetrazol-Kindled Mice.
Abstract Epilepsy comes after stroke as the most common chronic neurological disorder worldwide. Inflammation enhances neuronal hyperexcitability that could provide a background setting for the development of epilepsy. The aim of this study was to assess the effect of valproate (VAL), diclofenac (DIC), meloxicam (MEL), VAL + MEL and VAL + DIC in pentylenetetrazol (PTZ) kindled mice. Seventy mice were randomly allocated into 7 equal groups; Control, PTZ, VAL, DIC, MEL, VAL + MEL and VAL + DIC groups. Kindling was induced by PTZ (40 mg/kg, i.p.) injection every other day for 17 days. The drugs were...
Source: Neurochemical Research - May 12, 2020 Category: Neuroscience Authors: Elgarhi R, Shehata MM, Abdelsameea AA, Salem AE Tags: Neurochem Res Source Type: research

LncRNA MALAT1 Promotes OGD-Induced Apoptosis of Brain Microvascular Endothelial Cells by Sponging miR-126 to Repress PI3K/Akt Signaling Pathway.
This study aimed to investigate the role of MALAT1 in IS in vitro model and the related molecular mechanisms. The expressions of MALAT1 and miR-126 were detected by qPCR. The in vitro IS model was established by treating BMECs with oxygen-glucose deprivation (OGD). Cell viability and cell apoptosis were assessed by MTT assay and flow cytometry, respectively. Luciferase assay was conducted to examine the interplay between MALAT1 and miR-126. Western blotting was used to determine the protein levels of apoptosis-associated proteins (e.g. caspase 3, Bax and Bcl-2) and PI3K/Akt pathway-related proteins (e.g. PI3K, Akt, p-PI3K,...
Source: Neurochemical Research - June 25, 2020 Category: Neuroscience Authors: Zhang L, Yang H, Li WJ, Liu YH Tags: Neurochem Res Source Type: research

High-Frequency rTMS Improves Cognitive Function by Regulating Synaptic Plasticity in Cerebral Ischemic Rats.
Abstract Poststroke cognitive impairment (PSCI) is one of the most severe sequelae of stroke and lacks effective treatment. Previous studies have shown that high-frequency repetitive transcranial magnetic stimulation (rTMS) may be a promising PSCI therapeutic approach, but the underlying mechanism is unclear. To uncover the effect of rTMS on PSCI, a transient middle cerebral artery occlusion (tMCAO) model was established. Modified Neurological Severity Score (mNSS) test and Morris Water Maze (MWM) test were performed to assess the neurological and cognitive function of rats. Furthermore, to explore the underlying ...
Source: Neurochemical Research - November 2, 2020 Category: Neuroscience Authors: Hong J, Chen J, Li C, An D, Tang Z, Wen H Tags: Neurochem Res Source Type: research

Protective Effects of 28-O-Caffeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis.
Abstract 28-O-caffeoyl betulin (B-CA) has been demonstrated to reduce the cerebral infarct volume caused by transient middle cerebral artery occlusion (MCAO) injury. B-CA is a novel derivative of naturally occurring caffeoyl triterpene with little information associated with its pharmacological target(s). To date no data is available regarding the effect of B-CA on brain metabolism. In the present study, a 1H-NMR-based metabolomics approach was applied to investigate the therapeutic effects of B-CA on brain metabolism following MCAO in rats. Global metabolic profiles of the cortex in acute period (9 h after focal...
Source: Neurochemical Research - January 3, 2021 Category: Neuroscience Authors: Liu X, Ruan Z, Shao XC, Feng HX, Wu L, Wang W, Wang HM, Mu HY, Zhang RJ, Zhao WM, Zhang HY, Zhang NX Tags: Neurochem Res Source Type: research

LncRNA SNHG15 Knockdown Protects Against OGD/R-Induced Neuron Injury by Downregulating TP53INP1 Expression via Binding to miR-455-3p.
This study aims to reveal the effects of lncRNA small nucleolar RNA host gene 15 (SNHG15) on oxygen-glucose deprivation and reoxygenation (OGD/R)-induced neuron injury and underlying mechanism. The expression levels of SNHG15, microRNA-455-3p (miR-455-3p) and tumour protein p53 inducible nuclear protein 1 (TP53INP1) mRNA were determined by quantitative real time polymerase chain reaction in P12 cells. The protein levels of TP53INP1, cleaved caspase-3, caspase-3, B-cell lymphoma-2 and BCL2-associated x protein (Bax) were detected by western blot in P12 cells. Cell viability and apoptosis were revealed by cell counting kit-8...
Source: Neurochemical Research - February 2, 2021 Category: Neuroscience Authors: Fan Y, Wei L, Zhang S, Song X, Yang J, He X, Zheng X Tags: Neurochem Res Source Type: research

Involvement of Supraoptic Astrocytes in Basilar Artery Occlusion-Evoked Differential Activation of Vasopressin Neurons and Vasopressin Secretion in Rats.
Abstract Vasopressin (VP) is a key factor in the development of brain injury in ischemic stroke. However, the regulation of VP secretion in basilar artery occlusion (BAO) remains unclear. To clarify the regulation of VP secretion in BAO and the underlying mechanisms, we performed this study in a rat model of BAO with (BC) or without common carotid artery occlusion (CCAO). The results showed that BAO and BC time-dependently increased neurological scores and that BC also increased water contents in the medulla at 2 h and in the pontine at 8 h. Moreover, plasma VP level increased significantly at BAO-8 h, CCAO and...
Source: Neurochemical Research - February 2, 2021 Category: Neuroscience Authors: Li D, Cui D, Jia S, Liu X, Wang X, Qiu D, Wang YF Tags: Neurochem Res Source Type: research

Activated Microglia Exosomes Mediated miR-383-3p Promotes Neuronal Necroptosis Through Inhibiting ATF4 Expression in Intracerebral Hemorrhage.
In this study, ICH model was construct in rats and cells. Injury of cells in brain was detected by PI staining. Necroptosis in rats and cells was detected by western blot and flow cytometry. The expression of miR-383-3p was detected by RT-qPCR. The roles of activated microglia-secreted exosomes and exosome-contained miR-383-3p were detected through co-culturing medium or exosomes with neurons. The target gene of miR-383-3p was determined by luciferase assay and the expression of target gene was detected by western blot. Rescue experiments were used to confirm the mechanism of miR-383-3p in neurons necroptosis. The miR-383-...
Source: Neurochemical Research - February 16, 2021 Category: Neuroscience Authors: Wei M, Li C, Yan Z, Hu Z, Dong L, Zhang J, Wang X, Li Y, Zhang H Tags: Neurochem Res Source Type: research

Long Noncoding RNA SNHG14 Promotes Ischemic Brain Injury via Regulating miR-199b/AQP4 Axis.
CONCLUSIONS: Knockdown of SNHG14 attenuated ischemic brain injury by inhibiting inflammation and oxidative stress through the miR-199b/AQP4 axis. PMID: 33609254 [PubMed - as supplied by publisher]
Source: Neurochemical Research - February 20, 2021 Category: Neuroscience Authors: Zhang G, Li T, Chang X, Xing J Tags: Neurochem Res Source Type: research

Gastrodin Alleviates Cerebral Ischaemia/Reperfusion Injury by Inhibiting Pyroptosis by Regulating the lncRNA NEAT1/miR-22-3p Axis
Neurochem Res. 2021 Apr 11. doi: 10.1007/s11064-021-03285-2. Online ahead of print.ABSTRACTCerebral ischaemia/reperfusion (I/R) injury-induced irreversible brain injury is a major cause of mortality and functional impairment in ageing people. Gastrodin (GAS), derived from the traditional Chinese herbal medicine Tianma, has been reported to inhibit the progression of stroke, but the mechanism whereby GAS modulates the progression of cerebral I/R remains unclear. The middle cerebral artery occlusion method was used as a model of I/R in vivo. Rats were pretreated with GAS by intraperitoneal injection 7 days before I/R surgery...
Source: Neurochemical Research - April 11, 2021 Category: Neuroscience Authors: Heng-Sheng Zhang Bo Ouyang Xiong-Ying Ji Mei-Fang Liu Source Type: research

Knockdown of XIST Attenuates Cerebral Ischemia/Reperfusion Injury Through Regulation of miR-362/ROCK2 Axis
In conclusion, depletion of XIST attenuated I/R-induced neurological impairment and inflammatory response via the miR-362/ROCK2 axis. These findings offer a potential novel strategy for ischemic stroke therapy.PMID:34037903 | DOI:10.1007/s11064-021-03354-6
Source: Neurochemical Research - May 26, 2021 Category: Neuroscience Authors: Jingtao Wang Zhenqiang Fu Menghan Wang Jingjing Lu Hecheng Yang Hong Lu Source Type: research

Therapeutic Effects of Resveratrol on Ischemia-Reperfusion Injury in the Nervous System
Neurochem Res. 2021 Aug 7. doi: 10.1007/s11064-021-03412-z. Online ahead of print.ABSTRACTResveratrol is a phenol compound produced by some plants in response to pathogens, infection, or physical injury. It is well-known that resveratrol has antioxidant and protective roles in damages potentially caused by cancer or other serious disorders. Thus, it is considered as a candidate agent for the prevention and treatment of human diseases. Evidence has confirmed other bioactive impacts of resveratrol, including cardioprotective, anti-tumorigenic, anti-inflammatory, phytoestrogenic, and neuroprotective effects. Ischemia-reperfus...
Source: Neurochemical Research - August 8, 2021 Category: Neuroscience Authors: Alireza Sarkaki Mojtaba Rashidi Mina Ranjbaran Aram Asareh Zadegan Dezfuli Zahra Shabaninejad Ebrahim Behzad Maryam Adelipour Source Type: research