Filtered By:
Source: Neurochemical Research

This page shows you your search results in order of relevance. This is page number 7.

Order by Relevance | Date

Total 300 results found since Jan 2013.

Long Non-coding RNA ANRIL Downregulation Alleviates Neuroinflammation in an Ischemia Stroke Model via Modulation of the miR-671-5p/NF- κB Pathway
Neurochem Res. 2022 Mar 31. doi: 10.1007/s11064-022-03585-1. Online ahead of print.ABSTRACTThe aim of this study was to investigate the role and underlying mechanism of the long non-coding RNA ANRIL (antisense noncoding RNA in the INK4 locus, ANRIL) in ischemia stroke (IS) injury. Downregulation of ANRIL by right intracerebroventricular injected si-ANRIL in middle cerebral artery occlusion-reperfusion (MCAO/R) C57/BL6 mice and by transferring si-ANRIL in oxygen glucose deprivation/reperfusion (OGD/R) HT22 cells. The results showed that ANRIL levels increased in IS model, downregulation of ANRIL reduced infract area, neurol...
Source: Neurochemical Research - April 1, 2022 Category: Neuroscience Authors: Ling Deng Jin Jiang Sha Chen Xing Lin Tianrui Zuo Qingwen Hu Yu Wu Xiaomei Fan Zhi Dong Source Type: research

Cerebral Ischemia/Reperfusion Injury and Pharmacologic Preconditioning as a Means to Reduce Stroke-induced Inflammation and Damage
Neurochem Res. 2022 Nov 3. doi: 10.1007/s11064-022-03789-5. Online ahead of print.ABSTRACTStroke is one of the leading causes of death and long-term serious disability. Current therapeutic strategy is limited to thrombolytic agents, consequently, boosting endogenous neuroprotective mechanisms of the brain to protect itself against harmful stimuli and restore from damages are widely studied. Preconditioned brain to tolerate cerebral ischemia/reperfusion injury could be initiated by several different pharmacological and mechanical strategies, such as ischemic preconditioning, ethanol pharmacological preconditioning and other...
Source: Neurochemical Research - November 3, 2022 Category: Neuroscience Authors: Huajun Yang Chengxuan Qi Fang Su Wei Shan Anchen Guo Jianping Wu Yongjun Wang Hong You Qun Wang Source Type: research

The Role of Circular RNAs in Ischemic Stroke
Neurochem Res. 2023 May 1. doi: 10.1007/s11064-023-03935-7. Online ahead of print.ABSTRACTIschemic stroke (IS), a devastating condition characterized by intracranial artery stenosis and middle cerebral artery occlusion leading to insufficient oxygen supply to the brain, is a major cause of death and physical disability worldwide. Recent research has demonstrated the critical role of circular RNAs (circRNAs), a class of covalently enclosed noncoding RNAs that are widespread in eukaryotic cells, in regulating various physiological and pathophysiological cellular processes, including cell apoptosis, autophagy, synaptic plasti...
Source: Neurochemical Research - May 1, 2023 Category: Neuroscience Authors: Weiwei Jiang Xiongquan Long Zhicheng Li Mi Hu Yangkai Zhang Huiling Lin Wanying Tang Yuxin Ouyang Liping Jiang Jinzhi Chen Pingping He Xinping Ouyang Source Type: research

Treatment with Isorhamnetin Protects the Brain Against Ischemic Injury in Mice.
In conclusion, treatment with isorhamnetin protected the brain against ischemic injury in mice. Isorhamnetin could thus be envisaged as a countermeasure for ischemic stroke but remains to be tested in humans. PMID: 27161367 [PubMed - as supplied by publisher]
Source: Neurochemical Research - May 8, 2016 Category: Neuroscience Authors: Zhao JJ, Song JQ, Pan SY, Wang K Tags: Neurochem Res Source Type: research

Tetrandrine Attenuated Cerebral Ischemia/Reperfusion Injury and Induced Differential Proteomic Changes in a MCAO Mice Model Using 2-D DIGE.
Abstract Ischemic stroke is the most common type of stroke and brings about a big disease burden because of high mortality and disability in China. Tetrandrine, a bisbenzylisoquinoline alkaloid isolated from the Chinese herb Radix Stephania tetrandra, has been demonstrated to possess anti-inflammatory and free radical scavenging effects and even regulate astrocyte activation, but the possible role of tetrandrine in ameliorating cerebral ischemia/reperfusion injury of ischemic stroke remains unknown. The aim of this study was to determine the effects of tetrandrine on neurological injury and differential proteomic ...
Source: Neurochemical Research - June 19, 2013 Category: Neuroscience Authors: Ruan L, Huang HS, Jin WX, Chen HM, Li XJ, Gong QJ Tags: Neurochem Res Source Type: research

Down-Regulation of miRNA-30a Alleviates Cerebral Ischemic Injury Through Enhancing Beclin 1-Mediated Autophagy.
In this study, the effects of miRNA-30a on ischemic injury in N2A cells and cultured cortical neurons after oxygen glucose deprivation (OGD), and mouse brain with MCAO-induced ischemic stroke were evaluated. The results showed that miRNA-30a expression levels were up regulated in the brain of mice after 6 h MCAO without reperfusion, but significantly down regulated in the peri-infarct region of mice with 1 h MCAO/24 h reperfusion and in N2A cells after 1 h OGD/6-48 h reoxygenation. Both the conversion ratio of microtubule-associated protein 1 light chain 3 (LC3)-II/LC3-I and Beclin 1 protein level increased in N2A cel...
Source: Neurochemical Research - April 26, 2014 Category: Neuroscience Authors: Wang P, Liang J, Li Y, Li J, Yang X, Zhang X, Han S, Li S, Li J Tags: Neurochem Res Source Type: research

Peroxynitrite-Induced Tyrosine Nitration Contributes to Matrix Metalloprotease-3 Activation: Relevance to Hyperglycemic Ischemic Brain Injury and Tissue Plasminogen Activator.
Abstract Matrix metalloprotease-3 (MMP3) activation mediates the tissue plasminogen activator (tPA)-induced hemorrhagic transformation after stroke. Hyperglycemia (HG) further exacerbates this outcome. We have recently shown that HG increases MMP3 activity in the brain after stroke. However, the combined HG-tPA effect on MMP3 activation, and the mechanisms through which MMP3 is activated were not previously reported. Accordingly, this study tested the hypothesis that tPA and HG increases MMP3 activity in the brain after stroke through peroxynitrite induced tyrosine nitration. Normoglycemic and mildly hyperglycemic...
Source: Neurochemical Research - October 3, 2017 Category: Neuroscience Authors: Hafez S, Abdelsaid M, Fagan SC, Ergul A Tags: Neurochem Res Source Type: research

Targeting Complement C3a Receptor to Improve Outcome After Ischemic Brain Injury
Neurochem Res. 2021 Aug 11. doi: 10.1007/s11064-021-03419-6. Online ahead of print.ABSTRACTIschemic stroke is a major cause of disability. No efficient therapy is currently available, except for the removal of the occluding blood clot during the first hours after symptom onset. Loss of function after stroke is due to cell death in the infarcted tissue, cell dysfunction in the peri-infarct region, as well as dysfunction and neurodegeneration in remote brain areas. Plasticity responses in spared brain regions are a major contributor to functional recovery, while secondary neurodegeneration in remote regions is associated wit...
Source: Neurochemical Research - August 11, 2021 Category: Neuroscience Authors: Marcela Pekna Anna Stokowska Milos Pekny Source Type: research

Adiponectin Promotes Neurogenesis After Transient Cerebral Ischemia Through STAT3 Mediated BDNF Upregulation in Astrocytes
In conclusion, adiponectin enhances neurogenesis and functional recovery after ischemic stroke via STAT3/BDNF pathway in astrocytes.PMID:36315369 | DOI:10.1007/s11064-022-03790-y
Source: Neurochemical Research - October 31, 2022 Category: Neuroscience Authors: Liang Yu Jiajia Wang Ying Xia Wugang Hou Xi Yao Yaru Guo Jin Wang Haidong Wei Shiquan Wang Source Type: research