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Source: Neurochemical Research
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Total 300 results found since Jan 2013.
Therapeutic Effects of Resveratrol on Ischemia-Reperfusion Injury in the Nervous System
Neurochem Res. 2021 Aug 7. doi: 10.1007/s11064-021-03412-z. Online ahead of print.ABSTRACTResveratrol is a phenol compound produced by some plants in response to pathogens, infection, or physical injury. It is well-known that resveratrol has antioxidant and protective roles in damages potentially caused by cancer or other serious disorders. Thus, it is considered as a candidate agent for the prevention and treatment of human diseases. Evidence has confirmed other bioactive impacts of resveratrol, including cardioprotective, anti-tumorigenic, anti-inflammatory, phytoestrogenic, and neuroprotective effects. Ischemia-reperfus...
Source: Neurochemical Research - August 8, 2021 Category: Neuroscience Authors: Alireza Sarkaki Mojtaba Rashidi Mina Ranjbaran Aram Asareh Zadegan Dezfuli Zahra Shabaninejad Ebrahim Behzad Maryam Adelipour Source Type: research
Autophagy Inhibition by ATG3 Knockdown Remits Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury and Inflammation in Brain Microvascular Endothelial Cells
In conclusion, autophagy inhibition by ATG3 knockdown remitted OGD/R-induced injury and inflammation in brain microvascular endothelial cells via activation of the PI3K/Akt pathway.PMID:34379294 | DOI:10.1007/s11064-021-03423-w
Source: Neurochemical Research - August 11, 2021 Category: Neuroscience Authors: Zhaolong Peng Daofei Ji Lukuan Qiao Yuedong Chen Hongjuan Huang Source Type: research
Correction to: miR ‑671‑5p Attenuates Neuroinflammation via Suppressing NF‑κB Expression in an Acute Ischemic Stroke Model
Neurochem Res. 2021 Aug 12. doi: 10.1007/s11064-021-03421-y. Online ahead of print.NO ABSTRACTPMID:34383251 | DOI:10.1007/s11064-021-03421-y
Source: Neurochemical Research - August 12, 2021 Category: Neuroscience Authors: Ling Deng Yi Guo Jingdong Liu Xuan Wang Sha Chen Qian Wang Jianyan Rao Yuchun Wang Tianrui Zuo Qingwen Hu Xiahong Zhao Zhi Dong Source Type: research
Autophagy Inhibition by ATG3 Knockdown Remits Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury and Inflammation in Brain Microvascular Endothelial Cells
In conclusion, autophagy inhibition by ATG3 knockdown remitted OGD/R-induced injury and inflammation in brain microvascular endothelial cells via activation of the PI3K/Akt pathway.PMID:34379294 | DOI:10.1007/s11064-021-03423-w
Source: Neurochemical Research - August 11, 2021 Category: Neuroscience Authors: Zhaolong Peng Daofei Ji Lukuan Qiao Yuedong Chen Hongjuan Huang Source Type: research
Serum Exosomal mir-340-5p Promotes Angiogenesis in Brain Microvascular Endothelial Cells During Oxygen-Glucose Deprivation
Neurochem Res. 2022 Jan 7. doi: 10.1007/s11064-021-03492-x. Online ahead of print.ABSTRACTIschemic stroke (IS) is a cerebrovascular disease with high morbidity, recurrence, and mortality. The purpose of the present study was to investigate the role and mechanism of human serum exosomes on angiogenesis after IS. The middle cerebral artery occlusion (MCAO) in vivo model and oxygen-glucose deprivation (OGD) in vitro model were established. Human serum exosomes from healthy samples (NC-exo) and IS samples (IS-exo) were injected into MCAO mice. Neurobehavioral tests were performed to assess the extent of neurological deficits. ...
Source: Neurochemical Research - January 7, 2022 Category: Neuroscience Authors: Chuan Xu Hailong Yu Beilei Chen Yuan Ma Penghua Lv Source Type: research
Mechanistic Insight on Autophagy Modulated Molecular Pathways in Cerebral Ischemic Injury: From Preclinical to Clinical Perspective
Neurochem Res. 2022 Jan 7. doi: 10.1007/s11064-021-03500-0. Online ahead of print.ABSTRACTCerebral ischemia is one of the most devastating brain injuries and a primary cause of acquired and persistent disability worldwide. Despite ongoing therapeutic interventions at both the experimental and clinical levels, options for stroke-related brain injury are still limited. Several evidence suggests that autophagy is triggered in response to cerebral ischemia, therefore targeting autophagy-related signaling pathways can provide a new direction for the therapeutic implications in the ischemic injury. Autophagy is a highly conserve...
Source: Neurochemical Research - January 7, 2022 Category: Neuroscience Authors: Palak Kalra Heena Khan Amarjot Kaur Thakur Gurjeet Singh Source Type: research
Serum Exosomal mir-340-5p Promotes Angiogenesis in Brain Microvascular Endothelial Cells During Oxygen-Glucose Deprivation
Neurochem Res. 2022 Jan 7. doi: 10.1007/s11064-021-03492-x. Online ahead of print.ABSTRACTIschemic stroke (IS) is a cerebrovascular disease with high morbidity, recurrence, and mortality. The purpose of the present study was to investigate the role and mechanism of human serum exosomes on angiogenesis after IS. The middle cerebral artery occlusion (MCAO) in vivo model and oxygen-glucose deprivation (OGD) in vitro model were established. Human serum exosomes from healthy samples (NC-exo) and IS samples (IS-exo) were injected into MCAO mice. Neurobehavioral tests were performed to assess the extent of neurological deficits. ...
Source: Neurochemical Research - January 7, 2022 Category: Neuroscience Authors: Chuan Xu Hailong Yu Beilei Chen Yuan Ma Penghua Lv Source Type: research
Mechanistic Insight on Autophagy Modulated Molecular Pathways in Cerebral Ischemic Injury: From Preclinical to Clinical Perspective
Neurochem Res. 2022 Jan 7. doi: 10.1007/s11064-021-03500-0. Online ahead of print.ABSTRACTCerebral ischemia is one of the most devastating brain injuries and a primary cause of acquired and persistent disability worldwide. Despite ongoing therapeutic interventions at both the experimental and clinical levels, options for stroke-related brain injury are still limited. Several evidence suggests that autophagy is triggered in response to cerebral ischemia, therefore targeting autophagy-related signaling pathways can provide a new direction for the therapeutic implications in the ischemic injury. Autophagy is a highly conserve...
Source: Neurochemical Research - January 7, 2022 Category: Neuroscience Authors: Palak Kalra Heena Khan Amarjot Kaur Thakur Gurjeet Singh Source Type: research
Persistent Acidic Environment Induces Impaired Phagocytosis via ERK in Microglia
In this study, we found that acidic stimuli (pH 6.8) increased rapidly interleukin (IL)-1β and IL-6 mRNA levels and subsequently reduced IL-10, transforming growth factor (TGF)-β1, Cx3cr1, and P2ry12 as the exposure time to acidic environment increase in BV2 cells. In addition, persistent acidic environment (pH 6.8 for 6 h) induced impaired phagocytic function in BV2 cells. Short-term acidic exposure (pH 6.8 for 30 min) increased cyclic AMP (cAMP) and phospho-protein kinase A (PKA) but inhibited phospho-extracellular signal-regulated kinase (p-ERK). However, under persistent acidic environment (pH 6.8 for 6 h), cyclic AM...
Source: Neurochemical Research - February 1, 2022 Category: Neuroscience Authors: Kyu-Beom Jang Min-Jung You Bohyun Yang Chan Rim Hui-Ju Kim Min-Soo Kwon Source Type: research
Carbon Monoxide Protects Neural Stem Cells Against Iron Overload by Modulating the Crosstalk Between Nrf2 and NF- κB Signaling
Neurochem Res. 2022 Mar 8. doi: 10.1007/s11064-022-03537-9. Online ahead of print.ABSTRACTAlthough accumulating evidences have demonstrated pro-survival effects of CO against various insults, the precise mechanism explaining how neural stem cells (NSCs) are protected by CO also remains largely unknown. Here we report CO pro-survival effect on NSCs against iron overload was comparable to that obtained with pharmacological inhibitors of reactive oxygen species (ROS). Its pro-survival effect was accompanied by the inhibition of ROS and subsequent inhibition of NF-κB which is mediated through nuclear factor erythroid 2-relate...
Source: Neurochemical Research - March 8, 2022 Category: Neuroscience Authors: Xie Zhengxing Hu Aiying Zhang Zongqiang Miao Zengli Source Type: research
Correction to: Electroacupuncture Ameliorates Cognitive Impairment Through the Inhibition of NLRP3 Inflammasome Activation by Regulating Melatonin-Mediated Mitophagy in Stroke Rats
Neurochem Res. 2022 Mar 31. doi: 10.1007/s11064-022-03590-4. Online ahead of print.NO ABSTRACTPMID:35357601 | DOI:10.1007/s11064-022-03590-4
Source: Neurochemical Research - March 31, 2022 Category: Neuroscience Authors: Xiaoyong Zhong Bin Chen Zuanfang Li Ruhui Lin Su Ruan Fang Wang Hui Liang Jing Tao Source Type: research
Kaempferol Mediated AMPK/mTOR Signal Pathway Has a Protective Effect on Cerebral Ischemic-Reperfusion Injury in Rats by Inducing Autophagy
Neurochem Res. 2022 May 7. doi: 10.1007/s11064-022-03604-1. Online ahead of print.ABSTRACTIschemia/reperfusion (I/R) caused by ischemic stroke treatments leads to brain injury and its pathological mechanism is related to autophagy. The underlying mechanism of kaempferol on cerebral I/R injury needs to be explored. To establish I/R injury, we used a middle cerebral artery occlusion-reperfusion (MCAO) model in rats. MCAO rats were treated with the same amount of saline (I/R group); Treatment group rats were treated orally with kaempferol (50, 100, 200 mg/kg) for 7 days before surgery. After reperfusion for 24 h, the scores o...
Source: Neurochemical Research - May 7, 2022 Category: Neuroscience Authors: Yajing Yuan Fei Xia Rong Gao Yang Chen Yu Zhang Zhongping Cheng Hongwei Zhao Liming Xu Source Type: research
