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Source: Neurochemical Research

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Total 300 results found since Jan 2013.

Probenecid Protects Against Transient Focal Cerebral Ischemic Injury by Inhibiting HMGB1 Release and Attenuating AQP4 Expression in Mice.
Abstract Stroke results in inflammation, brain edema, and neuronal death. However, effective neuroprotectants are not available. Recent studies have shown that high mobility group box-1 (HMGB1), a proinflammatory cytokine, contributes to ischemic brain injury. Aquaporin 4 (AQP4), a water channel protein, is considered to play a pivotal role in ischemia-induced brain edema. More recently, studies have shown that pannexin 1 channels are involved in cerebral ischemic injury and the cellular inflammatory response. Here, we examined whether the pannexin 1 channel inhibitor probenecid could reduce focal ischemic brain i...
Source: Neurochemical Research - December 7, 2013 Category: Neuroscience Authors: Xiong XX, Gu LJ, Shen J, Kang XH, Zheng YY, Yue SB, Zhu SM Tags: Neurochem Res Source Type: research

Silencing VEGF-B Diminishes the Neuroprotective Effect of Candesartan Treatment After Experimental Focal Cerebral Ischemia.
In this study, we aimed to silence VEGF-B expression to assess its contribution to candesartan's benefit on stroke outcome. Silencing VEGF-B expression was achieved by bilateral intracerebroventricular injections of lentiviral particles containing short hairpin RNA (shRNA) against VEGF-B. Two weeks after lentiviral injections, rats were subjected to either 90 min or 3 h of middle cerebral artery occlusion (MCAO) and randomized to intravenous candesartan (1 mg/kg) or saline at reperfusion. Animals were sacrificed at 24 or 72 h and brains were collected and analyzed for hemoglobin (Hb) excess and infarct size, respective...
Source: Neurochemical Research - August 7, 2018 Category: Neuroscience Authors: Ishrat T, Soliman S, Eldahshan W, Pillai B, Ergul A, Fagan SC Tags: Neurochem Res Source Type: research

Assessment of recombinant tissue plasminogen activator (rtPA) toxicity in cultured neural cells and subsequent treatment with poly-arginine peptide R18D.
Abstract Thrombolytic therapy with recombinant tissue plasminogen activator (rtPA) in ischaemic stroke has been associated with neurotoxicity, blood brain barrier (BBB) disruption and intra-cerebral hemorrhage. To examine rtPA cellular toxicity we investigated the effects of rtPA on cell viability in neuronal, astrocyte and brain endothelial cell (bEnd.3) cultures with and without prior exposure to oxygen-glucose deprivation (OGD). In addition, the neuroprotective peptide poly-arginine-18 (R18D; 18-mer of D-arginine) was examined for its ability to reduce rtPA toxicity. Studies demonstrated that a 4- or 24-h expos...
Source: Neurochemical Research - March 4, 2020 Category: Neuroscience Authors: Kenna JE, Anderton RS, Knuckey NW, Meloni BP Tags: Neurochem Res Source Type: research

Protective Mechanism and Treatment of Neurogenesis in Cerebral Ischemia.
This article reviews several possible mechanisms of stroke and neurogenesis and introduces novel neurogenic agents (fibroblast growth factors, brain-derived neurotrophic factor, purine nucleosides, resveratrol, S-nitrosoglutathione, osteopontin, etc.) as well as other treatments that have shown neuroprotective or neurogenesis-promoting effects. PMID: 32794152 [PubMed - as supplied by publisher]
Source: Neurochemical Research - August 12, 2020 Category: Neuroscience Authors: Li W, Ye A, Ao L, Zhou L, Yan Y, Hu Y, Fang W, Li Y Tags: Neurochem Res Source Type: research

Salidroside Inhibits Reactive Astrogliosis and Glial Scar Formation in Late Cerebral Ischemia via the Akt/GSK-3 β Pathway.
In this study, male adult C57/BL6 mice were subjected to transient cerebral ischemia injury followed by intravenous salidroside treatment. Primary astrocytes were treated with lipopolysaccharide (LPS) or conditioned medium from cultured primary neurons subjected to oxygen-glucose deprivation (CM-OGD). Salidroside significantly improved long-term functional outcomes following ischemic stroke in the rotarod and corner tests. It also reduced brain glial scar volume and decreased expression of the glial scar marker, glial fibrillary acidic protein (GFAP) and inhibited astrocyte proliferation. In primary astrocyte cultures, sal...
Source: Neurochemical Research - January 3, 2021 Category: Neuroscience Authors: Dong C, Wen S, Zhao S, Sun S, Zhao S, Dong W, Han P, Chen Q, Gong T, Chen W, Liu W, Liu X Tags: Neurochem Res Source Type: research

LncRNA XIST Promoted OGD-Induced Neuronal Injury Through Modulating/miR-455-3p/TIPARP Axis
In this study, we found that oxygen-glucose deprivation (OGD) induced XIST expression, inhibited miR-455-3p expression and promoted TIPARP mRNA and protein expression in neurons. Furthermore, XIST could affect cell growth of OGD-induced neuronal cells. Further analysis showed that XIST could regulate TIPARP by binding to miR-455-3p, and overexpression of miR-455-3p or inhibition of TIPARP could reverse the effects of high XIST expression on OGD-induced neuronal cells. On the contrary, suppression of miR-455-3p or promotion of TIPARP could reverse the effects of low XIST expression on OGD-induced neuronal cells. XIST could ...
Source: Neurochemical Research - March 19, 2021 Category: Neuroscience Authors: Ying Wang Yunfei Li Chaoyang Ma Ting Zhou Chi Lu Lin Ding Lei Li Source Type: research

Oleuropein Protects Against Cerebral Ischemia Injury in Rats: Molecular Docking, Biochemical and Histological Findings
This study was designed to evaluate the underlying protective mechanisms of oleuropein involved in alleviating brain damage in a rat model of ischemic stroke. Male Wistar rats were divided into four groups; Control, stroke (MCAO), MCAO + clopidogrel (Clop) and MCAO + oleuropein (Ole). Results showed that the MCAO group evidenced significant brain edema (+ 9%) as well as increases of plasma cardiac markers such as lactate deshydrogenase (LDH), creatine kinase (CK-MB), fibrinogen and Trop-T by 11 %, 43%, 168 and 590%, respectively, as compared to the control group. Moreover, infarcted rats exhibited remarkable elevated level...
Source: Neurochemical Research - May 19, 2021 Category: Neuroscience Authors: Kais Mnafgui Lakhdar Ghazouani Raouf Hajji Abir Tlili Fatma Derbali Francisco Ivan da Silva Joabe Lima Ara újo Bianca de Oliveira Schinoff Jos é Fernando Ruggiero Bachega Ant ônia Laíres da Silva Santos Noureddine Allouche Source Type: research

Neuroprotection by Mucuna pruriens in Neurodegenerative Diseases
Neurochem Res. 2022 Apr 5. doi: 10.1007/s11064-022-03591-3. Online ahead of print.ABSTRACTThe medicinal plant Mucuna pruriens (Fabaceae) is widely known for its anti-oxidative and anti-inflammatory properties. It is a well-established drug in Ayurveda and has been widely used for the treatment of neurological disorders and male infertility for ages. The seeds of the plant have potent medicinal value and its extract has been tested in different models of neurodegenerative diseases, especially Parkinson's disease (PD). Apart from PD, Mucuna pruriens is now being studied in models of other nervous systems disorders such as Al...
Source: Neurochemical Research - April 5, 2022 Category: Neuroscience Authors: Walia Zahra Hareram Birla Saumitra Sen Singh Aaina Singh Rathore Hagera Dilnashin Richa Singh Priyanka Kumari Keshri Priyanka Gautam Surya Pratap Singh Source Type: research

Exosomal ZEB1 Derived from Neural Stem Cells Reduces Inflammation Injury in OGD/R-Treated Microglia via the GPR30-TLR4-NF- κB Axis
Neurochem Res. 2023 Jan 30. doi: 10.1007/s11064-023-03866-3. Online ahead of print.ABSTRACTIschemic stroke (IS) is the most common type of stroke and the second leading cause of death overall. Neural stem cells play protective roles in IS, but the underlying mechanism remains to be determined. Neural stem cells (NSC) were obtained from the fetal brain tissue of C57BL/6J mice. NSC-derived exosomes (NSC-Exos) were identified in the conditioned medium. Internalization of NSC-Exos was analyzed by fluorescence microscopy. In vitro microglia ischemic stroke injury model was induced using oxygen glucose deprivation/re-oxygenation...
Source: Neurochemical Research - January 30, 2023 Category: Neuroscience Authors: Jun Peng Zhengtao Yu Rongjun Xiao Xiqi Hu Ying Xia Source Type: research

APP96-110 Elicits Neuroprotective Effects Following Ischemic Insult in Animal Models
Neurochem Res. 2023 Apr 17. doi: 10.1007/s11064-023-03928-6. Online ahead of print.ABSTRACTCompetitive amyloidogenic pathways play an important role in many neurological diseases such as the onset of various degenerative diseases and ischemic stroke. Overexpression of amyloid precursor protein (APP) and amyloid-beta is modulated via the amyloidogenic pathway, which plays a crucial role in neuroinflammation. During ischemic conditions, the activity of the anti-inflammatory non-amyloidogenic pathway decreases, thus increasing the activity of amyloidogenic pathway. The soluble alpha form of APP (sAPPα), formed via the non-am...
Source: Neurochemical Research - April 17, 2023 Category: Neuroscience Authors: Ren ée Kosonen Ji Young Chang Seowoo Lee Jiwon Kim Jong Youl Kim Jong Eun Lee Source Type: research

Protection of Oxygen Glucose Deprivation-Induced Human Brain Vascular Pericyte Injury: Beneficial Effects of Bellidifolin in Cellular Pyroptosis
Neurochem Res. 2023 May 2. doi: 10.1007/s11064-023-03943-7. Online ahead of print.ABSTRACTPericytes play critical roles in the maintenance of brain vascular homeostasis. However, very little is currently known about how pericytes regulate ischemic stroke-induced brain injury. Inflammation is a key event in the pathobiology of stroke, in which the nod-like receptor protein-3 (NLRP3) inflammasome is involved in, triggering sterile inflammatory responses and pyroptosis. In the current study, an immortalized cell line derived from human brain vascular pericytes (HBVPs) was constructed, and it showed that HBVPs challenged with ...
Source: Neurochemical Research - May 1, 2023 Category: Neuroscience Authors: Di An Weixiao Xu Yingxin Ge Yaning Ge Linwei Zhang Yi Zhu Zhongman Zhang Junting Fan Rong Gao Lei Jiang Peipei Huang Jun Wang Xufeng Chen Source Type: research