cPKC γ Inhibits Caspase-9-Initiated Neuronal Apoptosis in an Ischemia Reperfusion Model In Vitro Through p38 MAPK-p90RSK-Bad Pathway

In conclusion, our results suggest that cPKCγ partly alleviates ischemic injury through activating the p38 MAPK-p90RSK-Bad pathway and inhibiting Caspase-9 initiated apoptosis. This may have potential as a therapeutic target for ischemic stroke.PMID:36152136 | DOI:10.1007/s11064-022-03747-1

Source: Neurochemical Research - September 24, 2022 Category: Neuroscience Authors: Hai-Ping Wei Zhi-Feng Peng Kang-Mei Shao Pei-Hao Zhang Lei Chen Jin-An Hu Hui Chai Jin-Mei Liu Source Type: research