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Cancer: Glioma

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Total 252 results found since Jan 2013.

Identification of Circulating MicroRNAs as Potential Biomarkers for Detecting Acute Ischemic Stroke.
In conclusion, we identified the changed expression pattern of miRNAs in IS. Serum miR-32-3p, miR-106-5p, miR-1246, and miR-532-5p may serve as potential diagnostic biomarkers for IS. Our results also demonstrate a novel role for miRNAs in the pathogenesis of IS. PMID: 25410304 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Neurobiology - November 20, 2014 Category: Cytology Authors: Li P, Teng F, Gao F, Zhang M, Wu J, Zhang C Tags: Cell Mol Neurobiol Source Type: research

The subpopulation of microglia expressing functional muscarinic acetylcholine receptors expands in stroke and Alzheimer's disease.
Abstract Microglia undergo a process of activation in pathology which is controlled by many factors including neurotransmitters. We found that a subpopulation (11 %) of freshly isolated adult microglia respond to the muscarinic acetylcholine receptor agonist carbachol with a Ca(2+) increase and a subpopulation of similar size (16 %) was observed by FACS analysis using an antibody against the M3 receptor subtype. The carbachol-sensitive population increased in microglia/brain macrophages isolated from tissue of mouse models for stroke (60 %) and Alzheimer's disease (25 %), but not for glioma and multiple sclero...
Source: Brain Structure and Function - December 19, 2014 Category: Neuroscience Authors: Pannell M, Meier MA, Szulzewsky F, Matyash V, Endres M, Kronenberg G, Prinz V, Waiczies S, Wolf SA, Kettenmann H Tags: Brain Struct Funct Source Type: research

A Generative Probabilistic Model and Discriminative Extensions for Brain Lesion Segmentation— With Application to Tumor and Stroke
We introduce a generative probabilistic model for segmentation of brain lesions in multi-dimensional images that generalizes the EM segmenter, a common approach for modelling brain images using Gaussian mixtures and a probabilistic tissue atlas that employs expectation-maximization (EM), to estimate the label map for a new image. Our model augments the probabilistic atlas of the healthy tissues with a latent atlas of the lesion. We derive an estimation algorithm with closed-form EM update equations. The method extracts a latent atlas prior distribution and the lesion posterior distributions jointly from the image data. It ...
Source: IEE Transactions on Medical Imaging - March 31, 2016 Category: Biomedical Engineering Source Type: research

Keeping up with Amanda: Life after brain surgery
In most ways, Amanda LePage is just like any other rambunctious fourth grader. She loves school, dance class, playing basketball and keeping up with her twin sister Macy and older brother Nathan. Sometimes it just takes her a little longer to do these everyday things. That’s because Amanda has been through a lot in her short nine years. Amanda was just 5 months old when she was brought by helicopter to Boston Children’s Hospital for a hemorrhage in her brain from an intracranial aneurysm, a type of vascular malformation. Despite long odds, Amanda survived two life-saving brain surgeries and a massive stroke that left ...
Source: Thrive, Children's Hospital Boston - May 22, 2017 Category: Pediatrics Authors: Ellen Greenlaw Tags: Our Patients’ Stories brain aneurysm Dr. Caroline Robson Dr. Craig McClain Dr. Edward Smith Dr. Peter Manley Hydrocephalus low-grade glioma pediatric stroke Source Type: news

Incidence and impact of stroke following surgery for low-grade gliomas.
CONCLUSIONS: Recurrent surgeries and insular tumor locations are risk factors for intraoperative strokes. Although they do not affect survival, these strokes negatively affect patient activity and performance status, mainly during the first 3 postoperative months, with gradual functional improvement over 1 year. Several intraoperative parameters may suggest the impending development of an infarct. PMID: 31881532 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - December 26, 2019 Category: Neurosurgery Authors: Berger A, Tzarfati G, Costa M, Serafimova M, Korn A, Vendrov I, Alfasi T, Krill D, Aviram D, Ben Moshe S, Kashanian A, Ram Z, Grossman R Tags: J Neurosurg Source Type: research

The Cerebral Microvasculature: Basic and Clinical Perspectives on Stroke and Glioma
AbstractMicrovascular networks are vital components of the cardiovascular system, performing many key roles in maintaining the health and homeostasis of the tissues and organs in which they develop. As discussed in this review, the molecular and cellular components within the microcirculation orchestrate critical processes to establish functional capillary beds, including organization of endothelial cell (EC) polarity, guiding investment of vascular pericytes (PCs), and building the specialized extracellular matrix (ECM) that comprises the vascular basement membrane (vBM). Herein, we further discuss the unique features of ...
Source: Microcirculation - November 10, 2020 Category: Research Authors: Maruf M. Hoque, Hanaa Abdelazim, Clifton Jenkins ‐Houk, Dawn Wright, Biraj M. Patel, John C. Chappell Tags: INVITED REVIEW Source Type: research

The cerebral microvasculature: Basic and clinical perspectives on stroke and glioma
AbstractMicrovascular networks are vital components of the cardiovascular system, performing many key roles in maintaining the health and homeostasis of the tissues and organs in which they develop. As discussed in this review, the molecular and cellular components within the microcirculation orchestrate critical processes to establish functional capillary beds, including organization of endothelial cell (EC) polarity, guiding investment of vascular pericytes (PCs), and building the specialized extracellular matrix (ECM) that comprises the vascular basement membrane (vBM). Herein, we further discuss the unique features of ...
Source: Microcirculation - November 23, 2020 Category: Research Authors: Maruf M. Hoque, Hanaa Abdelazim, Clifton Jenkins ‐Houk, Dawn Wright, Biraj M. Patel, John C. Chappell Tags: INVITED REVIEWS Source Type: research

The subpopulation of microglia expressing functional muscarinic acetylcholine receptors expands in stroke and Alzheimer’s disease
Abstract Microglia undergo a process of activation in pathology which is controlled by many factors including neurotransmitters. We found that a subpopulation (11 %) of freshly isolated adult microglia respond to the muscarinic acetylcholine receptor agonist carbachol with a Ca2+ increase and a subpopulation of similar size (16 %) was observed by FACS analysis using an antibody against the M3 receptor subtype. The carbachol-sensitive population increased in microglia/brain macrophages isolated from tissue of mouse models for stroke (60 %) and Alzheimer’s disease (25 %), but not for glioma and multiple sclero...
Source: Anatomy and Embryology - December 18, 2014 Category: Anatomy Source Type: research

A glioma presenting as a posterior circulation stroke.
PMID: 32329427 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - April 23, 2020 Category: Neurology Authors: Lu F, Fowler A, Tam K, Camara-Lemarroy CR Tags: Can J Neurol Sci Source Type: research

A Stroke Alert With Unexpected Outcome
Conclusion: We report a case of thrombolysis administered in a patient with high-grade glioma with no apparent complications.
Source: The Neurologist - September 1, 2022 Category: Neurology Tags: Case Report/Case Series Source Type: research

Cn-14 * retrospective analysis of ischemic cerebral strokes in patients diagnosed with a glioblastoma during the course of a bevacizumab treatment
Bevacizumab is an anti-vascular endothelial growth factor approved in the treatment of recurrent glioblastoma. It prolongs progression-free survival, improes radiologic response and contributes to reduce the dose of dexamethasone required to control peritumoral edema. Arterial and venous thromboembolic events represent significant toxicities related to the use of angiogenesis inhibitors. Various mechanisms could be implicated in bevacizumab-related strokes, as cardioembolic, lacunar stroke related to hypertension, deep venous thrombosis passing through a patent foramen ovale, pro-coagulant effect of the underlying glioblas...
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Maurice, C., Mason, W. P. Tags: COMPLICATIONS OF THERAPY AND NEUROTOXICITY Source Type: research

Arterial Spin Labeling Imaging Characteristics of Anti-leucine-rich Glioma-Inactivated 1 Encephalitis: A Qualitative and Quantitative Analysis
DiscussionIn this preliminary study of six patients, we demonstrate an ASL hyperperfusion pattern, with a possible predilection for the right mesial temporal lobe on both qualitative and quantitative assessments in patients with seropositive LGI1. Larger scale studies are necessary to further characterize the strength of these associations.
Source: Frontiers in Neurology - July 28, 2022 Category: Neurology Source Type: research

Multiple Mechanistic Models Reveal the Neuroprotective Effects of Diterpene Ginkgolides against Astrocyte-Mediated Demyelination via the PAF-PAFR Pathway
Am J Chin Med. 2022 Jul 29:1-33. doi: 10.1142/S0192415X22500665. Online ahead of print.ABSTRACTCurrently, therapies for ischemic stroke are limited. Ginkgolides, unique Folium Ginkgo components, have potential benefits for ischemic stroke patients, but there is little evidence that ginkgolides improve neurological function in these patients. Clinical studies have confirmed the neurological improvement efficacy of diterpene ginkgolides meglumine injection (DGMI), an extract of Ginkgo biloba containing ginkgolides A (GA), B (GB), and K (GK), in ischemic stroke patients. In the present study, we performed transcriptome analys...
Source: The American Journal of Chinese Medicine - July 28, 2022 Category: Complementary Medicine Authors: Tuan-Jie Wang Zi-Yin Wu Chun-Hua Yang Liang Cao Zhen-Zhong Wang Ze-Yu Cao Ming-Yang Yu Meng-Ru Zhao Chen-Feng Zhang Wen-Jun Liu Bin-Jiang Zhao Xue-Qi Shang Yu Feng Hui Wang Li-Li Deng Bao-Guo Xiao Hong-Yan Guo Wei Xiao Source Type: research