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Cancer: Glioma

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Total 252 results found since Jan 2013.

Translational potential of astrocytes in brain disorders
Publication date: Available online 16 September 2015 Source:Progress in Neurobiology Author(s): Alexei Verkhratsky, Luca Steardo, Vladimir Parpura, Vedrana Montana Fundamentally, all brain disorders can be broadly defined as the homeostatic failure of this organ. As the brain is composed of many different cells types, including but not limited to neurons and glia, it is only logical that all the cell types/constituents could play a role in health and disease. Yet, for a long time the sole conceptualization of brain pathology was focused on the well-being of neurons. Here, we challenge this neuron-centric view and pre...
Source: Progress in Neurobiology - September 17, 2015 Category: Neuroscience Source Type: research

Small Peptide and Protein-based Molecular Probes for Imaging Neurological Diseases.
Abstract Neurologic disorders are prevalent diseases in the population and represent a major cause of death and disability. Despite the advances made during recent decades, the early diagnosis of these diseases remains a challenge. Determining the pathophysiology of such disorders is also challenging and is a requirement for the development of new drugs and treatments. Molecular neuroimaging studies can help fill these gaps in knowledge by providing clinicians with the tools necessary to diagnose and monitor treatment response and by providing data to help researchers understand the mechanisms of disease. Molecula...
Source: Current Protein and Peptide Science - January 1, 2016 Category: Biochemistry Authors: Venturin GT, Cheng Z Tags: Curr Protein Pept Sci Source Type: research

TAT-HSA-α-MSH fusion protein with extended half-life inhibits tumor necrosis factor-α in brain inflammation of mice.
Abstract Neuroinflammation constitutes a principal process involved in the progression of various central nervous system (CNS) disorders, including Parkinson's disease, Alzheimer's disease, ischemic stroke, and traumatic brain injury. The safety and efficacy of potential neuroprotective therapeutic agents is controversial and limited. Alpha-melanocyte-stimulating hormone (α-MSH) as a tridecapeptide derived from pro-opiomelanocortin displays potent anti-inflammatory and protective effects with a wide therapeutic window in brain damage. However, it is difficult to deliver effective concentrations of α-MSH into bra...
Source: Applied Microbiology and Biotechnology - January 27, 2016 Category: Microbiology Authors: Wang M, Zhi D, Wang H, Ru Y, Ren H, Wang N, Liu Y, Li Y, Li H Tags: Appl Microbiol Biotechnol Source Type: research

Mild Sedation Exacerbates or Unmasks Focal Neurologic Dysfunction in Neurosurgical Patients with Supratentorial Brain Mass Lesions in a Drug-specific Manner
Conclusions Midazolam and propofol augmented or revealed neurologic dysfunction more frequently than fentanyl and dexmedetomidine at equivalent sedation levels. Patients with high-grade gliomas were more susceptible than those with low-grade gliomas.
Source: Anesthesiology - February 17, 2016 Category: Anesthesiology Source Type: research

Mapping neuroplastic potential in brain-damaged patients
It is increasingly acknowledged that the brain is highly plastic. However, the anatomic factors governing the potential for neuroplasticity have hardly been investigated. To bridge this knowledge gap, we generated a probabilistic atlas of functional plasticity derived from both anatomic magnetic resonance imaging results and intraoperative mapping data on 231 patients having undergone surgery for diffuse, low-grade glioma. The atlas includes detailed level of confidence information and is supplemented with a series of comprehensive, connectivity-based cluster analyses. Our results show that cortical plasticity is generally...
Source: Brain - February 25, 2016 Category: Neurology Authors: Herbet, G., Maheu, M., Costi, E., Lafargue, G., Duffau, H. Tags: CNS Injury and Stroke Original Articles Source Type: research

Chapter 17 Rehabilitation of patients with glioma
Publication date: 2016 Source:Handbook of Clinical Neurology, Volume 134 Author(s): Mary Vargo, Roger Henriksson, Pär Salander Disabling sequelae occur in a majority of patients diagnosed with brain tumor, including glioma, such as cognitive deficits, weakness, and visual perceptual changes. Often, multiple impairments are present concurrently. Healthcare staff must be aware of the “biographic disruption” the patient with glioma has experienced. While prognostic considerations factor into rehabilitation goals and expectations, regardless of prognosis the treatment team must offer cohesive support, facilitating ho...
Source: Handbook of Clinical Neurology - March 4, 2016 Category: Neurology Source Type: research

Pseudotumoral presentation of cerebral amyloid angiopathy-related inflammation
Conclusion: The identification of one or several nonenhancing space-occupying lesions, especially in elderly patients presenting with cognitive impairment, should raise suspicion for the pseudotumoral presentation of CAA-I and lead to T2*-GRE sequences. Perfusion MRI and MRS appear to be useful techniques for the differential diagnosis of this entity.
Source: Neurology - March 7, 2016 Category: Neurology Authors: Ronsin, S., Deiana, G., Geraldo, A. F., Durand-Dubief, F., Thomas-Maisonneuve, L., Formaglio, M., Desestret, V., Meyronet, D., Nighoghossian, N., Berthezene, Y., Honnorat, J., Ducray, F. Tags: MRI, MRS, Other cerebrovascular disease/ Stroke, Primary brain tumor ARTICLE Source Type: research

Leucine-Rich Glioma Inactivated-1 and Voltage-Gated Potassium Channel Autoimmune Encephalitis Associated with Ischemic Stroke: A Case Report
Marisa McGinley, Sarkis Morales-Vidal, Sean Ruland
Source: Frontiers in Neurology - May 8, 2016 Category: Neurology Source Type: research

Evaluation of laser bacterial anti‐fouling of transparent nanocrystalline yttria‐stabilized‐zirconia cranial implant
ConclusionsOur results show that E. coli biofilm formation across the thickness of the nc‐YSZ implant can be disrupted using NIR laser treatment. The results of this in vitro study suggest that using nc‐YSZ as a cranial implant in vivo may also allow for locally selective, non‐invasive, chronic treatment of bacterial layers (fouling) that might form under cranial implants, without causing adverse thermal damage to the underlying host tissue when appropriate laser parameters are used. Lasers Surg. Med. © 2016 Wiley Periodicals, Inc.
Source: Lasers in Surgery and Medicine - June 30, 2016 Category: Laser Surgery Authors: Yasaman Damestani, Natalie De Howitt, David L. Halaney, Javier E. Garay, Guillermo Aguilar Tags: Basic Science Source Type: research

Evaluation of laser bacterial anti ‐fouling of transparent nanocrystalline yttria‐stabilized‐zirconia cranial implant
ConclusionsOur results show that E. coli biofilm formation across the thickness of the nc‐YSZ implant can be disrupted using NIR laser treatment. The results of this in vitro study suggest that using nc‐YSZ as a cranial implant in vivo may also allow for locally selective, non‐invasive, chronic treatment of bacterial layers (fouling) that might form under cranial implants, without causing adverse thermal damage to the underlying host tissue when appropriate laser parameters are used. Lasers Surg. Med. © 2016 Wiley Periodicals, Inc.
Source: Lasers in Surgery and Medicine - July 7, 2016 Category: Laser Surgery Authors: Yasaman Damestani, Natalie De Howitt, David L. Halaney, Javier E. Garay, Guillermo Aguilar Tags: Basic Science Source Type: research

OS5.8 Intravascular lymphoma affecting the central nervous system: features and outcomes in a case series of the Primary CNS Lymphoma Collaborative Group (IPCG)
We present a retrospective case series of 65 adults with IVL from 14 cancer centers in 6 countries. IVL was restricted to the CNS in 29 cases, with a mean age of 60 years and 91% of patients having neurological deficits at the time of diagnosis. There was a mean diagnostic delay of 20 weeks after presentation of stroke-like symptoms or myelopathy. Ninety-three percent had a poor functional status with an Eastern Cooperative Oncology Group (ECOG) performance status ≥2. Serum LDH was elevated in 87% of patients with no correlation with treatment outcome. Frontline treatment with intravenous high-dose methotrexate-bas...
Source: Neuro-Oncology - September 20, 2016 Category: Cancer & Oncology Authors: Zukas, A. M., Bennani, N., Chou, C., Johnston, P., ONeill, B., Nijland, M., Batchelor, T., Nayak, L., Mrugala, M., Schiff, D. Tags: OS5 Glioma: Clinical Source Type: research

P05.04 Morphine pretreatment improves the therapeutic efficacy of doxorubicin in an orthotopic model of human glioblastoma
Conclusions:The present findings show that molecules as morphine are able to interfere with molecules normally unable to cross the BBB. This mechanism could be used for new approaches in therapy of refractory CNS tumors as glioblastoma.
Source: Neuro-Oncology - September 20, 2016 Category: Cancer & Oncology Authors: Da Ros, M. Tags: P05 In vitro / in vivo models Source Type: research

P08.46 Rechallenge with bevacizumab in a long-term survivor with glioblastoma
The prognosis of patients with glioblastoma multiforme (GBM, WHO grade IV), the most common primary brain tumor in adults, is generally poor with median survival of less than one year in untreated patients and approximately 15 months following standard of care therapy. However, 10 % survival at 5 years was observed in a randomized phase III study. At GBM recurrence, the addition of bevacizumab (BEV), a humanized monoclonal antibody against circulating vascular endothelial growth factor (VEGF), resulted in a 3–4 month prolongation of progression-free survival (PFS) without improving overall survival (OS...
Source: Neuro-Oncology - September 20, 2016 Category: Cancer & Oncology Authors: Koeppen, S., Hense, J. Tags: P08 Glioblastom and Anaplastic gliomas Source Type: research

Atim-02. successful cancer-selective gene delivery following intravenous toca 511 delivery in patients with recurrent high grade glioma (hgg)
This study demonstrates successful gene transduction following IV delivery of Toca 511 and shows encouraging survival data. Updated safety and efficacy data will be presented.
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Cloughesy, T., Walbert, T., Bota, D., Vogelbaum, M., Liau, L., Ostertag, D., Jolly, D., Gruber, H., Yang, L., Shorr, J., Kalkanis, S. Tags: ADULT CLINICAL TRIALS (IMMUNOLOGICAL) Source Type: research

Atim-18. phase i dose escalation study of d2c7-it administered intratumorally via convection-enhanced delivery (ced) for recurrent malignant glioma (mg)
CONCLUSION:Infusion of D2C7-IT via CED is safe thus far and encouraging efficacy results are observed. Enrollment is ongoing.
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Desjardins, A., Randazzo, D., Chandramohan, V., Sampson, J., Peters, K., Vlahovic, G., Threatt, S., Herndon, J., Boulton, S., Lally-Goss, D., Healy, P., Lipp, E., Friedman, A., Friedman, H., Bigner, D. Tags: ADULT CLINICAL TRIALS (IMMUNOLOGICAL) Source Type: research