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Cancer: Glioma
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Total 252 results found since Jan 2013.
Vascular adhesion protein-1 (VAP-1) in vascular inflammatory diseases
Vasa. 2022 Oct 6. doi: 10.1024/0301-1526/a001031. Online ahead of print.ABSTRACT Vascular adhesion protein-1 (VAP-1) also known as amino oxidase copper containing 3 (AOC3) is a pro-inflammatory and versatile molecule with adhesive and enzymatic properties. VAP-1 is a primary amine oxidase belonging to the semicarbazide-sensitive amine oxidase (SSAO) family, which catalyzes the oxidation of primary amines leading to the production of ammonium, formaldehyde, methylglyoxal, and hydrogen peroxide. VAP-1 is mainly expressed by endothelial cells, smooth muscle cells, adipocytes and pericytes. It is involved in a repertoire of bi...
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - October 6, 2022 Category: Surgery Authors: Marianna Danielli Roisin Clare Thomas Lauren Marie Quinn Bee Kang Tan Source Type: research
Phytochemicals targeting lncRNAs: A novel direction for neuroprotection in neurological disorders
Biomed Pharmacother. 2023 Apr 12;162:114692. doi: 10.1016/j.biopha.2023.114692. Online ahead of print.ABSTRACTNeurological disorders with various etiologies impacting the nervous system are prevalent in clinical practice. Long non-coding RNA (lncRNA) molecules are functional RNA molecules exceeding 200 nucleotides in length that do not encode proteins, but participate in essential activities. Research indicates that lncRNAs may contribute to the pathogenesis of neurological disorders, and may be potential targets for their treatment. Phytochemicals in traditional Chinese herbal medicine (CHM) have been found to exert neuro...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2023 Category: Drugs & Pharmacology Authors: Hang Zhao Lin Wang Lijuan Zhang Hongyu Zhao Source Type: research
Organotypic brain slices: a model to study the neurovascular unit micro-environment in epilepsies
This study demonstrates that NVU regulation can be investigated using OHCs. We observed in this model system an increase in vascularization and a down-regulation of TJ proteins, similar to the vascular changes described in a chronic focus of epileptic patients, and in rodent models of epilepsy or inflammation. We observed that Zonula occludens-1 (ZO-1) protein disappeared after seizures associated with neuronal damage. In these conditions, the angiopoeitin-1 system was down-regulated, and the application of r-angiopoeitin-1 allowed TJ re-assembly. This article demonstrates that organotypic culture is a useful model to deci...
Source: Cerebrospinal Fluid Research - February 7, 2013 Category: Neurology Authors: Mélanie Morin-BrureauFrédéric De BockMireille Lerner-Natoli Source Type: research
Drugs to be offered to women at high risk of breast cancer
The National Institute of Health and Care Excellence (NICE) has today released updated guidelines on the care of women who are at increased risk of breast cancer due to their family history. One of the main changes to the original guidance from 2004 is that NICE now recommends drug treatment with tamoxifen or raloxifene to reduce risk of breast cancer in a specific group of women who are at high risk of breast cancer and have not had the disease.
They say that these treatments could help prevent breast cancer in about 488,000 women aged 35 years and older.
The updated guideline has also made changes to the recommende...
Source: NHS News Feed - June 25, 2013 Category: Consumer Health News Tags: Cancer Medical practice QA articles Source Type: news
Glutamate quantification in patients with supratentorial gliomas using chemical shift imaging
This study aimed to evaluate and validate chemical shift imaging (CSI) for in vivo glutamate (Glu) quantification in patients with supratentorial gliomas. If validated, CSI could become an extremely useful tool to investigate metabolic dysfunction of Glu in excitotoxic neuropathologies.
Quantitative CSI estimates of Glu concentrations were compared with known concentrations of Glu in aqueous phantom solutions. Forty‐one patients with known or likely supratentorial gliomas underwent preoperative CSI. The spectra obtained were analyzed for Glu concentrations and Glu to creatine (Cr) ratios. These in vivo measurements were ...
Source: NMR in Biomedicine - March 24, 2014 Category: Radiology Authors: S. V. Liubinas, K. J. Drummond, P. M. Desmond, A. Bjorksten, A. P. Morokoff, A. H. Kaye, T. J. O'Brien, B. A. Moffat Tags: Research article Source Type: research
"Pseudostroke": Clinically Diagnosed Ischemia Shown to Be Multiple Sclerosis at Autopsy, A Case Report (P6.266)
CONCLUSIONS:This case emphasizes the difficult clinical and neuroradiological differential between acute stroke and acute MS in a patient presenting with new neurologic deficits with sudden onset. It appears that ADC in very acute lesions of MS may show low signal, contrary to the usual expectations. The high ADC signal reflects the increased extracellular space produced by extracellular edema or demyelination. Acute MS lesions can thus present as "Pseudostrokes".Disclosure: Dr. Uppal has nothing to disclose. Dr. Kataria has nothing to disclose. Dr. Rani has nothing to disclose. Dr. Miller has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Uppal, G., Kataria, N., Rani, P., Miller, D. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research
Technical considerations on the validity of blood oxygenation level‐dependent‐based MR assessment of vascular deoxygenation
A blood oxygenation level‐dependent (BOLD)‐based apparent relative oxygen extraction fraction (rOEF) as a semi‐quantitative marker of vascular deoxygenation has recently been introduced in clinical studies of patients with glioma and stroke, yielding promising results. These rOEF measurements are based on independent quantification of the transverse relaxation times T2 and T2* and relative cerebral blood volume (rCBV). Simulations demonstrate that small errors in any of the underlying measures may result in a large deviation of the calculated rOEF. Therefore, we investigated the validity of such measurements. For thi...
Source: NMR in Biomedicine - May 9, 2014 Category: Radiology Authors: Nuria M. Hirsch, Vivien Toth, Annette Förschler, Hendrik Kooijman, Claus Zimmer, Christine Preibisch Tags: Research article Source Type: research
Question 1: Should a child with neurofibromatosis type 1 be screened for central nervous system tumours with neuroimaging?
Scenario A 4-year-old boy with a recent diagnosis of neurofibromatosis type 1 (NF1) attends your outpatient clinic. His mother has read that optic pathway gliomas (OPG) occur in 15–20% of children with NF1 under 6 years of age. She is worried about the complications of this type of brain tumour, which include visual loss and precocious puberty. She asks you if her son can have an MRI scan to check for an optic pathway glioma. He has a normal ophthalmological examination. Question In a child with neurofibromatosis type 1 (NF1) (patient), does screening for OPGs with MRI (intervention) compared to standard clinica...
Source: Archives of Disease in Childhood - May 15, 2014 Category: Pediatrics Authors: Bodey, C., Seal, A. Tags: ADC Archimedes, Oncology, Eye Diseases, Immunology (including allergy), Drugs: CNS (not psychiatric), Neuromuscular disease, Neurooncology, Stroke, Reproductive medicine, Ophthalmology, Child health, Radiology, Disability, Sexual health, Clinical diagnost Source Type: research
