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Cancer: Glioma
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Total 252 results found since Jan 2013.
Assessment of the praxis circuit in glioma surgery to reduce the incidence of postoperative and long-term apraxia: a new intraoperative test.
CONCLUSIONS The HMt is a safe and feasible intraoperative tool that allowed surgeons to prevent the occurrence of long-term hand apraxia while attaining resection goals for the surgical treatment of glioma.
PMID: 29473778 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - February 23, 2018 Category: Neurosurgery Authors: Rossi M, Fornia L, Puglisi G, Leonetti A, Zuccon G, Fava E, Milani D, Casarotti A, Riva M, Pessina F, Cerri G, Bello L Tags: J Neurosurg Source Type: research
Implication of the Kallikrein-Kinin System on Neurological Disorders: Quest for Potential Biomarkers and Mechanisms
Publication date: Available online 31 January 2018 Source:Progress in Neurobiology Author(s): Amaly Nokkari, Hadi Abou-El-Hassan, Yehia Mechref, Stefania Mondello, Mark S. Kindy, Ayad A. Jaffa, Firas Kobeissy Neurological disorders represent major health concerns in terms of comorbidity and mortality worldwide. Despite a tremendous increase in our understanding of the pathophysiological processes involved in disease progression and prevention, the accumulated knowledge so far resulted in relatively moderate translational benefits in terms of therapeutic interventions and enhanced clinical outcomes. Aiming at specific neur...
Source: Progress in Neurobiology - March 2, 2018 Category: Neuroscience Source Type: research
Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms
Publication date: June–August 2018 Source:Progress in Neurobiology, Volumes 165–167 Author(s): Amaly Nokkari, Hadi Abou-El-Hassan, Yehia Mechref, Stefania Mondello, Mark S. Kindy, Ayad A. Jaffa, Firas Kobeissy Neurological disorders represent major health concerns in terms of comorbidity and mortality worldwide. Despite a tremendous increase in our understanding of the pathophysiological processes involved in disease progression and prevention, the accumulated knowledge so far resulted in relatively moderate translational benefits in terms of therapeutic interventions and enhanced clinical outcomes. Aiming at specific...
Source: Progress in Neurobiology - June 26, 2018 Category: Neuroscience Source Type: research
Targeting nitric oxide and NMDA receptor-associated pathways in treatment of high grade glial tumors. Hypotheses for nitro-memantine and nitrones
Publication date: Available online 13 October 2017Source: Nitric OxideAuthor(s): Meric A. Altinoz, İlhan ElmaciAbstractGlioblastoma multiforme (GBM) is a devastating brain cancer with no curative treatment. Targeting Nitric Oxide (NO) and glutamatergic pathways may help as adjunctive treatments in GBM. NO at low doses promotes tumorigenesis, while at higher levels (above 300 nM) triggers apoptosis. Gliomas actively secrete high amounts of glutamate which activates EGR signaling and mediates degradation of peritumoral tissues via excitotoxic injury. Memantine inhibits NMDA-subtype of glutamate receptors (NMDARs) and induc...
Source: Nitric Oxide - July 5, 2018 Category: Chemistry Source Type: research
Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms
Publication date: June–August 2018Source: Progress in Neurobiology, Volumes 165–167Author(s): Amaly Nokkari, Hadi Abou-El-Hassan, Yehia Mechref, Stefania Mondello, Mark S. Kindy, Ayad A. Jaffa, Firas KobeissyAbstractNeurological disorders represent major health concerns in terms of comorbidity and mortality worldwide. Despite a tremendous increase in our understanding of the pathophysiological processes involved in disease progression and prevention, the accumulated knowledge so far resulted in relatively moderate translational benefits in terms of therapeutic interventions and enhanced clinical outcomes. Aiming at spe...
Source: Progress in Neurobiology - July 10, 2018 Category: Neuroscience Source Type: research
Targeting nitric oxide and NMDA receptor-associated pathways in treatment of high grade glial tumors. Hypotheses for nitro-memantine and nitrones
Publication date: Available online 13 October 2017Source: Nitric OxideAuthor(s): Meric A. Altinoz, İlhan ElmaciAbstractGlioblastoma multiforme (GBM) is a devastating brain cancer with no curative treatment. Targeting Nitric Oxide (NO) and glutamatergic pathways may help as adjunctive treatments in GBM. NO at low doses promotes tumorigenesis, while at higher levels (above 300 nM) triggers apoptosis. Gliomas actively secrete high amounts of glutamate which activates EGR signaling and mediates degradation of peritumoral tissues via excitotoxic injury. Memantine inhibits NMDA-subtype of glutamate receptors (NMDARs) and induc...
Source: Nitric Oxide - July 11, 2018 Category: Chemistry Source Type: research
Functional brain mapping: overview of techniques and their application to neurosurgery
This article reviews the physical principles, applications, merits, shortcomings, and latest developments of nine FBM techniques. Other than neurosurgical operations, these techniques have also been applied to studies of stroke, Alzheimer’s, and cognition. There are strong indications that the future of brain mapping shall see the non-invasive techniques playing a more dominant role as they become more sensitive and accurate due to advances in physics, refined algorithms, and subsequent validation against invas ive techniques.
Source: Neurosurgical Review - July 13, 2018 Category: Neurosurgery Source Type: research
Targeting pericytes for therapeutic approaches to neurological disorders
AbstractMany central nervous system diseases currently lack effective treatment and are often associated with defects in microvascular function, including a failure to match the energy supplied by the blood to the energy used on neuronal computation, or a breakdown of the blood–brain barrier. Pericytes, an u nder-studied cell type located on capillaries, are of crucial importance in regulating diverse microvascular functions, such as angiogenesis, the blood–brain barrier, capillary blood flow and the movement of immune cells into the brain. They also form part of the “glial” scar isolating damaged parts of the CN...
Source: Acta Neuropathologica - August 10, 2018 Category: Neurology Source Type: research
Features of diffuse gliomas that are misdiagnosed on initial neuroimaging: a case control study
ConclusionSeveral clinical and radiologic metrics are associated with diffuse gliomas that are missed or misdiagnosed on the initial neuroimaging study. Knowledge of these associations may aid in avoiding misinterpretation and accurately diagnosing such cases in clinical practice.
Source: Journal of Neuro-Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research
Targeting pericytes for therapeutic approaches to neurological disorders
AbstractMany central nervous system diseases currently lack effective treatment and are often associated with defects in microvascular function, including a failure to match the energy supplied by the blood to the energy used on neuronal computation, or a breakdown of the blood–brain barrier. Pericytes, an u nder-studied cell type located on capillaries, are of crucial importance in regulating diverse microvascular functions, such as angiogenesis, the blood–brain barrier, capillary blood flow and the movement of immune cells into the brain. They also form part of the “glial” scar isolating damaged parts of the CN...
Source: Acta Neuropathologica - October 1, 2018 Category: Neurology Source Type: research
Features of diffuse gliomas that are misdiagnosed on initial neuroimaging: a case control study
ConclusionSeveral clinical and radiologic metrics are associated with diffuse gliomas that are missed or misdiagnosed on the initial neuroimaging study. Knowledge of these associations may aid in avoiding misinterpretation and accurately diagnosing such cases in clinical practice.
Source: Journal of Neuro-Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research
Evaluating Spelling in Glioma Patients Undergoing Awake Surgery: a Systematic Review
AbstractA main goal of awake surgery is to preserve language in order to facilitate return to work and maintain quality of life. Although spelling has become crucial in daily life, it has received little attention in awake surgery practice. We review assessments of spelling carried out in awake surgery studies, to inspect how current neurofunctional theories of spelling may guide pre-, intra- and post-operative neurosurgical practice. A systematic database search in Embase, Medline, PubMed and Web of Science identified studies reporting on spelling assessment in glioma patients undergoing awake surgery. Twenty-three studie...
Source: Neuropsychology Review - December 21, 2018 Category: Neuroscience Source Type: research
Contrast enhancing spots as a new pattern of late onset pseudoprogression in glioma patients
ConclusionWe hypothesize that the late onset phenomenon of NCES predominantly represents a form of radiation-induced vasculopathy that is different from early pseudoprogression and should be considered especially in younger patients with IDH-mutated glioma before initiation of new therapy.
Source: Journal of Neuro-Oncology - January 2, 2019 Category: Cancer & Oncology Source Type: research
Protective Effects of Alpha-Lipoic Acid on Glutamate-Induced Cytotoxicity in C6 Glioma Cells.
In this study, we investigated the protective effects of alpha-lipoic acid (ALA), a naturally occurring thiol antioxidant, on glutamate-induced cytotoxicity in cultured C6 astroglial cells. Exposure to high-dose glutamate (10 mM) caused oxidative stress and mitochondrial dysfunction through the elevation of reactive oxygen species, depletion of glutathione, and loss of the mitochondrial membrane potential (ΔΨm). Pretreatment with ALA (200 µM), however, significantly inhibited the glutamate-induced oxidative stress and mitochondrial dysfunction. ALA pretreatment dose-dependently suppressed glutamate-induced apoptotic...
Source: Biological and Pharmaceutical Bulletin - January 6, 2019 Category: Drugs & Pharmacology Authors: Park E, Gim J, Kim DK, Kim CS, Chun HS Tags: Biol Pharm Bull Source Type: research
