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No, You Probably Shouldn ’t Drink 25 Cups of Coffee a Day
Research making the rounds in Monday’s headlines could make you jittery just thinking about it. Drinking up to 25 cups of coffee per day, the headlines say, is still safe for the heart. The research, which was presented at the British Cardiovascular Society’s conference on Monday and has not yet been published in a peer-reviewed journal, was based on an analysis of about 8,500 people in the U.K. Compared to those who drank less than a cup of coffee a day, the researchers found, people in the highest tier of consumption—those who averaged five cups a day, but some of whom drank up to 25—did not have ...
Source: TIME: Health - June 4, 2019 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Diet/Nutrition Source Type: news

Mesenchymal Stromal Cells (Cyto-MSC) are Well-tolerated and Associated with Renal Function Improvement in Patients with Chronic Kidney Disease: An Observational Retrospective Study
Conclusion MethodologyThere were 4 clinical trials approved at the National University Malaysia in collaboration with Cytopeutics (Cyberjaya, Malaysia) which provided the mesenchymal stromal cells (Cyto-MSC) for treatment of acute stroke, heart failure, diabetes with critical limb ischemia and severe deforming osteoarthritis. All patients received 65-130 × 106 Cyto-MSC intravenously. Severity of chronic kidney disease is based on baseline estimated glomerular filtration rate (eGFR) and serum creatinine which are markers of renal dysfunction. These and other blood tests including fasting blood sugar (FBS) and Hba1c (ma...
Source: Cytotherapy - May 24, 2019 Category: Cytology Source Type: research

Detection of serum high-density lipoprotein cholesterol high levels in monks practicing Samatha and Vipassana meditation
ConclusionMeditating monks had a higher HDL cholesterol, lowest total cholesterol: HDL ratio and the other parameters tested had mean levels closer to the lower limit of the normal range, indicating a possible protective effect of meditation on cardiovascular diseases and stroke. These results may be related to the duration of practicing Samatha and Vipassana meditation but require confirmation using appropriate clinical trial.
Source: European Journal of Integrative Medicine - May 7, 2019 Category: Complementary Medicine Source Type: research

NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance
Conclusion and Perspectives Gliomas are the most prevalent primary brain cancer in adults and include a broad category of tumors including astrocytoma, oligodendroglioma, and GBM. Regardless of tumor aggressiveness, malignancy, and infiltration, these glia-derived tumors rarely exceed a median survival time of 12–14 months. Driven by the infiltrative nature of these tumors, the clinical approach is difficult and relapses often occur with fatal consequences. These unsuccessful attempts to control glioma's fate have fostered research looking for more effective therapies. (GSCs) are a small subset of CD133&#...
Source: Frontiers in Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research

Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
Conclusion Principal findings of this work are that abnormal Ca2+ transient amplitude, contractile dysfunction; and impaired relaxation of MetS cardiomyocytes underlies intrinsic dysfunctional RyR2 and SERCA pump. Abnormal activity of RyRs was evidenced by its decreased ability to bind [3H]-ryanodine. Although the MetS condition does not modify RyR2 protein expression, its phosphorylation at Ser2814 is decreased, which impairs its capacity for activation during ECC. The dysfunctional RyRs, together with a decreased activity of SERCA pump due to decreased Thr17-PLN phosphorylation suggest a downregulation of CaMKII in MetS...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress Model
This study was carried out in accordance with the recommendations of the “Institutional Animal Care and Use Committee of China Medical University.” The protocol was approved by the “Institutional Animal Care and Use Committee of China Medical University.”Author ContributionsXWu and GW conceived and designed the experiments. YLi, RD, XR, WR, HYa, and YT performed the experiments. HYu, XZ, JY and XWa helped to analyze and interpret the data. GW drafted the manuscript. XWu, EX, YLu, and GZ provided critical revisions. All the authors reviewed and approved the final manuscript.FundingThe present stu...
Source: Frontiers in Psychiatry - April 29, 2019 Category: Psychiatry Source Type: research

A Copernican Approach to Brain Advancement: The Paradigm of Allostatic Orchestration
The objective of this presentation is to explore historical, scientific, interventional, and other differences between the two paradigms, so that innovators, researchers, practitioners, policy-makers, patients, end-users, and others can gain clarity with respect to both the explicit and implicit assumptions associated with brain advancement agendas of any kind. Over the course of three decades, a series of brain-centric, evolution-inspired insights have been articulated with increasing refinement, as principles of allostasis (Sterling and Eyer, 1988; Sterling, 2004, 2012, 2014). Allostasis recognizes that the role of the ...
Source: Frontiers in Human Neuroscience - April 25, 2019 Category: Neuroscience Source Type: research

Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke
Conclusion In summary, SSS extraction significantly ameliorates cerebral energy metabolism via boosting citrate cycle, which mainly embodies the enhancements of blood glucose concentration, glucose and lactate transportation and glucose utilization, as well as the regulations of relative enzymes activities in citrate cycle. These ameliorations ultimately resulted in numerous ATP yield after stroke, which improved neurological function and infarcted volume. Collectively, it suggests that SSS extraction has exerted advantageous effect in the treatment of cerebral ischemia. Ethics Statement All animal operations were accor...
Source: Frontiers in Pharmacology - April 22, 2019 Category: Drugs & Pharmacology Source Type: research

Apr 19 2019 This Week in Cardiology Apr 19 2019 This Week in Cardiology
Anticoagulation for embolic stroke of unknown origin, added-sugar labels, AF-patient knowledge, LDL-C and hemorrhagic stroke, and genetic signals in cancer-care cardiomyopathy are discussed this week.theheart.org on Medscape
Source: Medscape Cardiology Headlines - April 19, 2019 Category: Cardiology Tags: Cardiology Commentary Source Type: news

Want to Live Longer? Science Says to Do These 5 Things
When it comes to staying healthy, most people have the same motivation: living as long and fulfilling a life as possible. And while science has yet to find a true fountain of youth, researchers have identified certain behaviors that can increase longevity. One study, published in the journal Circulation last year, even argued that adhering to just five healthy habits could extend your lifespan by roughly a decade. Here’s what they are, and what research to date says about living your longest life. Eating a healthy diet Diet is strongly linked to longevity. Research has long suggested that following a Mediterranean di...
Source: TIME: Health - April 19, 2019 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Longevity Source Type: news

Scientists Restore Some Brain Activity in Recently Slaughtered Pigs
(NEW YORK) — Scientists restored some activity within the brains of pigs that had been slaughtered hours before, raising hopes for some medical advances and questions about the definition of death. The brains could not think or sense anything, researchers stressed. By medical standards “this is not a living brain,” said Nenad Sestan of the Yale School of Medicine, one of the researchers reporting the results Wednesday in the journal Nature. But the work revealed a surprising degree of resilience among cells within a brain that has lost its supply of blood and oxygen, he said. “Cell death in the brai...
Source: TIME: Health - April 17, 2019 Category: Consumer Health News Tags: Uncategorized Brain Activity onetime Source Type: news

Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
Conclusion The high prevalence of comorbidities in patients with stroke indicates the need for therapies in preclinical studies that take into account these comorbidities in order to avoid failures in translation to the patient. Preclinical studies are beginning to evaluate the efficacy of MSC treatment in stroke associated with comorbidities, especially hypertension, for ischemic and hemorrhagic stroke. Regarding aging and diabetes, only ischemic stroke studies have been performed. For the moment, few studies have been performed and contradictory results are being reported. These contradictory results may be due to the u...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Type 2 diabetes warning: Working during these hours could increase risk of condition
TYPE 2 diabetes is a condition that causes a person ’s blood sugar levels to become too high. Left untreated it can lead to problems with the eyes and feet, heart attack and stroke. But what causes it? A new study has suggested working certain hours at your job could increase your risk.
Source: Daily Express - Health - April 4, 2019 Category: Consumer Health News Source Type: news

Stay Away From Sugary Sodas, Spare Your Heart
People who consumed at least two sugar-sweetened drinks per day were about one-third more likely to die of heart disease or stroke, versus those who rarely had these drinks.
Source: WebMD Health - March 18, 2019 Category: Consumer Health News Source Type: news