Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress Model

In this study, C57BL/6 and Tau KO mice were used. For Tau KO mice, Western blot results of anti-Tau protein specific antibodies showed that Tau KO mice had no positive bands at 50–55 kDa (Tau protein position), while C57BL/6 mice normally expressed Tau protein (Figure 1).FIGURE 1Figure 1 Tau knockout (KO) mice did not express Tau protein.The C57BL/6 mice exhibited depressive behaviors, including anxiety, anhedonia, and depression-like after CUMS, and ketamine treatment alleviated their depressive behavior. Tau KO mice did not exhibit depressive behavior after CUMS. After treatment with ketamine at the same dose, there was no significant change in the behavioral results between CUMS+KET and CON and CUMS groups.Sucrose-Preference TestThe CUMS procedures simulated anhedonia in the C57BL/6 mice, and ketamine reduced this behavior. Figure 2A shows the sucrose preference of the three groups of C57BL/6 mice. Six weeks of chronic stress produced a significant decrease in sucrose consumption in the CUMS group compared to the CON group of C57BL/6 mice, and ketamine reversed this decrease [Figure 2A: F(2,60) = 7.222, p 0.05).FIGURE 2Figure 2 Effects of chronic unpredictable mild stress (CUMS) on the anhedonia, anxiety, and depression-like behaviors of C57BL/6 mice, and ketamine reversal of these behaviors. (A) Preference for the sucrose solution on the sucrose-preference test. (B) Total distance traversed in the open-field test. (C) Time spent in the center area of the open-field ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

Related Links:

Do you guys ever get pissed off when people in the general public do not really know what we do and our training to get to where we are? Little do they know we can transition from being primary care to emergency room to critical care doctors in a blink of an eye. What do you guys say to the misinformed that think all we did is push some medications into an IV and then wake someone back up?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Anesthesiology Source Type: forums
Hello, Is Any one getting refunds from LA LAU CONSULTANTS, which paid for WREB patient. Now that it is all in Manikin, are you getting refunds from him? He is giving me lot of trouble, basically he does not want to return money. Please let me know any one having same problem. Thank you. Here is his address. LU LAU CONSULTANTS Eric Gonzales 2835 Inez Street Los Angeles, California 90023 United States 2133698640 lulaudc@gmail.com
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: International Dental Source Type: forums
Publication date: Available online 24 May 2020Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Maira Jaqueline da Cunha, Katia Daniele Rech, Ana Paula Salazar, Aline Souza Pagnussat
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research
Publication date: Available online 24 May 2020Source: Journal of the American College of RadiologyAuthor(s): Donald Chan, Surav Sakya, Cory M. Pfeifer
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
ConclusionsThe e-ASPECTS software generates robust values for e-ASPECTS and acute infarct volumes when using ST ≤ 4 mm with ST = 1 mm yielding the best performance for predicting baseline stroke severity and clinical outcome after 90 days.Key Points•Clinical utility of automatically derived ASPECTS from computed tomography scans was shown in patients with acute ischemic stroke and treatment with mechanical thrombectomy.•Thin slices (=  1 mm) had the highest clinical utility in comparison with thicker slices (2–10 mm) by having the strongest correlation...
Source: European Radiology - Category: Radiology Source Type: research
Psychologists say anxiety and uncertainty prompt irrational decisions — like turning down a transplant when an organ becomes available.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Transplants Emergency Medical Treatment Coronavirus (2019-nCoV) Liver Fear (Emotion) Anxiety and Stress Cancer Heart your-feed-science your-feed-healthcare Source Type: news
American seniors are struggling with a growing sense of isolation, distress and depression amid the coronavirus pandemic. The guidance for the elderly to remain sheltered in place as society slowly reopens is a burden that's becoming hard to take.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
The Trump administration ’s report to Congress sees states taking responsibility for coronavirus testing with federal guidance.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Coronavirus (2019-nCoV) Tests (Medical) United States Politics and Government States (US) Centers for Disease Control and Prevention Health and Human Services Department Trump, Donald J your-feed-science your-feed-healthcare Source Type: news
TYPE 2 diabetes does not pose a threat if you keep blood sugar levels under control. Diet acts as the ultimate bulwark against high blood sugar levels and a natural green powder has been proven to lower blood sugar.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Americans paid a mostly low-key tribute to those who died serving in the U.S. Armed Forces on Monday, with many Memorial Day events canceled due to the coronavirus outbreak that has killed nearly 100,000 people in the United States alone.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
More News: Academia | Alzheimer's | Anesthesia | Anesthesiology | Anxiety | Biochemistry | Biology | Bipolar | Brain | Celexa | China Health | Citalopram | Clinical Trials | Dementia | Depression | Education | Fluoxetine | Forensic Medicine | Genetics | Grants | Hospitals | Imipramine | Laboratory Medicine | Learning | Low Testosterone | Mania | Medical Ethics | Men | Menopause | Milk | National Institutes of Health (NIH) | Neurology | Neuroscience | Pathology | Postnatal Depression | Prozac | Psychiatry | Reproduction Medicine | Science | Sevoflurane | Sodium | Statistics | Stroke | Study | Sugar | Toxicology | Training | Translocation | Ultane | Universities & Medical Training | Urology & Nephrology | USA Health | Zinc