Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress Model
In this study, C57BL/6 and Tau KO mice were used. For Tau KO mice, Western blot results of anti-Tau protein specific antibodies showed that Tau KO mice had no positive bands at 50–55 kDa (Tau protein position), while C57BL/6 mice normally expressed Tau protein (Figure 1).FIGURE 1Figure 1 Tau knockout (KO) mice did not express Tau protein.The C57BL/6 mice exhibited depressive behaviors, including anxiety, anhedonia, and depression-like after CUMS, and ketamine treatment alleviated their depressive behavior. Tau KO mice did not exhibit depressive behavior after CUMS. After treatment with ketamine at the same dose, there was no significant change in the behavioral results between CUMS+KET and CON and CUMS groups.Sucrose-Preference TestThe CUMS procedures simulated anhedonia in the C57BL/6 mice, and ketamine reduced this behavior. Figure 2A shows the sucrose preference of the three groups of C57BL/6 mice. Six weeks of chronic stress produced a significant decrease in sucrose consumption in the CUMS group compared to the CON group of C57BL/6 mice, and ketamine reversed this decrease [Figure 2A: F(2,60) = 7.222, p 0.05).FIGURE 2Figure 2 Effects of chronic unpredictable mild stress (CUMS) on the anhedonia, anxiety, and depression-like behaviors of C57BL/6 mice, and ketamine reversal of these behaviors. (A) Preference for the sucrose solution on the sucrose-preference test. (B) Total distance traversed in the open-field test. (C) Time spent in the center area of the open-field ...
Do you guys ever get pissed off when people in the general public do not really know what we do and our training to get to where we are? Little do they know we can transition from being primary care to emergency room to critical care doctors in a blink of an eye. What do you guys say to the misinformed that think all we did is push some medications into an IV and then wake someone back up?
Hello, Is Any one getting refunds from LA LAU CONSULTANTS, which paid for WREB patient. Now that it is all in Manikin, are you getting refunds from him? He is giving me lot of trouble, basically he does not want to return money. Please let me know any one having same problem. Thank you. Here is his address. LU LAU CONSULTANTS Eric Gonzales 2835 Inez Street Los Angeles, California 90023 United States 2133698640 firstname.lastname@example.org
Publication date: Available online 24 May 2020Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Maira Jaqueline da Cunha, Katia Daniele Rech, Ana Paula Salazar, Aline Souza Pagnussat
Publication date: Available online 24 May 2020Source: Journal of the American College of RadiologyAuthor(s): Donald Chan, Surav Sakya, Cory M. Pfeifer
ConclusionsThe e-ASPECTS software generates robust values for e-ASPECTS and acute infarct volumes when using ST ≤ 4 mm with ST = 1 mm yielding the best performance for predicting baseline stroke severity and clinical outcome after 90 days.Key Points•Clinical utility of automatically derived ASPECTS from computed tomography scans was shown in patients with acute ischemic stroke and treatment with mechanical thrombectomy.•Thin slices (= 1 mm) had the highest clinical utility in comparison with thicker slices (2–10 mm) by having the strongest correlation...
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