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Source: Journal of the Neurological Sciences
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Total 856 results found since Jan 2013.
Influence of oral anticoagulation on stroke severity and outcomes: A propensity score matching case-control study
Oral anticoagulants (OAC) such as vitamin K antagonists (VKA) and direct-acting OACs (DOAC) remain the mainstay for prevention of cardioembolic stroke. The influence of previous OAC treatment on stroke severity and outcomes is not well stablished. We compared patients with incident cardioembolic strokes according to pre-stroke treatment.
Source: Journal of the Neurological Sciences - January 13, 2020 Category: Neurology Authors: A. Plaza Herr áiz, L. Lobato-Pérez, M. Ramírez-Torres, I. De Lorenzo, M. Alonso de Leciñana, E. Díez-Tejedor, B. Fuentes, J. Rodríguez-Pardo Source Type: research
Muscle biopsy is not diagnostic for MELAS
With interest we read the article by Lu et al. about a histopathological study of 12 patients with mitochondrial encephalopathy, lactic acidosis, and stroke-like episode syndrome (MELAS) who were negative for ragged-red fibers (RRFs) and cytochrome-c-oxidase (COX) deficient muscle fibers (group-1) and 99 MELAS patients positive for RRFs and COX-deficient muscle fibers on muscle biopsy (group-2) [1]. Interestingly, four of the 12 patients with COX- and RRF-negative muscle biopsy had vessels on muscle biopsy which strongly stained for succinate dehydrogenase (SDH) (strongly succinate dehydrogenase positive vessels (SSVs)) [1].
Source: Journal of the Neurological Sciences - January 4, 2020 Category: Neurology Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research
Predicting major neurologic improvement and long-term outcome after thrombolysis using artificial neural networks
To develop artificial neural network (ANN)-based functional outcome prediction models for patients with acute ischemic stroke (AIS) receiving intravenous thrombolysis based on immediate pretreatment parameters.
Source: Journal of the Neurological Sciences - January 4, 2020 Category: Neurology Authors: Chen-Chih Chung, Chien-Tai Hong, Yao-Hsien Huang, Emily Chia-Yu Su, Lung Chan, Chaur-Jong Hu, Hung-Wen Chiu Source Type: research
Ultra-early improvement after endovascular thrombectomy and long-term outcome in anterior circulation acute ischemic stroke
The use of post-treatment measures after acute ischemic stroke is important to predict good functional outcome. The most studied is 24 h National Institutes of Health Stroke Scale (NIHSS) score and existing literature is scarce regarding the use of earlier indicators, namely NIHSS immediately after endovascular thrombectomy (EVT). We hypothesized that an immediate neurological improvement after EVT, that we called ultra-early ne urological improvement (UENI), would be a reliable functional independence predictor in anterior circulation acute ischemic stroke patients.
Source: Journal of the Neurological Sciences - January 4, 2020 Category: Neurology Authors: Ant ónioMartins de Campos, Andreia Carvalho, Marta Rodrigues, Sofia Figueiredo, Tiago Gregório, Henrique Costa, Ludovina Paredes, André Cunha, Sérgio Castro, Manuel Ribeiro, Miguel Veloso, Pedro Barros Source Type: research
A contemporary and comprehensive analysis of the costs of stroke in the United States
While several studies have determined direct costs associated with stroke there is a paucity of research involving indirect costs, especially in younger patients.
Source: Journal of the Neurological Sciences - December 23, 2019 Category: Neurology Authors: Tarun Girotra, Alain Lekoubou, Kinfe G. Bishu, Bruce Ovbiagele Source Type: research
A contemporary and comprehensive analsyis of the costs of stroke in the United States
While several studies have determined direct costs associated with stroke there is a paucity of research involving indirect costs, especially in younger patients.
Source: Journal of the Neurological Sciences - December 23, 2019 Category: Neurology Authors: Tarun Girotra, Alain Lekoubou, Kinfe G. Bishu, Bruce Ovbiagele Source Type: research
Lemierre's syndrome with stroke and stenosis of the internal carotid artery suggesting focal vasculitis
Here we present a patient with oropharynx infection by Fusobacterium necrophorum (F. necrophorum) who developed arterial wall inflammation and longitudinal stenosis of the right internal carotid artery and right hemispheric ischemic stroke. To our knowledge, longitudinal stenosis caused by F. necrophorum in Lemierre's syndrome has not previously been described.
Source: Journal of the Neurological Sciences - December 10, 2019 Category: Neurology Authors: Dewah Rahimi, Annika Reynberg Langkilde, Helle Klingenberg Iversen, Thomas Clement Truelsen Tags: Letter to the Editor Source Type: research
12 versus 24 h bed rest after acute ischemic stroke thrombolysis: a preliminary experience
The practice of ≥24 h of bed rest after acute ischemic stroke thrombolysis is common among hospitals, but its value compared to shorter periods of bed rest is unknown.
Source: Journal of the Neurological Sciences - December 4, 2019 Category: Neurology Authors: Brian Silver, Tariq Hamid, Muhib Khan, Mario Di Napoli, Reza Behrouz, Gustavo Saposnik, Jo-Ann Sarafin, Susan Martin, Majaz Moonis, Nils Henninger, Richard Goddeau, Adalia Jun-O'Connell, Shawna M. Cutting, Ali Saad, Shadi Yaghi, Wiley Hall, Susanne Muehls Source Type: research
Pathogenicity of the variant m.13376 T > C in ND5 remains unproven
With interest we read the article by Sasaki et al. about a 14 years old Japanese female with mitochondrial encephalopathy, lactic acidosis, and stroke-like episode (MELAS) syndrome being attributed to the variant m.13376 T > C in ND5 [1]. The variant had been transmitted via the maternal line as the mother carried the same variant with high heteroplasmy rate but manifested differentially with only short stature and headache [1] The study has a number of shortcomings.
Source: Journal of the Neurological Sciences - December 4, 2019 Category: Neurology Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research
Low heteroplasmy rates in clinically affected m.3243A > G carriers not necessarily explain the phenotype
In a recent article, Liu et al. reported about 17 patients from 7 Han families all carrying the m.3243A > G variant who manifested phenotypically with mitochondrial leukoencephalopathy, lactic acidosis, and stroke-like episodes (MELAS) (n = 5), myopathy (n = 2), neuropathy, ataxia, and retinitis pigmentosa (NARP) (n = 1), diabetes (n = 6), and hypoacusis (n = 3) [1]. Heteroplasmy rates in bl ood lymphocytes in these patients were highly variable, discordant to the clinical manifestations [1]. Among the clinically manifesting mutation carriers mutation loads ranged between 0 and 79% [1].
Source: Journal of the Neurological Sciences - December 4, 2019 Category: Neurology Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research
12 versus 24 h bed rest after acute ischemic stroke thrombolysis
The practice of ≥24 h of bed rest after acute ischemic stroke thrombolysis is common among hospitals, but its value compared to shorter periods of bed rest is unknown.
Source: Journal of the Neurological Sciences - December 4, 2019 Category: Neurology Authors: Brian Silver, Tariq Hamid, Muhib Khan, Mario DiNapoli, Reza Behrouz, Gustavo Saposnik, Jo-Ann Sarafin, Susan Martin, Majaz Moonis, Nils Henninger, Richard Goddeau, Adalia Jun-O'Connell, Shawna M. Cutting, Ali Saad, Shadi Yaghi, Wiley Hall, Susanne Muehlsc Source Type: research
Pathogenicity of the variant m.13376 T > C in ND5 remains unproven
With interest we read the article by Sasaki et al. about a 14 years old Japanese female with mitochondrial encephalopathy, lactic acidosis, and stroke-like episode (MELAS) syndrome being attributed to the variant m.13376 T > C in ND5 [1]. The variant had been transmitted via the maternal line as the mother carried the same variant with high heteroplasmy rate but manifested differentially with only short stature and headache [1] The study has a number of shortcomings.
Source: Journal of the Neurological Sciences - December 4, 2019 Category: Neurology Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research
Low heteroplasmy rates in clinically affected m.3243A > G carriers not necessarily explain the phenotype
In a recent article, Liu et al. reported about 17 patients from 7 Han families all carrying the m.3243A > G variant who manifested phenotypically with mitochondrial leukoencephalopathy, lactic acidosis, and stroke-like episodes (MELAS) (n = 5), myopathy (n = 2), neuropathy, ataxia, and retinitis pigmentosa (NARP) (n = 1), diabetes (n = 6), and hypoacusis (n = 3) [1]. Heteroplasmy rates in blood lymphocytes in these patients were highly variable, discordant to the clinical manifestations [1]. Among the clinically manifesting mutation carriers mutation loads ranged between 0 and 79% [1].
Source: Journal of the Neurological Sciences - December 4, 2019 Category: Neurology Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research
Predictors of malignant cerebral edema in cerebral artery infarction: A meta-analysis
Malignant cerebral edema (MCE) is a life-threatening complication of acute cerebral stroke. To date, the focus has been on symptomatic treatment, rather than on prevention. Therefore, to identify high-risk patients and explore potential therapeutic approaches, we investigated the possible predictors of MCE. Specifically, we performed a meta-analysis to identify the potential predictors of MCE in patients with acute cerebral infarction. We searched the MEDLINE, Embase, Cochrane, China National Knowledge Infrastructure, Wanfang Data, and VIP databases from their inception to July 2018 for cohort and case control studies on t...
Source: Journal of the Neurological Sciences - December 2, 2019 Category: Neurology Authors: Jinfeng Miao, Xiaoyan Song, Wenzhe Sun, Xiuli Qiu, Yan Lan, Zhou Zhu Tags: Review Article Source Type: research
Risk of perioperative neck hematoma in TIA and non-disabling stroke patients with symptomatic carotid artery stenosis undergoing endarterectomy within 14 days from cerebrovascular event
Perioperative neck hematoma (PNH) requiring re-intervention is an important complication after carotid endarterectomy (CEA). There are limited data regarding the potential risk factors associated with PNH. The aim of this prospective, multicenter study was to document the rate of PNH in symptomatic carotid artery stenosis (sCAS) patients treated with CEA within the first 14 days of cerebrovascular symptom onset and to identify possible predictors of this complication.
Source: Journal of the Neurological Sciences - November 21, 2019 Category: Neurology Authors: Andromachi Roussopoulou, Andreas Lazaris, Georgios Tsivgoulis, Christos Krogias, Konstantinos Moulakakis, George S. Georgiadis, John D. Kakisis, Christina Zompola, Simon Faissner, Lina Palaiodimou, Aikaterini Theodorou, Thomas Hummel, Apostolos Safouris, Source Type: research
