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Source: Journal of the Neurological Sciences

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Total 856 results found since Jan 2013.

Cyclic adenosine monophosphate in acute ischemic stroke: Some to update, more to explore
The development of effective treatment for ischemic stroke, which is a common cause of morbidity and mortality worldwide, remains an unmet goal because the current first-line treatment management interventional therapy has a strict time window and serious complications. In recent years, a growing body of evidence has shown that the elevation of intracellular and extracellular cyclic adenosine monophosphate (cAMP) alleviates brain damage after ischemic stroke by attenuating neuroinflammation in the central nervous system and peripheral immune system.
Source: Journal of the Neurological Sciences - March 11, 2020 Category: Neurology Authors: Meiying Xin, Jiachun Feng, Yulei Hao, Jiulin You, Xinyu Wang, Xiang Yin, Pei Shang, Di Ma Tags: Review Article Source Type: research

Primary aldosteronism in young adults with acute stroke: Prevalence and clinical characteristics
The objectives of the study were to investigate the prevalence of PA in patients under 45  years old with history of acute stroke and the clinical characteristics during stroke attack. We retrieved the medical records of 116 patients once admitted due to acute stroke and cross-sectionally conducted screening test as well as confirmatory test among those patients.
Source: Journal of the Neurological Sciences - March 10, 2020 Category: Neurology Authors: Ziwei Tang, Haiyan Chen, Wenwen He, Linqiang Ma, Ying Song, Mei mei, Ting Luo, Zhipeng Du, Jinbo Hu, Shumin Yang, Qingfeng Cheng, Zhihong Wang, Qifu Li, the Chongqing Primary Aldosteronism Study(CONPASS) Group Source Type: research

Low blood pressure levels & incident stroke risk among elderly Ghanaians with hypertension
Clinical trial data indicate that more intensive blood pressure (BP) lowering below standard cut-off targets is associated with lower risks of strokes in the elderly. There is a relative paucity of real-world practice data on this issue, especially among Africans.Objective: To assess BP control rates, its determinants, and whether a lower BP  
Source: Journal of the Neurological Sciences - March 3, 2020 Category: Neurology Authors: Fred Stephen Sarfo, Linda Meta Mobula, Titus Adade, Yvonne Commodore-Mensah, Martin Agyei, Collins Kokuro, Rexford Adu-Gyamfi, Christiana Duah, Bruce Ovbiagele Source Type: research

Vascular-brain Injury Progression after Stroke (VIPS) study: concept for understanding racial and geographic determinants of cognitive decline after stroke
Cognitive impairment and dementia (CID) are major public health problems with substantial personal, social, and financial burdens. African Americans are at a heightened risk for Vascular Cognitive Impairment (VCI) compared to European Americans. Recent lines of evidence also suggest a high burden of Post-stroke VCI among indigenous Africans. A better understanding of the cause(s) of the racial disparity in CID, specifically VCI, is needed in order to develop strategies to reduce it.We propose and discuss the conceptual framework for a unique tri-population, trans-continental study titled The Vascular brain Injury Progressi...
Source: Journal of the Neurological Sciences - February 18, 2020 Category: Neurology Authors: Fred Stephen Sarfo, Rufus Akinyemi, George Howard, Virginia J. Howard, Kolawole Wahab, Mary Cushman, Deborah A. Levine, Adesola Ogunniyi, Fred Unverzagt, Mayowa Owolabi, Bruce Ovbiagele Tags: Review Article Source Type: research

A calcium channel or angiotensin converting enzyme inhibitor/angiotensin receptor blocker regime to reduced blood pressure variability in acute ischaemic stroke (CAARBS): A feasibility trial
Trials of lowering blood pressure in patients with acute ischaemic stroke not undergoing thrombolysis have not demonstrated improved outcomes with intervention. Rather than absolute levels, it may be that blood pressure variability is important. However, there are no prospective randomised trials investigating the benefit of reducing blood pressure variability in this patient group.
Source: Journal of the Neurological Sciences - February 18, 2020 Category: Neurology Authors: William J. Davison, Karen Appiah, Thompson G. Robinson, Iain J. McGurgan, Peter M. Rothwell, John F. Potter Source Type: research

Recurrent stroke due to quasi-moyamoya disease associated with POEMS syndrome: An autopsy case
POEMS syndrome, an acronym for polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes, is a fatal disorder associated with plasmacytoma and overproduction of vascular endothelial growth factor (VEGF) [1,2]. Nowadays, a new diagnostic criteria is proposed with high sensitivity and specificity: it demands both three mandatory major criteria (polyneuropathy, monoclonal plasma cell proliferative disorder and elevated VEGF) and at least two of the four minor criteria (oedema/effusion, skin changes, organomegaly and sclerotic bone lesions) [2].
Source: Journal of the Neurological Sciences - February 14, 2020 Category: Neurology Authors: Teruhiko Sekiguchi, Satoru Ishibashi, Jo Sasame, Jun-Ichi Mukae, Kotaro Noda, Hiroaki Tanaka, Koh Yamamoto, Yasunori Takemoto, Jiro Kumagai, Takanori Yokota Tags: Letter to the Editor Source Type: research

Impact of thrombus migration on clinical outcomes in patients with internal carotid artery occlusions and patent middle cerebral artery
Patency of the middle cerebral artery (MCA) in acute ischemic stroke with internal carotid artery (ICA) occlusions is associated with less severe stroke and favorable outcomes. However, thrombus migration to distal intracranial vessels may lead to unfavorable outcomes. We investigated the influence of thrombus migration on clinical outcomes in patients with ICA occlusions and patent MCA.
Source: Journal of the Neurological Sciences - February 14, 2020 Category: Neurology Authors: Junpei Koge, Shoji Matsumoto, Ichiro Nakahara, Akira Ishii, Taketo Hatano, Yujiro Tanaka, Daisuke Kondo, Jun-ichi Kira, Izumi Nagata Source Type: research

The role of cerebral microbleeds in the incidence of post-stroke dementia
Microbleeds are a marker of cerebrovascular disease however its role in incident post-stroke dementia (PSD) remains unclear. We investigated whether microbleeds are associated with incident PSD, domain-specific cognitive impairment and cognitive decline over a 2-year follow-up; and whether microbleeds interact with acute stroke-related infarcts to synergistically affect cognitive outcomes. In a cohort of patients with first-episode mild ischemic stroke and no pre-stroke dementia, we found patients with 3 or more mixed microbleeds (presence of both lobar and deep) were 4 times more at risk of developing PSD compared to pati...
Source: Journal of the Neurological Sciences - February 14, 2020 Category: Neurology Authors: Chathuri Yatawara, Anne Cristine Guevarra, Kok Pin Ng, Russell Chander, Bonnie Yin Ka Lam, Adrian Wong, Vincent Mok, Nagaendran Kandiah Source Type: research

CT radiomics features as a diagnostic tool for classifying basal ganglia infarction onset time
This study was aimed to discuss the application of radiomics using CT analysis in basal ganglia infarction (BGI) for determining the time since stroke onset (TSS) which could provide critical information to clinicians in deciding stroke treatment options such as thrombolysis.
Source: Journal of the Neurological Sciences - February 9, 2020 Category: Neurology Authors: Xiang Yao, Ling Mao, Shunli Lv, Zhenghong Ren, Wentao Li, Ke Ren Source Type: research

Changing the face of stroke care in the Middle East North Africa region
The Middle East North Africa consists of seventeen countries and extends Eastern Asia to Morocco in the West. The region has an estimated population of 411 million. In the absence of good quality data on stroke incidence and prevalence from the region, the exact burden of this devastating disease is hard to determine. However, as these countries undergo epidemiological transition, the burden of non-communicable diseases is found to be on the rise and a recent review of the available literature, suggests an increase in the stroke incidence and mortality in the region [1].
Source: Journal of the Neurological Sciences - February 6, 2020 Category: Neurology Authors: Maria Khan, Suhail Al-Rukn, Adel Ali Alhazzani, Hany Aref, Tiago Moreira, Nils Wahlgren Tags: Letter to the Editor Source Type: research

Metabolic stroke or stroke-like lesion: Peculiarities of a phenomenon
One of the most frequent cerebral lesions in mitochondrial disorders(MIDs) on imaging is the stroke-like lesion(SLL) clinically manifesting as stroke-like episode (SLE, metabolic stroke). This review aims at discussing recent advances concerning the presentation, diagnosis, and treatment of SLLs.
Source: Journal of the Neurological Sciences - February 6, 2020 Category: Neurology Authors: Josef Finsterer, Rahim Aliyev Tags: Review Article Source Type: research

Sleep disorders and disrupted sleep in addiction, withdrawal and abstinence with focus on alcohol and opioids
Sleep is very important for our physical and mental health. Sleep disturbances increase risk of substance use disorders as well as risk of onset and worsening of medical and other primary psychiatric problems like diabetes, kidney disease, high blood pressure, heart disease, stroke, and depression [1,2]. Substance use disorders, particularly alcohol and opioids can cause or exacerbate sleep disturbances [3,4] leading to even greater problems with our health in addition to the consequences of substance use [1,2].
Source: Journal of the Neurological Sciences - January 29, 2020 Category: Neurology Authors: William-Bernard Reid-Varley, Caridad Ponce-Martinez, Khurshid A. Khurshid Tags: Review Article Source Type: research

Re-examining the exclusion criterion of early recurrent ischemic stroke in intravenous thrombolysis: A meta-analysis
Current guidelines preclude the administration of intravenous tissue plasminogen activator in patients with early recurrent stroke (prior ischemic stroke within three months).
Source: Journal of the Neurological Sciences - January 26, 2020 Category: Neurology Authors: Katrina Hannah D. Ignacio, Jose Danilo B. Diestro, Adrian I. Espiritu, Julian Spears, Maria Cristina Z. San Jose Source Type: research

Left thalamus infarction in the thalamotuberal artery perfusion area causing subcortical diaschisis and transcortical sensory aphasia
The thalamus is related to language function, and some thalamic stroke cases can cause aphasia [1]. However, most previous cases reporting thalamic damage-induced ipsilateral subcortical diaschisis and aphasia were hemorrhagic stroke [1,2]. Only a few left thalamus infarction cases showed cortical hypoperfusion concerned with the aphasia, but no single-photon emission computed tomography (SPECT) or thalamic nucleus data were available [3]. Thus, aphasia pathology due to cortical hypoperfusion following thalamus infarction, especially with respect to thalamic nuclei, is still unknown.
Source: Journal of the Neurological Sciences - January 24, 2020 Category: Neurology Authors: Kosuke Matsuzono, Kohei Furuya, Azusa Karube, Akie Horikiri, Tadashi Ozawa, Takafumi Mashiko, Haruo Shimazaki, Reiji Koide, Ryota Tanaka, Shigeru Fujimoto Tags: Letter to the Editor Source Type: research

Concentrations of dabigatran administered after acute ischemic stroke
The aim of this study was to evaluate the anticoagulation intensity of dabigatran for acute ischemic stroke patients and hemorrhagic/ischemic events after early initiation of dabigatran.
Source: Journal of the Neurological Sciences - January 21, 2020 Category: Neurology Authors: Shinichi Wada, Manabu Inoue, Takayuki Matsuki, Takuya Okata, Masaya Kumamoto, Naoki Tagawa, Sohei Yoshimura, Akira Okamoto, Toshiyuki Miyata, Masafumi Ihara, Kazunori Toyoda, Masatoshi Koga Source Type: research