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Condition: ALS

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Total 644 results found since Jan 2013.

Therapeutic Approach of a High Functioning Individual With Traumatic Brain Injury and Subsequent Emotional Volatility With Features of Pathological Laughter and Crying With Dextromethorphan/Quinidine
Abstract: Pathological laughing and crying, or pseudobulbar affect (PBA), has been described in patients with neurological disorders such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, and traumatic brain injury (TBI) since the 19th century (Schiffer 2005). The syndrome is characterized by inappropriate episodes of laughing or crying after minor stimuli. It was first coined a disinhibition of cortical control by Kinnier Wilson in 1924. It was observed in brain disease and seen with mild TBI. It can impair social and occupational function and is largely underrecognized in clinical setting...
Source: Medicine - March 1, 2016 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Proteostasis impairment in ALS.
Abstract In physiological conditions the maintenance of the cellular proteome is a prerequisite for optimal cell functioning and cell survival. Additionally, cells need to constantly sense and adapt to their changing environment and associated stressors. Cells achieve this via a set of molecular chaperones, protein clearance pathways as well as stress-associated signaling networks which work together to prevent protein misfolding, its aggregation and accumulation in subcellular compartments. These processes together form the proteostasis network which helps in maintaining cellular proteostasis. Imbalance or impair...
Source: Brain Research - March 27, 2016 Category: Neurology Authors: Ruegsegger C, Saxena S Tags: Brain Res Source Type: research

Parakinesia Brachialis Oscitans after an Acute Internal Capsule Infarct (P1.014)
Conclusions:Involuntary stereotyped movements of an otherwise plegic arm while yawning was first observed in 1844 and coined "parakinesia brachialis oscitans" in 2010. The term parakinesia was used to differentiate the movements from synkinesia. The causes are diverse and include ischemic or hemorrhagic strokes, pontine tuberculoma, and amyotrophic lateral sclerosis. Ischemic strokes are most often implicated and typically involve a lenticulostriate branch of the middle cerebral artery. Lesions affecting the pyramidal tracts are the common denominator. The phenomenon may be observed acutely when the limb is flaccid or mont...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Koo, B., Wang, E. Tags: Movement Disorders ePoster Session Source Type: research

The Changing Landscape of Ethical Issues in Neurology Practice and Research (P1.365)
Conclusions: As technological advancements provide neurologists with more diagnostic and treatment options ethical considerations need to be reassessed in order to ensure adherence to medical and neurological professional codes of conduct. Many of these technological advancements have provided neurologists with tools and treatment options which although appear promising, are far from universally understood or accepted. New concerns regarding Brain death, neuro-enhancement, and TBI have emerged and merit further study.Disclosure: Dr. Bergquist has nothing to disclose. Dr. Theriault has nothing to disclose. Dr. Etienne has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Bergquist, P., Theriault, M., Etienne, M. Tags: Ethics and Policy Source Type: research

The Evaluation and Management of Alternative Diagnoses in Amyotrophic Lateral Sclerosis (P5.091)
Conclusions: Treatment with intravenous steroids, immunoglobulin and surgical interventions prior to diagnosis of ALS is associated with a significantly prolonged mean ODI.Disclosure: Dr. Kannan has nothing to disclose. Dr. Glass has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Kannan, M., Glass, J. Tags: Neuroepidemiology: Neuro-oncology and ALS Source Type: research

Diseases Neglected by the Media in Espírito Santo, Brazil in 2011–2012
Conclusions Media visibility acts as a strategy for legitimising priorities and contextualizing various realities. Therefore, we propose that the health problems identified should enter the public agenda and begin to be recognized as legitimate demands.
Source: PLoS Neglected Tropical Diseases - April 25, 2016 Category: Tropical Medicine Authors: Aline Guio Cavaca Source Type: research

Neurotrophic and Neuroprotective effects of muscle contraction.
CONCLUSION: Physical activity could represent an additional approach to fight against such diseases. PMID: 27121507 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - April 27, 2016 Category: Drugs & Pharmacology Authors: Arnao V, Di Raimondo D, Tuttolomondo A, Pinto A Tags: Curr Pharm Des Source Type: research

Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk
Conclusions Rather than structural brain changes, increased FC may be among the earliest detectable brain abnormalities in asymptomatic carriers of ALS-causing gene mutations. With replication and significant refinement, this technique has potential in the future assessment of neuroprotective strategies.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 12, 2016 Category: Neurosurgery Authors: Menke, R. A. L., Proudfoot, M., Wuu, J., Andersen, P. M., Talbot, K., Benatar, M., Turner, M. R. Tags: Open access, Genetics, Brain stem / cerebellum, Motor neurone disease, Neuromuscular disease, Spinal cord, Stroke, Radiology, Radiology (diagnostics) Neurodegeneration Source Type: research

Therapeutic Approach to Neurodegenerative Disorders Using a TFP5-Peptide
This invention discloses methods for treating neurodegenerative diseases by administering cyclin dependent kinase 5 (Cdk5) inhibitory peptides derived from P35, the activator of Cdk5. Abnormally hyperactive Cdk5 has been shown to be associated with a variety of neurodegenerative disorders. Disclosed in this invention are isolated peptide fragments, pharmaceutical compositions and methods for use of such for treating subjects with a neurodegenerative disease, such as Alzheimer’s disease (AD), Amyotrophic Lateral Sclerosis (ALS) and Parkinson’s disease (PD). An inhibitory fragment, TFP5, disclosed in this invention, has ...
Source: NIH OTT Licensing Opportunities - March 15, 2011 Category: Research Authors: admin Source Type: research

PRISM II: an open-label study to assess effectiveness of dextromethorphan/quinidine for pseudobulbar affect in patients with dementia, stroke or traumatic brain injury
Phase 3 trials supporting dextromethorphan/quinidine (DM/Q) use as a treatment for pseudobulbar affect (PBA) were conducted in patients with amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS). The ...
Source: BMC Neurology - June 9, 2016 Category: Neurology Authors: Flora M. Hammond, David N. Alexander, Andrew J. Cutler, Stephen D’Amico, Rachelle S. Doody, William Sauve, Richard D. Zorowitz, Charles S. Davis, Paul Shin, Fred Ledon, Charles Yonan, Andrea E. Formella and Joao Siffert Source Type: research

Myeloperoxidase: Bridging the gap in Neurodegeneration
Publication date: Available online 22 June 2016 Source:Neuroscience & Biobehavioral Reviews Author(s): R.S. Ray, Anju Katyal Neurodegenerative conditions present a group of complex disease pathologies mostly due to unknown aetiology resulting in neuronal death and permanent neurological disability. Any undesirable stress to the brain, disrupts homeostatic balance, through a remarkable convergence of pathophysiological changes and immune dysregulation. The crosstalk between inflammatory and oxidative mechanisms results in the release of neurotoxic mediators apparently spearheaded by myeloperoxidase derived from ...
Source: Neuroscience and Biobehavioral Reviews - June 22, 2016 Category: Neuroscience Source Type: research

Neuropharmacologic Approaches to Restore the Brain’s Microenvironment
Abstract Maintaining the central nervous system microenvironment after injury, infection, inflammatory and degenerative diseases is contingent upon adequate control of glial homeostatic functions. Disease is caused by microbial, environmental and endogenous factors that compromise ongoing nervous system functions. The final result is neuronal injury, dropout and nerve connection loss, and these underlie the pathobiology of Alzheimer’s and Parkinson’s disease, amyotrophic lateral sclerosis, stroke, and bacterial, parasitic and viral infections. However, what promotes disease are homeostatic changes in the brain...
Source: Journal of NeuroImmune Pharmacology - June 27, 2016 Category: Drugs & Pharmacology Source Type: research

Promising new insights into ALS
Research into amyotrophic lateral sclerosis (ALS) has led to interesting and unexpected conclusions. When scientists were investigating the relevance of the higher expression of the IP3R2 protein in blood of ALS patients, the general expectation was that lowering the expression of this protein would have a protective effect on the affected motor neurons. But the exact opposite was true: IP3R2 turned out to be a protector against the negative effects of inflammation during ALS. Even more, the same mechanism may also apply to other diseases, such as stroke and multiple sclerosis, say investigators.
Source: ScienceDaily Headlines - July 14, 2016 Category: Science Source Type: news

Neuropharmacologic Approaches to Restore the Brain ’s Microenvironment
Abstract Maintaining the central nervous system microenvironment after injury, infection, inflammatory and degenerative diseases is contingent upon adequate control of glial homeostatic functions. Disease is caused by microbial, environmental and endogenous factors that compromise ongoing nervous system functions. The final result is neuronal injury, dropout and nerve connection loss, and these underlie the pathobiology of Alzheimer ’s and Parkinson’s disease, amyotrophic lateral sclerosis, stroke, and bacterial, parasitic and viral infections. However, what promotes disease are homeostatic changes in the brain’s mi...
Source: Journal of NeuroImmune Pharmacology - June 27, 2016 Category: Drugs & Pharmacology Source Type: research

Tongue implant for assistive technologies: Test of migration, tissue reactivity and impact on tongue function
Some 12,000 individuals in the United States suffer spinal cord injury (SCI) each year; of these, individuals with incomplete (39.5%) and complete (16.9%) tetraplegia have limited options for and high costs of assistive devices (National Spinal Cord Injury Statistical Center, Spinal Cord Injury Facts and Figures, 2011). Despite advances in neuroprostheses and brain-computer interfaces, individuals with high-level SCI (i.e. C4 and above) and other neurological diseases which lead to tetraplegia, such as amyotrophic lateral sclerosis and brainstem stroke, have limited options for control of their environments.
Source: Archives of Oral Biology - June 16, 2016 Category: Dentistry Authors: Sylive Mimche, Dukju Ahn, Mehdi Kiani, Hassan Elahi, Kyle Murray, Kirk Easley, Alan Sokoloff, Maysam Ghovanloo Source Type: research