Making Sense of Gut Feelings in the Traumatic Brain Injury Pathogenesis
Publication date: Available online 16 May 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Luiz Fernando Freire Royes, Fernando Gomez-PinillaAbstractTraumatic brain injury (TBI) is a devastating condition which often initiates a sequel of neurological disorders that can last throughout lifespan. From metabolic perspective, TBI also compromises systemic physiology including the function of body organs with subsequent malfunctions in metabolism. The emerging panorama is that the effects of TBI on the periphery strike back on the brain and exacerbate the overall TBI pathogenesis. An increasing number of clinical...
Source: Neuroscience and Biobehavioral Reviews - May 17, 2019 Category: Neuroscience Source Type: research

Abuse potential and toxicity of the synthetic cathinones (i.e., “Bath salts”)
Publication date: Available online 14 May 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Anthony L. Riley, Katharine H. Nelson, Peter To, Raul López-Arnau, Peng Xu, Dan Wang, Youmei Wang, Hao-wei Shen, Donald M. Kuhn, Mariana Angoa-Perez, John H. Anneken, Dawn Muskiewicz, F. Scott HallAbstractThe synthetic cathinones are derived from the naturally occurring drug cathinone found in the khat plant (Catha edulis) and have chemical structures and neurochemical consequences similar to other psychostimulants. This class of new psychoactive substances (NPS) also has potential for use and abuse coupled with ...
Source: Neuroscience and Biobehavioral Reviews - May 15, 2019 Category: Neuroscience Source Type: research

Reviewing working memory training gains in healthy older adults: A meta-analytic review of transfer for cognitive outcomes
The objective of this meta-analytic review was to systematically assess the effects of working memory training on healthy older adults. We identified 552 entries, of which 27 experiments met our inclusion criteria. The final database included 1130 participants. Near- and far-transfer effects were analysed with measures of short-term memory, working memory, and reasoning. Small significant and long-lasting transfer gains were observed in working memory tasks. Effects on reasoning was very small and only marginally significant. The effects of working memory training on both near and far transfer in older adults were moderate...
Source: Neuroscience and Biobehavioral Reviews - May 15, 2019 Category: Neuroscience Source Type: research

The Effects of Proteasome on Baseline and Methamphetamine-dependent Dopamine transmission
Publication date: Available online 13 May 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Fiona Limanaqi, Francesca Biagioni, Carla Letizia Busceti, Larisa Ryskalin, Francesco FornaiAbstractThe Ubiquitin Proteasome System (UPS) is a major multi-catalytic machinery, which guarantees cellular proteolysis and turnover. Beyond cytosolic and nuclear cell compartments, the UPS operates at the synapse to modulate neurotransmission and plasticity. In fact, dysregulations of the UPS are linked with early synaptic alterations occurring in a variety of dopamine (DA)-related brain disorders. This is the case of psychiat...
Source: Neuroscience and Biobehavioral Reviews - May 15, 2019 Category: Neuroscience Source Type: research

Polyphenols as food bioactive compounds in the context of Autism Spectrum Disorders: a critical mini-review
Publication date: Available online 11 May 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Diana Serra, Leonor M. Almeida, Teresa C.P. DinisAbstractDietary polyphenols are bioactive compounds with potential in preventing and treating several chronic disorders, mainly due to their ability to modulate key pro-inflammatory and pro-oxidant signalling pathways. Although some studies have expressed concern about their efficacy in vivo, accumulating evidence has suggested that these compounds may achieve large concentrations in the gastrointestinal tract, which may be important in the context of intestinal and of ne...
Source: Neuroscience and Biobehavioral Reviews - May 12, 2019 Category: Neuroscience Source Type: research

Neural Underpinnings of Numerical and Spatial Cognition: An fMRI Meta-Analysis of Brain Regions Associated with Symbolic Number, Arithmetic, and Mental Rotation
Publication date: Available online 10 May 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Zachary Hawes, H. Moriah Sokolowski, Chuka Bosah Ononye, Daniel AnsariAbstractWhere and under what conditions do spatial and numerical skills converge and diverge in the brain? To address this question, we conducted a meta-analysis of brain regions associated with basic symbolic number processing, arithmetic, and mental rotation. We used Activation Likelihood Estimation (ALE) to construct quantitative meta-analytic maps synthesizing results from 83 neuroimaging papers (24–31 studies/cognitive process). All three c...
Source: Neuroscience and Biobehavioral Reviews - May 11, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: June 2019Source: Neuroscience & Biobehavioral Reviews, Volume 101Author(s): (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - May 11, 2019 Category: Neuroscience Source Type: research

TET enzymes in neurophysiology and brain function
Publication date: Available online 9 May 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Cláudia Antunes, Nuno Sousa, Luisa Pinto, C. Joana MarquesAbstractThe dynamic nature of epigenetic DNA modifications is crucial for regulating gene expression in an experience-dependent manner and, thus, a potential mediator of neuronal plasticity and behavior. The discovery of the involvement of 5-hydroxymethylcytosine (5hmC) and Ten Eleven Translocation (TET) family of enzymes in the demethylation pathway uncovered a potential link between neuronal TET protein function and cognitive processes. In this review, we...
Source: Neuroscience and Biobehavioral Reviews - May 11, 2019 Category: Neuroscience Source Type: research

Are transcranial brain stimulation effects long-lasting in post-stroke aphasia? A comparative systematic review and meta-analysis on naming performance
Publication date: Available online 8 May 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Madalina Bucur, Costanza PapagnoAbstractIn the last decade, the effects of NIBS on language recovery in post-stroke aphasia have been evaluated, but little is known about the long-term effectiveness.To this aim, we conducted a systematic review and meta-analysis to determine whether positive effects, mainly on naming performance, are maintained in time, and rTMS and/or tDCS (either as an add-on therapy to SLT or as monotherapy) can be considered effective and reliable interventions for naming rehabilitation.Sixteen studi...
Source: Neuroscience and Biobehavioral Reviews - May 9, 2019 Category: Neuroscience Source Type: research

Role of the social actor during social interaction and learning in human-monkey paradigms
Publication date: Available online 6 May 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Simon Nougaret, Lorenzo Ferrucci, Aldo GenovesioAbstractThe social interactions between primates is drawn by their ability to predict others’ behaviours, to learn from others’ actions and to represent others’ intentions. It allows them to extract information by observation to understand which action is leading to which outcome and to maximize the efficiency of their own future behaviours. These processes have mainly been investigated studying non-human primates observing conspecifics, but more recently ...
Source: Neuroscience and Biobehavioral Reviews - May 8, 2019 Category: Neuroscience Source Type: research

The Role of Hedonics in the Human Affectome
We describe the neurobiological systems of hedonics and factors that modulate hedonic experiences (e.g., cognition, learning, sensory input). Further, we review maladaptive and adaptive pleasure and displeasure functions in mental disorders and well-being, as well as the experience of aesthetics. As a centerpiece of the Human Affectome Project, language used to express pleasure and displeasure was also analyzed, and showed that most of these analyzed words overlap with expressions of emotions, actions, and bodily states. Our review shows that hedonics are typically investigated as processes that accompany other functions, ...
Source: Neuroscience and Biobehavioral Reviews - May 8, 2019 Category: Neuroscience Source Type: research

The Failing Cascade: Comorbid Post Traumatic- and Opioid Use Disorders
Publication date: Available online 4 May 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Igor Elman, David BorsookAbstractOpioid use disorder (OUD) is a mounting public health problem with substantial morbidity and mortality. Stress involvement in the course of OUD is generally accepted, but little is understood about the underlying neurobiological mechanisms in part due to a lack of laboratory-based models for chronic stress exposure. Post-traumatic stress disorder (PTSD) may be construed as a psychopathological prototype of chronic stress owing to the essential diagnostic criteria of experiencing and reliv...
Source: Neuroscience and Biobehavioral Reviews - May 6, 2019 Category: Neuroscience Source Type: research

Chemotherapy-Induced Cognitive Impairments: A Systematic Review of the Animal Literature
Publication date: Available online 4 May 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): A. Matsos, I.N. JohnstonAbstractWhilst chemotherapy is a widely used anti-cancer treatment, a subset of patients experience cognitive decline. However, cancer type, treatment regimen, fatigue and anxiety can influence cognitive status. Rodent research has overcome these confounds to systematically evaluate cognitive domains and underlying neural mechanisms disrupted by chemotherapy treatment. Therefore, a systematic review was conducted in June 2017 to examine the relationship between chemotherapy and cognitive decline i...
Source: Neuroscience and Biobehavioral Reviews - May 6, 2019 Category: Neuroscience Source Type: research

Behavioral neuroscience of autism
Publication date: Available online 3 May 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Toru Takumi, Kota Tamada, Fumiyuki Hatanaka, Nobuhiro Nakai, Patrick F. BoltonAbstractAutism spectrum disorder (ASD) is a neurodevelopmental disorder Several genetic causes of ASD have been identified and this has enabled researchers to construct mouse models. Mouse behavioral tests reveal impaired social interaction and communication, as well as increased repetitive behavior and behavioral inflexibility in these mice, which correspond to core behavioral deficits observed in individuals with ASD. However, the connection ...
Source: Neuroscience and Biobehavioral Reviews - May 4, 2019 Category: Neuroscience Source Type: research

Why neuroscience does not disprove free will
Publication date: Available online 3 May 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Marcel Brass, Ariel Furstenberg, Alfred R. MeleAbstractWhile the question whether free will exists or not has concerned philosophers for centuries, empirical research on this question is relatively young. About 35 years ago Benjamin Libet designed an experiment that challenged the common intuition of free will, namely that conscious intentions are causally efficacious. Libet demonstrated that conscious intentions are preceded by a specific pattern of brain activation, suggesting that unconscious processes determine our d...
Source: Neuroscience and Biobehavioral Reviews - May 4, 2019 Category: Neuroscience Source Type: research

Genetic Mechanisms of Regression in Autism Spectrum Disorder
Publication date: Available online 3 May 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Kristiina TammimiesAbstractDevelopmental regression occurs in approximately one-third of children with autism spectrum disorder (ASD). There is a strong genetic influence in ASD and hundreds of genes have been implicated. Theories suggest that regressive ASD is a neurobiological subtype with potentially different causes. This review examines the evidence of genetic influences in regression and provides a summary of its frequency among ASD-associated single-gene disorders. The few twin- and family studies reporting on the...
Source: Neuroscience and Biobehavioral Reviews - May 4, 2019 Category: Neuroscience Source Type: research

Retrosplenial cortex and its role in cue-specific learning and memory
Publication date: Available online 2 May 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Travis P. Todd, Danielle I. Fournier, David J. BucciAbstractThe retrosplenial cortex (RSC) contributes to spatial navigation, as well as contextual learning and memory. However, a growing body of research suggests that the RSC also contributes to learning and memory for discrete cues, such as auditory or visual stimuli. In this review, we summarize and assess the Pavlovian and instrumental conditioning experiments that have examined the role of the RSC in cue-specific learning and memory. We use the term cue-specific to ...
Source: Neuroscience and Biobehavioral Reviews - May 3, 2019 Category: Neuroscience Source Type: research

The expectant social mind: A systematic review of face processing during pregnancy and the effect of depression and anxiety
Publication date: Available online 2 May 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Pietro De Carli, Ilaria Costantini, Paola Sessa, Silvia Visentin, Rebecca M. Pearson, Alessandra SimonelliAbstractPregnancy carries enormous changes in the psychological and neurophysiological domains. It has been suggested that pregnant women undergo a cognitive reorganization aimed at increasing the salience of social stimuli (i.e., the tendency of social cues to capture observer’s attention, so that their processing results prioritized). The goal of the present work was to systematically review the empirical evi...
Source: Neuroscience and Biobehavioral Reviews - May 3, 2019 Category: Neuroscience Source Type: research

The behavioral phenotype of early life adversity: a 3-level meta-analysis of rodent studies
Publication date: Available online 29 April 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): V. Bonapersona, J. Kentrop, C.J. Van Lissa, R. van der Veen, M. Joëls, R.A. SarabdjitsinghAbstractAltered cognitive performance is considered an intermediate phenotype mediating early life adversity (ELA) effects on later-life development of mental disorders, e.g. depression. Whereas most human studies are limited to correlational conclusions, rodent studies can prospectively investigate how ELA alters cognitive performance in several domains. Despite the volume of reports, there is no consensus on i) the behavio...
Source: Neuroscience and Biobehavioral Reviews - April 30, 2019 Category: Neuroscience Source Type: research

Toward an integrative science of social vision in intergroup bias
Publication date: Available online 28 April 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Arianna Bagnis, Alessia Celeghin, Cristina Onesta Mosso, Marco TamiettoAbstractSocial neuroscience is unveiling how the brain coordinates the construal of social categories and the generation of intergroup biases from facial perception. Recent evidence indicates that social categorization is more sensitive and malleable to elemental facial features than previously assumed. At the same time, perception of social categories can be crafted by top-down factors, including prior knowledge, motivations, and social expectatio...
Source: Neuroscience and Biobehavioral Reviews - April 29, 2019 Category: Neuroscience Source Type: research

The effect of treating obstructive sleep apnea with continuous positive airway pressure on posttraumatic stress disorder: A systematic review and meta-analysis with hypothetical model
Publication date: Available online 28 April 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Ye Zhang, Rong Ren, Linghui Yang, Junying Zhou, Larry D. Sanford, Xiangdong TangAbstractThe present study explored that whether continuous positive airway pressure (CPAP) treatment impacts nightmare and overall posttraumatic stress disorder (PTSD) symptoms in patients with PTSD and obstructive sleep apnea (OSA). The meta-analysis for six eligibile studies indicates that CPAP can significantly improve nightmare (standardized mean differences (SMD) = -0.778; 95% confidence interval (CI) = -1.228 to -0.327) and overall P...
Source: Neuroscience and Biobehavioral Reviews - April 29, 2019 Category: Neuroscience Source Type: research

How the Motor System Integrates with Working Memory
Publication date: Available online 27 April 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Cherie L. Marvel, Owen E. Morgan, Sharif I. KronemerAbstractWorking memory is vital for basic functions in everyday life. During working memory, one holds a finite amount of information in mind until it is no longer required or when resources to maintain this information are depleted. Convergence of neuroimaging data indicates that working memory is supported by the motor system, and in particular, by regions that are involved in motor planning and preparation, in the absence of overt movement. These “secondary ...
Source: Neuroscience and Biobehavioral Reviews - April 28, 2019 Category: Neuroscience Source Type: research

Reframing schizophrenia and autism as self-consciousness disorders associating a deficit of theory of mind and empathy with social communication impairments
In conclusion, a new model is proposed integrating results of studies presented here and stating the existence of bodily self-consciousness disorders in schizophrenia and autism associated with altered/absent intermodal sensory integration (especially visual-kinesthetic-tactile integration). This would result in problems of self-other differentiation, leading in turn to a deficit of theory of mind and empathy as well as social communication impairments. This model opens new perspectives to understand better self-consciousness disorders and social communication impairments in schizophrenia and ASD and to develop therapeutic...
Source: Neuroscience and Biobehavioral Reviews - April 27, 2019 Category: Neuroscience Source Type: research

Postmortem brain tissue as an underutilized resource to study the molecular pathology of neuropsychiatric disorders across different ethnic populations
Publication date: Available online 24 April 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Eric Vornholt, Dan Luo, Wenying Qiu, Gowon O. McMichael, Yangyang Liu, Nathan Gillespie, Chao Ma, Vladimir I. VladimirovAbstractIn recent years, large scale meta-analysis of genome-wide association studies (GWAS) have reliably identified genetic polymorphisms associated with neuropsychiatric disorders such as schizophrenia (SCZ), bipolar disorder (BPD) and major depressive disorder (MDD). However, the majority of disease-associated single nucleotide polymorphisms (SNPs) appear within functionally ambiguous non-coding ...
Source: Neuroscience and Biobehavioral Reviews - April 25, 2019 Category: Neuroscience Source Type: research

Neurofilament light chain protein in neurodegenerative dementia: A systematic review and network meta-analysis
Publication date: Available online 24 April 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Yinan Zhao, Yanguo Xin, Su Meng, Zhiyi He, Wenyu HuAbstractThe diagnostic value of neurofilament light chain protein in neurodegenerative dementia diseases is still controversial. A systematic literature search was performed to identify relevant case-control studies conducted through October 2018. Traditional and net meta-analyses were performed based on 42 studies that tested the diagnostic performance of neurofilament light chain protein (NfL) concentration in CSF and serum/plasma from patients with neurodegenerativ...
Source: Neuroscience and Biobehavioral Reviews - April 24, 2019 Category: Neuroscience Source Type: research

When the body is the target—Representations of one’s own body and bodily sensations in self-harm: A systematic review
ConclusionOur results emphasise the strong link between body representations and self-protection, as well as a need for investigating self-harm interventions that take body image and awareness into account. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - April 22, 2019 Category: Neuroscience Source Type: research

Incorporating the social context into neurocognitive models of adolescent decision-making: A neuroimaging meta-analysis
Publication date: Available online 18 April 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jorien van Hoorn, Holly Shablack, Kristen A. Lindquist, Eva H. TelzerAbstractNeurobiological models of adolescent decision-making emphasize developmental changes in brain regions involved in affect (e.g., ventral striatum) and cognitive control (e.g., lateral prefrontal cortex). Although social context plays an important role in adolescent decision-making, current models do not discuss brain regions implicated in processing social information (e.g., dorsomedial prefrontal cortex). We conducted a coordinate-based meta-...
Source: Neuroscience and Biobehavioral Reviews - April 19, 2019 Category: Neuroscience Source Type: research

At the Forefront of Psychoneuroimmunology in Pregnancy: Implications for Racial Disparities in Birth Outcomes PART 1: Behavioral Risks Factors
Publication date: Available online 18 April 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Lisa M. ChristianAbstractBirth prior to full term is a substantial public health issue. In the US, ˜400,000 babies per year are born preterm (1 million are early term (37–386/7 weeks). Birth prior to full term confers risk both immediate and long term, including neonatal intensive care, decrements in school performance, and increased mortality risk from infancy through young adulthood. Risk for low birth weight and preterm birth are 1.5-2 times greater among African Americans versus Whites. Psychosocial st...
Source: Neuroscience and Biobehavioral Reviews - April 19, 2019 Category: Neuroscience Source Type: research

Stress, Epigenetics and Depression: A Systematic Review
Publication date: Available online 18 April 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Caroline Park, Joshua Rosenblat, Elisa Brietzke, Zihang Pan, Yena Lee, Bing Cao, Hannah Zuckerman, Anastasia Kalantarova, Roger S. McIntyreAbstractEnvironmental stressors, such as childhood maltreatment, have been recognized to contribute to the development of depression. Growing evidence suggests that epigenetic changes are a key mechanism by which stressors interact with the genome leading to stable changes in DNA structure, gene expression, and behaviour. The current review aimed to evaluate the relationship betwee...
Source: Neuroscience and Biobehavioral Reviews - April 19, 2019 Category: Neuroscience Source Type: research

Fractionating adaptive learning: A meta-analysis of the reversal learning paradigm
Publication date: Available online 18 April 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Zachary A. Yaple, Rongjun YuAbstractIn constantly changing environments, individuals need to overcome old habitual behaviors in order to learn new associations. Neuroimaging studies have focused on prediction errors, reversal errors and reversal switching in the reversal learning paradigm. Due to the inconsistencies of brain functioning across studies, we attempt to shed light on the concordant activity by performing meta-analyses on different components of reversal learning. While all contrasts yielded anterior cingu...
Source: Neuroscience and Biobehavioral Reviews - April 18, 2019 Category: Neuroscience Source Type: research

Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials
Publication date: Available online 17 April 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Richard T. Liu, Rachel F.L. Walsh, Ana E. SheehanAbstractWith growing interest in the gut microbiome, prebiotics and probiotics have received considerable attention as potential treatments for depression and anxiety. We conducted a random-effects meta-analysis of 34 controlled clinical trials evaluating the effects of prebiotics and probiotics on depression and anxiety. Prebiotics did not differ from placebo for depression (d = −.08, p = .51) or anxiety (d = .12, p = .11)....
Source: Neuroscience and Biobehavioral Reviews - April 18, 2019 Category: Neuroscience Source Type: research

Prediction and perception: insights for (and from) tinnitus
Publication date: Available online 15 April 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jeffrey Hullfish, William Sedley, Sven VannesteAbstractMore than 150 years have passed since Helmholtz first described perception as a process of unconscious inference about the causes of sensations. His ideas have since inspired a wealth of literature investigating the mechanisms underlying these inferences. In recent years, much of this work has converged on the notion that the brain is a hierarchical generative model of its environment that predicts sensations and updates itself based on prediction errors. Here, we...
Source: Neuroscience and Biobehavioral Reviews - April 16, 2019 Category: Neuroscience Source Type: research

Depression in Neurodegenerative Diseases: Common Mechanisms and Current Treatment Options
Publication date: Available online 15 April 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Ciaran P.C. Galts, Luis E.B. Bettio, David C. Jewett, Charles C. Yang, Patricia S. Brocardo, Ana Lucia S. Rodrigues, Jonathan S. Thacker, Joana Gil-MohapelAbstractMajor depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major cause of disability worldwide. This neurological condition is commonly associated with neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD) and Huntington's Disease (HD), and has a significant impact on the increasing burden of these neurop...
Source: Neuroscience and Biobehavioral Reviews - April 15, 2019 Category: Neuroscience Source Type: research

DNA Methylation Studies of Depression with Onset in the Peripartum: A Critical Systematic Review
ConclusionNo longitudinal MDP-DNAm studies exist. Earlier MDP-DNAm studies should be interpreted with caution, and future research must commit to sharing methodology and data to facilitate cross-study comparisons and maximize dataset utility. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - April 12, 2019 Category: Neuroscience Source Type: research

Enhancing cognition through pharmacological and environmental interventions: Examples from preclinical models of neurodevelopmental disorders
Publication date: Available online 10 April 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Lorenzo Morè, Julie C. Lauterborn, Francesco Papaleo, Riccardo BrambillaAbstractIn this review we discuss the role of environmental and pharmacological treatments to enhance cognition with special regards to neurodevelopmental related disorders and aging. How the environment influences brain structure and function, and the interactions between rearing conditions and gene expression, are fundamental questions that are still poorly understood. We propose a model that can explain some of the discrepancies in findi...
Source: Neuroscience and Biobehavioral Reviews - April 12, 2019 Category: Neuroscience Source Type: research

Noise Exposure Accelerates the Risk of Cognitive Impairment and Alzheimer’s Disease: Adulthood, Gestational, and Prenatal Mechanistic Evidence from Animal Studies
Publication date: Available online 9 April 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Zahra Jafari, Bryan E. Kolb, Majid H. MohajeraniAbstractThis review examines the adverse impacts of different noise exposure paradigms on the neuroendocrine system, hippocampal and neocortical structures, cognitive performances, and the development of Alzheimer's disease (AD)-like neuropathological changes in the brain of laboratory animals. Studies were reviewed in three periods during the lifespan including: adult animals exposed to noise, female rodents exposed to noise during gestation, and offspring exposed to noi...
Source: Neuroscience and Biobehavioral Reviews - April 11, 2019 Category: Neuroscience Source Type: research

The prevalence and clinical correlates of cannabis use and cannabis use disorder among patients with bipolar disorder: a systematic review with meta-analysis and meta-regression
In conclusion, cannabis use present in almost one-quarter of patients with BD and is associated with factors that are highly relevant for both clinical practice and public health. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - April 9, 2019 Category: Neuroscience Source Type: research

Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in humans
Publication date: Available online 7 April 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jacob Raber, Shahar Arzy, Julie Boulanger Bertolus, Brendan Depue, Haley E. Haas, Maria Kangas, Elizabeth Kensinger, Christopher A. Lowry, Hilary A. Marusak, Jessica Minnier, Anne-Marie Mouly, Andreas Muehlberger, Seth Davin Norrholm, Kirsi Peltonen, Graziano Pinna, Christine Rabinak, Youssef Shiban, Hermona Soreq, Michael A. van der Kooij, Leroy LoweAbstractFear is an emotion that serves as a driving factor in how organisms move through the world. In this review, we discuss the current understandings of the subjective...
Source: Neuroscience and Biobehavioral Reviews - April 9, 2019 Category: Neuroscience Source Type: research

Impact of sex differences and gender specificity on behavioral characteristics and pathophysiology of neurodegenerative disorders
Publication date: Available online 5 April 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Mohammad Fahad Ullah, Aamir Ahmad, Showket Hussain Bhat, Faisel M. Abu-Duhier, George E. Barreto, Ghulam Md AshrafAbstractThe impact of neurodegenerative disorders in humans has multiple consequences because of the progressive decline in cognitive and physical performances. These disorders have diverse manifestations and are influenced by genetic and lifestyle factors, concurrent health conditions as well as un-modifiable predisposing risk factors, including gender and advanced age. Accumulating evidence indicates a ge...
Source: Neuroscience and Biobehavioral Reviews - April 7, 2019 Category: Neuroscience Source Type: research

Validation of hippocampal biomarkers of cumulative affective experience
Publication date: Available online 3 April 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Colline Poirier, Melissa Bateson, Fabio Gualtieri, Elena A. Armstrong, Grace C. Laws, Timothy Boswell, Tom V. SmuldersAbstractProgress in improving the welfare of captive animals has been hindered by a lack of objective indicators to assess the quality of lifetime experience, often called cumulative affective experience. Recent developments in stress biology and psychiatry have shed new light on the role of the mammalian hippocampus in affective processes. Here we review these findings and argue that structural hippoca...
Source: Neuroscience and Biobehavioral Reviews - April 4, 2019 Category: Neuroscience Source Type: research

Sugar Rush or Sugar Crash? A Meta-Analysis of Carbohydrate Effects on Mood
We examined the time-course of CHO-mood interactions and considered the role of moderator variables potentially affecting the CHO-mood relationship. Analysis of 176 effect sizes (31 studies, 1259 participants) revealed no positive effect of CHOs on any aspect of mood at any time-point following their consumption. However, CHO administration was associated with higher levels of fatigue and less alertness compared with placebo within the first hour post-ingestion. These findings challenge the idea that CHOs can improve mood, and might be used to increase the public's awareness that the ‘sugar rush’ is a myth, inf...
Source: Neuroscience and Biobehavioral Reviews - April 4, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: May 2019Source: Neuroscience & Biobehavioral Reviews, Volume 100Author(s): (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - April 4, 2019 Category: Neuroscience Source Type: research

Avoidance learning and classical eyeblink conditioning as model systems to explore a learning diathesis model of PTSD
We present a body of evidence supporting a learning diathesis model in which behaviorally inhibited organisms exhibit enhanced acquisition and resistance to extinction in these tasks. Vulnerable individuals show learning-related enhancements when the learning situation involves some degree of uncertainty. We review the known brain circuitry involved in classical eyeblink conditioning in the context of the learning diathesis model. Finally, the data reviewed here demonstrate the value of studying vulnerability factors in humans and a rodent model using cerebellar-dependent learning tasks for understanding the acquisition an...
Source: Neuroscience and Biobehavioral Reviews - April 4, 2019 Category: Neuroscience Source Type: research

Race reporting and disparities in clinical trials on Alzheimer’s disease: a systematic review
DiscussionRace has insufficiently been reported in previous interventional studies on AD. Its potential association with the effectiveness and safety/tolerability of the tested medications has completely been neglected. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - April 2, 2019 Category: Neuroscience Source Type: research

Pros and Cons of Clinically Relevant Methods to Assess Pain in Rodents
The objective of this review is to describe and discuss several of these tests. We focus on: Grimace Scale, Operant Behavior, Wheel Running, Burrowing, Nesting, Home Cage Monitoring, Gait Analysis and Conditioned Place Preference/ Aversion. A brief description of each method is presented along with an analysis of the advantages and limitations. The pros and cons of each test will help researchers identify the assessment tool most appropriate to meet their particular objective to assess pain in rodents. These tests provide another tool to unravel the mechanisms underlying chronic pain and help overcome the translational gap...
Source: Neuroscience and Biobehavioral Reviews - April 2, 2019 Category: Neuroscience Source Type: research

A review of visual aftereffects in schizophrenia
Publication date: Available online 30 March 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Katharine N. Thakkar, Steven M. Silverstein, Jan W. BrascampAbstractPsychosis—a cardinal symptom of schizophrenia—has been associated with a failure to appropriately create or use stored regularities about past states of the world to guide the interpretation of incoming information, which leads to abnormal perceptions and beliefs. The visual system provides a test bed for investigating the role of prior experience and prediction, as accumulated knowledge of the world informs our current perception. More sp...
Source: Neuroscience and Biobehavioral Reviews - March 31, 2019 Category: Neuroscience Source Type: research

Biological markers evaluated in randomized trials of psychological treatments for depression: a systematic review and meta-analysis
We report the first systematic review and meta-analysis of biological variables assessed, as outcomes or predictors of response, in randomized controlled trials of psychotherapy for adult depression. Fifty-one trials (5123 participants) and a pooled analysis were included. Biological markers were outcomes in 43 studies and predictors of treatment response in 9. At post-treatment, psychotherapy could not be distinguished from control conditions for glycaemic control (Hb1AC), 7 trials, Hedges’ g= -.01, 95% CI -0.30 to 0.29, I2 = 65% and cortisol concentration after-wake, 5 trials, Hedges’ g= -.19, 9...
Source: Neuroscience and Biobehavioral Reviews - March 27, 2019 Category: Neuroscience Source Type: research

Neural mechanisms of attending to items in working memory
Publication date: Available online 26 March 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Sanjay G. Manohar, Nahid Zokaei, Sean J. Fallon, Tim Vogels, Masud HusainAbstractWorking memory, the ability to keep recently accessed information available for immediate manipulation, has been proposed to rely on two mechanisms that appear difficult to reconcile: self-sustained neural firing, or the opposite—activity-silent synaptic traces. Here we review and contrast models of these two mechanisms, and then show that both phenomena can co-exist within a unified system in which neurons hold information in both ...
Source: Neuroscience and Biobehavioral Reviews - March 27, 2019 Category: Neuroscience Source Type: research

Reciprocal interactions across and within multiple levels of monoamine and cortico-limbic systems in stress-induced depression: A systematic review
Publication date: Available online 24 March 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Eun-Hwa Lee, Pyung-Lim HanAbstractThe monoamine hypothesis of depression, namely that the reduction in synaptic serotonin and dopamine levels causes depression, has prevailed in past decades. However, clinical and preclinical studies have identified various cortical and subcortical regions whose altered neural activities also regulate depressive-like behaviors, independently from the monoamine system. Our systematic review indicates that neural activities of specific brain regions and associated neural circuitries are...
Source: Neuroscience and Biobehavioral Reviews - March 25, 2019 Category: Neuroscience Source Type: research

Regression in Autism Spectrum Disorder: A Critical Overview of Retrospective Findings and Recommendations for Future Research: Invited Contribution to the Special Issue of Neuroscience and Biobehavioral Reviews on “Regression in Developmental Disorders”
Publication date: Available online 24 March 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Sofie Boterberg, Tony Charman, Peter B. Marschik, Sven Bölte, Herbert RoeyersAbstractHistorically, two onset patterns in autism spectrum disorder (ASD) were described: an early onset of symptoms and a regression in which one-third appear to show a loss of previously established skills in the second year of life. Since this phenomenon could represent a distinct ASD subtype and provide more insight into the etiology, diagnosis and prognosis, many studies have compared these two groups. The present review discusses ...
Source: Neuroscience and Biobehavioral Reviews - March 25, 2019 Category: Neuroscience Source Type: research