Challenges and Demand for Modeling Disorders of Consciousness following Traumatic Brain Injury
Publication date: Available online 11 December 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): John C. O’Donnell, Kevin D. Browne, Todd J. Kilbaugh, H. Isaac Chen, John Whyte, D. Kacy CullenAbstractFollowing severe traumatic brain injury (TBI), many patients experience coma — an unresponsive state lacking wakefulness or awareness. Coma rarely lasts more than two weeks, and emergence involves passing through a state of wakefulness without awareness of self or environment. Patients that linger in these Disorders of Consciousness (DoC) undergo clinical assessments of awareness for diagnosis into Unr...
Source: Neuroscience and Biobehavioral Reviews - December 12, 2018 Category: Neuroscience Source Type: research

The uncertain brain: A co-ordinate based meta-analysis of the neural signatures supporting uncertainty during different contexts
We examined the neural basis of each category by using a coordinate based meta-analysis, where brain activation foci from previously published fMRI experiments were drawn together (1998-2017; 87 studies). The analyses revealed shared and discrete patterns of neural activation for uncertainty, such as the insula and amygdala, depending on the category. Such findings will have relevance for researchers attempting to conceptualise uncertainty, as well as clinical researchers examining the neural basis of uncertainty in relation to psychopathology. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - December 12, 2018 Category: Neuroscience Source Type: research

Upregulated levels and pathological aggregation of abnormally phosphorylated Tau-Protein in children with neurodevelopmental disorders
Publication date: Available online 11 December 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Marija Rankovic, Markus ZweckstetterAbstractThe tubulin-associated unit (Tau) protein is an intrinsically disordered protein that plays a well-established role in promoting microtubule assembly and stabilization in neuronal axons at all stages of development. Identification of new interacting partners and different sub-cellular localizations of Tau in recent years led to the discovery of novel physiological functions in regulation of neuronal activity, neurogenesis, long-term depression, iron export and genomic int...
Source: Neuroscience and Biobehavioral Reviews - December 12, 2018 Category: Neuroscience Source Type: research

Dance for neuroplasticity: a descriptive systematic review
Publication date: Available online 10 December 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Lavinia Teixeira-Machado, Ricardo Mario Arida, Jair de Jesus MariAbstractWe conducted a systematic review of randomized clinical trials to investigate whether dance practice promotes neuroplasticity. We also determined how dancing is able to alter (1) brain volumes and structures (2) brain function, (3) psychomotor adjustment and (4) levels of neurotrophic factors. This systematic review formulated a research question based on PICO, according to the guidelines for systematic reviews and meta-analyzes (PRISMA), &ldq...
Source: Neuroscience and Biobehavioral Reviews - December 11, 2018 Category: Neuroscience Source Type: research

Exploring the potential role of mesocorticolimbic circuitry in motivation for and adherence to chronic pain self-management interventions
Publication date: Available online 10 December 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Janelle E. Letzen, David A. Seminowicz, Claudia M. Campbell, Patrick H. FinanAbstractAdherence to pain self-management strategies is associated with favorable psychobehavioral outcomes among individuals with chronic pain. Substantive adherence to treatments teaching these adaptive skills proves challenging, resulting in poor individual and societal outcomes. Evidence demonstrates motivation for behavior change as a key predictor of treatment adherence. Despite behavioral techniques that target motivation, however, ...
Source: Neuroscience and Biobehavioral Reviews - December 11, 2018 Category: Neuroscience Source Type: research

A systematic review on the therapeutic effectiveness of non-invasive brain stimulation for the treatment of anxiety disorders
Publication date: Available online 10 December 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): C.M Vicario, M.A Salehinejad, K. Felmingham, G. Martino, M A NitscheAbstractThe interest in the use of non-invasive brain stimulation for enhancing neural functions and reducing symptoms in anxiety disorders is growing. Based on the DSM-V classification for anxiety disorders, we examined all available research using repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) for the treatment of specific phobias, social anxiety disorder, panic disorder, agoraphobia, and ge...
Source: Neuroscience and Biobehavioral Reviews - December 11, 2018 Category: Neuroscience Source Type: research

Regression in Children with Epilepsy
Publication date: Available online 8 December 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Peter Camfield, Carol CamfieldAbstractRegression in children with epilepsy may involve loss of cognitive abilities, failure to progress or a slowing of developmental trajectory. A few seizures do not lead to regression. Large numbers of seizures may be associated with regression but the cause is an important cofounder. Individual spike discharges on EEG are associated with transient cognitive impairment and continuous spike discharges with regression. Regression may be global in continuous spike wave in slow sleep (...
Source: Neuroscience and Biobehavioral Reviews - December 9, 2018 Category: Neuroscience Source Type: research

A meta-analytical evaluation of the dual-hormone hypothesis: Does cortisol moderate the relationship between testosterone and status, dominance, risk taking, aggression, and psychopathy?
Publication date: Available online 7 December 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Mr Tycho DekkersAbstractAccording to the dual-hormone hypothesis, the relationship between testosterone and status-relevant behavior is moderated by cortisol, suggesting this relationship only exists when cortisol is low. In the current study, a meta-analysis (including 30 papers with 33 studies, 49 effect sizes, n = 8538) on the interaction effect of testosterone and cortisol on status-relevant behavior (i.e. status, dominance, risk taking, aggression, and psychopathy) was performed. There was only ma...
Source: Neuroscience and Biobehavioral Reviews - December 8, 2018 Category: Neuroscience Source Type: research

Chronic Unpredictable Mild Stress for Modeling Depression in Rodents:Meta-analysis of Model Reliability
Publication date: Available online 6 December 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Svitlana Antoniuk, Monika Bijata, Evgeni Ponimaskin, Jakub WlodarczykAbstractDepression is currently among the top five leading causes of the global burden of disease. Chronic unpredictable mild stress (CUMS) is currently the most commonly used, reliable, and effective rodent model of depression. However, for unclear reasons, this protocol is often difficult to reproduce in different laboratories. We performed a meta-analysis of studies that used the CUMS paradigm to evaluate depressive-like behavior in rodents. We ...
Source: Neuroscience and Biobehavioral Reviews - December 7, 2018 Category: Neuroscience Source Type: research

Time perception and impulsivity: A proposed relationship in addictive disorders
Publication date: Available online 6 December 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Cecilia Paasche, Sébastien Weibel, Marc Wittmann, Laurence LalanneAbstractAddictive disorders are characterized by impulsive behavior that leads to difficulties in preventing certain behaviors despite negative consequences. This symptom predisposes to a vulnerability in developing addictive disorders and is also aggravated by the addiction process itself. As such, understanding the underlying mechanisms of impulsivity is a challenge for understanding the pathophysiology of addiction. One common link between i...
Source: Neuroscience and Biobehavioral Reviews - December 7, 2018 Category: Neuroscience Source Type: research

Fentanyl: Receptor Pharmacology, Abuse Potential, and Implications for Treatment
Publication date: Available online 5 December 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Sandra D. Comer, Catherine M. CahillAbstractOpioid overdoses, many of which are attributed to use of illicit fentanyl, are currently one of the leading causes of death in the U.S. Although fentanyl has been used safely for decades in clinical settings, the widespread use of illicit fentanyl is a recent phenomenon. Starting in 2013, illicitly manufactured fentanyl and its analogs began to appear on the streets. These substances were added to or sold as heroin, often unbeknownst to the user. Because fentanyl is so pot...
Source: Neuroscience and Biobehavioral Reviews - December 6, 2018 Category: Neuroscience Source Type: research

From “bedside” to “bench” and back: a translational approach to studying dopamine dysfunction in schizophrenia
Publication date: Available online 5 December 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Anissa Abi-DarghamAbstractDespite multiple lines of research, a mechanistic understanding of schizophrenia remains elusive. Neuroimaging studies have yielded observations that can be used in translational studies in animals to attempt to uncover their cellular and circuit basis and their significance for the diseased human brain. Enhanced D2 stimulation in the striatum is a well replicated and established observation in patients with schizophrenia. This “bedside” observation was reproduced “at the ...
Source: Neuroscience and Biobehavioral Reviews - December 6, 2018 Category: Neuroscience Source Type: research

Apolipoprotein E and affective symptoms in mild cognitive impairment and Alzheimer’s disease dementia: a systematic review and meta-analysis
ConclusionsThere is no evidence that APOE ε4 carriership or zygosity is associated with the presence of depression, anxiety, apathy, agitation, irritability or sleep disturbances in cognitively impaired subjects. Future research should shift its focus from this single polymorphism to a more integrated view of other biological factors. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - December 2, 2018 Category: Neuroscience Source Type: research

A SNARC in the mind or in the hand? A response to Shaki & Fischer
Publication date: Available online 30 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Elizabeth Y. Toomarian, Edward M. Hubbard (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - December 1, 2018 Category: Neuroscience Source Type: research

Chronic tobacco smoking and neuropsychological impairments: A systematic review and meta-analysis
Publication date: Available online 28 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): A.A. Conti, L. McLean, S. Tolomeo, J.D. Steele, A. BaldacchinoAbstractThe link between neuropsychological impairments and chronic tobacco smoking is not clear and in the current literature there is a lack of robust analyses investigating this association. A systematic review of the literature was conducted in order to identify relevant longitudinal and cross-sectional studies conducted from 1946 to 2017. A meta-analysis was performed from 24 studies testing the performance of chronic tobacco smokers compared with n...
Source: Neuroscience and Biobehavioral Reviews - November 29, 2018 Category: Neuroscience Source Type: research

Regulating Emotion Through Distancing: A Taxonomy, Neurocognitive Model, and Supporting Meta-Analysis
Publication date: Available online 28 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): John P. Powers, Kevin S. LaBarAbstractDistancing is a type of emotion regulation that involves simulating a new perspective to alter the psychological distance and emotional impact of a stimulus. The effectiveness and versatility of distancing relative to other types of emotion regulation make it a promising tool for clinical applications. However, the neurocognitive mechanisms of this tactic are unclear, and inconsistencies in terminology and methods across studies make it difficult to synthesize the literature. T...
Source: Neuroscience and Biobehavioral Reviews - November 29, 2018 Category: Neuroscience Source Type: research

Hypothalamic-Pituitary-Adrenal Axis Functioning in Borderline Personality Disorder: A Meta-Analysis
Publication date: Available online 27 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Elisa Drews, Eric A. Fertuck, Julian Koenig, Michael Kaess, Arnoud ArntzAbstractBorderline Personality Disorder (BPD) has been associated with altered hypothalamic-pituitary-adrenal (HPA) axis functioning. However, evidence is inconsistent. Therefore, the present series of meta-analyses aimed to quantify HPA axis functioning in BPD patients based on singular and continuous cortisol assessments and measures of reactivity to pharmacological and psychosocial stress. Case-control studies comparing adult BPD patients an...
Source: Neuroscience and Biobehavioral Reviews - November 28, 2018 Category: Neuroscience Source Type: research

Epigenetic variability in the human oxytocin receptor (OXTR) gene: a possible pathway from early life experiences to psychopathologies
Publication date: Available online 26 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Eline J. Kraaijenvanger, Yujie He, Hannah Spencer, Alicia K. Smith, Peter A. Bos, Marco P.M. BoksAbstractThe human oxytocin (OXT) system is implicated in the regulation of complex social behaviors, as well as in psychopathologies characterized by social deficits. Emerging evidence suggests that variation in epigenetic regulation of the oxytocin receptor gene (OXTR) provides the oxytocin system with flexibility in response to environmental events, especially those occurring during early childhood. Changes in DNA met...
Source: Neuroscience and Biobehavioral Reviews - November 27, 2018 Category: Neuroscience Source Type: research

Systems biology and gene networks in Alzheimer’s disease
Publication date: January 2019Source: Neuroscience & Biobehavioral Reviews, Volume 96Author(s): Zuo-Teng Wang, Chen-Chen Tan, Lan Tan, Jin-Tai YuAbstractGene mining has been a fruitful approach in the study of Alzheimer’s disease (AD). As a new starting point for studying AD, genetic and genomic investigations consistently strive to discover causative variants that are related to disease pathophysiology. Currently, genetic and genomic approaches have identified numerous loci. However, the elaboration of AD mechanism lagged behind gene discovery. The extensive use of parallel, high-throughput, next-generation sequ...
Source: Neuroscience and Biobehavioral Reviews - November 27, 2018 Category: Neuroscience Source Type: research

What is the key mediator of the neurovascular coupling response?
This article presents a systematic review and analysis of published data reporting the effects of pharmacological or genetic blockade of all hypothesised signalling pathways of neurovascular coupling. Our primary outcome measure was the percent reduction of the neurovascular response assessed using in vivo animal models. Selection criteria were met by 56 primary sources reporting the effects of 79 treatments. Experimental conditions were grouped into categories targeting mechanisms mediated by nitric oxide (NO), prostanoids, purines, potassium, amongst others. Blockade of neuronal NO synthase was found to have the largest ...
Source: Neuroscience and Biobehavioral Reviews - November 25, 2018 Category: Neuroscience Source Type: research

Addressing sequelae of developmental regression associated with developmental disabilities: A systematic review of behavioral and educational intervention studies
Publication date: Available online 24 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jeff Sigafoos, Mark F. O’Reilly, Katherine Ledbetter-Cho, Nataly Lim, Giulio E. Lancioni, Peter B. MarschikAbstractDevelopmental regression is characteristic of Rett syndrome and it also occurs in a number of other developmental disabilities. To assist clinicians in identifying promising therapeutic approaches, we identified 38 studies that sought to improve adaptive behavior functioning in cases where developmental regression had either already occurred or was likely to occur. Studies were summarized in term...
Source: Neuroscience and Biobehavioral Reviews - November 25, 2018 Category: Neuroscience Source Type: research

Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation
Publication date: Available online 24 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Patricia Sampedro-Piquero, David Ladrón de Guevara-Miranda, Francisco J. Pavón, Antonia Serrano, Juan Suárez, Fernando Rodríguez de Fonseca, Luis J. Santín, Estela Castilla-OrtegaAbstractDrug addiction is a chronic and relapsing disorder in which repeated drug exposure compromises brain neuroplasticity. Brain areas normally involved in learning and goal-directed behaviors become corrupted, which may lead to cognitive deficits that coexist with other addiction symptoms and predict ...
Source: Neuroscience and Biobehavioral Reviews - November 25, 2018 Category: Neuroscience Source Type: research

Editorial Board
Publication date: December 2018Source: Neuroscience & Biobehavioral Reviews, Volume 95Author(s): (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - November 25, 2018 Category: Neuroscience Source Type: research

The role of brain reward pathways in stress resilience and health
Publication date: December 2018Source: Neuroscience & Biobehavioral Reviews, Volume 95Author(s): Janine M. Dutcher, J. David CreswellAbstractWhile it is well established that stress can increase risk for a broad range of health and disease outcomes (e.g., major depression, cardiovascular disease), less is known about factors supporting resilience. An emerging literature indicates that activation of the brain’s reward system can mitigate subsequent stress responses to a broad range of stressors in animals and humans, suggesting reward pathways as a novel mechanistic target for fostering resilience under stress. Th...
Source: Neuroscience and Biobehavioral Reviews - November 25, 2018 Category: Neuroscience Source Type: research

Prefrontal cortical trkB, glucocorticoids, and their interactions in stress and developmental contexts
Publication date: December 2018Source: Neuroscience & Biobehavioral Reviews, Volume 95Author(s): Elizabeth T. Barfield, Shannon L. GourleyAbstractThe tropomyosin/tyrosine receptor kinase B (trkB) and glucocorticoid receptor (GR) regulate neuron structure and function and the hormonal stress response. Meanwhile, disruption of trkB and GR activity (e.g., by chronic stress) can perturb neuronal morphology in cortico-limbic regions implicated in stressor-related illnesses like depression. Further, several of the short- and long-term neurobehavioral consequences of stress depend on the developmental timing and context of st...
Source: Neuroscience and Biobehavioral Reviews - November 25, 2018 Category: Neuroscience Source Type: research

Quantitative neurosymptomatics; linking quantitative biology to neuropsychiatry
Publication date: Available online 23 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Martien J. Kas, Alessandro Serretti, Hugh Marston (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - November 24, 2018 Category: Neuroscience Source Type: research

Toxoplasmosis: A pathway to neuropsychiatric disorders
Publication date: Available online 23 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Shiraz Tyebji, Simona Seizova, Anthony J Hannan, Christopher J TonkinAbstractToxoplasma gondii is an obligate intracellular parasite that resides, in a latent form, in the human central nervous system. Infection with Toxoplasma drastically alters the behaviour of rodents and is associated with the incidence of specific neuropsychiatric conditions in humans. But the question remains: how does this pervasive human pathogen alter behaviour of the mammalian host? This fundamental question is receiving increasing attent...
Source: Neuroscience and Biobehavioral Reviews - November 24, 2018 Category: Neuroscience Source Type: research

Cross-Species Examination of Single- and Multi-Strain Probiotic Treatment Effects on Neuropsychiatric Outcomes
Publication date: Available online 22 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jamie M. Joseph, Catrin LawAbstractInterest in elucidating gut-brain-behavior mechanisms and advancing neuropsychiatric disorder treatments has led to a recent proliferation of probiotic trials. Yet, a considerable gap remains in our knowledge of probiotic efficacy across populations and experimental contexts. We conducted a cross-species examination of single- and multi-strain combinations of established probiotics. Forty-eight human (seven infant/child, thirty-six young/middle-aged adult, five older adult) and fi...
Source: Neuroscience and Biobehavioral Reviews - November 23, 2018 Category: Neuroscience Source Type: research

Characterizing vulnerable brain areas and circuits in mouse models of autism: Towards understanding pathogenesis and new therapeutic approaches
Publication date: Available online 22 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Kelvin Hui, Yuta Katayama, Keiichi I. Nakayama, Jun Nomura, Takeshi SakuraiAbstractRecent human genetics studies have identified many genetic variants that may be responsible for autism spectrum disorder (ASD). ASD mouse models with genetic modifications mimicking these rare genetic variants have provided invaluable mechanistic insights into the disruption of various biological processes and brain areas/circuitry affected in ASD patients. In this review, we begin by reviewing several mouse models for ASD-associated...
Source: Neuroscience and Biobehavioral Reviews - November 23, 2018 Category: Neuroscience Source Type: research

Polymorphisms in genes related to the hypothalamic-pituitary-adrenal axis and antidepressant response – systematic review
ConclusionsReplication studies and additional investigations exploring gene x environment and drug x environment interactions are necessary before pharmacological treatments may be adjusted based on a patient’s genetic profile. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - November 21, 2018 Category: Neuroscience Source Type: research

Corrigendumto “Transcranial magnetic stimulation in basic and clinical neuroscience: A comprehensive review of fundamental principles and novel insights” [Neurosci. Biobehav. Rev. 83 (2017) 381–404]
Publication date: Available online 19 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Antoni Valero-Cabré, Julià L. Amengual, Chloé Stengel, Alvaro Pascual-Leone, Olivier A. Coubard (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - November 21, 2018 Category: Neuroscience Source Type: research

Systems Biology and Gene Networks in Alzheimer's Disease
Publication date: Available online 20 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Zuo-Teng Wang, Chen-Chen Tan, Lan Tan, Jin-Tai YuAbstractGene mining has been a fruitful approach in the study of Alzheimer’s disease (AD). As a new starting point for studying AD, genetic and genomic investigations consistently strive to discover causative variants that are related to disease pathophysiology. Currently, genetic and genomic approaches have identified numerous loci. However, the elaboration of AD mechanism lagged behind gene discovery. The extensive use of parallel, high-throughput, next-gener...
Source: Neuroscience and Biobehavioral Reviews - November 21, 2018 Category: Neuroscience Source Type: research

Neuroimaging of chronic MDMA (“ecstasy”) effects: A meta-analysis
Publication date: January 2019Source: Neuroscience & Biobehavioral Reviews, Volume 96Author(s): Felix Müller, Raphael Brändle, Matthias E. Liechti, Stefan BorgwardtAbstractIn this meta-analysis, we aimed to assess the evidence from neuroimaging studies for chronic alterations in the brains of MDMA users. The databases PubMed, Embase, and Web of Science were searched for studies published from inception to August 24, 2018, without any language restriction. Sixteen independent studies comprising 356 MDMA users and 311 controls were included. Of these, five studies investigated frontal and occipital N-acetylaspa...
Source: Neuroscience and Biobehavioral Reviews - November 19, 2018 Category: Neuroscience Source Type: research

Anxious brain networks: a coordinate-based activation likelihood estimation meta-analysis of resting-state functional connectivity studies in anxiety
Publication date: Available online 17 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jie Xu, Nicholas T. Van Dam, Chunliang Feng, Yuejia Luo, Hui Ai, Ruolei Gu, Pengfei XuAbstractAnxiety and anxiety disorders are associated with specific alterations to functional brain networks, including intra-networks and inter-networks. Given the heterogeneity within anxiety disorders and inconsistencies in functional network differences across studies, identifying common patterns of altered brain networks in anxiety is imperative. Here, we conducted an activation likelihood estimation meta-analysis of resting-s...
Source: Neuroscience and Biobehavioral Reviews - November 17, 2018 Category: Neuroscience Source Type: research

Neuroimaging of chronic MDMA (“ecstasy”) effects: A meta-analysis of the literature
Publication date: Available online 12 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Felix Müller, Raphael Brändle, Matthias E. Liechti, Stefan BorgwardtAbstractIn this meta-analysis, we aimed to assess the evidence from neuroimaging studies for chronic alterations in the brains of MDMA users. The databases PubMed, Embase, and Web of Science were searched for studies published from inception to August 24, 2018, without any language restriction. Sixteen independent studies comprising 356 MDMA users and 311 controls were included. Of these, five studies investigated frontal and occipital N-...
Source: Neuroscience and Biobehavioral Reviews - November 14, 2018 Category: Neuroscience Source Type: research

Emotional control, reappraised
Publication date: Available online 6 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Saskia B.J. Koch, Rogier B. Mars, Ivan Toni, Karin RoelofsAbstractWe are frequently challenged with situations requiring the control of our emotions, often under substantial time-pressure and rapidly changing contextual demands. Coping with those demands requires the ability to flexibly and rapidly switch between different emotional control strategies. However, this ability has been largely neglected by current neurocognitive models on emotional control. Drawing on the decision-making literature, we propose that rap...
Source: Neuroscience and Biobehavioral Reviews - November 7, 2018 Category: Neuroscience Source Type: research

Attachment style: the neurobiological substrate, interaction with genetics and role in neurodevelopmental disorders risk pathways
Publication date: Available online 6 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Linda A. Antonucci, Paolo Taurisano, Gabrielle Coppola, Rosalinda CassibbaAbstractLiterature has suggested that attachment insecurity has been previously associated with subsequent onset of several psychiatric conditions characterized by emotion dysregulation. Nevertheless, only few studies have investigated the neurobiological basis of attachment style and whether attachment insecurity may share a common neurobiological substrate with neurodevelopmental disorders. In this narrative contribution, we aimed to review ...
Source: Neuroscience and Biobehavioral Reviews - November 7, 2018 Category: Neuroscience Source Type: research

Empathy is not in our genes
Publication date: Available online 3 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Cecilia HeyesAbstractIn academic and public life empathy is seen as a fundamental force of morality – a psychological phenomenon, rooted in biology, with profound effects in law, policy, and international relations. But the roots of empathy are not as firm as we like to think. The matching mechanism that distinguishes empathy from compassion, envy, schadenfreude, and sadism is a product of learning. Here I present a dual system model that distinguishes Empathy1, an automatic process that catches the feelings o...
Source: Neuroscience and Biobehavioral Reviews - November 4, 2018 Category: Neuroscience Source Type: research

Relating constructs of attention and working memory to social withdrawal in Alzheimer’s disease and schizophrenia: issues regarding paradigm selection
Publication date: Available online 3 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Gary Gilmour, Stefano Porcelli, Valérie Bertaina-Anglade, Estibaliz Arce, Juergen Dukart, Anja Hayen, Antonio Lobo, Raul Lopez Anton, Emilio Merlo Pich, Darrel J. Pemberton, Martha N. Havenith, Jeffrey Glennon, Brian Harel, Gerard Dawson, Hugh Marston, Rouba Kozak, Alessandro SerrettiAbstractCentral nervous system diseases are not currently diagnosed based on knowledge of biological mechanisms underlying their symptoms. Greater understanding may be offered through an agnostic approach to traditional disease c...
Source: Neuroscience and Biobehavioral Reviews - November 4, 2018 Category: Neuroscience Source Type: research

Motor output, neural states and auditory perception
Publication date: Available online 2 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Daniel Reznik, Roy MukamelAbstractBehavior is a complex product of interactions between sensory influx arising from the environment and the neural state of the organism. Therefore, identical sensory input can elicit different behavioral responses in different contexts. Research in recent years has demonstrated that perception is modulated when an organism is engaged in active behavior – suggesting that neural activity in motor pathways is one factor governing the neural state of networks engaged in sensory pro...
Source: Neuroscience and Biobehavioral Reviews - November 3, 2018 Category: Neuroscience Source Type: research

Oral Anticoagulants and Risk of Dementia: A Systematic Review and Meta-analysis of Observational Studies and Randomized Controlled Trials
Publication date: Available online 2 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Pajaree Mongkhon, Abdallah Y. Naser, Laura Fanning, Gary Tse, Wallis C.Y. Lau, Ian C.K. Wong, Chuenjid KongkaewAbstractAtrial fibrillation (AF) is a documented risk factor for dementia. However, it is unclear whether oral anticoagulant (OAC) treatment can reduce the development of dementia or cognitive impairment. We conducted a systematic review and meta-analysis of the association between OAC use and subsequent dementia development in AF patients by searching databases from their inception to February 2018 without...
Source: Neuroscience and Biobehavioral Reviews - November 3, 2018 Category: Neuroscience Source Type: research

Fatigue and its management in the workplace
Publication date: Available online 2 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): John A. Caldwell, J. Lynn Caldwell, Lauren A. Thompson, Harris R. LiebermanAbstractFatigue, or workplace sleepiness, is a consequence of modern industrial society. It is a complex biological phenomenon that occurs as a function of time awake, time-of-day, workload, health, and off-duty lifestyle. Fatigue is a function of two major biological factors – the homeostatic drive for sleep and circadian rhythm of sleepiness. The greatest cause of fatigue is insufficient or disrupted sleep. Excessive sleepiness in the...
Source: Neuroscience and Biobehavioral Reviews - November 3, 2018 Category: Neuroscience Source Type: research

Review of interventions for the management of anxiety symptoms in children with ASD
ConclusionsVarious methods for coping with anxiety in children with ASD have been applied,including pharmacotherapy, psychosocial andCBT interventions, parent education and school-based programs. A combination of approachesshould be selected,based onassessment of each child's particular characteristics. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - November 3, 2018 Category: Neuroscience Source Type: research

Nutritional Interventions and Cognitive-related Outcomes in Patients with Late-life Cognitive Disorders: A Systematic Review
Publication date: Available online 3 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Vincenzo Solfrizzi, Pasquale Agosti, Madia Lozupone, Carlo Custodero, Andrea Schilardi, Vincenzo Valiani, Andrea Santamato, Rodolfo Sardone, Vittorio Dibello, Luca Di Lena, Roberta Stallone, Maurizio Ranieri, Antonello Bellomo, Antonio Greco, Antonio Daniele, Davide Seripa, Carlo Sabbà, Giancarlo Logroscino, Francesco PanzaAbstractThere have been a large number of observational studies on the impact of nutrition on neuroprotection, however, there was a lack of evidence from randomized clinical trials (RCTs). ...
Source: Neuroscience and Biobehavioral Reviews - November 3, 2018 Category: Neuroscience Source Type: research

Regular cannabis use is associated with altered activation of central executive and default mode networks even after prolonged abstinence in adolescent users: results from a complementary meta-analysis
Publication date: Available online 3 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Grace Blest-Hopley, Vincent Giampietro, Sagnik BhattacharyyaAbstractWhether the effects of cannabis use on brain function persist or recover following abstinence remains unclear. Therefore, using meta-analytic techniques, we examined whether functional alterations measured using fMRI persist in cannabis users abstinent for over 25 days (or 600 hours) as evidence suggests that the effects on cognitive performance no longer persist beyond this period. Systematic literature search identified 20 studies, of which...
Source: Neuroscience and Biobehavioral Reviews - November 3, 2018 Category: Neuroscience Source Type: research

Aetiology of Eating Behaviours: a possible mechanism to understand obesity development in early childhood
Publication date: Available online 1 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Nikki Boswell, Rebecca Byrne, Peter S.W. DaviesAbstractChildhood obesity is an issue of public health concern that is understood to emerge due to disequilibrium in energy homeostasis. This commentary explores literature regarding neuro-biological mechanisms of energy homeostasis and the relationship between subjective measures of children’s eating behaviours and objective measures of appetite, in order to better understand the aetiology of childhood obesity. Early life influences, such as in utero exposure, br...
Source: Neuroscience and Biobehavioral Reviews - November 2, 2018 Category: Neuroscience Source Type: research

Neural mechanisms of emotion regulation and their role in endocrine and immune functioning: A review with implications for treatment of affective disorders
Publication date: Available online 29 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Richard B. Lopez, Bryan T. Denny, Christopher P. FagundesAbstractIn the past century, medical progress has helped increase life expectancy and improve health outcomes more generally. Despite this progress, psychiatric disorders—especially affective disorders including depressive and anxiety disorders—are quite common and have been linked to dysfunction in endocrine and immune systems. In this review, we discuss neurobiological correlates of emotion regulation strategies and their effects on mental and ph...
Source: Neuroscience and Biobehavioral Reviews - October 30, 2018 Category: Neuroscience Source Type: research

Fear as a Translational Mechanism in the Psychopathology of Anorexia Nervosa
Publication date: Available online 28 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Stuart B. Murray, Michael Strober, Michelle G. Craske, Scott Griffiths, Cheri A. Levinson, Irina A. StrigoAbstractAnorexia nervosa (AN) is an often chronic and potentially lethal psychiatric disorder, for which the precise etiology remains elusive. While current treatment outcomes are modest at best, it is thought that the identification of translational mechanisms driving the psychopathology of AN will assist in the development and optimization of novel treatments. AN is a disorder characterized by fear and avoidan...
Source: Neuroscience and Biobehavioral Reviews - October 29, 2018 Category: Neuroscience Source Type: research

Biological preparedness and resistance to extinction of skin conductance responses conditioned to fear relevant animal pictures: A systematic review
Publication date: Available online 28 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Fredrik Åhs, Jörgen Rosén, Granit Kastrati, Mats Fredrikson, Thomas Agren, Johan N. LundströmAbstractPreparedness theory is one of the most influential ideas in explaining the origin of specific phobias. The theory proposes that fear conditioning is selective to animals that have posed a threat to survival throughout human evolution, and that acquired fear memories to such threats are resistant to extinction. We reviewed fear conditioning studies testing whether autonomic responses conditioned...
Source: Neuroscience and Biobehavioral Reviews - October 29, 2018 Category: Neuroscience Source Type: research

A REVIEW OF psychiatric conceptions of mental and behavioural disorders in PRADER-WILLI SYNDROME
We present a review of psychiatric associations with comorbid mental and behavioural disorders affecting people with Prader-Willi syndrome (PWS). This literature review suggests that some assumptions about psychiatric associations of PWS behaviours are unjustified (eg skin picking as OCD) and that genetic aetiology should be considered when making associations between PWS mental and behavioural disorders and psychiatric disorders in the general populationThe literature review also demonstrates the limitations of the studies in terms of small numbers, non-representativeness, and lack of replication. (Source: Neuroscience an...
Source: Neuroscience and Biobehavioral Reviews - October 29, 2018 Category: Neuroscience Source Type: research