Environmental stressors and alcoholism development: focus on molecular targets and their epigenetic regulation
Publication date: Available online 11 July 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Mariangela Pucci, Maria Vittoria Micioni Di Bonaventura, Aranza Wille-Bille, Macarena Soledad Fernández, Mauro Maccarrone, Ricardo Marcos Pautassi, Carlo Cifani, Claudio D’AddarioAbstractAlcohol exposure and stressful events in life can induce long-lasting changes in physiology, behavior and gene expression patterns, eventually facilitating the development of psychiatric diseases like alcohol use disorders (AUD). Epigenetic mechanisms have been recently proposed to play a role in the cellular actions of al...
Source: Neuroscience and Biobehavioral Reviews - July 11, 2018 Category: Neuroscience Source Type: research

Modulation of the endocannabinoid system by sex hormones: Implications for Posttraumatic Stress Disorder
Publication date: Available online 11 July 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Luke John Ney, Allison Matthews, Raimondo Bruno, Kim Louise FelminghamAbstractThe endocannabinoid system is an increasingly recognised pharmacological target for treating stress and anxiety disorders, including post-traumatic stress disorder (PTSD). Recent preclinical developments have implicated the endocannabinoid system in stress responses, emotional memories and fear extinction, all critical to PTSD aetiology. However, preclinical research in endocannabinoid biology has neglected the influential role of sex hormone...
Source: Neuroscience and Biobehavioral Reviews - July 11, 2018 Category: Neuroscience Source Type: research

Investigating the influence of social support on experimental pain and related physiological arousal: A systematic review and meta-analysis
In this study, a meta-analysis was conducted to characterise these effects. A total of 2416 studies were identified in a systematic search, among which 21 were eligible for the quantitative review. The mere presence of another person was not sufficient to modulate pain perception. However, stranger presence was identified to decrease pain-related arousal (SMD = -0.31), and the presence of a significant other increased facial expression of pain (SMD = 0.21). We further found verbal support to decrease pain (SMD = -0.69) and arousal (SMD = -0.99), and we demonstrated moderate to large analgesic effects of intimate relati...
Source: Neuroscience and Biobehavioral Reviews - July 11, 2018 Category: Neuroscience Source Type: research

Coordinate based meta-analysis does not show grey matter atrophy in narcolepsy
Publication date: Available online 5 November 2016Source: Neuroscience & Biobehavioral ReviewsAuthor(s): C.R. Tench, Radu Tanasescu, W.J. Cottam, C.S. Constantinescu, D.P. Auer (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Transfer of maternal psychosocial stress to the fetus
Publication date: Available online 22 February 2017Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Florian Rakers, Sven Rupprecht, Michelle Dreiling, Christoph Bergmeier, Otto W. Witte, Matthias SchwabAbstractPsychosocial maternal stress experienced during different vulnerable periods throughout gestation is thought to increase the individual’s risk to develop neuropsychiatric, cardiovascular and metabolic disease in later life. Cortisol has generally been identified as the major mediator of maternal stress transfer to the fetus. Its lipophilic nature allows a trans-placental passage and thus excessive mat...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Prenatal stress and epigenetics
Publication date: Available online 18 May 2017Source: Neuroscience & Biobehavioral ReviewsAuthor(s): L. Cao-Lei, S.R. de Rooij, S. King, S.G. Matthews, G.A.S. Metz, T.J. Roseboom, M. SzyfAbstractIn utero exposure to environmental stress in both animals and humans could result in long-term epigenome alterations which further lead to consequences for adaptation and development in the offspring. Epigenetics, especially DNA methylation, is considered one of the most widely studied and well-characterized mechanisms involved in the long-lasting effects of in utero stress exposure. In this review, we outlined evidence from an...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Experience-induced transgenerational (re-)programming of neuronal structure and functions: Impact of stress prior and during pregnancy
Publication date: Available online 29 May 2017Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Katharina Braun, Jörg Bock, Tamar Wainstock, Emmanuel Matas, Inna Gaisler-Salomon, Jörg Fegert, Ute Ziegenhain, Menahem SegalAbstractThis review focuses on the inter- and transgenerational effects of stress experience prior to and during gestation. We provide an overview of findings from studies in humans as well as in animal models on brain structural and physiological functions and on the development of cognitive and executive functions. We also discuss the concept of stress-induced (re-)programming in more ...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy
Publication date: Available online 28 July 2017Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Bea R.H. Van den Bergh, Marion I. van den Heuvel, Marius Lahti, Marijke Braeken, Susanne R. de Rooij, Sonja Entringer, Dirk Hoyer, Tessa Roseboom, Katri Räikkönen, Suzanne King, Matthias SchwabAbstractAccumulating research shows that prenatal exposure to maternal stress increases the risk for behavioral and mental health problems later in life. This review systematically analyzes the available human studies to identify harmful stressors, vulnerable periods during pregnancy, specificities in the outcome and bi...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Transgenerational effects of early environmental insults on aging and disease incidence
Publication date: Available online 12 August 2017Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Mirela Ambeskovic, Tessa J. Roseboom, Gerlinde A.S. MetzAbstractAdverse early life experiences are major influences on developmental trajectories with potentially life-long consequences. Prenatal or early postnatal exposure to stress, undernutrition or environmental toxicants may reprogram brain development and increase risk of behavioural and neurological disorders later in life. Not only experience within a single lifetime, but also ancestral experience affects health trajectories and chances of successful aging. T...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Epigenetic regulation of motivated behaviors by histone deacetylase inhibitors
Publication date: Available online 8 October 2017Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Lindsay Elvir, Florian Duclot, Zuoxin Wang, Mohamed KabbajAbstractGrowing evidence has begun to elucidate the contribution of epigenetic mechanisms in the modulation and maintenance of gene expression and behavior. Histone acetylation is one such epigenetic mechanism, which has been shown to profoundly alter gene expression and behaviors. In this review, we begin with an overview of the major epigenetic mechanisms including histones acetylation. We next focus on recent evidence about the influence of environmental st...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Interpretation of published meta-analytical studies affected by implementation errors in the GingerALE software
Publication date: Available online 2 November 2017Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jane R. Garrison, John Done, Jon S. Simons (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

A quantitative approach to neuropsychiatry: The why and the how
Publication date: Available online 12 December 2017Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Martien J. Kas, Brenda Penninx, Bernd Sommer, Alessandro Serretti, Celso Arango, Hugh MarstonAbstractThe current nosology of neuropsychiatric disorders allows for a pragmatic approach to treatment choice, regulation and clinical research. However, without a biological rationale for these disorders, drug development has stagnated. The recently EU-funded PRISM project aims to develop a quantitative biological approach to the understanding and classification of neuropsychiatric diseases to accelerate the discovery and...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Social withdrawal as psychopathology of mental disorders
Publication date: Available online 27 December 2017Source: Neuroscience & Biobehavioral ReviewsAuthor(s): William T. Carpenter (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Multisensory cortical processing and dysfunction across the neuropsychiatric spectrum
Publication date: Available online 26 February 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Betty E. Hornix, Robbert Havekes, Martien J.H. KasAbstractSensory processing is affected in multiple neuropsychiatric disorders like schizophrenia and autism spectrum disorders. Genetic and environmental factors guide the formation and fine-tuning of brain circuitry necessary to receive, organize, and respond to sensory input in order to behave in a meaningful and consistent manner. During certain developmental stages the brain is sensitive to intrinsic and external factors. For example, disturbed expression levels...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Factors influencing spatial frequency extraction in faces: A review
Publication date: Available online 9 March 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Coline Jeantet, Stéphanie Caharel, Raymund Schwan, Joëlle Lighezzolo-Alnot, Vincent LaprevoteAbstractJEANTET, C., Caharel, S., Schwan, R., Lighezzolo-Alnot, J., and Laprevote, V. Factors influencing spatial frequencies extraction in faces: a review. NEUROSCI BIOBEHAV REV XX(X) XXX-XXX, 2017.Spatial frequency is an elementary aspect of visual perception. Moreover, faces elicit distinct responses by the human visual system when compared to other visual objects. This review examines the factors influencing spa...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Working memory training mostly engages general-purpose large-scale networks for learning
Publication date: Available online 21 March 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Juha Salmi, Lars Nyberg, Matti LaineAbstractThe present meta-analytic study examined brain activation changes following working memory (WM) training, a form of cognitive training that has attracted considerable interest. Comparisons with perceptual-motor (PM) learning revealed that WM training engages domain-general large-scale networks for learning encompassing the dorsal attention and salience networks, sensory areas, and striatum. Also the dynamics of the training-induced brain activation changes within these netwo...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Central fatigue theory and endurance exercise: Toward an interoceptive model
Publication date: Available online 30 March 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Terry McMorris, Martin Barwood, Jo CorbettAbstractWe propose a model of exercise-induced central fatigue based on interoception and motivation. Predictions of the expected sensory feedback are fed forward by the dorsolateral (DL) prefrontal cortex (PFC) to the anterior insula cortex (AIC). During exercise, the AIC receives feedback from lamina Ⅰ lateral spinothalamic and nucleus tractus solitarii medullothalamic pathways. The feedback is compared to the predictions in order to generate a current awareness state, whi...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Animal models of binge drinking, current challenges to improve face validity
Publication date: Available online 5 May 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jérôme Jeanblanc, Benjamin Rolland, Fabien Gierski, Margaret P. Martinetti, Mickael NaassilaAbstractBinge drinking (BD), i.e., consuming a large amount of alcohol in a short period of time, is an increasing public health issue. Though no clear definition has been adopted worldwide the speed of drinking seems to be a keystone of this behavior. Developing relevant animal models of BD is a priority for gaining a better characterization of the neurobiological and psychobiological mechanisms underlying this dange...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Non-invasive biomarkers of fetal brain development reflecting prenatal stress: An integrative multi-scale multi-species perspective on data collection and analysis
Publication date: Available online 30 May 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Martin G. Frasch, Silvia M. Lobmaier, Tamara Stampalija, Paula Desplats, María Eugenia Pallarés, Verónica Pastor, Marcela A. Brocco, Hau-tieng Wu, Jay Schulkin, Christophe L. Herry, Andrew J.E. Seely, Gerlinde A.S. Metz, Yoram Louzoun, Marta C. AntonelliAbstractPrenatal stress (PS) impacts early postnatal behavioural and cognitive development. This process of ‘fetal programming’ is mediated by the effects of the prenatal experience on the developing hypothalamic–pituitary–adr...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Amygdala where art thou?
Publication date: Available online 7 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Miquel A. Fullana, Anton Albajes-Eizagirre, Carles Soriano-Mas, Bram Vervliet, Narcís Cardoner, Olívia Benet, Joaquim Radua, Ben J. Harrison (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Clinical use of semantic space models in psychiatry and neurology: A systematic review and meta-analysis
Publication date: Available online 8 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): J.N. de Boer, A.E. Voppel, M.J.H. Begemann, H.G. Schnack, F. Wijnen, I.E.C. SommerAbstractVerbal communication disorders are a hallmark of many neurological and psychiatric illnesses. Recent developments in computational analysis provide objective characterizations of these language abnormalities. We conducted a meta-analysis assessing semantic space models as a diagnostic or prognostic tool in psychiatric or neurological disorders. Diagnostic test accuracy analyses revealed reasonable sensitivity and specificity and hi...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

From controlled to compulsive drug-taking: The role of the habenula in addiction
Publication date: Available online 21 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Victor Mathis, Paul J. KennyAbstractAddiction is now recognized as a neurobiological and cognitive brain disorder and is generally viewed as a switch from recreational or voluntary to compulsive substance use despite aversive consequences. The habenula, composed of medial (MHb) and lateral (LHb) domains, has been implicated in regulating behavioral flexibility and anxiety-related behaviors and is considered a core component of the brain “anti-reward” system. These functions position the habenula to influenc...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Why cognitive event-related potentials (ERPs) should have a role in the management of alcohol disorders
Publication date: Available online 21 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Salvatore Campanella, Elisa Schroder, Hendrik Kajosch, Xavier Noel, Charles KornreichAbstractAlcohol dependence is currently one of the most serious public health problems. Indeed, 3–8% of all deaths worldwide are attributable to effects of alcohol consumption. Although the first step in alcohol dependence treatment is straightforward, the main problem for clinicians lies with the prevention of relapse, as 40–70% of patients who only undergo psychosocial therapy resume alcohol use within a year following tr...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Role of Kynurenine Pathway and its Metabolites in Mood Disorders: A Systematic Review and Meta-Analysis of Clinical Studies
Publication date: Available online 22 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Danilo Arnone, Smita Saraykar, Haitham Salem, Antonio L. Teixeira, Robert Dantzer, Sudhakar SelvarajABSTRACTActivation of the kynurenine pathway is one of the described mechanisms by which inflammation can induce depression. It involves multiple pathways including interference with the bioavailability of tryptophan central to the synthesis of the neurotransmitter serotonin.In this systematic review, we examine the relationship between kynurenine metabolites (kynurenine, kynurenic acid, tryptophan, quinolinic acid, the ...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Overview of the clinical implementation of a study exploring social withdrawal in patients with schizophrenia and Alzheimer’s disease
Publication date: Available online 22 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Amy C. Bilderbeck, Brenda W.J.H. Penninx, Celso Arango, Nic van der Wee, René Kahn, Inge Winter-van Rossum, Anja Hayen, Martien J. Kas, Anke Post, Gerard R. DawsonABSTRACTTrans-diagnostic, domain- or symptom-focused approaches have been heralded as advancing psychiatric research, but relatively few clinical research programmes have been undertaken to leverage their potential. In this manuscript we describe the approach and protocol for an exploratory study, PRISM (Psychiatric Ratings using Intermediate Stratifie...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Executive Dysfunction in Parkinson’s Disease: A Meta-Analysis on the Wisconsin Card Sorting Test Literature
Publication date: Available online 23 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Florian Lange, Carolin Brückner, Aylin Knebel, Caroline Seer, Bruno KoppAbstractExecutive dysfunctions are a frequently described non-motor symptom in patients with Parkinson’s disease (PD). However, the nature, extent, variability, and determinants of executive dysfunctions in PD are still poorly understood. To improve the characterization of executive dysfunctions in PD, we conducted a meta-analysis of the studies administering the Wisconsin Card Sorting Test (WCST) to patients with PD and healthy controls...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Strategies for integrated analysis in imaging genetics studies
Publication date: Available online 23 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Natàlia Vilor-Tejedor, Silvia Alemany, Alejandro Cáceres, Mariona Bustamante, Jesús Pujol, Jordi Sunyer, Juan R. GonzálezAbstractImaging Genetics (IG) integrates neuroimaging and genomic data from the same individual, deepening our knowledge of the biological mechanisms behind neurodevelopmental domains and neurological disorders. Although the literature on IG has exponentially grown over the past years, the majority of studies have mainly analyzed associations between candidate brain region...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Working definitions, subjective and objective assessments and experimental paradigms in a study exploring social withdrawal in schizophrenia and Alzheimer’s disease
Publication date: Available online 24 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Nic. J.A. van der Wee, Amy C. Bilderbeck, Maria Cabello, Jose L. Ayuso-Mateos, Ilya M.J. Saris, Erik J. Giltay, Brenda WJH. Penninx, Celso Arango, Anke Post, Stefano PorcelliAbstractSocial withdrawal is one of the first and common signs of early social dysfunction in a number of important neuropsychiatric disorders, likely because of the enormous amount and complexity of brain processes required to initiate and maintain social relationships (Adolphs, 2009). The Psychiatric Ratings using Intermediate Stratified Markers ...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Neuropeptide modulation of addiction: Focus on galanin
Publication date: Available online 24 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Shannyn G. Genders, Karlene J. Scheller, Elvan DjoumaAbstractAddiction is a chronic, relapsing disorder characterised by the use of a substance or act to the point of compulsion. There are a number of medical treatments available for the intervention of these disorders, however, the effectiveness of current therapeutics is far from adequate. Neuropeptides are known to modulate addictive behaviours and may provide new therapeutic targets for the treatment of substance abuse. Accumulating evidence has suggested galanin a...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

A systematic review and meta-analysis of structural magnetic resonance imaging studies investigating cognitive and social activity levels in older adults
Publication date: Available online 27 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): M. Anatürk, N. Demnitz, K.P. Ebmeier, C.E. SextonAbstractPopulation aging has prompted considerable interest in identifying modifiable factors that may help protect the brain and its functions. Collectively, epidemiological studies show that leisure activities with high mental and social demands are linked with better cognition in old age. The extent to which socio-intellectual activities relate to the brain’s structure is, however, not yet fully understood. This systematic review and meta-analysis summarize...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Purinergic modulation of glutamate transmission: An expanding role in stress-linked neuropathology
Publication date: Available online 28 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): J. Mayhew, B.A. Graham, K. Biber, M. Nilsson, F.R. WalkerAbstractChronic stress has been extensively linked to disturbances in glutamatergic signalling. Emerging from this field of research is a considerable number of studies identifying the ability of purines at the pre-, post-, and peri-synaptic levels to tune glutamatergic neurotransmission. While the evidence describing purinergic control of glutamate has continued to grow, there has been relatively little attention given to how chronic stress modulates purinergic ...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

It's time: A commentary on fear extinction in the human brain using fMRI
Publication date: Available online 30 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jayne Morriss, Shannon Hoare, Carien M. van ReekumAbstractThe recent meta-analysis by Fullana et al. (2018) is both timely and significant, providing a vital milestone towards understanding the neural networks involved in threat extinction in humans. Fullana et al. (2018) examined both threat extinction and recall separately using sophisticated meta-analytic methods based on raw contrast maps. Importantly, the meta-analysis highlighted a lack of consistent activation across studies for key neural “players” ...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Prenatal exposure to environmental insults and enhanced risk of developing Schizophrenia and Autism Spectrum Disorder: Focus on biological pathways and epigenetic mechanisms
Publication date: Available online 4 July 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Nadia Cattane, Juliet Richetto, Annamaria CattaneoaAbstractWhen considering neurodevelopmental disorders (NDDs), Schizophrenia (SZ) and Autism Spectrum Disorder (ASD) are considered to be among the most severe in term of prevalence, morbidity and impact on the society.Similar features and overlapping symptoms have been observed at multiple levels, suggesting common pathophysiological bases. Indeed, recent genome-wide association studies (GWAS) and epidemiological data report shared vulnerability genes and environmental ...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Food intake and addictive-like eating behaviors: time to think about the circadian clock(s)
Publication date: Available online 7 July 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jorge MendozaAbstractCompulsive feeding has been considered as an addicted-like behavior with similarities to drug addiction. Food intake is brain controlled involving a balance between metabolic and hedonic pathways that modulate respectively how much and what is eaten. Pathological conditions such as compulsive feeding or an eating addiction can interfere with this balance and obesity may develop. Daily feeding times are also centrally controlled by the circadian clock in the suprachiasmatic nucleus. Disruptions of th...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Editorial Board
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Editorial: Jeffrey Glennon & Simone Macrì
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Understanding heterogeneity in conduct disorder: A review of psychophysiological studies
In conclusion, it might be important to redefine CD diagnostic criteria based on physiological heterogeneity to enable the identification of distinct subtypes of CD. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Psychiatric evaluation of youths with Disruptive Behavior Disorders and psychopathic traits: A critical review of assessment measures
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Gabriele Masi, Annarita Milone, Paola Brovedani, Simone Pisano, Pietro MuratoriAbstractDisruptive Behavior Disorders (DBDs) are stable and impairing disorders, heterogeneous in presentation, developmental pathways, and treatment needs. Disentangling subtypes according to psychopathological dimensions is helpful for timely diagnoses, precise prognoses and tailored interventions. Psychopathic traits are relevant in subtyping DBDs with severe antisocial and aggressive behaviors. Three psychopathy dimensions have been found: 1) a...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Mapping the developmental pathways of child conduct problems through the neurobiology of empathy
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Caroline Moul, David J. Hawes, Mark R. DaddsAbstractThe notion that antisocial behavior reflects failures of empathy has a long history in the clinical literature, yet only recently has evidence emerged to support neuroscientific accounts of empathy and the development of child conduct problems. Much of this evidence has come from research into callous-unemotional traits, which correspond to the affective component of psychopathy and therefore encompass deficits in empathy within a broader cluster of emotional impairments. In...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Clock genes, ADHD and aggression
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Floriana Mogavero, Amanda Jager, Jeffrey C. GlennonAbstractAttention deficit/hyperactivity disorder (ADHD) is frequently associated with comorbid aggression and sleep disturbances. The sleep/wake cycle is under the control of the circadian system which is moderated by clock genes. Clock genes can regulate the transcription of monoamine oxidase A, which is involved in the degradation of monoamines. Disturbances in monoamine interaction with clock genes in those with monoamine gene polymorphisms may regulate susceptibility of A...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Neuro-cognitive system dysfunction and symptom sets: A review of fMRI studies in youth with conduct problems
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): R.J.R. Blair, K. Veroude, J.K. BuitelaarAbstractIn this paper, we review fMRI work on neuro-cognitive systems that are considered to be dysfunctional in individuals with conduct problems (i.e., individuals with Conduct Disorder (CD), Oppositional Defiant Disorder (ODD) or antisocial behavior without formal clinical diagnosis). These are: empathy, the acute threat response, reinforcement-based decision-making, response inhibition and the Default Mode Network. Evidence regarding the Default Mode Network is somewhat inconsistent...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Genetic influences on conduct disorder
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Jessica E. Salvatore, Danielle M. DickAbstractConduct disorder (CD) is a moderately heritable psychiatric disorder of childhood and adolescence characterized by aggression toward people and animals, destruction of property, deceitfulness or theft, and serious violation of rules. Genome-wide scans using linkage and association methods have identified a number of suggestive genomic regions that are pending replication. A small number of candidate genes (e.g., GABRA2, MAOA, SLC6A4, AVPR1A) are associated with CD related phenotyp...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Can laboratory animals violate behavioural norms? Towards a preclinical model of conduct disorder
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Simone Macrì, Francesca Zoratto, Flavia Chiarotti, Giovanni LaviolaAbstractConduct disorder (CD), a disturbance characterised by excess rates of aggression – often associated with callousness, lack of empathy and shallow/deficient affect – is extremely prevalent (2–10%) in the juvenile population. CD symptoms are quantitative rather than qualitative in nature whereby, rather than exhibiting abnormal behaviours, CD patients indulge in normal behaviours at abnormal rates. Although genetic and environmen...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Preclinical models of conduct disorder – principles and pharmacologic perspectives
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Jozsef HallerAbstractThe translational value of preclinical research was recently enhanced by abnormal aggression models, which focus on deviant behaviors induced by the exposure of rodents to etiological factors of aggression-related psychopathologies. Prompted by similar trials in other psychiatric disorders, here we investigate models of abnormal aggression from the perspective of DSM5 criteria. After proposing principles based on which analogies can be established between psychopathology symptoms and rodent behavioral dys...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Towards an animal model of callousness
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Julen Hernandez-Lallement, Marijn van Wingerden, Tobias KalenscherAbstractCallous-unemotional traits – the insensitivity to other’s welfare and well-being – are characterized by a lack of empathy. They are characteristic of psychopathy and can be found in other anti-social disorders, such as conduct disorder. Because of the increasing prevalence of anti-social disorders and the rising societal costs of violence and aggression, it is of great importance to elucidate the psychological and physiological mechani...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Behavioral and mechanistic insight into rodent empathy
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Sivaani Sivaselvachandran, Erinn L. Acland, Salsabil Abdallah, Loren J. MartinAbstractEmpathy is a psychological construct that allows individuals to understand and share the emotions of others. The ability to share emotional states relies on basic social mechanisms, such as mimicry and emotional contagion, which are considered building blocks for empathy. Mimicking another’s emotional or physical state is essential for successful social interactions and is found in a number of animal species. For the current review we ...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

The link between aberrant hypothalamic–pituitary–adrenal axis activity during development and the emergence of aggression—Animal studies
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Sophie E. Walker, Aurélie Papilloud, Damien Huzard, Carmen SandiAbstractAggressive behavior is not uniform, including proactive and reactive forms of aggression. Aberrant functioning of the hypothalamic–pituitary–adrenal (HPA) axis is frequently associated with abnormal aggression. Here, we review the rodent literature in order to assess whether developmental abnormalities in the HPA axis can be causally linked with the emergence of abnormal aggression. We examine studies that involve genetic models and lif...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Association of trauma, Posttraumatic Stress Disorder and Conduct Disorder: A systematic review and meta-analysis
ConclusionsStudies focusing on the association of trauma, PTSD and CD are still relatively rare. Possible comorbidity models are discussed considering psychological and biological risk factors in a comprehensive model. The high rate of PTSD in CD may be due to shared risk factors; furthermore, CD might increase the risk for comorbid PTSD due to CD inherent risk taking behavior. To study pathways of risk, especially longitudinal studies are necessary. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Antisocial behaviour and psychopathy: Uncovering the externalizing link in the P3 modulation
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Rita Pasion, Carina Fernandes, Mariana R. Pereira, Fernando BarbosaAbstractIn 2009, Gao and Raine's meta-analysis analysed P3 modulation over the antisocial spectrum. However, some questions remained open regarding the P3 modulation patterns across impulsive and violent manifestations of antisocial behaviour, phenotypic components of psychopathy, and P3 components. A systematic review of 36 studies was conducted (N = 3514) to extend previous results and to address these unresolved questions. A clear link between dec...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

The impact of chronic stress during adolescence on the development of aggressive behavior: A systematic review on the role of the dopaminergic system in rodents
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Jorim J Tielbeek, Zeineb Al-Itejawi, Josjan Zijlmans, Tinca JC Polderman, Joshua W Buckholtz, Arne PopmaAbstractPathological aggression, frequently observed in psychiatric patients and criminal subjects, poses a major burden on the health care and criminal justice system, necessitating better aetiological models to inform targets for prevention and intervention. Emerging evidence suggests that adverse experiences during development can cause long-lasting brain alterations associated with maladaptive behaviors, such as aggress...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research