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Condition: ALS

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Total 644 results found since Jan 2013.

Alternative medicine therapies in neurological disorders: Prevalence, reasons and associated factors. A systematic review
CONCLUSIONS: The prevalence of CAM use in neurological diseases is highly variable (16%-100%); the most used type of CAM was biological therapies and the associated factors were female sex, age between 40 and 50 years old and high socioeconomic level.PMID:36805318 | DOI:10.1016/j.ctim.2023.102932
Source: Complementary Therapies in Medicine - February 22, 2023 Category: Complementary Medicine Authors: Mar ía Soto-Lara Melissa Silva-Loredo Jos é Rodrigo Monroy-Córdoba Paola Flores-Ordo ñez Nelly G Cervera-Delgadillo Paul Carrillo-Mora Source Type: research

Tetracyclines and neuromuscular disorders.
Abstract Tetracyclines are a class of antibiotics which could act as neuroprotective molecules in several neurological disorders, such as Huntington disease, Parkinson disease, stroke and multiple sclerosis. The main biological effects of tetracyclines are the inhibition of microglial activation, the attenuation of apoptosis and the suppression of reactive oxygen species production. The anti-apoptotic effect of tetracyclines involves the mitochondrion, and the major target for neuroprotective effects of tetracyclines lies within the complex network that links mitochondria, oxidative stress and apoptosis.Neuromuscu...
Source: Current Neuropharmacology - June 1, 2012 Category: Drugs & Pharmacology Authors: Orsucci D, Mancuso M, Filosto M, Siciliano G Tags: Curr Neuropharmacol Source Type: research

Epidemiology of neurologically disabling disorders - Tennant A.
Neurological disorders place a considerable burden upon individuals, their families, and society. Some like stroke are common, while others like amyotrophic lateral sclerosis are much rarer. Some conditions such as multiple sclerosis are reported to vary b...
Source: SafetyLit: All (Unduplicated) - January 18, 2013 Category: Global & Universal Tags: Risk Factor Prevalence, Injury Occurrence Source Type: news

Neural stem cell‐based treatment for neurodegenerative diseases
Human neurodegenrative diseases such as Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) are caused by a loss of neurons and glia in the brain or spinal cord. Neurons and glial cells have successfully been generated from stem cells such as embryonic stem cells (ESCs), mesenchymal stem cells (MSCs) and neural stem cells (NSCs), and stem cell‐based cell therapies for neurodegenerative diseases have been developed. A recent advance in generatioin of a new class of pluripotent stem cells, induced pluripotent stem cells (iPSCs), derived from patients' own sk...
Source: Neuropathology - February 1, 2013 Category: Neurology Authors: Seung U. Kim, Hong J. Lee, Yun B. Kim Tags: Review Article Source Type: research

Toward gaze-independent brain-computer interfaces
The ability to communicate by speech, text or gestures is essential to human interaction. This ability is impaired in many people who are affected by debilitating neuromuscular disorders such as amyotrophic lateral sclerosis (ALS), brainstem stroke, or spinal cord injury. Conventional assistive devices (e.g., letter boards, cheek or tongue switches, or eye trackers) that aim to restore communication functions all require muscular control, which is often lost in the progress of neuromuscular disorders.
Source: Clinical Neurophysiology - March 6, 2013 Category: Neuroscience Authors: Peter Brunner, Gerwin Schalk Tags: Editorials Source Type: research

VIP and PACAP: Neuropeptide modulators of CNS inflammation, injury, and repair
Summary page Inflammatory processes play both regenerative and destructive roles in multiple sclerosis, stroke, CNS trauma, amyotrophic lateral sclerosis (ALS) and aging‐related neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. Endogenous defense mechanisms against these pathologies include those that are directly neuroprotective, and those that modulate the expression of inflammatory mediators in microglia, astrocytes, and invading inflammatory cells. While a number of mechanisms and molecules have been identified that can directly promote neuronal survival, less is known about how the brain...
Source: British Journal of Pharmacology - March 20, 2013 Category: Drugs & Pharmacology Authors: J A Waschek Tags: Review Article Source Type: research

Co-Enzyme Q10 to Treat Neurological Disorders: Basic Mechanisms, Clinical Outcomes, and Future Research Direction.
Abstract Coenzyme Q10 (CoQ10) plays a pivotal role in mitochondrial respiratory chain which is the cell power supply. CoQ10 serves as a physiological electron (e-) shuttle from complexes I and II to complex III, as well as a potent antioxidant. Neurons are characterized by high rates of metabolic activity and need to respond promptly to activity-dependent fluctuations in bioenergetic demand. Consequently, it is not surprising that mitochondrial alterations can promote neuronal dysfunction and degeneration. In several neurological disorders, dysfunction of the respiratory chain leads to reduced ATP levels and incre...
Source: CNS and Neurological Disorders Drug Targets - April 4, 2013 Category: Drugs & Pharmacology Authors: Salama M, Yuan TF, Machado S, Murillo-Rodríguez E, Vega JA, Menéndez-González M, Nardi AE, Arias-Carrión O Tags: CNS Neurol Disord Drug Targets Source Type: research

Chronic over‐expression of TGFβ1 alters hippocampal structure and causes learning deficits
Abstract The cytokine Transforming Growth Factor β1 (TGFβ1) is chronically upregulated in several neurodegenerative conditions, including Alzheimer's disease, Parkinson's disease, Creutzfeldt‐Jacob disease, amyotrophic lateral sclerosis and multiple sclerosis, and following stroke. While previous studies have shown that TGFβ1 may be neuroprotective, chronic exposure to elevated levels of this cytokine may contribute to disease pathology on its own. In order to study the effects of chronic exposure to TGFβ1 in isolation we used transgenic mice that over‐express a constitutively active porcine TGFβ1 in astrocytes. W...
Source: Hippocampus - June 27, 2013 Category: Neurology Authors: Alonso Martinez‐Canabal, Anne L. Wheeler, Dani Sarkis, Jason P. Lerch, Wei‐Yang Lu, Marion S. Buckwalter, Tony Wyss‐Coray, Sheena A. Josselyn, Paul W. Frankland Tags: Research Article Source Type: research

Posttrauma cotreatment with lithium and valproate: reduction of lesion volume, attenuation of blood-brain barrier disruption, and improvement in motor coordination in mice with traumatic brain injury.
Conclusions Cotreatment with subeffective doses of lithium and VPA significantly attenuated TBI-induced brain lesion, BBB disruption, and neurodegeneration, and robustly improved long-term functional recovery. These findings suggest that potentiating histone acetylation by HDAC inhibition is probably part of the mechanism underlying the beneficial effects associated with this combined treatment for TBI. Because both lithium and VPA have a long history of safe clinical use, the results suggest that using a combination of these 2 agents at subtherapeutic doses to treat patients with TBI may also reduce side effects and enhan...
Source: Journal of Neurosurgery - July 12, 2013 Category: Neurosurgery Authors: Yu F, Wang Z, Tanaka M, Chiu CT, Leeds P, Zhang Y, Chuang DM Tags: J Neurosurg Source Type: research

Fatigue in Healthy and Diseased Individuals.
CONCLUSIONS: Fatigue needs to be recognized as an important condition that is not only a symptom but may also be quantified and can be modified by various measures depending on the underlying cause. PMID: 23892338 [PubMed - as supplied by publisher]
Source: The American Journal of Hospice and Palliative Care - July 26, 2013 Category: Palliative Care Authors: Finsterer J, Mahjoub SZ Tags: Am J Hosp Palliat Care Source Type: research

Inhaled Stem Cells Might Replace Lost Neurons
Many diseases of the central nervous system involve the death of neurons--so, theoretically, the replacement of dead cells should improve symptoms of degenerative disorders such as Parkinson's, Huntington's, amyotrophic lateral sclerosis (ALS) and Alzheimer's, as well as stroke and brain tumors. Stem cell therapy may do just that even though evidence of its effectiveness is mixed. [More]
Source: Scientific American - Official RSS Feed - October 19, 2013 Category: Science Tags: Health,Health,Pharmaceuticals,Biotechnology,Biotechnology,Medical Technology,Biology,More Science Source Type: research

Mitochondrial metals as a potential therapeutic target in neurodegeneration
Summary Transition metals are critical for enzyme function and protein folding, but in excess can mediate neurotoxic oxidative processes. As mitochondria are particularly vulnerable to oxidative damage due to radicals generated during ATP production, mitochondrial biometal homeostasis must therefore be tightly controlled to safely harness the redox potential of metal enzyme cofactors. Dysregulation of metal functions is evident in numerous neurological disorders including Alzheimer's disease, stroke, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and Friedrich's Ataxia. This review describes the m...
Source: British Journal of Pharmacology - November 11, 2013 Category: Drugs & Pharmacology Authors: A Grubman, A R White, J R Liddell Tags: Review Article – Mitochondrial Pharmacology: Energy, Injury & Beyond Themed Issue Source Type: research

NRF2-regulation in brain health and disease: implication of cerebral inflammation.
Abstract The nuclear factor erythroid 2 related factor 2 (NRF2) is a key regulator of endogenous inducible defense systems in the body. Under physiological conditions NRF2 is mainly located in the cytoplasm. However, in response to oxidative stress, NRF2 translocates to the nucleus and binds to specific DNA sites termed "anti-oxidant response elements" or "electrophile response elements" to initiate transcription of cytoprotective genes. Acute oxidative stress to the brain, such as stroke and traumatic brain injury is increased in animals that are deficient in NRF2. Insufficient NRF2 activation in humans has been ...
Source: Neuropharmacology - November 18, 2013 Category: Drugs & Pharmacology Authors: Sandberg M, Patil J, D'Angelo B, Weber SG, Mallard C Tags: Neuropharmacology Source Type: research

What Causes Muscle Weakness?
Discussion Muscle tone is the slight tension that is felt in a muscle when it is voluntarily relaxed. It can be assessed by asking the patient to relax and then taking the muscles through a range of motion such as moving the wrists, forearm and upper arm. Muscle strength is the muscle’s force against active resistance. Impaired strength is called weakness or paresis. There are 5 levels of muscle strength. 0 = No muscle contraction detected 1 = Barely detected flicker of contraction 2 = Active movement with gravity eliminated 3 = Active movement against gravity 4 = Active movement against gravity and some resistance ...
Source: PediatricEducation.org - December 9, 2013 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news