Differential responsivity of neurons in perirhinal cortex, lateral entorhinal cortex, and dentate gyrus during time ‐bridging learning
AbstractMany studies have focused on the function of hippocampal region CA1 as a critical site for associative memory, but much less is known about changes in the afferents to CA1. Here we report the activity of multiple single neurons from perirhinal and entorhinal cortex and from dentate gyrus during trace eyeblink conditioning as well as consolidated recall, and in pseudo ‐conditioned control rabbits. We also report an analysis of theta activity filtered from the local field potential (LFP). Our results show early associative changes in single‐neuron firing rate as well as theta oscillations in lateral entorhinal co...
Source: Hippocampus - November 25, 2018 Category: Neurology Authors: Eug énie E. Suter,
Craig Weiss,
John F. Disterhoft Tags: RESEARCH ARTICLE Source Type: research
Remodeling of cholinergic input to the hippocampus after noise exposure and tinnitus induction in guinea pigs
ConclusionsThe robust changes in VAChT labeling in the hippocampus two weeks after noise exposure suggest involvement of this circuitry in auditory processing. After chronic tinnitus induction, tinnitus ‐specific changes occurred in synapse‐rich layers of the hippocampus, suggesting that synaptic processing in the hippocampus may play an important role in the pathophysiology of tinnitus.This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - November 24, 2018 Category: Neurology Authors: Liqin Zhang,
Calvin Wu,
David T. Martel,
Michael West,
Michael A. Sutton,
Susan E. Shore Tags: RESEARCH ARTICLE Source Type: research
Memory Image Completion: Establishing a task to behaviorally assess pattern completion in humans
AbstractFor memory retrieval, pattern completion is a crucial process that restores memories from partial or degraded cues. Neurocognitive aging models suggest that the aged memory system is biased toward pattern completion, resulting in a behavioral preference for retrieval over encoding of memories. Here, we built on our previously developed behavioral recognition memory paradigm —the Memory Image Completion (MIC) task—a task to specifically target pattern completion. First, we used the original design with concurrent eye‐tracking in order to rule out perceptual confounds that could interact with recognition perfor...
Source: Hippocampus - November 23, 2018 Category: Neurology Authors: Paula Vieweg,
Martin Riemer,
David Berron,
Thomas Wolbers Tags: RESEARCH ARTICLE Source Type: research
Cover Image, Volume 28, Issue 11
Cover legend: This cover image is based on the Research Article.A new human delayed ‐matching‐to‐place test in a virtual environment reverse‐translated from the rodent watermaze paradigm: characterization of performance measures and sex differences, by Matthew G. Buckley and Tobias Bast, DOI:10.1002/hipo.22992. (Source: Hippocampus)
Source: Hippocampus - November 23, 2018 Category: Neurology Authors: Matthew G. Buckley,
Tobias Bast Tags: COVER IMAGE Source Type: research
Issue Information ‐ TOC
Hippocampus, Volume 28, Issue 11, Page C4-C4, November 2018. (Source: Hippocampus)
Source: Hippocampus - November 23, 2018 Category: Neurology Tags: ISSUE INFORMATION ‐ TOC Source Type: research
Issue Information ‐ Editorial Board
Hippocampus, Volume 28, Issue 11, Page 765-765, November 2018. (Source: Hippocampus)
Source: Hippocampus - November 23, 2018 Category: Neurology Tags: ISSUE INFORMATION ‐ EDITORIAL BOARD Source Type: research
Temporal coding and rate remapping: Representation of nonspatial information in the hippocampus
AbstractHippocampal place cells represent nonspatial information through a process called rate remapping, which involves a change in the firing rate of a place cell without changes in its spatial specificity. However, many hippocampal phenomena occur on very short time scales over which long ‐term average firing rates are not an appropriate description of activity. To understand how rate remapping relates to fine‐scale temporal firing phenomena, we asked how rate remapping affected burst firing and trial‐to‐trial spike count variability. In addition, we looked at how rate remapp ing relates to the theta‐frequency...
Source: Hippocampus - November 22, 2018 Category: Neurology Authors: Honi Sanders,
Daoyun Ji,
Takuya Sasaki,
Jill K. Leutgeb,
Matthew A. Wilson,
John E. Lisman Tags: RESEARCH ARTICLE Source Type: research
Cover Image, Volume 28, Issue 10
Cover legend: This cover image is based on the Research ArticleChanges in patterns of neural activity underlie a time ‐dependent transformation of memory in rats and humans by Melanie J. Sekeres et al., DOI:10.1002/hipo.23009. (Source: Hippocampus)
Source: Hippocampus - November 21, 2018 Category: Neurology Authors: Melanie J. Sekeres,
Gordon Winocur,
Morris Moscovitch,
John A. E. Anderson,
Sara Pishdadian,
J. Martin Wojtowicz,
Marie St ‐Laurent,
Mary Pat McAndrews,
Cheryl L. Grady Tags: COVER IMAGE Source Type: research
Issue Information ‐ TOC
Hippocampus, Volume 28, Issue 10, Page C4-C4, October 2018. (Source: Hippocampus)
Source: Hippocampus - November 21, 2018 Category: Neurology Tags: ISSUE INFORMATION ‐ TOC Source Type: research
Issue Information ‐ Editorial Board
Hippocampus, Volume 28, Issue 10, Page 689-689, October 2018. (Source: Hippocampus)
Source: Hippocampus - November 21, 2018 Category: Neurology Tags: ISSUE INFORMATION ‐ EDITORIAL BOARD Source Type: research
Priming of LTP in amygdala and hippocampus by prior paired pulse facilitation paradigm in mice lacking brain serotonin
This study focuses on analyzing long term potentiation (LTP) changes in the lateral nucleus of the amygdala (LA) and in the CA1 region of the hippocampus in slices derived from mice deficient in tryptophan hydroxylase 2 (TPH2‐/‐), the rate ‐limiting enzyme for 5‐HT synthesis in the brain. We found a reduced LTP in both brain structures in TPH2‐/‐ mice. However, we found no changes in the magnitude of LTP in TPH2‐/‐ mice compared to wildtype mice when it was preceded by a paired pulse protocol. Whereas the magnitude of long term depression (LTD) did not differ between wildtype and TPH2‐/‐ mice, priming s...
Source: Hippocampus - November 20, 2018 Category: Neurology Authors: Christine Gebhardt,
Valentina Mosienko,
Natalia Alenina,
Doris Albrecht Tags: RESEARCH ARTICLE Source Type: research
A new human delayed ‐matching‐to‐place test in a virtual environment reverse‐translated from the rodent watermaze paradigm: Characterization of performance measures and sex differences
AbstractWatermaze tests of place learning and memory in rodents and corresponding reverse ‐translated human paradigms in real or virtual environments are key tools to study hippocampal function. In common variants, the animal or human participant has to find a hidden goal that remains in the same place over many trials, allowing for incremental learning of the place with reference to d istal cues surrounding the circular, featureless maze. Although the hippocampus is involved in incremental place learning, rodent studies have shown that the delayed‐matching‐to‐place (DMP) watermaze test is a more sensitive assay of...
Source: Hippocampus - November 19, 2018 Category: Neurology Authors: Matthew G. Buckley,
Tobias Bast Tags: RESEARCH ARTICLE Source Type: research
Frequency ‐specific noninvasive modulation of memory retrieval and its relationship with hippocampal network connectivity
This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - November 17, 2018 Category: Neurology Authors: Molly S. Hermiller,
Stephen VanHaerents,
Tommi Raij,
Joel L. Voss Tags: RESEARCH ARTICLE Source Type: research
Targeting hippocampal adult neurogenesis using transcription factors to reduce Alzheimer's disease ‐associated memory impairments
This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - November 14, 2018 Category: Neurology Authors: Robin Dard,
Lionel Dahan,
Claire Rampon Tags: RESEARCH ARTICLE Source Type: research
A neural microcircuit model for a scalable scale ‐invariant representation of time
AbstractScale ‐invariant timing has been observed in a wide range of behavioral experiments. The firing properties of recently describedtime cells provide a possible neural substrate for scale ‐invariant behavior. Earlier neural circuit models do not produce scale‐invariant neural sequences. In this article, we present a biologically detailed network model based on an earlier mathematical algorithm. The simulations incorporate exponentially decaying persistent firing maintained by the calcium‐activated nonspecific (CAN) cationic current and a network structure given by the inverse Laplace transform to generate time...
Source: Hippocampus - November 13, 2018 Category: Neurology Authors: Yue Liu,
Zoran Tiganj,
Michael E. Hasselmo,
Marc W. Howard Tags: RESEARCH ARTICLE Source Type: research
