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Condition: Addison's Disease

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Total 48 results found since Jan 2013.

Effect of Postural Hypotension on Recurrent Stroke: Secondary Prevention of Small Subcortical Strokes (SPS3) Study
Background: Orthostatic hypotension (OH) has been independently associated with increased risk of stroke and other cardiovascular events. We sought to investigate the relationship between OH at follow-up and recurrent stroke risk in SPS3 (Secondary Prevention of Small Subcortical Strokes) trial patient cohort. This is a retrospective cohort analysis. Methods: We included all SPS3 trial participants with blood pressure measurements in both sitting and standing position per protocol at baseline, with at least 1 follow-up visit to establish the relationship between OH at follow-up and recurrent stroke risk (primary outcome).
Source: Journal of Stroke and Cerebrovascular Diseases - May 26, 2019 Category: Neurology Authors: Tapan Mehta, Leslie A. McClure, Carole L. White, Addison Taylor, Oscar R. Benavente, Kamakshi Lakshminarayan Source Type: research

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly
Conclusions World population is aging and the increase in life expectancy is often unhealthy. In particular, musculoskeletal aging, which leads to sarcopenia and osteoporosis, has several causes such as changes in body composition, inflammation, and hormonal imbalance. Sarcopenia, osteoporosis, and more frequently, sarcopenic obesity are commonly associated with aging and frequently closely linked each other, often leading to the development of a frailty syndrome. Frailty syndrome favors an increased risk of loss function in daily activities, for cardiovascular diseases, cancers, falls, and mortality. As the number of eld...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research

Beneficial Effects of Adrenal Androgen Supplement in Bleeding Cirrhotic Rats
In conclusion, androgen deficiency exists in bleeding cirrhotic rats. DHEA augments terlipressin-induced amelioration of shock without influencing splanchnic hemodynamics, possibly rendering it a feasible adjunct to vasoconstrictors in variceal hemorrhage.
Source: Shock - November 14, 2018 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

Current practices and safety of medication use during rapid sequence intubation
Conclusions Medication practices during RSI vary amongst provider and medications are often used inappropriately. There is opportunity for optimization of medication use during RSI.
Source: Journal of Critical Care - March 23, 2018 Category: Gastroenterology Source Type: research

The Medical Emergency Of Otto Warmbier
All that the doctors who treated Cincinnati, Ohio resident Otto Warmbier knew is what they had seen or maybe read in the news. They knew he had just been released on June 13 from imprisonment in North Korea where he had been held by for more than 17 months. He had been sentenced in March 2016 to 15 years of hard labor for allegedly removing a propaganda poster from a wall at a Pyongyang hotel where he had been staying. The University of Virginia honors student had been visiting the authoritarian state during a five-day trip with a group called Young Pioneer Tours, which is a group out of China – an important note. Ot...
Source: Healthy Living - The Huffington Post - June 22, 2017 Category: Consumer Health News Source Type: news

Transcatheter aortic valve implantation in patients on corticosteroid therapy
AbstractTranscatheter aortic valve implantation (TAVI) is recommended for patients who are inoperable or at high risk for surgical aortic valve replacement (SAVR). Corticosteroid therapy is considered to be a risk factor for SAVR, but there is a paucity of information about TAVI in patients taking corticosteroids. The aim of this study is to elucidate the outcome of TAVI in patients on chronic corticosteroid therapy, compared with SAVR. We retrospectively analyzed patients on corticosteroid therapy who underwent TAVI (n = 21) or SAVR (n = 30) for severe aortic stenosis in Sakakibara Heart Institute. Primary outcome was...
Source: Heart and Vessels - May 23, 2017 Category: Cardiology Source Type: research

SMART-AF: Development of a decision support smartphone app to improve antithrombotic prescribing in atrial fibrillation
Appropriate thromboprophylaxis in patients with atrial fibrillation (AF) is highly effective in reducing the risk of stroke. Previous studies have demonstrated underuse of anticoagulants in high-risk patients, and while the introduction of non-vitamin K antagonist oral anticoagulants (NOACs) may increase access to anticoagulation, these agents are associated with a new range of clinical problems necessitating improved prescriber support.
Source: Research in Social and Administrative Pharmacy - August 21, 2016 Category: Pharmaceuticals Authors: Leanne Chalmers, Luke R.E. Bereznicki, Ritam Prasad, Nicole Hancock, Paul D. MacIntyre, Duncan S. McKenzie, Camille M. Boland, Bridget E. Frain, Paris Buttfield-Addison Tags: Online Abstract Source Type: research

Risk Factor Optimization and Guideline-Directed Medical Therapy in US Veterans With Peripheral Arterial and Ischemic Cerebrovascular Disease Compared to Veterans With Coronary Heart Disease
Cardiovascular disease (CVD) is a systemic process involving multiple vascular beds and includes coronary heart disease (CHD), ischemic cerebrovascular disease (ICVD), and peripheral arterial disease (PAD). All these manifestations are associated with an increased risk of subsequent myocardial infarction, stroke, and death. Guideline-directed medical therapy is recommended for all patients with CVD. In a cohort of US veterans, we identified 1,242,015 patients with CVD receiving care in 130 Veterans Affairs facilities from October 1, 2013 to September 30, 2014.
Source: The American Journal of Cardiology - July 28, 2016 Category: Cardiology Authors: Ravi S. Hira, Jennifer B. Cowart, Julia M. Akeroyd, David J. Ramsey, Yashashwi Pokharel, Vijay Nambi, Hani Jneid, Anita Deswal, Ali Denktas, Addison Taylor, Khurram Nasir, Christie M. Ballantyne, Laura A. Petersen, Salim S. Virani Tags: Coronary Artery Disease Source Type: research

Risk Factor Optimization And Guideline Directed Medical Therapy In US Veterans With Peripheral Arterial And Ischemic Cerebrovascular Disease Compared To Veterans With Coronary Heart Disease
Cardiovascular disease (CVD) is a systemic process involving multiple vascular beds and includes coronary heart disease (CHD), ischemic cerebrovascular disease (ICVD) and peripheral arterial disease (PAD). All these manifestations are associated with an increased risk of subsequent myocardial infarction, stroke and death. GDMT is recommended for all patients with CVD. In a cohort of US veterans, we identified 1,242,015 patients with CVD receiving care in 130 Veterans Affairs facilities between 10/1/2013 and 9/30/2014.
Source: The American Journal of Cardiology - July 28, 2016 Category: Cardiology Authors: Ravi S. Hira, Jennifer B. Cowart, Julia M. Akeroyd, David J. Ramsey, Yashashwi Pokharel, Vijay Nambi, Hani Jneid, Anita Deswal, Ali Denktas, Addison Taylor, Khurram Nasir, Christie M. Ballantyne, Laura A. Petersen, Salim S. Virani Source Type: research

Autism in the Son of a Woman with Mitochondrial Myopathy and Dysautonomia: A Case Report
Conclusion Given emerging evidence that mitochondrial dysfunction, particularly in the electron transport chain needed for cellular energy production, is an underlying pathophysiological mechanism for some varieties of ASD, clinicians should have a high index of suspicion for mitochondrial disease, especially when they encounter a patient with unusual neurological or constitutional symptoms. The prevalence of mitochondrial disease in ASD patients may be as high as five percent, which means that it is not the “zebra”[27] diagnosis that it might be in a non-ASD patient, where prevalence is about 0.01 percent.10 Reference...
Source: Innovations in Clinical Neuroscience - October 9, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Asperger's syndrome Autism Behavioral and Cognitive Neurology Case Report Current Issue Intellectual Disability Neurologic Systems and Symptoms Pervasive Developmental Disorders ASD autism spectrum disorder dysauton Source Type: research

Hypopituitarism in neurocritical patients: A Case Report.
We report a case of a 72-year-old woman showing clinical signs and laboratory data suggesting a secondary adrenal insufficiency following a recent acute brain ischemia. Cortisone therapy significantly improved this pituitary dysfunction. Therefore, clinicians must pay attention to the hypothalamic-pituitary axis in neurocritical patients because hormonal replacement therapy may be life-saving. PMID: 26420547 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 3, 2015 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Inpatient complications in patients with giant cell arteritis: decreased mortality and increased risk of thromboembolism, delirium and adrenal insufficiency
Conclusion: Hospitalized GCA patients have lower mortality compared with the general inpatient population but greater risk of venous thromboembolism, delirium and adrenal insufficiency.
Source: Rheumatology - July 14, 2015 Category: Rheumatology Authors: Unizony, S., Menendez, M. E., Rastalsky, N., Stone, J. H. Tags: Vasculitis CLINICAL SCIENCE Source Type: research

Relative Adrenal Insufficiency amongst Hospitalized Mild to Moderate Acute Ischemic Stroke Patients.
CONCLUSION: This is the first study demonstrating the prevalence of relative adrenal insufficiency amongst acute ischemic stroke patients. Utilizing the LDST, relative adrenal insufficiency was found more sensitive in detecting relative adrenal insufficiency in patients with acute ischemic stroke as compared to SDST. PMID: 25644796 [PubMed - in process]
Source: Archives of Iranian Medicine - February 1, 2015 Category: Middle East Health Authors: Wahab NA, Abdul Razak NZ, Sukor N, Zainudin S, Razali AM, Mustafa N, Wan Yahya WN, Kamaruddin NA Tags: Arch Iran Med Source Type: research

Influence of Intracerebral Hemorrhage Location on Incidence, Characteristics, and Outcome: Population-Based Study Clinical Sciences
Conclusions— The baseline characteristics and outcome of lobar ICH differ from other locations.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Samarasekera, N., Fonville, A., Lerpiniere, C., Farrall, A. J., Wardlaw, J. M., White, P. M., Smith, C., Al-Shahi Salman, R., for the Lothian Audit of the Treatment of Cerebral Haemorrhage Collaborators, Addison, Ahmad, Alhadad, Andrews, Bisset, Bodkin, B Tags: Acute Cerebral Hemorrhage Clinical Sciences Source Type: research