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Condition: Inflammatory Bowel Disease

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Total 222 results found since Jan 2013.

Pentraxin 3 in Cardiovascular Disease
Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier
We examined a possible protective effect of OX-A against LPS-induced ROS formation and microglia activation. To mimic in vitro the connection between gut and brain and to study the putative effect on the cortical microglia, we used a co-culture of Caco-2 cells and primary cortical microglia with Caco-2 cells placed at the apical side of a transwell and primary cortical microglia at the basolateral side. All treatments used to study the apical vs. basal connection were applied to the apical compartment. We used DHR (10 μM, 20 min), a cell-permeable fluorogenic probe useful for the detection of ROS formation, to dete...
Source: Frontiers in Endocrinology - April 9, 2019 Category: Endocrinology Source Type: research

Not Just Acid Reflux: The Need to Think Worst First
Discussion Heart disease is the leading cause of death in the United States.1 This year, 720,000 Americans will have a new coronary event—defined as first hospitalized myocardial infarction (MI) or coronary heart disease death—and around 335,000 will have a recurrent event. Approximately 35% of people who experience a coronary event in a given year and around 14% of patients who have an acute coronary syndrome will die from it.1 Roughly 60% of patients with an acute coronary syndrome are transported to the emergency department via ambulance.2–4. Up to one-third of patients experiencing an MI may not complain of chest...
Source: JEMS Special Topics - January 13, 2019 Category: Emergency Medicine Authors: Stephen Sanko, MD, FACEP Tags: Exclusive Articles Cardiac & Resuscitation Source Type: news

Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke
Emerging evidence suggests that gut-brain-microbiota axis (GBMAx) may play a pivotal role linking gastrointestinal and neuronal disease. In this review, we summarize the latest advances in studies of GBMAx in ...
Source: Journal of Neuroinflammation - December 11, 2018 Category: Neurology Authors: Liang Zhao, Qiutang Xiong, Creed M. Stary, Omer Kamal Mahgoub, Yingze Ye, Lijuan Gu, Xiaoxing Xiong and Shengmei Zhu Tags: Review Source Type: research

Air Pollution and Non-Communicable Diseases: A review by the Forum of International Respiratory Societies' Environmental Committee. Part 2: Air pollution and organ systems.
Abstract Although air pollution is well-known to be harmful to the lung and airways, it can also damage most other organ systems of the body. It is estimated that about 500,000 lung cancer deaths and 1.6 million chronic obstructive pulmonary disease (COPD) deaths can be attributed to air pollution, but air pollution may also account for 19% of all cardiovascular deaths and 21% of all stroke deaths. Air pollution has been linked to other malignancies, such as bladder cancer and childhood leukemia. Lung development in childhood is stymied with exposure to air pollutants, and poor lung development in children predict...
Source: Chest - November 9, 2018 Category: Respiratory Medicine Authors: Schraufnagel DE, Balmes J, Cowl CT, De Matteis S, Jung SH, Mortimer K, Perez-Padilla R, Rice MB, Riojas-Rodroguez H, Sood A, Thurston GD, To T, Vanker A, Wuebbles DJ Tags: Chest Source Type: research

Concise Review: Using Fat to Fight Disease: A Systematic Review of Nonhomologous Adipose ‐Derived Stromal/Stem Cell Therapies
The objective of this Review is to describe the safety and efficacy of adipose stem/stromal cells (ASC) and stromal vascular fraction (SVF) in treating common diseases and the next steps in research that must occur prior to clinical use. Pubmed, Ovid Medline, Embase, Web of Science, and the Cochrane Library were searched for articles about use of SVF or ASC for disease therapy published between 2012 and 2017. One meta ‐analysis, 2 randomized controlled trials, and 16 case series were included, representing 844 human patients. Sixty‐nine studies were performed in preclinical models of disease. ASCs improved symptoms, fi...
Source: Stem Cells - September 5, 2018 Category: Stem Cells Authors: Marjorie E. Bateman, Amy L. Strong, Jeffrey M. Gimble, Bruce A. Bunnell Tags: Regenerative Medicine Source Type: research

Cardiac and autonomic function in patients with Crohn's disease during remission.
CONCLUSIONS: Crohn's disease patients in remission have preserved cardiac and autonomic function in response to cardiovascular reflex tests with a shift in cardiovascular autonomic regulation towards sympathetic predominate in the rest position. PMID: 30053718 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - July 24, 2018 Category: Biomedical Science Authors: Zawadka-Kunikowska M, Słomko J, Kłopocka M, Liebert A, Tafil-Klawe M, Klawe JJ, Newton JL, Zalewski P Tags: Adv Med Sci Source Type: research

Vascular Involvement in Axial Spondyloarthropathies
Publication date: Available online 19 May 2018Source: Joint Bone SpineAuthor(s): Clément Prati, Céline Demougeot, Xavier Guillot, Maxime Sondag, Frank Verhoeven, Daniel WendlingAbstractAnkylosing spondylitis (AS) is a chronic inflammatory joint disease that involves the entheses, causing inflammatory pain and functional impairments. Patients may experience extraarticular manifestations such as uveitis, psoriasis, and inflammatory bowel disease. These, together with the increased risk of cardiovascular disease and osteoporosis and the development of spinal fusion, are the main determinants of adverse disease outcomes. As ...
Source: Joint Bone Spine - July 10, 2018 Category: Orthopaedics Source Type: research

Risk of gallstones in patients with obstructive sleep apnea: a nationwide observational cohort study
ConclusionThe study shows a strong association between OSA and gallstones. Moreover, our findings suggest the requirement for survey and health education for gallstones in OSA and further studies to verify whether the treatment of OSA can reduce the risk of gallstones.
Source: Sleep and Breathing - July 7, 2018 Category: Respiratory Medicine Source Type: research

Risk of gallstones in patients with obstructive sleep apnea: a nationwide observational cohort study.
CONCLUSION: The study shows a strong association between OSA and gallstones. Moreover, our findings suggest the requirement for survey and health education for gallstones in OSA and further studies to verify whether the treatment of OSA can reduce the risk of gallstones. PMID: 29980983 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - July 7, 2018 Category: Sleep Medicine Authors: Chen CH, Lin CL, Hsu CY, Kao CH Tags: Sleep Breath Source Type: research

Vascular Involvement in Axial Spondyloarthropathies
Publication date: Available online 19 May 2018Source: Joint Bone SpineAuthor(s): Clément Prati, Céline Demougeot, Xavier Guillot, Maxime Sondag, Frank Verhoeven, Daniel WendlingAbstractAnkylosing spondylitis (AS) is a chronic inflammatory joint disease that involves the entheses, causing inflammatory pain and functional impairments. Patients may experience extraarticular manifestations such as uveitis, psoriasis, and inflammatory bowel disease. These, together with the increased risk of cardiovascular disease and osteoporosis and the development of spinal fusion, are the main determinants of adverse disease outcomes. As ...
Source: Joint Bone Spine - July 5, 2018 Category: Orthopaedics Source Type: research

IJERPH, Vol. 15, Pages 513: Association between Inflammatory Bowel Disease and Cholelithiasis: A Nationwide Population-Based Cohort Study
g Kao We assessed the subsequent risk of cholelithiasis development in patients with inflammatory bowel diseases (IBDs) such as Crohn’s disease (CD) or ulcerative colitis (UC). We identified 8186 patients who aged ≥20 years and were diagnosed with IBD between 2000 and 2010 as the study cohort. A total of 8186 patients without IBD were selected by frequency-matching according to age, sex, comorbidities, and the index date of diagnosis, and they were identified as the control cohort. To measure the incidence of cholelithiasis, all patients were followed up until the end of 2011. The risk of developing cholelithiasis,...
Source: International Journal of Environmental Research and Public Health - March 14, 2018 Category: Environmental Health Authors: Chien-Hua Chen Cheng-Li Lin Chia-Hung Kao Tags: Article Source Type: research