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Condition: Inflammatory Bowel Disease
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Total 222 results found since Jan 2013.
Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review)
Int J Mol Med. 2023 Apr;51(4):35. doi: 10.3892/ijmm.2023.5238. Epub 2023 Mar 24.ABSTRACTThe inflammasome regulates innate immunity by serving as a signaling platform. The Nod‑like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein apoptosis‑associated speck‑like protein (ASC) and pro‑caspase‑1, is by far the most extensively studied and well‑characterized inflammasome. A variety of stimuli can activate the NLRP3 inflammasome. When activated, the NLRP3 protein recruits the adaptor ASC protein and activates pro‑caspase‑1, resulting in inflammatory cytokine maturation and secreti...
Source: International Journal of Molecular Medicine - March 24, 2023 Category: Molecular Biology Authors: Xiaolu Zhang Ziyu Wang Yujia Zheng Qun Yu Miao Zeng Liding Bai Lin Yang Maojuan Guo Xijuan Jiang Jiali Gan Source Type: research
Antimicrobial peptide cathelicidin LL-37 preserves intestinal barrier and organ function in rats with heat stroke
Biomed Pharmacother. 2023 Mar 21;161:114565. doi: 10.1016/j.biopha.2023.114565. Online ahead of print.ABSTRACTGlobal warming increases the incidence of heat stroke (HS) and HS causes the reduction of visceral blood flow during hyperthermia, leading to intestinal barrier disruption, microbial translocation, systemic inflammation and multiple organ failure. Cathelicidin LL-37 exhibits antimicrobial activities, helps innate immunity within the gut to maintain intestinal homeostasis, and augments intestinal wound healing and barrier function. Thus, we evaluated the effects and possible mechanisms of cathelicidin LL-37 on HS. W...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2023 Category: Drugs & Pharmacology Authors: Chih-Chin Shih Wei-Chieh Liao Hung-Yen Ke Chia-Wen Kuo Cheng-Ming Tsao Wen-Chiuan Tsai Yi-Lin Chiu Hsieh-Chou Huang Chin-Chen Wu Source Type: research
Acori Tatarinowii Rhizoma: A comprehensive review of its chemical composition, pharmacology, pharmacokinetics and toxicity
Acori Tatarinowii Rhizoma (ATR, Shi Chang Pu in Chinese), a natural product with multiple targets in various diseases. This review provides the comprehensive summary of the chemical composition, pharmacological effects, pharmacokinetics parameters and toxicity of ATR. The results indicated that ATR possesses a wide spectrum of chemical composition, including volatile oil, terpenoids, organic acids, flavonoids, amino acids, lignin, carbohydrates and so on. Accumulating evidence from various studies has shown that ATR exerts a wide range of pharmacological properties, including protecting nerve cells, alleviating learning an...
Source: Frontiers in Pharmacology - March 16, 2023 Category: Drugs & Pharmacology Source Type: research
Inflammatory Bowel Disease and Neurodegenerative Diseases
Gut Liver. 2023 Feb 27. doi: 10.5009/gnl220523. Online ahead of print.ABSTRACTA growing body of evidence has demonstrated an intricate association between inflammatory bowel disease (IBD) and neurodegenerative conditions, expanding beyond previous foci of comorbidities between IBD and mood disorders. These new discoveries stem from an improved understanding of the gut-microbiome-brain axis: specifically, the ability of the intestinal microbiota to modulate inflammation and regulate neuromodulatory compounds. Clinical retrospective studies incorporating large sample sizes and population-based cohorts have demonstrated and c...
Source: Gut and Liver - February 27, 2023 Category: Gastroenterology Authors: Jin Sun Kim Mu-Hong Chen Hohui E Wang Ching-Liang Lu Yen-Po Wang Bing Zhang Source Type: research
