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Specialty: Endocrinology
Condition: Heart Disease

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Total 288 results found since Jan 2013.

Abdominal fat increases heart disease risk of healthy weight women
According to a long-term study, published in theEuropean Heart Journal, even women of healthy weight who tend to carry more abdominal fat than leg fat have an elevated risk of heart disease and stroke postmenopause.BBC News
Source: Society for Endocrinology - July 1, 2019 Category: Endocrinology Source Type: news

Prediction of 5-year risk of diabetes mellitus in relatively low risk middle-aged and elderly adults
ConclusionsFasting plasma glucose level, BMI, and triglyceride level were still dominated factors to predict 5-year diabetic risk among the relatively low risk participants. The cutoff values for fasting plasma glucose, TG, and BMI set as 5.89  mmol/L, 1.1 mmol/L, and 24 kg/m2, respectively, had the best predictive discrimination of diabetes.
Source: Acta Diabetologica - June 11, 2019 Category: Endocrinology Source Type: research

Vitamin D status and cardiovascular outcome
AbstractIntroductionVitamin D is classically involved in maintaining bone and mineral health, but it has been shown to exert many extraskeletal functions, including pleiotropic effects on cardiovascular system.Materials and methodThis review aims to summarize evidences in literature about vitamin D and cardiovascular outcome.Results and conclusionsCalcitriol or 1,25(OH)2D, the active hormone, binds to the specific nuclear receptor VDR, which is expressed in rat and human heart and vasculature and has effects on myocardiocytes, smooth cells, and endothelial cells. 25-Hydroxy-vitamin D (25OHD) represents the biomarker of vit...
Source: Journal of Endocrinological Investigation - June 5, 2019 Category: Endocrinology Source Type: research

Subclinical vascular disease in patients with diabetes is associated with insulin resistance
Publication date: Available online 23 May 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): María M. Adeva-Andany, Raquel Funcasta-Calderón, Carlos Fernández-Fernández, Eva Ameneiros-Rodríguez, Alberto Domínguez-MonteroAbstractPatients with diabetes experience increased cardiovascular risk that is not fully explained by deficient glycemic control or traditional cardiovascular risk factors such as smoking and hypercholesterolemia. Asymptomatic patients with diabetes show structural and functional vascular damage that includes impaired vasodilation, arterial stiffness, increased intima-me...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - May 23, 2019 Category: Endocrinology Source Type: research

Cardiovascular Disease in Patients with Type 2 Diabetes and in Patients Starting Empagliflozin Treatment: Nationwide Survey
ConclusionThe prevalence of CVD in patients with type 2 diabetes in clinical practice in Sweden was 28.3% during the study period, and it was 11.5% in the patients starting empagliflozin treatment. Patients of the latter cohort were, however, younger, more obese, and more likely to have unsatisfactory glycemic control, requiring additional treatment. Overall, a large proportion of type 2 diabetes patients should be considered at high cardiovascular risk.FundingBoehringer Ingelheim AB, Sweden.
Source: Diabetes Therapy - May 13, 2019 Category: Endocrinology Source Type: research

The dietary transition and its association with cardiometabolic mortality among Chinese adults, 1982–2012: a cross-sectional population-based study
Publication date: Available online 10 May 2019Source: The Lancet Diabetes & EndocrinologyAuthor(s): Yuna He, Yanping Li, Xiaoguang Yang, Elena C Hemler, Yuehui Fang, Liyun Zhao, Jian Zhang, Zhenyu Yang, Zhu Wang, Li He, Jing Sun, Dong D Wang, Jingzhong Wang, Jianhua Piao, Xiaofeng Liang, Gangqiang Ding, Frank B HuSummaryBackgroundFew studies have used nationally representative data to describe dietary trends and the related cardiometabolic mortality burden in China. Thus, we aimed to characterise the trends in disease-related dietary factors as well as their associated disease burden among Chinese adults from 1982 to 2012....
Source: The Lancet Diabetes and Endocrinology - May 12, 2019 Category: Endocrinology Source Type: research

Editorial: Telomeres and Epigenetics in Endocrinology
This study was hypothesis-driven; the genetic variants were selected for being previously and substantially genotyped. The big sample size and the rich panel of other biomarkers allowed the authors to conduct much more detailed analyses on this topic. The third article by Provenzi et al. proposed their perspectives on the role of telomeres in premature birth and discussed the potential implications for early adversity and care in the neonatal intensive care unit (Pavanello et al.). Indeed, the speculation of telomeres in aging begins in the premature aging syndrome. It is thus interesting to examine if telomeres also play...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research

Association of C-peptide with diabetic vascular complications in type 2 diabetes.
CONCLUSION: -: C-peptide was positively associated with CVD, but inversely associated with DR progression. The association between C-peptide and CVD could be due to associated metabolic risk factors. PMID: 31026551 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism - April 22, 2019 Category: Endocrinology Authors: Wang Y, Wan H, Chen Y, Xia F, Zhang W, Wang C, Fang S, Zhang K, Li Q, Wang N, Lu Y Tags: Diabetes Metab Source Type: research

Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - April 8, 2019 Category: Endocrinology Source Type: research

Aging and the Male Reproductive System.
Authors: Kaufman JM, Lapauw B, Mahmoud A, T'Sjoen G, Huhtaniemi IT Abstract This narrative review presents an overview of present knowledge on fertility and reproductive hormones changes in aging men, the factors driving and modulating these changes, their clinical consequences, and benefits and risks of testosterone (T) therapy. Aging is accompanied by moderate decline of gamete quality and fertility. Population mean levels show mild total T decline, SHBG increase, steeper free T decline, and moderate LH increase with important contribution of comorbidities (e.g. obesity) to these changes. Sexual symptoms and lowe...
Source: Endocrine Reviews - March 20, 2019 Category: Endocrinology Tags: Endocr Rev Source Type: research

Trans fatty acids and lipid profile: A serious risk factor to cardiovascular disease, cancer and diabetes
The objective of the review to demonstrate the causal association between trans fatty acid intake and increase the risk of coronary heart disease through their influence on lipoprotein, association with atherosclerosis, stroke, diabetes and cancer.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - March 17, 2019 Category: Endocrinology Source Type: research

Role of protein kinase C inhibition in the development of diabetic microvascular complications.
Authors: Skljarevski V, Ferdinand SJ, Kles KA Abstract Diabetes mellitus affects millions of people in the USA and throughout the world. The global epidemic may be attributed to both the increasing age of the population and the increasing rates of obesity. Diabetes is associated with chronic microvascular (diabetic neuropathy, retinopathy and nephropathy) and macrovascular complications (heart disease, stroke and peripheral vascular disease). Patients with diabetes benefit from a comprehensive approach to prevent complications, including weight loss, smoking cessation, antiplatelet agents, and glycemic and blood pr...
Source: Expert Review of Endocrinology and Metabolism - February 15, 2019 Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research

Behavioral Strategies to Lower Postprandial Glucose in Those with Type 2 Diabetes May Also Lower Risk of Coronary Heart Disease
ConclusionThese secondary analyses suggest that broad-spectrum lifestyle interventions that focus on lowering PPG may lower the risk of future CHD, which could guide future research.Trial RegistrationClinicalTrials.gov ID: NCT02432391.
Source: Diabetes Therapy - December 18, 2018 Category: Endocrinology Source Type: research

Use of liraglutide and risk of major cardiovascular events: a register-based cohort study in Denmark and Sweden
Publication date: Available online 5 December 2018Source: The Lancet Diabetes & EndocrinologyAuthor(s): Henrik Svanström, Peter Ueda, Mads Melbye, Björn Eliasson, Ann-Marie Svensson, Stefan Franzén, Soffia Gudbjörnsdottir, Kristian Hveem, Christian Jonasson, Björn PasternakSummaryBackgroundTrial evidence shows that the glucagon-like peptide-1 receptor agonist liraglutide significantly reduces the risk of major cardiovascular events among patients with type 2 diabetes who have established cardiovascular disease or are at high cardiovascular risk. We aimed to assess the cardiovascular effectiveness of liraglutide in rou...
Source: The Lancet Diabetes and Endocrinology - December 6, 2018 Category: Endocrinology Source Type: research

Galectin ‐3 and risk of cardiovascular events and all‐cause mortality in type 2 diabetes
ConclusionsSerum galectin ‐3 is associated with adverse cardiovascular outcomes in persons with type 2 diabetes independent of traditional risk factors.
Source: Diabetes/Metabolism Research and Reviews - November 15, 2018 Category: Endocrinology Authors: Kathryn C.B. Tan, Ching ‐Lung Cheung, Alan C.H. Lee, Joanne K.Y. Lam, Ying Wong, Sammy W.M. Shiu Tags: RESEARCH ARTICLE Source Type: research