Towards a Robust Definition of Sport Sex
Endocr Rev. 2024 Apr 5:bnae013. doi: 10.1210/endrev/bnae013. Online ahead of print.ABSTRACTElite individual sports in which success depends on power, speed or endurance are conventionally divided into male and female events using traditional binary definitions of sex. Male puberty creates durable physical advantages due to the 20-30-fold increase in circulating testosterone producing a sustained uplift in men's muscle, bone, hemoglobin, and cardiorespiratory function resulting from male puberty and sustained during men's lives. These male physical advantages provide strong justification for separate protected category of f...
Source: Endocrine Reviews - April 5, 2024 Category: Endocrinology Authors: David J Handelsman Source Type: research
The glucocorticoid receptor: isoforms, functions, and contribution to glucocorticoid sensitivity
Endocr Rev. 2024 Mar 29:bnae008. doi: 10.1210/endrev/bnae008. Online ahead of print.ABSTRACTGlucocorticoids exert pleiotropic effects on all tissues to regulate cellular and metabolic homeostasis. Synthetic forms are used therapeutically in a wide range of conditions for their anti-inflammatory benefits at the cost of dose and duration-dependent side effects. Significant variability occurs between tissues, disease states, and individuals with regard to both the beneficial and deleterious effects. The glucocorticoid receptor is the site of action for these hormones and a vast body of work has been conducted understanding it...
Source: Endocrine Reviews - March 29, 2024 Category: Endocrinology Authors: Jack Lockett Warrick J Inder Vicki L Clifton Source Type: research
