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Specialty: Endocrinology
Condition: Heart Disease

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Total 288 results found since Jan 2013.

Polymorphisms of rs174616 in the gene cluster is associated with a reduced risk of type 2 diabetes mellitus in northern Han Chinese people
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease and is a major risk factor for serious complications such as coronary heart disease, stroke and peripheral arterial disease [1].
Source: Diabetes Research and Clinical Practice - March 26, 2015 Category: Endocrinology Authors: Min Yao, Jing Li, Tian Xie, Tianbo He, Lijia Fang, Yun Shi, Lianguo Hou, Kaoqi Lian, Ruiying Wang, Lingling Jiang Source Type: research

The association of atopy with incidence of ischemic heart disease, stroke, and diabetes
Abstract Allergy is a systemic inflammatory disease that could theoretically affect the risk of cardiovascular disease (CVD) and diabetes through inflammatory pathways or mast cell-induced coronary spasm. Whether allergy is associated with an increased risk of CVD and diabetes is largely unknown. We investigated the association between atopy as assessed by IgE sensitization, a well-accepted biomarker of allergy, and incidence of ischemic heart disease, stroke, and diabetes in five Danish population-based cohorts. A total of 14,849 participants were included in the study. Atopy was defined as serum-specific IgE po...
Source: Endocrine - March 1, 2015 Category: Endocrinology Source Type: research

Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis
Publication date: Available online 26 February 2015 Source:The Lancet Diabetes & Endocrinology Background To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of inflammation. Methods We created a genetic score combining the effects of alleles of two common variants (rs6743376 and rs1542176) that are located upstream of IL1RN, the gene encoding the IL-1 receptor antagonist (IL-1Ra; an endogenous inhibitor of both IL-1α and IL-1β); both alleles increase soluble IL-1Ra ...
Source: The Lancet Diabetes and Endocrinology - February 26, 2015 Category: Endocrinology Source Type: research

Emerging cardiovascular indications of mineralocorticoid receptor antagonists.
Abstract Mineralocorticoid receptor (MR) antagonism is a well-established treatment modality for patients with hypertension, heart failure, and left ventricular systolic dysfunction (LVSD) post-myocardial infarction (MI). There are emerging data showing potential benefits of MR antagonists in other cardiovascular conditions. Studies have shown association between MR activation and the development of myocardial fibrosis, coronary artery disease, metabolic syndrome, and cerebrovascular diseases. This review examines the preclinical and clinical data of MR antagonists for novel indications including heart failure wit...
Source: Trends in Endocrinology and Metabolism: TEM - February 20, 2015 Category: Endocrinology Authors: Parviz Y, Iqbal J, Pitt B, Adlam D, Al-Mohammad A, Zannad F Tags: Trends Endocrinol Metab Source Type: research

Subclinical hypothyroidism and the associations with macrovascular complications and chronic kidney disease in patients with Type 2 diabetes
ConclusionsThis study provides evidence that SCH in patients with Type 2 diabetes is associated with a high prevalence of CHD (and CKD in severe SCH), although not with ischaemic stroke.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - February 12, 2015 Category: Endocrinology Authors: Fang Jia, Jing Tian, Fuxue Deng, Gangyi Yang, Min Long, Wei Cheng, Bo Wang, Jinlin Wu, Dongfang Liu Tags: Research Article Source Type: research

Risk of all-cause mortality and vascular events in women versus men with type 1 diabetes: a systematic review and meta-analysis
Publication date: Available online 6 February 2015 Source:The Lancet Diabetes & Endocrinology Author(s): Rachel R Huxley , Sanne A E Peters , Gita D Mishra , Mark Woodward Background Studies have suggested sex differences in the mortality rate associated with type 1 diabetes. We did a meta-analysis to provide reliable estimates of any sex differences in the effect of type 1 diabetes on risk of all-cause mortality and cause-specific outcomes. Methods We systematically searched PubMed for studies published between Jan 1, 1966, and Nov 26, 2014. Selected studies reported sex-specific estimates of the standardised m...
Source: The Lancet Diabetes and Endocrinology - February 6, 2015 Category: Endocrinology Source Type: research

Endogenous Testosterone and its relationship to preclinical and clinical measures of cardiovascular disease in the Atherosclerosis Risk in Communities (ARIC) Study.
Conclusions: Low male plasma T is cross-sectionally associated with key CVD risk factors, but after adjustment there was no association with mean cIMT, incident cardiac events, or mortality. Our results are reassuring that neither high nor low T levels directly predict atherosclerosis, but are a marker for other cardiovascular risk factors. PMID: 25584720 [PubMed - as supplied by publisher]
Source: Diabetes Metab - January 13, 2015 Category: Endocrinology Authors: Srinath R, Hill Golden S, Carson KA, Dobs A Tags: J Clin Endocrinol Metab Source Type: research

Contrary to popular belief, not all obese people are at risk for disease
Findings published this week in The Journal of Clinical Investigation demonstrate that some obese people are protected from the adverse metabolic effects of moderate weight gain (such as, diabetes, heart disease and stroke) while others are predisposed to these problems. Medical Daily  
Source: Society for Endocrinology - January 5, 2015 Category: Endocrinology Source Type: news

Cardiovascular Risk Associated with Acarbose versus Metformin as the First-line Treatment in Patients with Type 2 Diabetes: a Nationwide Cohort Study.
Conclusion: Our data do not support that acarbose has a cardio-protective effect similar to metformin as a first-line anti-diabetic agent. PMID: 25555040 [PubMed - as supplied by publisher]
Source: Diabetes Metab - January 2, 2015 Category: Endocrinology Authors: Chang C, Chang Y, Lin J, Chen S, Chuang L, Lai M Tags: J Clin Endocrinol Metab Source Type: research

Biomarkers of progression in diabetic nephropathy – the past, present and future
This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - January 1, 2015 Category: Endocrinology Authors: CH Lee, KSL Lam Tags: Editorial Source Type: research

Association of leptin levels with pathogenetic risk of coronary heart disease and stroke: a meta-analysis
Conclusion There was a significant association of leptin with pathogenetic risk of CHD and stroke, and raised leptin levels could significantly increase the pathogenetic risk of CHD. Objetivo O objetivo desta metanálise foi investigar a associação entre os níveis de leptina e o risco patogenético de doença arterial coronariana e acidente vascular cerebral. Materiais e métodos Foram identificados estudos nas bases de dados PubMed, Embase e Springer Link sem restrição quanto à língua. A razão de chances (OR) e os intervalos de confiança de 95% correspondentes (95% CI) foram usados como índices de efeitos. A as...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - December 11, 2014 Category: Endocrinology Source Type: research

Impact of diabetes‐related complications on healthcare costs: new results from the UK Prospective Diabetes Study
ConclusionsDiabetic complications are associated with substantial immediate and long‐term healthcare costs. Our comprehensive new estimates of these costs, derived from detailed recent UK Prospective Diabetes Study post‐trial data, should aid researchers and health policy analyses.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - November 29, 2014 Category: Endocrinology Authors: M. L. Alva, A. Gray, B. Mihaylova, J. Leal, R. R. Holman Tags: Research Article Source Type: research

The impact of diabetes‐related complications on healthcare costs: new results from the UKPDS (UKPDS 84)
ConclusionsDiabetic complications are associated with substantial immediate and long‐term healthcare costs. Our comprehensive new estimates of these costs, derived from detailed recent UK Prospective Diabetes Study post‐trial data, should aid researchers and health policy analyses.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - November 29, 2014 Category: Endocrinology Authors: M. L. Alva, A. Gray, B. Mihaylova, J. Leal, R. R. Holman Tags: Research Article Source Type: research

Cardiovascular risk factors and events in women with androgen excess
Abstract Androgen excess (AE) was approximated to be present in 7 % of the adult population of women. Polycystic ovary syndrome (PCOS) is the most prevalent among them, followed by idiopathic hirsutism (IH), congenital adrenal hyperplasia (CAH), hyperandrogenic insulin-resistant acanthosis nigricans (HAIRAN) syndrome, and androgen-secreting neoplasms (ASNs). Increased cardiovascular risk was implicated in women with AE. Serum testosterone independently increases risk for cardiovascular disease (CVD), and correlates even with indices of subclinical atherosclerosis in various populations of postmenopausal women. Hy...
Source: Journal of Endocrinological Investigation - November 28, 2014 Category: Endocrinology Source Type: research

The role of triglyceride in cardiovascular disease in asian patients with type 2 diabetes--a systematic review.
Authors: Chen AH, Tseng CH Abstract In Asian populations, diabetes mellitus is increasing and has become an important health problem in recent decades. Cardiovascular disease (CVD) is one of the most important complications and the most common cause of death in diabetic patients. Among the risk factors of CVD, elevated low-density lipoprotein cholesterol has been a major concern. Studies suggested that serum triglyceride may also play a role in predicting CVD in patients with type 2 diabetes mellitus, but the association is still debated. In this review, we summarized published studies focusing on the relationship ...
Source: Review of Diabetic Studies - November 19, 2014 Category: Endocrinology Tags: Rev Diabet Stud Source Type: research